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Journal Articles

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors

Clin Cancer Res (2016) 22 (13): 3227–3237.

DOI: https://doi.org/10.1158/1078-0432.CCR-15-0652

Published: 30 June 2016

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Includes: Supplementary data

Journal Articles

Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin

Ulka N. Vaishampayan, Angelika M. Burger, Edward A. Sausville, Lance K. Heilbrun, Jing Li, M. Naomi Horiba, Merrill J. Egorin, Percy Ivy, Simon Pacey, Patricia M. LoRusso

Clin Cancer Res (2010) 16 (14): 3795–3804.

DOI: https://doi.org/10.1158/1078-0432.CCR-10-0503

Published: 14 July 2010

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Journal Articles

Concluding Remarks: Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates

Edward A. Sausville

Clin Cancer Res (2003) 9 (10): 4022s–4023s.

Published: 31 August 2009

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Journal Articles

Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias

Ken Shiozawa, Takeo Nakanishi, Ming Tan, Hong-Bin Fang, Wen-chyi Wang, Martin J. Edelman, David Carlton, Ivana Gojo, Edward A. Sausville, Douglas D. Ross

Clin Cancer Res (2009) 15 (5): 1698–1707.

DOI: https://doi.org/10.1158/1078-0432.CCR-08-1587

Published: 27 February 2009

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Includes: Supplementary data

Journal Articles

Phospho-p70S6K/p85S6K and cdc2/cdk1 Are Novel Targets for Diffuse Large B-Cell Lymphoma Combination Therapy

Merry Y. Zhao, Aaron Auerbach, Anisha M. D'Costa, Aaron P. Rapoport, Angelika M. Burger, Edward A. Sausville, Sanford A. Stass, Feng Jiang, Amy M. Sands, Nadine Aguilera, X. Frank Zhao

Clin Cancer Res (2009) 15 (5): 1708–1720.

DOI: https://doi.org/10.1158/1078-0432.CCR-08-1543

Published: 27 February 2009

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Journal Articles

Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation

Curtis Hose, Gurmeet Kaur, Edward A. Sausville, Anne Monks

Clin Cancer Res (2005) 11 (17): 6370–6381.

DOI: https://doi.org/10.1158/1078-0432.CCR-05-0291

Published: 06 September 2005

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Journal Articles

7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr³⁰⁸ but not Ser⁴⁷³ Phosphorylation: A Basis for Decreased Insulin-Stimulated Glucose Transport

Sudhir B. Kondapaka, MaryJane Zarnowski, Dena R. Yver, Edward A. Sausville, Samuel W. Cushman

Clin Cancer Res (2004) 10 (21): 7192–7198.

DOI: https://doi.org/10.1158/1078-0432.CCR-04-0772

Published: 08 November 2004

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Journal Articles

Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel

Phyllis A. Svingen, David Loegering, Joe Rodriquez, Xue Wei Meng, Peter W. Mesner, Jr., Susan Holbeck, Anne Monks, Stan Krajewski, Dominic A. Scudiero, Edward A. Sausville, John C. Reed, Yuri A. Lazebnik, Scott H. Kaufmann

Clin Cancer Res (2004) 10 (20): 6807–6820.

DOI: https://doi.org/10.1158/1078-0432.CCR-0778-02

Published: 22 October 2004

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Journal Articles

Effects of α₁-Acid Glycoprotein on the Clinical Pharmacokinetics of 7-Hydroxystaurosporine

Alex Sparreboom, Huachen Chen, Milin R. Acharya, Adrian M. Senderowicz, Richard A. Messmann, Takashi Kuwabara, David J. Venzon, Anthony J. Murgo, Donna Headlee, Edward A. Sausville, William D. Figg

Clin Cancer Res (2004) 10 (20): 6840–6846.

DOI: https://doi.org/10.1158/1078-0432.CCR-04-0805

Published: 22 October 2004

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Journal Articles

In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines

Girija P. Dasmahapatra, Parijat Didolkar, Michael C. Alley, Somiranjan Ghosh, Edward A. Sausville, Krishnendu K. Roy

Clin Cancer Res (2004) 10 (15): 5242–5252.

DOI: https://doi.org/10.1158/1078-0432.CCR-03-0534

Published: 05 August 2004

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Journal Articles

Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator

Gurmeet Kaur, Dorina Belotti, Angelika M. Burger, Kirsten Fisher-Nielson, Patrizia Borsotti, Elena Riccardi, Jagada Thillainathan, Melinda Hollingshead, Edward A. Sausville, Raffaella Giavazzi

Clin Cancer Res (2004) 10 (14): 4813–4821.

DOI: https://doi.org/10.1158/1078-0432.CCR-03-0795

Published: 21 July 2004

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Journal Articles

Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma: A Potential Target for UCN-01

Panomwat Amornphimoltham, Virote Sriuranpong, Vyomesh Patel, Fernando Benavides, Claudio J. Conti, John Sauk, Edward A. Sausville, Alfredo A. Molinolo, J. Silvio Gutkind

Clin Cancer Res (2004) 10 (12): 4029–4037.

DOI: https://doi.org/10.1158/1078-0432.CCR-03-0249

Published: 24 June 2004

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Journal Articles

Is Another Bcr-Abl Inhibitor Needed for Chronic Myelogenous Leukemia?

Edward A. Sausville

Clin Cancer Res (2003) 9 (4): 1233–1234.

Published: 01 April 2003

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Journal Articles

Flavopiridol-related Proinflammatory Syndrome Is Associated with Induction of Interleukin-6

Richard A. Messmann, Claudio Dansky Ullmann, Tyler Lahusen, Audrey Kalehua, Jason Wasfy, Giovanni Melillo, Ivan Ding, Donna Headlee, William D. Figg, Edward A. Sausville, Adrian M. Senderowicz

Clin Cancer Res (2003) 9 (2): 562–570.

Published: 01 February 2003

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Journal Articles

Antitumor Activity of UCN-01 in Carcinomas of the Head and Neck Is Associated with Altered Expression of Cyclin D3 and p27^KIP1

Vyomesh Patel, Tyler Lahusen, Chidchanok Leethanakul, Tadashi Igishi, Marcus Kremer, Leticia Quintanilla-Martinez, John F. Ensley, Edward A. Sausville, J. Silvio Gutkind, Adrian M. Senderowicz

Clin Cancer Res (2002) 8 (11): 3549–3560.

Published: 01 November 2002

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Journal Articles

Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters : Commentary re: P. Münster et al ., Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner. Clin. Cancer Res., 7: 2228–2236, 2001.

Edward A. Sausville

Clin Cancer Res (2001) 7 (8): 2155–2158.

Published: 01 August 2001

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Journal Articles

Biochemical Correlates of mTOR Inhibition by the Rapamycin Ester CCI-779 and Tumor Growth Inhibition

Lorina Dudkin, Michael B. Dilling, Pamela J. Cheshire, Franklin C. Harwood, Melinda Hollingshead, Susan G. Arbuck, Robert Travis, Edward A. Sausville, Peter J. Houghton

Clin Cancer Res (2001) 7 (6): 1758–1764.

Published: 01 June 2001

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Journal Articles

Possible Mechanisms of Diarrheal Side Effects Associated with the Use of a Novel Chemotherapeutic Agent, Flavopiridol

Melissa E. S. Kahn, Adrian Senderowicz, Edward A. Sausville, Kim E. Barrett

Clin Cancer Res (2001) 7 (2): 343–349.

Published: 01 February 2001

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Journal Articles

A Phase I Study of Combination Therapy with Immunotoxins IgG-HD37-Deglycosylated Ricin A Chain (dgA) and IgG-RFB4-dgA (Combotox) in Patients with Refractory CD19(+), CD22(+) B Cell Lymphoma

Richard A. Messmann, Ellen S. Vitetta, Donna Headlee, Adrian M. Senderowicz, William D. Figg, John Schindler, Dennis F. Michiel, Steven Creekmore, Seth M. Steinberg, David Kohler, Elaine S. Jaffe, Maryalice Stetler-Stevenson, Huachun Chen, Victor Ghetie, Edward A. Sausville

Clin Cancer Res (2000) 6 (4): 1302–1313.

Published: 01 April 2000

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Journal Articles

Targeted Toxins

Arthur E. Frankel, Robert J. Kreitman, Edward A. Sausville

Clin Cancer Res (2000) 6 (2): 326–334.

Published: 01 February 2000

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NARROW

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors

Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin

Concluding Remarks: Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates

Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias

Phospho-p70S6K/p85S6K and cdc2/cdk1 Are Novel Targets for Diffuse Large B-Cell Lymphoma Combination Therapy

Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation

7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr³⁰⁸ but not Ser⁴⁷³ Phosphorylation: A Basis for Decreased Insulin-Stimulated Glucose Transport

Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel

Effects of α₁-Acid Glycoprotein on the Clinical Pharmacokinetics of 7-Hydroxystaurosporine

In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines

Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator

Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma: A Potential Target for UCN-01

Is Another Bcr-Abl Inhibitor Needed for Chronic Myelogenous Leukemia?

Flavopiridol-related Proinflammatory Syndrome Is Associated with Induction of Interleukin-6

Antitumor Activity of UCN-01 in Carcinomas of the Head and Neck Is Associated with Altered Expression of Cyclin D3 and p27^KIP1

Biochemical Correlates of mTOR Inhibition by the Rapamycin Ester CCI-779 and Tumor Growth Inhibition

Possible Mechanisms of Diarrheal Side Effects Associated with the Use of a Novel Chemotherapeutic Agent, Flavopiridol

A Phase I Study of Combination Therapy with Immunotoxins IgG-HD37-Deglycosylated Ricin A Chain (dgA) and IgG-RFB4-dgA (Combotox) in Patients with Refractory CD19(+), CD22(+) B Cell Lymphoma

Targeted Toxins

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