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Edward A. Sausville
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Journal Articles

Editor's Note: Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator

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Gurmeet Kaur, Dorina Belotti, Angelika M. Burger, Kirsten Fisher-Nielson, Patrizia Borsotti, Elena Riccardi, Jagada Thillainathan, Melinda Hollingshead, Edward A. Sausville, Raffaella Giavazzi
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1996.
https://doi.org/10.1158/1078-0432.CCR-24-0857
Published: 01 May 2024
View articletitled, Editor's Note: Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator
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Journal Articles

Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors

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Patricia M. LoRusso, Jing Li, Angelika Burger, Lance K. Heilbrun, Edward A. Sausville, Scott A. Boerner, Daryn Smith, Mary Jo Pilat, Jie Zhang, Sara M. Tolaney, James M. Cleary, Alice P. Chen, Lawrence Rubinstein, Julie L. Boerner, Adam Bowditch, Dongpo Cai, Tracy Bell, Andrew Wolanski, Allison M. Marrero, Yiping Zhang, Jiuping Ji, Katherine Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, Geoffrey I. Shapiro
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (13): 3227–3237.
https://doi.org/10.1158/1078-0432.CCR-15-0652
Published: 30 June 2016
View articletitled, Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin

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Ulka N. Vaishampayan, Angelika M. Burger, Edward A. Sausville, Lance K. Heilbrun, Jing Li, M. Naomi Horiba, Merrill J. Egorin, Percy Ivy, Simon Pacey, Patricia M. LoRusso
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (14): 3795–3804.
https://doi.org/10.1158/1078-0432.CCR-10-0503
Published: 14 July 2010
View articletitled, Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin
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Journal Articles

Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias

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Ken Shiozawa, Takeo Nakanishi, Ming Tan, Hong-Bin Fang, Wen-chyi Wang, Martin J. Edelman, David Carlton, Ivana Gojo, Edward A. Sausville, Douglas D. Ross
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (5): 1698–1707.
https://doi.org/10.1158/1078-0432.CCR-08-1587
Published: 27 February 2009
View articletitled, Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias
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Includes: Supplementary data
Journal Articles

Phospho-p70S6K/p85S6K and cdc2/cdk1 Are Novel Targets for Diffuse Large B-Cell Lymphoma Combination Therapy

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Merry Y. Zhao, Aaron Auerbach, Anisha M. D'Costa, Aaron P. Rapoport, Angelika M. Burger, Edward A. Sausville, Sanford A. Stass, Feng Jiang, Amy M. Sands, Nadine Aguilera, X. Frank Zhao
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (5): 1708–1720.
https://doi.org/10.1158/1078-0432.CCR-08-1543
Published: 27 February 2009
View articletitled, Phospho-p70S6K/p85S6K and cdc2/cdk1 Are Novel Targets for Diffuse Large B-Cell Lymphoma Combination Therapy
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Journal Articles

Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation

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Curtis Hose, Gurmeet Kaur, Edward A. Sausville, Anne Monks
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (17): 6370–6381.
https://doi.org/10.1158/1078-0432.CCR-05-0291
Published: 06 September 2005
View articletitled, Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation
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Journal Articles

7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr308 but not Ser473 Phosphorylation: A Basis for Decreased Insulin-Stimulated Glucose Transport

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Sudhir B. Kondapaka, MaryJane Zarnowski, Dena R. Yver, Edward A. Sausville, Samuel W. Cushman
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (21): 7192–7198.
https://doi.org/10.1158/1078-0432.CCR-04-0772
Published: 08 November 2004
View articletitled, 7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr308 but not Ser473 Phosphorylation: A Basis for Decreased Insulin-Stimulated Glucose Transport
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Journal Articles

Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel

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Phyllis A. Svingen, David Loegering, Joe Rodriquez, Xue Wei Meng, Peter W. Mesner, Jr., Susan Holbeck, Anne Monks, Stan Krajewski, Dominic A. Scudiero, Edward A. Sausville, John C. Reed, Yuri A. Lazebnik, Scott H. Kaufmann
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (20): 6807–6820.
https://doi.org/10.1158/1078-0432.CCR-0778-02
Published: 22 October 2004
View articletitled, Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel
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Journal Articles

Effects of α1-Acid Glycoprotein on the Clinical Pharmacokinetics of 7-Hydroxystaurosporine

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Alex Sparreboom, Huachen Chen, Milin R. Acharya, Adrian M. Senderowicz, Richard A. Messmann, Takashi Kuwabara, David J. Venzon, Anthony J. Murgo, Donna Headlee, Edward A. Sausville, William D. Figg
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (20): 6840–6846.
https://doi.org/10.1158/1078-0432.CCR-04-0805
Published: 22 October 2004
View articletitled, Effects of α1-Acid Glycoprotein on the Clinical Pharmacokinetics of 7-Hydroxystaurosporine
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Journal Articles

In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines

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Girija P. Dasmahapatra, Parijat Didolkar, Michael C. Alley, Somiranjan Ghosh, Edward A. Sausville, Krishnendu K. Roy
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (15): 5242–5252.
https://doi.org/10.1158/1078-0432.CCR-03-0534
Published: 05 August 2004
View articletitled, In vitro Combination Treatment with Perifosine and UCN-01 Demonstrates Synergism against Prostate (PC-3) and Lung (A549) Epithelial Adenocarcinoma Cell Lines
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Journal Articles

Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator

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Gurmeet Kaur, Dorina Belotti, Angelika M. Burger, Kirsten Fisher-Nielson, Patrizia Borsotti, Elena Riccardi, Jagada Thillainathan, Melinda Hollingshead, Edward A. Sausville, Raffaella Giavazzi
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (14): 4813–4821.
https://doi.org/10.1158/1078-0432.CCR-03-0795
Published: 21 July 2004
View articletitled, Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator
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Journal Articles

Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma: A Potential Target for UCN-01

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Panomwat Amornphimoltham, Virote Sriuranpong, Vyomesh Patel, Fernando Benavides, Claudio J. Conti, John Sauk, Edward A. Sausville, Alfredo A. Molinolo, J. Silvio Gutkind
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (12): 4029–4037.
https://doi.org/10.1158/1078-0432.CCR-03-0249
Published: 24 June 2004
View articletitled, Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma: A Potential Target for UCN-01
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Journal Articles

Concluding Remarks: Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates

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Edward A. Sausville
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (10): 4022s–4023s.
Published: 01 September 2003
View articletitled, Concluding Remarks: Ninth Conference on Cancer Therapy with Antibodies and Immunoconjugates
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Journal Articles

Is Another Bcr-Abl Inhibitor Needed for Chronic Myelogenous Leukemia?

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Edward A. Sausville
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1233–1234.
Published: 01 April 2003
View articletitled, Is Another Bcr-Abl Inhibitor Needed for Chronic Myelogenous Leukemia?
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Journal Articles

Flavopiridol-related Proinflammatory Syndrome Is Associated with Induction of Interleukin-6

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Richard A. Messmann, Claudio Dansky Ullmann, Tyler Lahusen, Audrey Kalehua, Jason Wasfy, Giovanni Melillo, Ivan Ding, Donna Headlee, William D. Figg, Edward A. Sausville, Adrian M. Senderowicz
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 562–570.
Published: 01 February 2003
View articletitled, Flavopiridol-related Proinflammatory Syndrome Is Associated with Induction of Interleukin-6
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Journal Articles

Antitumor Activity of UCN-01 in Carcinomas of the Head and Neck Is Associated with Altered Expression of Cyclin D3 and p27KIP1

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Vyomesh Patel, Tyler Lahusen, Chidchanok Leethanakul, Tadashi Igishi, Marcus Kremer, Leticia Quintanilla-Martinez, John F. Ensley, Edward A. Sausville, J. Silvio Gutkind, Adrian M. Senderowicz
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (11): 3549–3560.
Published: 01 November 2002
View articletitled, Antitumor Activity of UCN-01 in Carcinomas of the Head and Neck Is Associated with Altered Expression of Cyclin D3 and p27KIP1
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Journal Articles

Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters : Commentary re: P. Münster et al ., Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner. Clin. Cancer Res., 7: 2228–2236, 2001.

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Edward A. Sausville
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2155–2158.
Published: 01 August 2001
View articletitled, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters : Commentary re: P. Münster et al ., Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner. Clin. Cancer Res., 7: 2228–2236, 2001.
Open the PDF for Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters : Commentary re: P. Münster et al ., Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner. Clin. Cancer Res., 7: 2228–2236, 2001. in another window
Journal Articles

Biochemical Correlates of mTOR Inhibition by the Rapamycin Ester CCI-779 and Tumor Growth Inhibition

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Lorina Dudkin, Michael B. Dilling, Pamela J. Cheshire, Franklin C. Harwood, Melinda Hollingshead, Susan G. Arbuck, Robert Travis, Edward A. Sausville, Peter J. Houghton
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (6): 1758–1764.
Published: 01 June 2001
View articletitled, Biochemical Correlates of mTOR Inhibition by the Rapamycin Ester CCI-779 and Tumor Growth Inhibition
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Journal Articles

Possible Mechanisms of Diarrheal Side Effects Associated with the Use of a Novel Chemotherapeutic Agent, Flavopiridol

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Melissa E. S. Kahn, Adrian Senderowicz, Edward A. Sausville, Kim E. Barrett
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (2): 343–349.
Published: 01 February 2001
View articletitled, Possible Mechanisms of Diarrheal Side Effects Associated with the Use of a Novel Chemotherapeutic Agent, Flavopiridol
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Journal Articles

A Phase I Study of Combination Therapy with Immunotoxins IgG-HD37-Deglycosylated Ricin A Chain (dgA) and IgG-RFB4-dgA (Combotox) in Patients with Refractory CD19(+), CD22(+) B Cell Lymphoma

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Richard A. Messmann, Ellen S. Vitetta, Donna Headlee, Adrian M. Senderowicz, William D. Figg, John Schindler, Dennis F. Michiel, Steven Creekmore, Seth M. Steinberg, David Kohler, Elaine S. Jaffe, Maryalice Stetler-Stevenson, Huachun Chen, Victor Ghetie, Edward A. Sausville
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (4): 1302–1313.
Published: 01 April 2000
View articletitled, A Phase I Study of Combination Therapy with Immunotoxins IgG-HD37-Deglycosylated Ricin A Chain (dgA) and IgG-RFB4-dgA (Combotox) in Patients with Refractory CD19(+), CD22(+) B Cell Lymphoma
Open the PDF for A Phase I Study of Combination Therapy with Immunotoxins IgG-HD37-Deglycosylated Ricin A Chain (dgA) and IgG-RFB4-dgA (Combotox) in Patients with Refractory CD19(+), CD22(+) B Cell Lymphoma in another window