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Drew M. Pardoll
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Journal Articles

Divergent Clinical and Immunologic Outcomes Based on STK11 Co-mutation Status in Resectable KRAS-Mutant Lung Cancers Following Neoadjuvant Immune Checkpoint Blockade

Samuel Rosner, Sydney Connor, Khaled Sanber, Marianna Zahurak, Tianbei Zhang, Isha Gurumurthy, Zhen Zeng, Brad Presson, Dipika Singh, Roni Rayes, Lavanya Sivapalan, Gavin Pereira, Zhicheng Ji, Rohit Thummalapalli, Joshua E. Reuss, Stephen R. Broderick, David R. Jones, Julie S. Deutsch, Tricia R. Cottrell, Jamie E. Chaft, Jonathan Spicer, Janis Taube, Valsamo Anagnostou, Julie R. Brahmer, Drew M. Pardoll, Hongkai Ji, Patrick M. Forde, Kristen A. Marrone, Kellie N. Smith
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (2): 339–351.
https://doi.org/10.1158/1078-0432.CCR-24-2983
Published: 17 January 2025
View article titled, Divergent Clinical and Immunologic Outcomes Based on <em>STK11</em> Co-mutation Status in Resectable <em>KRAS-</em>Mutant Lung Cancers Following Neoadjuvant Immune Checkpoint Blockade
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Includes: Supplementary data
Journal Articles

Multidimensional Immunotyping of Human NF1-Associated Peripheral Nerve Sheath Tumors Uncovers Tumor-Associated Macrophages as Key Drivers of Immune Evasion in the Tumor Microenvironment

Lindy Zhang, Alexandre Maalouf, Stavriani C. Makri, Jineta Banerjee, Aditya Suru, Ada J. Tam, Ana Calizo, Kai Pollard, Jiawan Wang, Ludmila Danilova, Maria Ioannou, Adam S. Levin, Carol D. Morris, Daniel S. Rhee, Allan J. Belzberg, Jaishri O. Blakeley, Brian H. Ladle, Drew M. Pardoll, Calixto-Hope G. Lucas, Fausto J. Rodriguez, John M. Gross, Robert A. Anders, Christine A. Pratilas, Nicolas J. Llosa
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (23): 5459–5472.
https://doi.org/10.1158/1078-0432.CCR-24-1454
Published: 02 December 2024
View article titled, Multidimensional Immunotyping of Human NF1-Associated Peripheral Nerve Sheath Tumors Uncovers Tumor-Associated Macrophages as Key Drivers of Immune Evasion in the Tumor Microenvironment
Open the PDF for Multidimensional Immunotyping of Human NF1-Associated Peripheral Nerve Sheath Tumors Uncovers Tumor-Associated Macrophages as Key Drivers of Immune Evasion in the Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non–Small Cell Lung Cancer

Samuel Rosner, Joshua E. Reuss, Marianna Zahurak, Jiajia Zhang, Zhen Zeng, Janis Taube, Valsamo Anagnostou, Kellie N. Smith, Joanne Riemer, Peter B. Illei, Stephen R. Broderick, David R. Jones, Suzanne L. Topalian, Drew M. Pardoll, Julie R. Brahmer, Jamie E. Chaft, Patrick M. Forde
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (4): 705–710.
https://doi.org/10.1158/1078-0432.CCR-22-2994
Published: 16 February 2023
View article titled, Five-Year Clinical Outcomes after Neoadjuvant Nivolumab in Resectable Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors

Fyza Y. Shaikh, James R. White, Joell J. Gills, Taiki Hakozaki, Corentin Richard, Bertrand Routy, Yusuke Okuma, Mykhaylo Usyk, Abhishek Pandey, Jeffrey S. Weber, Jiyoung Ahn, Evan J. Lipson, Jarushka Naidoo, Drew M. Pardoll, Cynthia L. Sears
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2571–2583.
https://doi.org/10.1158/1078-0432.CCR-20-4834
Published: 01 May 2021
View article titled, A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors
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Includes: Supplementary data
Journal Articles

The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures

Lingling Chen, Teniola Oke, Nicholas Siegel, Gady Cojocaru, Ada J. Tam, Richard L. Blosser, Jessica Swailes, John A. Ligon, Andriana Lebid, Carol Morris, Adam Levin, Daniel S. Rhee, Fabian M. Johnston, Jonathan B. Greer, Christian F. Meyer, Brian H. Ladle, Elizabeth D. Thompson, Elizabeth A. Montgomery, Woonyoung Choi, David J. McConkey, Robert A. Anders, Drew M. Pardoll, Nicolas J. Llosa
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (15): 4018–4030.
https://doi.org/10.1158/1078-0432.CCR-19-3416
Published: 03 August 2020
View article titled, The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures
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Includes: Supplementary data
Journal Articles

Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non–Small Cell Lung Cancer

Jiajia Zhang, Zhicheng Ji, Justina X. Caushi, Margueritta El Asmar, Valsamo Anagnostou, Tricia R. Cottrell, Hok Yee Chan, Prerna Suri, Haidan Guo, Taha Merghoub, Jamie E. Chaft, Joshua E. Reuss, Ada J. Tam, Richard L. Blosser, Mohsen Abu-Akeel, John-William Sidhom, Ni Zhao, Jinny S. Ha, David R. Jones, Kristen A. Marrone, Jarushka Naidoo, Edward Gabrielson, Janis M. Taube, Victor E. Velculescu, Julie R. Brahmer, Franck Housseau, Matthew D. Hellmann, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (6): 1327–1337.
https://doi.org/10.1158/1078-0432.CCR-19-2931
Published: 13 March 2020
View article titled, Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade

Julie E. Stein, Evan J. Lipson, Tricia R. Cottrell, Patrick M. Forde, Robert A. Anders, Ashley Cimino-Mathews, Elizabeth D. Thompson, Mohamad E. Allaf, Mark Yarchoan, Josephine Feliciano, Hao Wang, Elizabeth M. Jaffee, Drew M. Pardoll, Suzanne L. Topalian, Janis M. Taube
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (3): 545–551.
https://doi.org/10.1158/1078-0432.CCR-19-2379
Published: 03 February 2020
View article titled, Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade
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Includes: Supplementary data
Journal Articles

Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors

Nicolas J. Llosa, Brandon Luber, Ada J. Tam, Kellie N. Smith, Nicholas Siegel, Anas H. Awan, Hongni Fan, Teniola Oke, JiaJia Zhang, Jada Domingue, Elizabeth L. Engle, Charles A. Roberts, Bjarne R. Bartlett, Laveet K. Aulakh, Elizabeth D. Thompson, Janis M. Taube, Jennifer N. Durham, Cynthia L. Sears, Dung T. Le, Luis A. Diaz, Drew M. Pardoll, Hao Wang, Robert A. Anders, Franck Housseau
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (17): 5250–5259.
https://doi.org/10.1158/1078-0432.CCR-19-0114
Published: 03 September 2019
View article titled, Intratumoral Adaptive Immunosuppression and Type 17 Immunity in Mismatch Repair Proficient Colorectal Tumors
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Includes: Supplementary data
Journal Articles

Transcriptional Mechanisms of Resistance to Anti–PD-1 Therapy

Maria L. Ascierto, Alvin Makohon-Moore, Evan J. Lipson, Janis M. Taube, Tracee L. McMiller, Alan E. Berger, Jinshui Fan, Genevieve J. Kaunitz, Tricia R. Cottrell, Zachary A. Kohutek, Alexander Favorov, Vladimir Makarov, Nadeem Riaz, Timothy A. Chan, Leslie Cope, Ralph H. Hruban, Drew M. Pardoll, Barry S. Taylor, David B. Solit, Christine A. Iacobuzio-Donahue, Suzanne L. Topalian
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (12): 3168–3180.
https://doi.org/10.1158/1078-0432.CCR-17-0270
Published: 14 June 2017
View article titled, Transcriptional Mechanisms of Resistance to Anti–PD-1 Therapy
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Includes: Supplementary data
Journal Articles

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

Jennifer E. Kim, Mira A. Patel, Antonella Mangraviti, Eileen S. Kim, Debebe Theodros, Esteban Velarde, Ann Liu, Eric W. Sankey, Ada Tam, Haiying Xu, Dimitrios Mathios, Christopher M. Jackson, Sarah Harris-Bookman, Tomas Garzon-Muvdi, Mary Sheu, Allison M. Martin, Betty M. Tyler, Phuoc T. Tran, Xiaobu Ye, Alessandro Olivi, Janis M. Taube, Peter C. Burger, Charles G. Drake, Henry Brem, Drew M. Pardoll, Michael Lim
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (1): 124–136.
https://doi.org/10.1158/1078-0432.CCR-15-1535
Published: 02 January 2017
View article titled, Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas
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Includes: Supplementary data
Journal Articles

Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination

Christopher M. Jackson, Christina M. Kochel, Christopher J. Nirschl, Nicholas M. Durham, Jacob Ruzevick, Angela Alme, Brian J. Francica, Jimmy Elias, Andrew Daniels, Thomas W. Dubensky, Jr, Peter Lauer, Dirk G. Brockstedt, Emily G. Baxi, Peter A. Calabresi, Janis M. Taube, Carlos A. Pardo, Henry Brem, Drew M. Pardoll, Michael Lim, Charles G. Drake
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (5): 1161–1172.
https://doi.org/10.1158/1078-0432.CCR-15-1516
Published: 29 February 2016
View article titled, Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination
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Includes: Supplementary data
Journal Articles

Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade

Janis M. Taube, Geoffrey D. Young, Tracee L. McMiller, Shuming Chen, January T. Salas, Theresa S. Pritchard, Haiying Xu, Alan K. Meeker, Jinshui Fan, Chris Cheadle, Alan E. Berger, Drew M. Pardoll, Suzanne L. Topalian
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (17): 3969–3976.
https://doi.org/10.1158/1078-0432.CCR-15-0244
Published: 31 August 2015
View article titled, Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
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Includes: Supplementary data
Journal Articles

Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy

Janis M. Taube, Alison Klein, Julie R. Brahmer, Haiying Xu, Xiaoyu Pan, Jung H. Kim, Lieping Chen, Drew M. Pardoll, Suzanne L. Topalian, Robert A. Anders
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19): 5064–5074.
https://doi.org/10.1158/1078-0432.CCR-13-3271
Published: 30 September 2014
View article titled, Association of PD-1, PD-1 Ligands, and Other Features of the Tumor Immune Microenvironment with Response to Anti–PD-1 Therapy
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Includes: Supplementary data
Journal Articles

AACR Cancer Progress Report 2013

Charles L. Sawyers, Cory Abate-Shen, Kenneth C. Anderson, Anna Barker, Jose Baselga, Nathan A. Berger, Margaret Foti, Ahmedin Jemal, Theodore S. Lawrence, Christopher I. Li, Elaine R. Mardis, Peter J. Neumann, Drew M. Pardoll, George C. Prendergast, John C. Reed, George J. Weiner
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20_Supplement): S1–S98.
https://doi.org/10.1158/1078-0432.CCR-13-2107
Published: 15 October 2013
View article titled, AACR Cancer Progress Report 2013
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Includes: Supplementary data
Journal Articles

Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 Antibody

Evan J. Lipson, William H. Sharfman, Charles G. Drake, Ira Wollner, Janis M. Taube, Robert A. Anders, Haiying Xu, Sheng Yao, Alice Pons, Lieping Chen, Drew M. Pardoll, Julie R. Brahmer, Suzanne L. Topalian
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (2): 462–468.
https://doi.org/10.1158/1078-0432.CCR-12-2625
Published: 16 January 2013
View article titled, Durable Cancer Regression Off-Treatment and Effective Reinduction Therapy with an Anti-PD-1 Antibody
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