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Douglas B. Johnson
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Journal Articles

Corticosteroids and Cancer Immunotherapy

Rachel S. Goodman, Douglas B. Johnson, Justin M. Balko
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (14): 2580–2587.
https://doi.org/10.1158/1078-0432.CCR-22-3181
Published: 14 July 2023
View article titled, Corticosteroids and Cancer Immunotherapy
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Journal Articles

Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with NRAS-mutant Melanoma

Martin Schuler, Lisa Zimmer, Kevin B. Kim, Jeffrey A. Sosman, Paolo A. Ascierto, Michael A. Postow, Filip Y.F.L. De Vos, Carla M.L. van Herpen, Matteo S. Carlino, Douglas B. Johnson, Carola Berking, Micaela B. Reddy, Allison S. Harney, Jordan D. Berlin, Rodabe N. Amaria
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (14): 3002–3010.
https://doi.org/10.1158/1078-0432.CCR-21-3872
Published: 15 July 2022
View article titled, Phase Ib/II Trial of Ribociclib in Combination with Binimetinib in Patients with <em>NRAS</em>-mutant Melanoma
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Includes: Supplementary data
Journal Articles

Early Use of High-Dose Glucocorticoid for the Management of irAE Is Associated with Poorer Survival in Patients with Advanced Melanoma Treated with Anti–PD-1 Monotherapy

Xue Bai, Jiani Hu, Allison Betof Warner, Henry T. Quach, Christopher G. Cann, Michael Z. Zhang, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoling Yang, Xiaoting Wei, Lalit Pallan, Catriona Harvey, Michael P. Manos, Olivia Ouyang, Michelle S. Kim, Gyulnara Kasumova, Justine V. Cohen, Donald P. Lawrence, Christine Freedman, Riley M. Fadden, Krista M. Rubin, Tatyana Sharova, Dennie T. Frederick, Keith T. Flaherty, Osama E. Rahma, Georgina V. Long, Alexander M. Menzies, Jun Guo, Alexander N. Shoushtari, Douglas B. Johnson, Ryan J. Sullivan, Genevieve M. Boland
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (21): 5993–6000.
https://doi.org/10.1158/1078-0432.CCR-21-1283
Published: 01 November 2021
View article titled, Early Use of High-Dose Glucocorticoid for the Management of irAE Is Associated with Poorer Survival in Patients with Advanced Melanoma Treated with Anti–PD-1 Monotherapy
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Includes: Supplementary data
Journal Articles

The State of Melanoma: Emergent Challenges and Opportunities

Michael B. Atkins, Clara Curiel-Lewandrowski, David E. Fisher, Susan M. Swetter, Hensin Tsao, Julio A. Aguirre-Ghiso, Maria S. Soengas, Ashani T. Weeraratna, Keith T. Flaherty, Meenhard Herlyn, Jeffrey A. Sosman, Hussein A. Tawbi, Anna C. Pavlick, Pamela B. Cassidy, Sunandana Chandra, Paul B. Chapman, Adil Daud, Zeynep Eroglu, Laura K. Ferris, Bernard A. Fox, Jeffrey E. Gershenwald, Geoffrey T. Gibney, Douglas Grossman, Brent A. Hanks, Douglas Hanniford, Eva Hernando, Joanne M. Jeter, Douglas B. Johnson, Samir N. Khleif, John M. Kirkwood, Sancy A. Leachman, Darren Mays, Kelly C. Nelson, Vernon K. Sondak, Ryan J. Sullivan, Glenn Merlino
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2678–2697.
https://doi.org/10.1158/1078-0432.CCR-20-4092
Published: 15 May 2021
View article titled, The State of Melanoma: Emergent Challenges and Opportunities
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Journal Articles

Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma

Paul Johannet, Nicolas Coudray, Douglas M. Donnelly, George Jour, Irineu Illa-Bochaca, Yuhe Xia, Douglas B. Johnson, Lee Wheless, James R. Patrinely, Sofia Nomikou, David L. Rimm, Anna C. Pavlick, Jeffrey S. Weber, Judy Zhong, Aristotelis Tsirigos, Iman Osman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 131–140.
https://doi.org/10.1158/1078-0432.CCR-20-2415
Published: 04 January 2021
View article titled, Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma
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Includes: Supplementary data
Journal Articles

Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition

Rebecca L. Shattuck-Brandt, Sheau-Chiann Chen, Emily Murray, Christopher Andrew Johnson, Holly Crandall, Jamye F. O'Neal, Rami Nayef Al-Rohil, Caroline A. Nebhan, Vijaya Bharti, Kimberly B. Dahlman, Gregory D. Ayers, Chi Yan, Mark C. Kelley, Rondi M. Kauffmann, Mary Hooks, Ana Grau, Douglas B. Johnson, Anna E. Vilgelm, Ann Richmond
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3803–3818.
https://doi.org/10.1158/1078-0432.CCR-19-1895
Published: 15 July 2020
View article titled, Metastatic Melanoma Patient–Derived Xenografts Respond to MDM2 Inhibition as a Single Agent or in Combination with BRAF/MEK Inhibition
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Includes: Supplementary data
Journal Articles

Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131)

Douglas B. Johnson, Fengmin Zhao, Marcus Noel, Gregory J. Riely, Edith P. Mitchell, John J. Wright, Helen X. Chen, Robert J. Gray, Shuli Li, Lisa M. McShane, Larry V. Rubinstein, David Patton, P. Mickey Williams, Stanly R. Hamilton, Barbara A. Conley, Carlos L. Arteaga, Lyndsay N. Harris, Peter J. O'Dwyer, Alice P. Chen, Keith T. Flaherty
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 1812–1819.
https://doi.org/10.1158/1078-0432.CCR-19-3443
Published: 15 April 2020
View article titled, Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131)
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Includes: Supplementary data
Journal Articles

Biological Consequences of MHC-II Expression by Tumor Cells in Cancer

Margaret L. Axelrod, Rebecca S. Cook, Douglas B. Johnson, Justin M. Balko
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2392–2402.
https://doi.org/10.1158/1078-0432.CCR-18-3200
Published: 15 April 2019
View article titled, Biological Consequences of MHC-II Expression by Tumor Cells in Cancer
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Journal Articles

Biomarkers for Immunotherapy Toxicity: Are Cytokines the Answer?

Douglas B. Johnson, Justin M. Balko
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (5): 1452–1454.
https://doi.org/10.1158/1078-0432.CCR-18-3858
Published: 01 March 2019
View article titled, Biomarkers for Immunotherapy Toxicity: Are Cytokines the Answer?
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Journal Articles

Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K BRAF-Mutant Melanoma

Inês Pires da Silva, Kevin Y.X. Wang, James S. Wilmott, Jeff Holst, Matteo S. Carlino, John J. Park, Camelia Quek, Matthew Wongchenko, Yibing Yan, Graham Mann, Douglas B. Johnson, Jennifer L. McQuade, Rajat Rai, Richard F. Kefford, Helen Rizos, Richard A. Scolyer, Jean Y.H. Yang, Georgina V. Long, Alexander M. Menzies
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1272–1279.
https://doi.org/10.1158/1078-0432.CCR-18-1680
Published: 15 February 2019
View article titled, Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K <em>BRAF</em>-Mutant Melanoma
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Includes: Supplementary data
Journal Articles

Class Matters: Sensitivity of BRAF-Mutant Melanoma to MAPK Inhibition

Douglas B. Johnson, Kimberly B. Dahlman
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (24): 6107–6109.
https://doi.org/10.1158/1078-0432.CCR-18-1795
Published: 13 December 2018
View article titled, Class Matters: Sensitivity of <em>BRAF</em>-Mutant Melanoma to MAPK Inhibition
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Journal Articles

Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

Curtis H. Kugel, III, Stephen M. Douglass, Marie R. Webster, Amanpreet Kaur, Qin Liu, Xiangfan Yin, Sarah A. Weiss, Farbod Darvishian, Rami N. Al-Rohil, Abibatou Ndoye, Reeti Behera, Gretchen M. Alicea, Brett L. Ecker, Mitchell Fane, Michael J. Allegrezza, Nikolaos Svoronos, Vinit Kumar, Daniel Y. Wang, Rajasekharan Somasundaram, Siwen Hu-Lieskovan, Alpaslan Ozgun, Meenhard Herlyn, Jose R. Conejo-Garcia, Dmitry Gabrilovich, Erica L. Stone, Theodore S. Nowicki, Jeffrey Sosman, Rajat Rai, Matteo S. Carlino, Georgina V. Long, Richard Marais, Antoni Ribas, Zeynep Eroglu, Michael A. Davies, Bastian Schilling, Dirk Schadendorf, Wei Xu, Ravi K. Amaravadi, Alexander M. Menzies, Jennifer L. McQuade, Douglas B. Johnson, Iman Osman, Ashani T. Weeraratna
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (21): 5347–5356.
https://doi.org/10.1158/1078-0432.CCR-18-1116
Published: 01 November 2018
View article titled, Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations
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Includes: Supplementary data
Journal Articles

Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti–PD-1 Therapies in Metastatic Melanoma

Douglas B. Johnson, Jennifer Bordeaux, Ju Young Kim, Christine Vaupel, David L. Rimm, Thai H. Ho, Richard W. Joseph, Adil I. Daud, Robert M. Conry, Elizabeth M. Gaughan, Leonel F. Hernandez-Aya, Anastasios Dimou, Pauline Funchain, James Smithy, John S. Witte, Svetlana B. McKee, Jennifer Ko, John M. Wrangle, Bashar Dabbas, Shabnam Tangri, Jelveh Lameh, Jeffrey Hall, Joseph Markowitz, Justin M. Balko, Naveen Dakappagari
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (21): 5250–5260.
https://doi.org/10.1158/1078-0432.CCR-18-0309
Published: 01 November 2018
View article titled, Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti–PD-1 Therapies in Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy

Daniel N. Cohen, Steven K. Lawson, Aaron C. Shaver, Liping Du, Harrison P. Nguyen, Qin He, Douglas B. Johnson, Wilfred A. Lumbang, Brent R. Moody, James L. Prescott, Pranil K. Chandra, Alan S. Boyd, Jeffrey P. Zwerner, Jason B. Robbins, Stephen K. Tyring, Peter L. Rady, James D. Chappell, Yu Shyr, Jeffrey R. Infante, Jeffrey A. Sosman
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (11): 2624–2634.
https://doi.org/10.1158/1078-0432.CCR-14-2667
Published: 31 May 2015
View article titled, Contribution of Beta-HPV Infection and UV Damage to Rapid-Onset Cutaneous Squamous Cell Carcinoma during BRAF-Inhibition Therapy
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Includes: Supplementary data
Journal Articles

Molecular Pathways: Targeting NRAS in Melanoma and Acute Myelogenous Leukemia

Douglas B. Johnson, Keiran S.M. Smalley, Jeffrey A. Sosman
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (16): 4186–4192.
https://doi.org/10.1158/1078-0432.CCR-13-3270
Published: 13 August 2014
View article titled, Molecular Pathways: Targeting <em>NRAS</em> in Melanoma and Acute Myelogenous Leukemia
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Journal Articles

Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies

Catherine B. Meador, Christine M. Micheel, Mia A. Levy, Christine M. Lovly, Leora Horn, Jeremy L. Warner, Douglas B. Johnson, Zhongming Zhao, Ingrid A. Anderson, Jeffrey A. Sosman, Cindy L. Vnencak-Jones, Kimberly B. Dahlman, William Pao
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (9): 2264–2275.
https://doi.org/10.1158/1078-0432.CCR-13-1591
Published: 30 April 2014
View article titled, Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies
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