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Dong M. Shin
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Journal Articles

Neoadjuvant chemotherapy and surgery versus surgery for organ preservation of T3 and T4a nasal and paranasal sinus squamous cell carcinoma (NPNSCC) ECOG-ACRIN EA3163

Nabil F. Saba, Yael Flamand, Derrick T. Lin, Christine H. Chung, Mark W. McDonald, Styliani Flampouri, Saad A. Khan, Carl H. Snyderman, Ehab Y. Hanna, Ivan H. El-Sayed, Clementino A. Solares, Christopher H. Le, Maged Ghaly, Peter H. Hwang, Dong M. Shin, Rita S. Axelrod, Chukwuemeka V. Ikpeazu, Douglas R. Adkins, Fenghai Duan, Marc Cohen, Michael A. Samuels, Paul L. Swiecicki, Rathan M. Subramaniam, A. Bapsi Chakravarthy, Barbara A. Burtness
Journal: Clinical Cancer Research
Clin Cancer Res (2025)
https://doi.org/10.1158/1078-0432.CCR-24-4085
Published: 14 April 2025
View articletitled, Neoadjuvant chemotherapy and surgery versus surgery for organ preservation of T3 and T4a nasal and paranasal sinus squamous cell carcinoma (NPNSCC) ECOG-ACRIN EA3163
Open the PDF for Neoadjuvant chemotherapy and surgery versus surgery for organ preservation of T3 and T4a nasal and paranasal sinus squamous cell carcinoma (NPNSCC) ECOG-ACRIN EA3163 in another window
Includes: Supplementary data
Journal Articles

Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis

Nabil F. Saba, Ritu Chaudhary, Kedar Kirtane, Angelo Marra, Asari Ekpenyong, Ashley McCook-Veal, Nicole C. Schmitt, Jennifer H. Gross, Mihir R. Patel, Jill Remick, James E. Bates, Mark W. McDonald, Soumon F. Rudra, William A. Stokes, Maria Biernacki, Xiaofei Song, Robbert J.C. Slebos, Yuan Liu, Conor E. Steuer, Dong M. Shin, Yong Teng, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4601–4608.
https://doi.org/10.1158/1078-0432.CCR-24-1202
Published: 15 October 2024
View articletitled, Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis
Open the PDF for Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis in another window
Includes: Supplementary data
Journal Articles

Abstract PO-050: Preliminary results from an early-phase, open-label study of tolinapant and radiation in cisplatin-ineligible patients with previously untreated, locally advanced head and neck cancer

Nicole C. Schmitt, William A. Stokes, James E. Bates, Madison Stallings, Brendan L. C. Kinney, Mark W. McDonald, Soumon Rudra, Jill Remick, Zachary S. Buchwald, Dong M. Shin, Azeem S. Kaka, Mihir R. Patel, Nabil F. Saba
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18_Supplement): PO-050.
https://doi.org/10.1158/1557-3265.AACRAHNS23-PO-050
Published: 15 September 2023
View articletitled, Abstract PO-050: Preliminary results from an early-phase, open-label study of tolinapant and radiation in cisplatin-ineligible patients with previously untreated, locally advanced head and neck cancer
Journal Articles

Phase II Multi-institutional Clinical Trial Result of Concurrent Cetuximab and Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

Christine H. Chung, Jiannong Li, Conor E. Steuer, Priyanka Bhateja, Matthew Johnson, Jude Masannat, Maria I. Poole, Feifei Song, Juan C. Hernandez-Prera, Helen Molina, Bruce M. Wenig, Sunil Kumar, Charlotte Kuperwasser, Philip J. Stephens, Joaquim M. Farinhas, Dong M. Shin, Julie A. Kish, Jameel Muzaffar, Kedar Kirtane, James W. Rocco, Michael J. Schell, Nabil F. Saba, Marcelo Bonomi
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2329–2338.
https://doi.org/10.1158/1078-0432.CCR-21-3849
Published: 01 June 2022
View articletitled, Phase II Multi-institutional Clinical Trial Result of Concurrent Cetuximab and Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma
Open the PDF for Phase II Multi-institutional Clinical Trial Result of Concurrent Cetuximab and Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Phase Ib Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck

Dong M. Shin, Sreenivas Nannapaneni, Mihir R. Patel, Qiuying Shi, Yuan Liu, Zhengjia Chen, Amy Y. Chen, Mark W. El-Deiry, Jonathan J. Beitler, Conor E. Steuer, Steven M. Roser, Adam M. Klein, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri, Zhuo G. Chen, Nabil F. Saba
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5860–5868.
https://doi.org/10.1158/1078-0432.CCR-20-2276
Published: 13 November 2020
View articletitled, Phase Ib Study of Chemoprevention with Green Tea Polyphenon E and Erlotinib in Patients with Advanced Premalignant Lesions (APL) of the Head and Neck
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Includes: Supplementary data
Journal Articles

Editor's Note: The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma

Dongsheng Wang, Susan Müller, A.R.M. Ruhul Amin, Donghai Huang, Ling Su, Zhongliang Hu, Mohammad Aminur Rahman, Sreenivas Nannapaneni, Lydia Koenig, Zhengjia Chen, Mourad Tighiouart, Dong M. Shin, Zhuo G. Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 5052.
https://doi.org/10.1158/1078-0432.CCR-20-3175
Published: 15 September 2020
View articletitled, Editor's Note: The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma
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Journal Articles

Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin

Xu Wang, Jonathan J. Beitler, Wen Huang, Guo Chen, Guoqing Qian, Kelly Magliocca, Mihir R. Patel, Amy Y. Chen, Jun Zhang, Sreenivas Nannapaneni, Sungjin Kim, Zhengjia Chen, Xingming Deng, Nabil F. Saba, Zhuo Georgia Chen, Jack L. Arbiser, Dong M. Shin
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 858–869.
https://doi.org/10.1158/1078-0432.CCR-17-0345
Published: 14 February 2018
View articletitled, Honokiol Radiosensitizes Squamous Cell Carcinoma of the Head and Neck by Downregulation of Survivin
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Includes: Supplementary data
Journal Articles

HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models

Dongsheng Wang, Guoqing Qian, Hongzheng Zhang, Kelly R. Magliocca, Sreenivas Nannapaneni, A.R.M. Ruhul Amin, Michael Rossi, Mihir Patel, Mark El-Deiry, J. Trad Wadsworth, Zhengjia Chen, Fadlo R. Khuri, Dong M. Shin, Nabil F. Saba, Zhuo G. Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (3): 677–686.
https://doi.org/10.1158/1078-0432.CCR-16-0558
Published: 31 January 2017
View articletitled, HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models
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Includes: Supplementary data
Journal Articles

CCR 20th Anniversary Commentary: Prospects and Challenges of Therapeutic Nanoparticles in Cancer

Mohammad Aminur Rahman, Dong M. Shin
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (20): 4499–4501.
https://doi.org/10.1158/1078-0432.CCR-14-3126
Published: 14 October 2015
View articletitled, CCR 20th Anniversary Commentary: Prospects and Challenges of Therapeutic Nanoparticles in Cancer
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Journal Articles

Phase II Study of Cetuximab in Combination with Cisplatin and Radiation in Unresectable, Locally Advanced Head and Neck Squamous Cell Carcinoma: Eastern Cooperative Oncology Group Trial E3303

Ann Marie Egloff, Ju-Whei Lee, Corey J. Langer, Harry Quon, Alec Vaezi, Jennifer R. Grandis, Raja R. Seethala, Lin Wang, Dong M. Shin, Athanassios Argiris, Donghua Yang, Ranee Mehra, John Andrew Ridge, Urjeet A. Patel, Barbara A. Burtness, Arlene A. Forastiere
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19): 5041–5051.
https://doi.org/10.1158/1078-0432.CCR-14-0051
Published: 30 September 2014
View articletitled, Phase II Study of Cetuximab in Combination with Cisplatin and Radiation in Unresectable, Locally Advanced Head and Neck Squamous Cell Carcinoma: Eastern Cooperative Oncology Group Trial E3303
Open the PDF for Phase II Study of Cetuximab in Combination with Cisplatin and Radiation in Unresectable, Locally Advanced Head and Neck Squamous Cell Carcinoma: Eastern Cooperative Oncology Group Trial E3303 in another window
Includes: Supplementary data
Journal Articles

RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy

Mohammad Aminur Rahman, A.R.M. Ruhul Amin, Dongsheng Wang, Lydia Koenig, Sreenivas Nannapaneni, Zhengjia Chen, Zhibo Wang, Gabriel Sica, Xingming Deng, Zhuo (Georgia) Chen, Dong M. Shin
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2013) 19 (13): 3416–3428.
https://doi.org/10.1158/1078-0432.CCR-13-0073
Published: 30 June 2013
View articletitled, RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy
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Includes: Supplementary data
Journal Articles

Chemoprevention of Head and Neck Cancer by Simultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies

Dong M. Shin, Hongzheng Zhang, Nabil F. Saba, Amy Y. Chen, Sreenivas Nannapaneni, A.R.M. Ruhul Amin, Susan Müller, Melinda Lewis, Gabriel Sica, Scott Kono, Johann C. Brandes, William J. Grist, Rachel Moreno-Williams, Jonathan J. Beitler, Sufi M. Thomas, Zhengjia Chen, Hyung Ju C. Shin, Jennifer R. Grandis, Fadlo R. Khuri, Zhuo Georgia Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (5): 1244–1256.
https://doi.org/10.1158/1078-0432.CCR-12-3149
Published: 03 March 2013
View articletitled, Chemoprevention of Head and Neck Cancer by Simultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies
Open the PDF for Chemoprevention of Head and Neck Cancer by Simultaneous Blocking of Epidermal Growth Factor Receptor and Cyclooxygenase-2 Signaling Pathways: Preclinical and Clinical Studies in another window
Includes: Supplementary data
Journal Articles

The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma

Dongsheng Wang, Susan Müller, A.R.M. Ruhul Amin, Donghai Huang, Ling Su, Zhongliang Hu, Mohammad Aminur Rahman, Sreenivas Nannapaneni, Lydia Koenig, Zhengjia Chen, Mourad Tighiouart, Dong M. Shin, Zhuo G. Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (17): 4589–4599.
https://doi.org/10.1158/1078-0432.CCR-11-3127
Published: 30 August 2012
View articletitled, The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma
Open the PDF for The Pivotal Role of Integrin β1 in Metastasis of Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Therapeutic Nanoparticles for Drug Delivery in Cancer

Kwangjae Cho, Xu Wang, Shuming Nie, Zhuo (Georgia) Chen, Dong M. Shin
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (5): 1310–1316.
https://doi.org/10.1158/1078-0432.CCR-07-1441
Published: 03 March 2008
View articletitled, Therapeutic Nanoparticles for Drug Delivery in Cancer
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Journal Articles

Phase I Clinical and Pharmacodynamic Evaluation of Oral CI-1033 in Patients with Refractory Cancer

Ralph G. Zinner, John Nemunaitis, Irene Eiseman, Hyung Ju C. Shin, Stephen C. Olson, James Christensen, Xin Huang, Peter F. Lenehan, Nicholas J. Donato, Dong M. Shin
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (10): 3006–3014.
https://doi.org/10.1158/1078-0432.CCR-06-1958
Published: 15 May 2007
View articletitled, Phase I Clinical and Pharmacodynamic Evaluation of Oral CI-1033 in Patients with Refractory Cancer
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Journal Articles

Enhancement of Docetaxel-Induced Cytotoxicity by Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 Pathways in Squamous Cell Carcinoma of the Head and Neck

Mi Sun Choe, Zhuo Chen, Carmen M. Klass, Xin Zhang, Dong M. Shin
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (10): 3015–3023.
https://doi.org/10.1158/1078-0432.CCR-06-2959
Published: 15 May 2007
View articletitled, Enhancement of Docetaxel-Induced Cytotoxicity by Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 Pathways in Squamous Cell Carcinoma of the Head and Neck
Open the PDF for Enhancement of Docetaxel-Induced Cytotoxicity by Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 Pathways in Squamous Cell Carcinoma of the Head and Neck in another window
Journal Articles

Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward

Gary J. Kelloff, Scott M. Lippman, Andrew J. Dannenberg, Caroline C. Sigman, Homer L. Pearce, Brian J. Reid, Eva Szabo, V. Craig Jordan, Margaret R. Spitz, Gordon B. Mills, Vali A. Papadimitrakopoulou, Reuben Lotan, Bharat B. Aggarwal, Robert S. Bresalier, Jeri Kim, Banu Arun, Karen H. Lu, Melanie E. Thomas, Helen E. Rhodes, Molly A. Brewer, Michele Follen, Dong M. Shin, Howard L. Parnes, Jill M. Siegfried, Alison A. Evans, William J. Blot, Wong-Ho Chow, Patricia L. Blount, Carlo C. Maley, Kenneth K. Wang, Stephen Lam, J. Jack Lee, Steven M. Dubinett, Paul F. Engstrom, Frank L. Meyskens, Jr., Joyce O'Shaughnessy, Ernest T. Hawk, Bernard Levin, William G. Nelson, Waun Ki Hong, for the AACR Task Force on Cancer Prevention
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (12): 3661–3697.
https://doi.org/10.1158/1078-0432.CCR-06-1104
Published: 15 June 2006
View articletitled, Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward
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Journal Articles

Fenretinide Activity in Retinoid-Resistant Oral Leukoplakia

Scott M. Lippman, J. Jack Lee, Jack W. Martin, Adel K. El-Naggar, Xiaochun Xu, Dong M. Shin, Margaret Thomas, Li Mao, Herbert A. Fritsche, Jr., Xian Zhou, Vassiliki Papadimitrakopoulou, Fadlo R. Khuri, Hai Tran, Gary L. Clayman, Walter N. Hittelman, Waun Ki Hong, Reuben Lotan
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (10): 3109–3114.
https://doi.org/10.1158/1078-0432.CCR-05-2636
Published: 17 May 2006
View articletitled, Fenretinide Activity in Retinoid-Resistant Oral Leukoplakia
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Journal Articles

Tumor Growth Inhibition by Simultaneously Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 in a Xenograft Model

Xin Zhang, Zhuo (Georgia) Chen, Mi Sun Choe, Yan Lin, Shi-Yong Sun, H. Samuel Wieand, Hyung Ju C. Shin, Amy Chen, Fadlo R. Khuri, Dong M. Shin
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (17): 6261–6269.
https://doi.org/10.1158/1078-0432.CCR-04-2102
Published: 06 September 2005
View articletitled, Tumor Growth Inhibition by Simultaneously Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 in a Xenograft Model
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Journal Articles

Phase 1 Clinical and Pharmacokinetics Evaluation of Oral CI-1033 in Patients with Refractory Cancer

John Nemunaitis, Irene Eiseman, Casey Cunningham, Neil Senzer, Adrienne Williams, Peter F. Lenehan, Stephen C. Olson, Paul Bycott, Michael Schlicht, Rebecca Zentgraff, Dong M. Shin, Ralph G. Zinner
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (10): 3846–3853.
https://doi.org/10.1158/1078-0432.CCR-04-1950
Published: 16 May 2005
View articletitled, Phase 1 Clinical and Pharmacokinetics Evaluation of Oral CI-1033 in Patients with Refractory Cancer
Open the PDF for Phase 1 Clinical and Pharmacokinetics Evaluation of Oral CI-1033 in Patients with Refractory Cancer in another window