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Don L. Gibbons
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Journal Articles

Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial

Marcelo V. Negrao, Alvaro G. Paula, David Molkentine, Laura Hover, Monique Nilsson, Natalie Vokes, Lars Engstrom, Andrew Calinisan, David M. Briere, Laura Waters, Jill Hallin, Lixia Diao, Mehmet Altan, George R. Blumenschein, Ferdinandos Skoulidis, Jing Wang, Scott E. Kopetz, David S. Hong, Don L. Gibbons, Peter Olson, James G. Christensen, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF13.
https://doi.org/10.1158/1078-0432.CCR-24-2310
Published: 06 February 2025
View article titled, Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial
Open the PDF for Impact of Co-mutations and Transcriptional Signatures in Non–Small Cell Lung Cancer Patients Treated with Adagrasib in the KRYSTAL-1 Trial in another window
Includes: Supplementary data
Journal Articles

YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities

C. Allison Stewart, Lixia Diao, Yuanxin Xi, Runsheng Wang, Kavya Ramkumar, Alejandra G. Serrano, Azusa Tanimoto, B. Leticia Rodriguez, Benjamin B. Morris, Li Shen, Bingnan Zhang, Yan Yang, Samera H. Hamad, Robert J. Cardnell, Alberto Duarte, Jr, Moushumi Sahu, Veronica Y. Novegil, Bernard E. Weissman, Michael Frumovitz, Neda Kalhor, Luisa Solis Soto, Pedro da Rocha, Natalie Vokes, Don L. Gibbons, Jing Wang, John V. Heymach, Bonnie Glisson, Lauren Averett Byers, Carl M. Gay
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4743–4754.
https://doi.org/10.1158/1078-0432.CCR-24-0361
Published: 15 October 2024
View article titled, YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities
Open the PDF for YAP1 Status Defines Two Intrinsic Subtypes of LCNEC with Distinct Molecular Features and Therapeutic Vulnerabilities in another window
Includes: Supplementary data
Journal Articles

ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC

Natalie I. Vokes, Ana Galan Cobo, Margarita Fernandez-Chas, David Molkentine, Santiago Treviño, III, Vitaly Druker, Yu Qian, Sonia Patel, Stephanie Schmidt, Lingzhi Hong, Jeff Lewis, Waree Rinsurongkawong, Vadeerat Rinsurongkawong, J. Jack Lee, Marcelo V. Negrao, Don L. Gibbons, Ara Vaporciyan, Xiuning Le, Jia Wu, Jianjun Zhang, Una Rigney, Sonia Iyer, Emma Dean, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (23): 4958–4972.
https://doi.org/10.1158/1078-0432.CCR-23-1122
Published: 01 December 2023
View article titled, <em>ATM</em> Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC
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Includes: Supplementary data
Journal Articles

Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer

Rohit Thummalapalli, Biagio Ricciuti, Chaitanya Bandlamudi, Daniel Muldoon, Hira Rizvi, Arielle Elkrief, Jia Luo, Joao V. Alessi, Federica Pecci, Giuseppe Lamberti, Alessandro Di Federico, Lingzhi Hong, Jianjun Zhang, John V. Heymach, Don L. Gibbons, Andrew J. Plodkowski, Vignesh Ravichandran, Mark T.A. Donoghue, Chad Vanderbilt, Marc Ladanyi, Charles M. Rudin, Mark G. Kris, Gregory J. Riely, Jamie E. Chaft, Matthew D. Hellmann, Natalie I. Vokes, Mark M. Awad, Adam J. Schoenfeld
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4408–4418.
https://doi.org/10.1158/1078-0432.CCR-23-1207
Published: 01 November 2023
View article titled, Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC

Sonia A. Patel, Monique B. Nilsson, Yan Yang, Xiuning Le, Hai T. Tran, Yasir Y. Elamin, Xiaoxing Yu, Fahao Zhang, Alissa Poteete, Xiaoyang Ren, Li Shen, Jing Wang, Seyed Javad Moghaddam, Tina Cascone, Michael Curran, Don L. Gibbons, John V. Heymach
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1292–1304.
https://doi.org/10.1158/1078-0432.CCR-22-3379
Published: 03 April 2023
View article titled, IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC
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Includes: Supplementary data
Journal Articles

Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC

Pedro Rocha, Jiexin Zhang, Raquel Laza-Briviesca, Alberto Cruz-Bermúdez, Neus Bota-Rabassedas, Beatriz Sanchez-Espiridon, Katsuhiro Yoshimura, Carmen Behrens, Wei Lu, Ximing Tang, Apar Pataer, Edwin R. Parra, Cara Haymaker, Junya Fujimoto, Stephen G. Swisher, John V. Heymach, Don L. Gibbons, J. Jack Lee, Boris Sepesi, Tina Cascone, Luisa M. Solis, Mariano Provencio, Ignacio I. Wistuba, Humam Kadara
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2461–2473.
https://doi.org/10.1158/1078-0432.CCR-21-3207
Published: 01 June 2022
View article titled, Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC
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Includes: Supplementary data
Journal Articles

A Phase I/II Study of Neoadjuvant Cisplatin, Docetaxel, and Nintedanib for Resectable Non–Small Cell Lung Cancer

Tina Cascone, Boris Sepesi, Heather Y. Lin, Neda Kalhor, Edwin R. Parra, Mei Jiang, Myrna C.B. Godoy, Jianjun Zhang, Frank V. Fossella, Anne S. Tsao, Vincent K. Lam, Charles Lu, Frank E. Mott, George R. Simon, Mara B. Antonoff, Reza J. Mehran, David C. Rice, Carmen Behrens, Annikka Weissferdt, Cesar Moran, Ara A. Vaporciyan, J. Jack Lee, Stephen G. Swisher, Don L. Gibbons, Ignacio I. Wistuba, William N. William, Jr., John V. Heymach
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (14): 3525–3536.
https://doi.org/10.1158/1078-0432.CCR-19-4180
Published: 15 July 2020
View article titled, A Phase I/II Study of Neoadjuvant Cisplatin, Docetaxel, and Nintedanib for Resectable Non–Small Cell Lung Cancer
Open the PDF for A Phase I/II Study of Neoadjuvant Cisplatin, Docetaxel, and Nintedanib for Resectable Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases

Fengju Chen, Yiqun Zhang, Don L. Gibbons, Benjamin Deneen, David J. Kwiatkowski, Michael Ittmann, Chad J. Creighton
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (9): 2182–2193.
https://doi.org/10.1158/1078-0432.CCR-17-3378
Published: 30 April 2018
View article titled, Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases
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Includes: Supplementary data
Journal Articles

Image Analysis–based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non–small Cell Lung Carcinoma Patients

Edwin R. Parra, Carmen Behrens, Jaime Rodriguez-Canales, Heather Lin, Barbara Mino, Jorge Blando, Jianjun Zhang, Don L. Gibbons, John V. Heymach, Boris Sepesi, Stephen G. Swisher, Annikka Weissferdt, Neda Kalhor, Julie Izzo, Humam Kadara, Cesar Moran, Jack J. Lee, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (24): 6278–6289.
https://doi.org/10.1158/1078-0432.CCR-15-2443
Published: 15 December 2016
View article titled, Image Analysis–based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non–small Cell Lung Carcinoma Patients
Open the PDF for Image Analysis–based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non–small Cell Lung Carcinoma Patients in another window
Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

Yanyan Lou, Lixia Diao, Edwin Roger Parra Cuentas, Warren L. Denning, Limo Chen, You Hong Fan, Lauren A. Byers, Jing Wang, Vassiliki A. Papadimitrakopoulou, Carmen Behrens, Jaime Canales Rodriguez, Patrick Hwu, Ignacio I. Wistuba, John V. Heymach, Don L. Gibbons
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (14): 3630–3642.
https://doi.org/10.1158/1078-0432.CCR-15-1434
Published: 14 July 2016
View article titled, Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
Open the PDF for Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Renata Ferrarotto, Ruchitha Goonatilake, Suk Young Yoo, Pan Tong, Uma Giri, Shaohua Peng, John Minna, Luc Girard, Yuehong Wang, Liguang Wang, Lerong Li, Lixia Diao, David H. Peng, Don L. Gibbons, Bonnie S. Glisson, John V. Heymach, Jing Wang, Lauren A. Byers, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1674–1686.
https://doi.org/10.1158/1078-0432.CCR-14-2890
Published: 31 March 2016
View article titled, Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer
Open the PDF for Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

Milena P. Mak, Pan Tong, Lixia Diao, Robert J. Cardnell, Don L. Gibbons, William N. William, Ferdinandos Skoulidis, Edwin R. Parra, Jaime Rodriguez-Canales, Ignacio I. Wistuba, John V. Heymach, John N. Weinstein, Kevin R. Coombes, Jing Wang, Lauren Averett Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 609–620.
https://doi.org/10.1158/1078-0432.CCR-15-0876
Published: 31 January 2016
View article titled, A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition
Open the PDF for A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition in another window
Includes: Supplementary data
Journal Articles

Abstract A21: microRNA-200 regulates tumor cell PD-L1 expression to control lung cancer metastasis.

Don L. Gibbons, Limo Chen, Sangeeta Goswami, Young-Ho Ahn, Lauren A. Byers, Lixia Diao, Jing Wang, Angelica Cortez, Jonathon Roybal, James Welsh, Xuejun Zhang, David Dwyer, Xiaohui Yi, Chen Lieping, Ignacio Wistuba, John V. Heymach, Jonathan M. Kurie, F. Xiao-Feng Qin
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2_Supplement): A21.
https://doi.org/10.1158/1078-0432.14AACRIASLC-A21
Published: 16 January 2014
View article titled, Abstract A21: microRNA-200 regulates tumor cell PD-L1 expression to control lung cancer metastasis.