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Journal Articles

The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia

Sarah E.M. Herman, Arnau Montraveta, Carsten U. Niemann, Helena Mora-Jensen, Michael Gulrajani, Fanny Krantz, Rose Mantel, Lisa L. Smith, Fabienne McClanahan, Bonnie K. Harrington, Dolors Colomer, Todd Covey, John C. Byrd, Raquel Izumi, Allard Kaptein, Roger Ulrich, Amy J. Johnson, Brian J. Lannutti, Adrian Wiestner, Jennifer A. Woyach
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11): 2831–2841.
https://doi.org/10.1158/1078-0432.CCR-16-0463
Published: 31 May 2017
View article titled, The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic Leukemia

Alba Matas-Céspedes, Anna Vidal-Crespo, Vanina Rodriguez, Neus Villamor, Julio Delgado, Eva Giné, Heleia Roca-Ho, Pablo Menéndez, Elías Campo, Armando López-Guillermo, Dolors Colomer, Gaël Roué, Adrian Wiestner, Paul W.H.I. Parren, Parul Doshi, Jeroen Lammerts van Bueren, Patricia Pérez-Galán
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1493–1505.
https://doi.org/10.1158/1078-0432.CCR-15-2095
Published: 14 March 2017
View article titled, The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic Leukemia
Open the PDF for The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia–Microenvironment Interactions in Chronic Lymphocytic Leukemia in another window
Includes: Supplementary data
Journal Articles

MYD88 L265P Mutations, But No Other Variants, Identify a Subpopulation of DLBCL Patients of Activated B-cell Origin, Extranodal Involvement, and Poor Outcome

Jordina Rovira, Kennosuke Karube, Alexandra Valera, Dolors Colomer, Anna Enjuanes, Lluís Colomo, Alejandra Martínez-Trillos, Eva Giné, Ivan Dlouhy, Laura Magnano, Julio Delgado, Antonio Martínez, Neus Villamor, Elías Campo, Armando López-Guillermo
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (11): 2755–2764.
https://doi.org/10.1158/1078-0432.CCR-15-1525
Published: 31 May 2016
View article titled, <em>MYD88</em> L265P Mutations, But No Other Variants, Identify a Subpopulation of DLBCL Patients of Activated B-cell Origin, Extranodal Involvement, and Poor Outcome
Open the PDF for <em>MYD88</em> L265P Mutations, But No Other Variants, Identify a Subpopulation of DLBCL Patients of Activated B-cell Origin, Extranodal Involvement, and Poor Outcome in another window
Includes: Supplementary data
Journal Articles

Disruption of Follicular Dendritic Cells–Follicular Lymphoma Cross-talk by the Pan-PI3K Inhibitor BKM120 (Buparlisib)

Alba Matas-Céspedes, Vanina Rodriguez, Susana G. Kalko, Anna Vidal-Crespo, Laia Rosich, Teresa Casserras, Patricia Balsas, Neus Villamor, Eva Giné, Elías Campo, Gaël Roué, Armando López-Guillermo, Dolors Colomer, Patricia Pérez-Galán
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (13): 3458–3471.
https://doi.org/10.1158/1078-0432.CCR-14-0154
Published: 30 June 2014
View article titled, Disruption of Follicular Dendritic Cells–Follicular Lymphoma Cross-talk by the Pan-PI3K Inhibitor BKM120 (Buparlisib)
Open the PDF for Disruption of Follicular Dendritic Cells–Follicular Lymphoma Cross-talk by the Pan-PI3K Inhibitor BKM120 (Buparlisib) in another window
Includes: Supplementary data
Journal Articles

Antitumoral Activity of Lenalidomide in In Vitro and In Vivo Models of Mantle Cell Lymphoma Involves the Destabilization of Cyclin D1/p27KIP1 Complexes

Alexandra Moros, Sophie Bustany, Julie Cahu, Ifigènia Saborit-Villarroya, Antonio Martínez, Dolors Colomer, Brigitte Sola, Gaël Roué
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2): 393–403.
https://doi.org/10.1158/1078-0432.CCR-13-1569
Published: 16 January 2014
View article titled, Antitumoral Activity of Lenalidomide in <em>In Vitro</em> and <em>In Vivo</em> Models of Mantle Cell Lymphoma Involves the Destabilization of Cyclin D1/p27<sup>KIP1</sup> Complexes
Open the PDF for Antitumoral Activity of Lenalidomide in <em>In Vitro</em> and <em>In Vivo</em> Models of Mantle Cell Lymphoma Involves the Destabilization of Cyclin D1/p27<sup>KIP1</sup> Complexes in another window
Includes: Supplementary data
Journal Articles

Sorafenib Inhibits Cell Migration and Stroma-Mediated Bortezomib Resistance by Interfering B-cell Receptor Signaling and Protein Translation in Mantle Cell Lymphoma

Sílvia Xargay-Torrent, Mónica López-Guerra, Arnau Montraveta, Ifigènia Saborit-Villarroya, Laia Rosich, Alba Navarro, Patricia Pérez-Galán, Gaël Roué, Elias Campo, Dolors Colomer
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (3): 586–597.
https://doi.org/10.1158/1078-0432.CCR-12-1935
Published: 31 January 2013
View article titled, Sorafenib Inhibits Cell Migration and Stroma-Mediated Bortezomib Resistance by Interfering B-cell Receptor Signaling and Protein Translation in Mantle Cell Lymphoma
Open the PDF for Sorafenib Inhibits Cell Migration and Stroma-Mediated Bortezomib Resistance by Interfering B-cell Receptor Signaling and Protein Translation in Mantle Cell Lymphoma in another window
Journal Articles

Counteracting Autophagy Overcomes Resistance to Everolimus in Mantle Cell Lymphoma

Laia Rosich, Sílvia Xargay-Torrent, Mónica López-Guerra, Elías Campo, Dolors Colomer, Gaël Roué
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5278–5289.
https://doi.org/10.1158/1078-0432.CCR-12-0351
Published: 30 September 2012
View article titled, Counteracting Autophagy Overcomes Resistance to Everolimus in Mantle Cell Lymphoma
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Includes: Supplementary data
Journal Articles

Vorinostat-Induced Apoptosis in Mantle Cell Lymphoma Is Mediated by Acetylation of Proapoptotic BH3-Only Gene Promoters

Sílvia Xargay-Torrent, Mónica López-Guerra, Ifigènia Saborit-Villarroya, Laia Rosich, Elias Campo, Gaël Roué, Dolors Colomer
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 3956–3968.
https://doi.org/10.1158/1078-0432.CCR-10-3412
Published: 15 June 2011
View article titled, Vorinostat-Induced Apoptosis in Mantle Cell Lymphoma Is Mediated by Acetylation of Proapoptotic BH3-Only Gene Promoters
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Journal Articles

In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts

Faustino Mollinedo, Janis de la Iglesia-Vicente, Consuelo Gajate, Ander Estella-Hermoso de Mendoza, Janny A. Villa-Pulgarin, Mercè de Frias, Gaël Roué, Joan Gil, Dolors Colomer, Miguel A. Campanero, Maria J. Blanco-Prieto
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (7): 2046–2054.
https://doi.org/10.1158/1078-0432.CCR-09-2456
Published: 31 March 2010
View article titled, <em>In vitro</em> and <em>In vivo</em> Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts
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Includes: Supplementary data
Journal Articles

p65 Activity and ZAP-70 Status Predict the Sensitivity of Chronic Lymphocytic Leukemia Cells to the Selective IκB Kinase Inhibitor BMS-345541

Mónica López-Guerra, Gaël Roué, Patricia Pérez-Galán, Roberto Alonso, Neus Villamor, Emili Montserrat, Elias Campo, Dolors Colomer
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (8): 2767–2776.
https://doi.org/10.1158/1078-0432.CCR-08-2382
Published: 15 April 2009
View article titled, p65 Activity and ZAP-70 Status Predict the Sensitivity of Chronic Lymphocytic Leukemia Cells to the Selective IκB Kinase Inhibitor BMS-345541
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Journal Articles

Bendamustine Is Effective in p53-Deficient B-Cell Neoplasms and Requires Oxidative Stress and Caspase-Independent Signaling

Gaël Roué, Mónica López-Guerra, Pierre Milpied, Patricia Pérez-Galán, Neus Villamor, Emili Montserrat, Elias Campo, Dolors Colomer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (21): 6907–6915.
https://doi.org/10.1158/1078-0432.CCR-08-0388
Published: 03 November 2008
View article titled, Bendamustine Is Effective in p53-Deficient B-Cell Neoplasms and Requires Oxidative Stress and Caspase-Independent Signaling
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Journal Articles

Lack of Methylthioadenosine Phosphorylase Expression in Mantle Cell Lymphoma Is Associated with Shorter Survival: Implications for a Potential Targeted Therapy

Silvia Marcé, Olga Balagué, Luis Colomo, Antonio Martinez, Sylvia Höller, Neus Villamor, Francesc Bosch, German Ott, Andreas Rosenwald, Lorenzo Leoni, Manel Esteller, Mario F. Fraga, Emili Montserrat, Dolors Colomer, Elias Campo
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (12): 3754–3761.
https://doi.org/10.1158/1078-0432.CCR-05-2780
Published: 15 June 2006
View article titled, Lack of Methylthioadenosine Phosphorylase Expression in Mantle Cell Lymphoma Is Associated with Shorter Survival: Implications for a Potential Targeted Therapy
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Journal Articles

ZAP-70 Expression in Normal Pro/Pre B Cells, Mature B Cells, and in B-Cell Acute Lymphoblastic Leukemia

Marta Crespo, Neus Villamor, Eva Giné, Ana Muntañola, Dolors Colomer, Teresa Marafioti, Margaret Jones, Mireia Camós, Elias Campo, Emili Montserrat, Francesc Bosch
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (3): 726–734.
https://doi.org/10.1158/1078-0432.CCR-05-1531
Published: 07 February 2006
View article titled, ZAP-70 Expression in Normal Pro/Pre B Cells, Mature B Cells, and in B-Cell Acute Lymphoblastic Leukemia
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Journal Articles

Prognostic Significance of the Detection of Circulating Malignant Cells by Reverse Transcriptase-Polymerase Chain Reaction in Long-Term Clinically Disease-free Melanoma Patients

Begoña Mellado, Lorena Gutierrez, Teresa Castel, Dolors Colomer, Montserrat Fontanillas, Josefa Castro, Jordi Estapé
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1843–1848.
Published: 01 July 1999
View article titled, Prognostic Significance of the Detection of Circulating Malignant Cells by Reverse Transcriptase-Polymerase Chain Reaction in Long-Term Clinically Disease-free Melanoma Patients
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