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Diether Lambrechts
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Journal Articles

Poor Outcome in Postpartum Breast Cancer Patients Is Associated with Distinct Molecular and Immunologic Features

Hanne Lefrère, Kat Moore, Giuseppe Floris, Joyce Sanders, Iris M. Seignette, Tycho Bismeijer, Dennis Peters, Annegien Broeks, Erik Hooijberg, Kristel Van Calsteren, Patrick Neven, Ellen Warner, Fedro Alessandro Peccatori, Sibylle Loibl, Charlotte Maggen, Sileny N. Han, Katarzyna J. Jerzak, Daniela Annibali, Diether Lambrechts, Karin E. de Visser, Lodewyk Wessels, Liesbeth Lenaerts, Frédéric Amant
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3729–3743.
https://doi.org/10.1158/1078-0432.CCR-22-3645
Published: 15 September 2023
View article titled, Poor Outcome in Postpartum Breast Cancer Patients Is Associated with Distinct Molecular and Immunologic Features
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Includes: Supplementary data
Journal Articles

Abstract PR03: Pretreatment immune cell composition and checkpoint ligand expression define the response to immunotherapy in advanced HCC: a study using single-cell sequencing

Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Jeroen Derkervel
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17_Supplement): PR03.
https://doi.org/10.1158/1557-3265.LIVERCA22-PR03
Published: 01 September 2022
View article titled, Abstract PR03: Pretreatment immune cell composition and checkpoint ligand expression define the response to immunotherapy in advanced HCC: a study using single-cell sequencing
Journal Articles

Abstract PO002: Pretreatment immune cell composition and checkpoint ligand expression define the response to immunotherapy in advanced HCC: a study using single-cell sequencing

Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Jeroen Derkervel
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17_Supplement): PO002.
https://doi.org/10.1158/1557-3265.LIVERCA22-PO002
Published: 01 September 2022
View article titled, Abstract PO002: Pretreatment immune cell composition and checkpoint ligand expression define the response to immunotherapy in advanced HCC: a study using single-cell sequencing
Journal Articles

Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer

Peter A. Fasching, Duan Liu, Steve Scully, James N. Ingle, Paulo C. Lyra, Jr., Brigitte Rack, Alexander Hein, Arif B. Ekici, Andre Reis, Andreas Schneeweiss, Hans Tesch, Tanja N. Fehm, Georg Heinrich, Matthias W. Beckmann, Matthias Ruebner, Hanna Huebner, Diether Lambrechts, Ebony Madden, Jess Shen, Jane Romm, Kim Doheny, Gregory D. Jenkins, Erin E. Carlson, Liang Li, Brooke L. Fridley, Julie M. Cunningham, Wolfgang Janni, Alvaro N.A. Monteiro, Daniel J. Schaid, Lothar Häberle, Richard M. Weinshilboum, Liewei Wang
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (15): 3342–3355.
https://doi.org/10.1158/1078-0432.CCR-20-4774
Published: 02 August 2022
View article titled, Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer
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Includes: Supplementary data
Journal Articles

Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib

Che-Jui Lee, Patrick Schöffski, Elodie Modave, Tom van Wezel, Bram Boeckx, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Maria Debiec-Rychter, Raf Sciot, Judith V.M.G. Bovée, Diether Lambrechts, Agnieszka Wozniak
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (24): 6737–6748.
https://doi.org/10.1158/1078-0432.CCR-21-1165
Published: 15 December 2021
View article titled, Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib
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Includes: Supplementary data
Journal Articles

Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer

Adam Lafferty, Alice C. O'Farrell, Giorgia Migliardi, Niraj Khemka, Andreas U. Lindner, Francesco Sassi, Eugenia R. Zanella, Manuela Salvucci, Evy Vanderheyden, Elodie Modave, Bram Boeckx, Luise Halang, Johannes Betge, Matthias P.A. Ebert, Patrick Dicker, Guillem Argilés, Josep Tabernero, Rodrigo Dienstmann, Enzo Medico, Diether Lambrechts, Andrea Bertotti, Claudio Isella, Livio Trusolino, Jochen H.M. Prehn, Annette T. Byrne
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (21): 5979–5992.
https://doi.org/10.1158/1078-0432.CCR-21-0818
Published: 01 November 2021
View article titled, Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Molecular Biomarkers of Response to Eribulin in Patients with Leiomyosarcoma

Agnieszka Wozniak, Bram Boeckx, Elodie Modave, Amy Weaver, Diether Lambrechts, Bruce A. Littlefield, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3106–3115.
https://doi.org/10.1158/1078-0432.CCR-20-4315
Published: 01 June 2021
View article titled, Molecular Biomarkers of Response to Eribulin in Patients with Leiomyosarcoma
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Includes: Supplementary data
Journal Articles

Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer

François Richard, Samira Majjaj, David Venet, Françoise Rothé, Julien Pingitore, Bram Boeckx, Caterina Marchio, Florian Clatot, François Bertucci, Odette Mariani, Christine Galant, Gert van den Eynden, Roberto Salgado, Elia Biganzoli, Diether Lambrechts, Anne Vincent-Salomon, Giancarlo Pruneri, Denis Larsimont, Christos Sotiriou, Christine Desmedt
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6254–6265.
https://doi.org/10.1158/1078-0432.CCR-20-2268
Published: 01 December 2020
View article titled, Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract A75: Serine auxotrophy: A novel metabolic vulnerability of platinum-resistant ovarian cancer?

Tom Van Nyen, Joao A.G. Duarte, Matteo Rossi, Mélanie Planque, Esther Zaal, Ali Talebi, Stijn Moens, Guy Eelen, Hugo Horlings, Johan Swinnen, Celia Berkers, Peter Carmeliet, Reuven Agami, Sarah-Maria Fendt, Diether Lambrechts, Daniela Annibali, Frederic Amant
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): A75.
https://doi.org/10.1158/1557-3265.OVCA19-A75
Published: 01 July 2020
View article titled, Abstract A75: Serine auxotrophy: A novel metabolic vulnerability of platinum-resistant ovarian cancer?
Journal Articles

Tamoxifen Metabolism and Efficacy in Breast Cancer: A Prospective Multicenter Trial

Patrick Neven, Lynn Jongen, Anneleen Lintermans, Kathleen Van Asten, Chantal Blomme, Diether Lambrechts, An Poppe, Hans Wildiers, Anne-Sophie Dieudonné, Olivier Brouckaert, Jan Decloedt, Patrick Berteloot, Didier Verhoeven, Markus Joerger, Peter Vuylsteke, Wim Wynendaele, Minne Casteels, Sabine Van Huffel, Willem Lybaert, Johan Van Ginderachter, Robert Paridaens, Ignace Vergote, Vincent Olaf Dezentjé, Ben Van Calster, Henk-Jan Guchelaar
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (10): 2312–2318.
https://doi.org/10.1158/1078-0432.CCR-17-3028
Published: 14 May 2018
View article titled, Tamoxifen Metabolism and Efficacy in Breast Cancer: A Prospective Multicenter Trial
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Includes: Supplementary data
Journal Articles

A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer

Caroline Kreuzinger, Angelika Geroldinger, Dominiek Smeets, Elena Ioana Braicu, Jalid Sehouli, Julia Koller, Andrea Wolf, Silvia Darb-Esfahani, Korinna Joehrens, Ignace Vergote, Adriaan Vanderstichele, Bram Boeckx, Diether Lambrechts, Hani Gabra, G. Bea A. Wisman, Fabian Trillsch, Georg Heinze, Reinhard Horvat, Stephan Polterauer, Els Berns, Charles Theillet, Dan Cacsire Castillo-Tong
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (24): 7621–7632.
https://doi.org/10.1158/1078-0432.CCR-17-1159
Published: 14 December 2017
View article titled, A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

Jeroen Depreeuw, Ellen Stelloo, Elisabeth M. Osse, Carien L. Creutzberg, Remi A. Nout, Matthieu Moisse, Diego A. Garcia-Dios, Michael Dewaele, Karen Willekens, Jean-Christophe Marine, Xavier Matias-Guiu, Frédéric Amant, Diether Lambrechts, Tjalling Bosse
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23): 7232–7241.
https://doi.org/10.1158/1078-0432.CCR-17-0566
Published: 30 November 2017
View article titled, Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma
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Includes: Supplementary data
Journal Articles

Chromosomal Instability in Cell-Free DNA as a Highly Specific Biomarker for Detection of Ovarian Cancer in Women with Adnexal Masses

Adriaan Vanderstichele, Pieter Busschaert, Dominiek Smeets, Chiara Landolfo, Els Van Nieuwenhuysen, Karin Leunen, Patrick Neven, Frédéric Amant, Sven Mahner, Elena Ioana Braicu, Robert Zeilinger, An Coosemans, Dirk Timmerman, Diether Lambrechts, Ignace Vergote
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2223–2231.
https://doi.org/10.1158/1078-0432.CCR-16-1078
Published: 30 April 2017
View article titled, Chromosomal Instability in Cell-Free DNA as a Highly Specific Biomarker for Detection of Ovarian Cancer in Women with Adnexal Masses
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Includes: Supplementary data
Journal Articles

Abstract A26: The successful application of endoscopic ultrasound guided fine needle biopsy to establish pancreatic patient-derived tumor xenografts

Els Hermans, Schalk Van der Merwe, Jeroen Depreeuw, Jeroen Dekervel, Enrico Radaelli, Baki Topal, Diether Lambrechts, Frédéric Amant
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A26.
https://doi.org/10.1158/1557-3265.PDX16-A26
Published: 15 August 2016
View article titled, Abstract A26: The successful application of endoscopic ultrasound guided fine needle biopsy to establish pancreatic patient-derived tumor xenografts
Journal Articles

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

Sharon E. Johnatty, Jonathan P. Tyrer, Siddhartha Kar, Jonathan Beesley, Yi Lu, Bo Gao, Peter A. Fasching, Alexander Hein, Arif B. Ekici, Matthias W. Beckmann, Diether Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote, Sandrina Lambrechts, Mary Anne Rossing, Jennifer A. Doherty, Jenny Chang-Claude, Francesmary Modugno, Roberta B. Ness, Kirsten B. Moysich, Douglas A. Levine, Lambertus A. Kiemeney, Leon F.A.G. Massuger, Jacek Gronwald, Jan Lubiński, Anna Jakubowska, Cezary Cybulski, Louise Brinton, Jolanta Lissowska, Nicolas Wentzensen, Honglin Song, Valerie Rhenius, Ian Campbell, Diana Eccles, Weiva Sieh, Alice S. Whittemore, Valerie McGuire, Joseph H. Rothstein, Rebecca Sutphen, Hoda Anton-Culver, Argyrios Ziogas, Simon A. Gayther, Aleksandra Gentry-Maharaj, Usha Menon, Susan J. Ramus, Celeste L. Pearce, Malcolm C. Pike, Daniel O. Stram, Anna H. Wu, Jolanta Kupryjanczyk, Agnieszka Dansonka-Mieszkowska, Iwona K. Rzepecka, Beata Spiewankiewicz, Marc T. Goodman, Lynne R. Wilkens, Michael E. Carney, Pamela J. Thompson, Florian Heitz, Andreas du Bois, Ira Schwaab, Philipp Harter, Jacobus Pisterer, Peter Hillemanns, on behalf of the AGO Study Group, Beth Y. Karlan, Christine Walsh, Jenny Lester, Sandra Orsulic, Stacey J. Winham, Madalene Earp, Melissa C. Larson, Zachary C. Fogarty, Estrid Høgdall, Allan Jensen, Susanne Kruger Kjaer, Brooke L. Fridley, Julie M. Cunningham, Robert A. Vierkant, Joellen M. Schildkraut, Edwin S. Iversen, Kathryn L. Terry, Daniel W. Cramer, Elisa V. Bandera, Irene Orlow, Tanja Pejovic, Yukie Bean, Claus Høgdall, Lene Lundvall, Ian McNeish, James Paul, Karen Carty, Nadeem Siddiqui, Rosalind Glasspool, Thomas Sellers, Catherine Kennedy, Yoke-Eng Chiew, Andrew Berchuck, Stuart MacGregor, Paul D.P. Pharoah, Ellen L. Goode, Anna deFazio, Penelope M. Webb, Georgia Chenevix-Trench
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5264–5276.
https://doi.org/10.1158/1078-0432.CCR-15-0632
Published: 30 November 2015
View article titled, Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium
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Includes: Supplementary data
Journal Articles

Germline Mutation in BRCA1 or BRCA2 and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer

Francisco J. Candido-dos-Reis, Honglin Song, Ellen L. Goode, Julie M. Cunningham, Brooke L. Fridley, Melissa C. Larson, Kathryn Alsop, Ed Dicks, Patricia Harrington, Susan J. Ramus, Anna de Fazio, Gillian Mitchell, Sian Fereday, Kelly L. Bolton, Charlie Gourley, Caroline Michie, Beth Karlan, Jenny Lester, Christine Walsh, Ilana Cass, Håkan Olsson, Martin Gore, Javier J. Benitez, Maria J. Garcia, Irene Andrulis, Anna Marie Mulligan, Gord Glendon, Ignacio Blanco, Conxi Lazaro, Alice S. Whittemore, Valerie McGuire, Weiva Sieh, Marco Montagna, Elisa Alducci, Siegal Sadetzki, Angela Chetrit, Ava Kwong, Susanne K. Kjaer, Allan Jensen, Estrid Høgdall, Susan Neuhausen, Robert Nussbaum, Mary Daly, Mark H. Greene, Phuong L. Mai, Jennifer T. Loud, Kirsten Moysich, Amanda E. Toland, Diether Lambrechts, Steve Ellis, Debra Frost, James D. Brenton, Marc Tischkowitz, Douglas F. Easton, Antonis Antoniou, Georgia Chenevix-Trench, Simon A. Gayther, David Bowtell, Paul D.P. Pharoah
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (3): 652–657.
https://doi.org/10.1158/1078-0432.CCR-14-2497
Published: 01 February 2015
View article titled, Germline Mutation in <em>BRCA1</em> or <em>BRCA2</em> and Ten-Year Survival for Women Diagnosed with Epithelial Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab

Christopher G. Smith, David Fisher, Bart Claes, Timothy S. Maughan, Shelley Idziaszczyk, Gilian Peuteman, Rebecca Harris, Michelle D. James, Angela Meade, Bharat Jasani, Richard A. Adams, Sarah Kenny, Richard Kaplan, Diether Lambrechts, Jeremy P. Cheadle
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (15): 4104–4113.
https://doi.org/10.1158/1078-0432.CCR-12-2581
Published: 31 July 2013
View article titled, Somatic Profiling of the Epidermal Growth Factor Receptor Pathway in Tumors from Patients with Advanced Colorectal Cancer Treated with Chemotherapy ± Cetuximab
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Includes: Supplementary data
Journal Articles

Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients

R. Stephanie Huang, Sharon E. Johnatty, Eric R. Gamazon, Hae Kyung Im, Dana Ziliak, Shiwei Duan, Wei Zhang, Emily O. Kistner, Peixian Chen, Jonathan Beesley, Shuangli Mi, Peter H. O'Donnell, Yarden S. Fraiman, Soma Das, Nancy J. Cox, Yi Lu, Stuart MacGregor, Ellen L. Goode, Robert A. Vierkant, Brooke L. Fridley, Estrid Hogdall, Susanne K. Kjaer, Allan Jensen, Kirsten B. Moysich, Matthew Grasela, Kunle Odunsi, Robert Brown, Jim Paul, Diether Lambrechts, Evelyn Despierre, Ignace Vergote, Jenny Gross, Beth Y. Karlan, Anna deFazio, Georgia Chenevix-Trench, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (16): 5490–5500.
https://doi.org/10.1158/1078-0432.CCR-11-0724
Published: 14 August 2011
View article titled, Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients
Open the PDF for Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients in another window
Includes: Supplementary data
Journal Articles

The Role of KRAS rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing

Paul D. P. Pharoah, Rachel T. Palmieri, Susan J. Ramus, Simon A. Gayther, Irene L. Andrulis, Hoda Anton-Culver, Natalia Antonenkova, Antonis C. Antoniou, David Goldgar, Mary S. Beattie, Matthias W. Beckmann, Michael J. Birrer, Natalia Bogdanova, Kelly L. Bolton, Wendy Brewster, Angela Brooks-Wilson, Robert Brown, Ralf Butzow, Trinidad Caldes, Maria Adelaide Caligo, Ian Campbell, Jenny Chang-Claude, Y. Ann Chen, Linda S. Cook, Fergus J. Couch, Daniel W. Cramer, Julie M. Cunningham, Evelyn Despierre, Jennifer A. Doherty, Thilo Dörk, Matthias Dürst, Diana M. Eccles, Arif B. Ekici, Douglas Easton, Peter A. Fasching, Anna de Fazio, David A. Fenstermacher, James M. Flanagan, Brooke L. Fridley, Eitan Friedman, Bo Gao, Olga Sinilnikova, Aleksandra Gentry-Maharaj, Andrew K. Godwin, Ellen L. Goode, Marc T. Goodman, Jenny Gross, Thomas V. O. Hansen, Paul Harnett, Matti Rookus, Tuomas Heikkinen, Rebecca Hein, Claus Høgdall, Estrid Høgdall, Edwin S. Iversen, Anna Jakubowska, Sharon E. Johnatty, Beth Y. Karlan, Noah D. Kauff, Stanley B. Kaye, Georgia Chenevix-Trench, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne Krüger Kjaer, Diether Lambrechts, James P. LaPolla, Conxi Lázaro, Nhu D. Le, Arto Leminen, Karin Leunen, Douglas A. Levine, Yi Lu, Lene Lundvall, Stuart Macgregor, Tamara Marees, Leon F. Massuger, John R. McLaughlin, Usha Menon, Marco Montagna, Kirsten B. Moysich, Steven A. Narod, Katherine L. Nathanson, Lotte Nedergaard, Roberta B. Ness, Heli Nevanlinna, Stefan Nickels, Ana Osorio, Jim Paul, Celeste Leigh Pearce, Catherine M. Phelan, Malcolm C. Pike, Paolo Radice, Mary Anne Rossing, Joellen M. Schildkraut, Thomas A. Sellers, Christian F. Singer, Honglin Song, Daniel O. Stram, Rebecca Sutphen, Annika Lindblom, Kathryn L. Terry, Ya-Yu Tsai, Anne M. van Altena, Ignace Vergote, Robert A. Vierkant, Allison F. Vitonis, Christine Walsh, Shan Wang-Gohrke, Barbara Wappenschmidt, Anna H. Wu, Argyrios Ziogas, Andrew Berchuck, Harvey A. Risch
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (11): 3742–3750.
https://doi.org/10.1158/1078-0432.CCR-10-3405
Published: 01 June 2011
View article titled, The Role of <em>KRAS</em> rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing
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Journal Articles

PIK3CA Mutations Are Not a Major Determinant of Resistance to the Epidermal Growth Factor Receptor Inhibitor Cetuximab in Metastatic Colorectal Cancer

Hans Prenen, Jef De Schutter, Bart Jacobs, Wendy De Roock, Bart Biesmans, Bart Claes, Diether Lambrechts, Eric Van Cutsem, Sabine Tejpar
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (9): 3184–3188.
https://doi.org/10.1158/1078-0432.CCR-08-2961
Published: 30 April 2009
View article titled, PIK3CA Mutations Are Not a Major Determinant of Resistance to the Epidermal Growth Factor Receptor Inhibitor Cetuximab in Metastatic Colorectal Cancer
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