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Diane M. Simeone
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Journal Articles

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

Edward J. Kim, Vaibhav Sahai, Ethan V. Abel, Kent A. Griffith, Joel K. Greenson, Naoko Takebe, Gazala N. Khan, John L. Blau, Ronald Craig, Ulysses G. Balis, Mark M. Zalupski, Diane M. Simeone
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (23): 5937–5945.
https://doi.org/10.1158/1078-0432.CCR-14-1269
Published: 30 November 2014
View article titled, Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
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Includes: Supplementary data
Journal Articles

HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s

Ling Li, Wenhua Tang, Xiaoqing Wu, David Karnak, Xiaojie Meng, Rachel Thompson, Xinbao Hao, Yongmin Li, Xiaotan T. Qiao, Jiayuh Lin, James Fuchs, Diane M. Simeone, Zhi-Nan Chen, Theodore S. Lawrence, Liang Xu
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (24): 6703–6715.
https://doi.org/10.1158/1078-0432.CCR-13-0621
Published: 16 December 2013
View article titled, HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s
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Includes: Supplementary data
Journal Articles

Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells

Wan-Ching Yen, Marcus M. Fischer, Mark Hynes, Jingjiang Wu, Edward Kim, Lucia Beviglia, V. Pete Yeung, Xiaomei Song, Ann M. Kapoun, John Lewicki, Austin Gurney, Diane M. Simeone, Timothy Hoey
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5374–5386.
https://doi.org/10.1158/1078-0432.CCR-12-0736
Published: 30 September 2012
View article titled, Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells
Open the PDF for Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent on Targeting DLL4-Notch Signaling in Both Tumor and Vasculature Cells in another window
Includes: Supplementary data
Journal Articles

Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition

Leslie A. Parsels, Yushen Qian, Daria M. Tanska, Marisa Gross, Lili Zhao, Maria C. Hassan, Sankari Arumugarajah, Joshua D. Parsels, Linda Hylander-Gans, Diane M. Simeone, Deborah Morosini, Jeffrey L. Brown, Sonya D. Zabludoff, Jonathan Maybaum, Theodore S. Lawrence, Meredith A. Morgan
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (11): 3706–3715.
https://doi.org/10.1158/1078-0432.CCR-10-3082
Published: 01 June 2011
View article titled, Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition
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Includes: Supplementary data
Journal Articles

Pancreatic Cancer Stem Cells: Implications for the Treatment of Pancreatic Cancer

Diane M. Simeone
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5646–5648.
https://doi.org/10.1158/1078-0432.CCR-08-0584
Published: 14 September 2008
View article titled, Pancreatic Cancer Stem Cells: Implications for the Treatment of Pancreatic Cancer
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Journal Articles

S100P Promotes Pancreatic Cancer Growth, Survival, and Invasion

Thiruvengadam Arumugam, Diane M. Simeone, Kenneth Van Golen, Craig D. Logsdon
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5356–5364.
https://doi.org/10.1158/1078-0432.CCR-05-0092
Published: 01 August 2005
View article titled, S100P Promotes Pancreatic Cancer Growth, Survival, and Invasion
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