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Journal Articles

Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells

Deepika Sharma Das, Abhishek Das, Arghya Ray, Yan Song, Mehmet Kemal Samur, Nikhil C. Munshi, Dharminder Chauhan, Kenneth C. Anderson

Clin Cancer Res (2017) 23 (15): 4280–4289.

https://doi.org/10.1158/1078-0432.CCR-16-2692

Published: 01 August 2017

View article titled, Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells

Includes: Supplementary data

Journal Articles

Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

Clin Cancer Res (2016) 22 (24): 6099–6109.

https://doi.org/10.1158/1078-0432.CCR-16-0630

Published: 15 December 2016

View article titled, Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

Includes: Supplementary data

Journal Articles

Abstract A21: Inhibition of USP7 for the treatment of multiple myeloma and other malignancies.

Benjamin Nicholson, Matthew P. Kodrasov, James P. LaRocque, Michael J. Eddins, Suresh Kumar, Dharminder Chauhan, Kenneth C. Anderson, Michael R. Mattern

Clin Cancer Res (2015) 21 (17_Supplement): A21.

https://doi.org/10.1158/1557-3265.HEMMAL14-A21

Published: 19 August 2015

View article titled, Abstract A21: Inhibition of USP7 for the treatment of multiple myeloma and other malignancies.

Journal Articles

Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease

Antonio Garcia-Gomez, Dalia Quwaider, Miriam Canavese, Enrique M. Ocio, Ze Tian, Juan F. Blanco, Allison J. Berger, Carlos Ortiz-de-Solorzano, Teresa Hernández-Iglesias, Anton C.M. Martens, Richard W.J. Groen, Joaquín Mateo-Urdiales, Susana Fraile, Miguel Galarraga, Dharminder Chauhan, Jesús F. San Miguel, Noopur Raje, Mercedes Garayoa

Clin Cancer Res (2014) 20 (6): 1542–1554.

https://doi.org/10.1158/1078-0432.CCR-13-1657

Published: 13 March 2014

View article titled, Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease

Journal Articles

In Vitro and In Vivo Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells

Dharminder Chauhan, Arghya Ray, Kristina Viktorsson, Jack Spira, Claudia Paba-Prada, Nikhil Munshi, Paul Richardson, Rolf Lewensohn, Kenneth C. Anderson

Clin Cancer Res (2013) 19 (11): 3019–3031.

https://doi.org/10.1158/1078-0432.CCR-12-3752

Published: 30 May 2013

View article titled, In Vitro and In Vivo Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells

Includes: Supplementary data

Journal Articles

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

Dharminder Chauhan, Ze Tian, Bin Zhou, Deborah Kuhn, Robert Orlowski, Noopur Raje, Paul Richardson, Kenneth C. Anderson

Clin Cancer Res (2011) 17 (16): 5311–5321.

https://doi.org/10.1158/1078-0432.CCR-11-0476

Published: 14 August 2011

View article titled, In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

Journal Articles

Antimyeloma Activity of a Multitargeted Kinase Inhibitor, AT9283, via Potent Aurora Kinase and STAT3 Inhibition Either Alone or in Combination with Lenalidomide

Loredana Santo, Teru Hideshima, Diana Cirstea, Madhavi Bandi, Erik A. Nelson, Gullu Gorgun, Scott Rodig, Sonia Vallet, Samantha Pozzi, Kishan Patel, Christine Unitt, Matt Squires, Yiguo Hu, Dharminder Chauhan, Anuj Mahindra, Nikhil C. Munshi, Kenneth C. Anderson, Noopur Raje

Clin Cancer Res (2011) 17 (10): 3259–3271.

https://doi.org/10.1158/1078-0432.CCR-10-3012

Published: 15 May 2011

View article titled, Antimyeloma Activity of a Multitargeted Kinase Inhibitor, AT9283, via Potent Aurora Kinase and STAT3 Inhibition Either Alone or in Combination with Lenalidomide

Journal Articles

Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib

Melissa G. Ooi, Patrick J. Hayden, Vassiliki Kotoula, Douglas W. McMillin, Elpida Charalambous, Emily Daskalaki, Noopur S. Raje, Nikhil C. Munshi, Dharminder Chauhan, Teru Hideshima, Leutz Buon, Martin Clynes, Peter O'Gorman, Paul G. Richardson, Constantine S. Mitsiades, Kenneth C. Anderson, Nicholas Mitsiades

Clin Cancer Res (2009) 15 (23): 7153–7160.

https://doi.org/10.1158/1078-0432.CCR-09-1071

Published: 30 November 2009

View article titled, Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib

Includes: Supplementary data

Journal Articles

Neutralizing B-Cell–Activating Factor Antibody Improves Survival and Inhibits Osteoclastogenesis in a Severe Combined Immunodeficient Human Multiple Myeloma Model

Paola Neri, Shaji Kumar, Maria Teresa Fulciniti, Sonia Vallet, Shweta Chhetri, Sidhartha Mukherjee, YuTzu Tai, Dharminder Chauhan, Pierfrancesco Tassone, Salvatore Venuta, Nikhil C. Munshi, Teru Hideshima, Kenneth C. Anderson, Noopur Raje

Clin Cancer Res (2007) 13 (19): 5903–5909.

https://doi.org/10.1158/1078-0432.CCR-07-0753

Published: 01 October 2007

View article titled, Neutralizing B-Cell–Activating Factor Antibody Improves Survival and Inhibits Osteoclastogenesis in a Severe Combined Immunodeficient Human Multiple Myeloma Model

Journal Articles

MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo

Teru Hideshima, Paola Neri, Pierfranchesco Tassone, Hiroshi Yasui, Kenji Ishitsuka, Noopur Raje, Dharminder Chauhan, Klaus Podar, Constantine Mitsiades, Lenny Dang, Nikhil Munshi, Paul Richardson, David Schenkein, Kenneth C. Anderson

Clin Cancer Res (2006) 12 (19): 5887–5894.

https://doi.org/10.1158/1078-0432.CCR-05-2501

Published: 04 October 2006

View article titled, MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo

Journal Articles

Intracellular Protein Degradation and Its Therapeutic Implications

Teru Hideshima, James E. Bradner, Dharminder Chauhan, Kenneth C. Anderson

Clin Cancer Res (2005) 11 (24): 8530–8533.

https://doi.org/10.1158/1078-0432.CCR-05-2305

Published: 16 December 2005

View article titled, Intracellular Protein Degradation and Its Therapeutic Implications

Journal Articles

Combination Therapy with Interleukin-6 Receptor Superantagonist Sant7 and Dexamethasone Induces Antitumor Effects in a Novel SCID-hu In vivo Model of Human Multiple Myeloma

Pierfrancesco Tassone, Paola Neri, Renate Burger, Rocco Savino, Masood Shammas, Laurence Catley, Klaus Podar, Dharminder Chauhan, Serena Masciari, Antonella Gozzini, Pierosandro Tagliaferri, Salvatore Venuta, Nikhil C. Munshi, Kenneth C. Anderson

Clin Cancer Res (2005) 11 (11): 4251–4258.

https://doi.org/10.1158/1078-0432.CCR-04-2611

Published: 01 June 2005

View article titled, Combination Therapy with Interleukin-6 Receptor Superantagonist Sant7 and Dexamethasone Induces Antitumor Effects in a Novel SCID-hu In vivo Model of Human Multiple Myeloma

Journal Articles

Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment

Toshiaki Hayashi, Teru Hideshima, Aaron N. Nguyen, Olivier Munoz, Klaus Podar, Makoto Hamasaki, Kenji Ishitsuka, Hiroshi Yasui, Paul Richardson, Sarvajit Chakravarty, Alison Murphy, Dharminder Chauhan, Linda S. Higgins, Kenneth C. Anderson

Clin Cancer Res (2004) 10 (22): 7540–7546.

https://doi.org/10.1158/1078-0432.CCR-04-0632

Published: 29 November 2004

View article titled, Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment

Journal Articles

Characterization of Signaling Cascades Triggered by Human Interleukin-6 versus Kaposi’s Sarcoma-associated Herpes Virus-encoded Viral Interleukin 6

Teru Hideshima, Dharminder Chauhan, Gerrard Teoh, Noopur Raje, Steven P. Treon, Yu-Tzu Tai, Yoshihito Shima, Kenneth C. Anderson

Clin Cancer Res (2000) 6 (3): 1180–1189.

Published: 01 March 2000

View article titled, Characterization of Signaling Cascades Triggered by Human Interleukin-6 versus Kaposi’s Sarcoma-associated Herpes Virus-encoded Viral Interleukin 6

NARROW

Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells

Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

Abstract A21: Inhibition of USP7 for the treatment of multiple myeloma and other malignancies.

Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease

In Vitro and In Vivo Antitumor Activity of a Novel Alkylating Agent, Melphalan-Flufenamide, against Multiple Myeloma Cells

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

Antimyeloma Activity of a Multitargeted Kinase Inhibitor, AT9283, via Potent Aurora Kinase and STAT3 Inhibition Either Alone or in Combination with Lenalidomide

Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib

Neutralizing B-Cell–Activating Factor Antibody Improves Survival and Inhibits Osteoclastogenesis in a Severe Combined Immunodeficient Human Multiple Myeloma Model

MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth In vitro and In vivo

Intracellular Protein Degradation and Its Therapeutic Implications

Combination Therapy with Interleukin-6 Receptor Superantagonist Sant7 and Dexamethasone Induces Antitumor Effects in a Novel SCID-hu In vivo Model of Human Multiple Myeloma

Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment

Characterization of Signaling Cascades Triggered by Human Interleukin-6 versus Kaposi’s Sarcoma-associated Herpes Virus-encoded Viral Interleukin 6

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