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Denis Larsimont
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Journal Articles

Integrating Molecular Imaging and Transcriptomic Profiling in Advanced HER2-Positive Breast Cancer Receiving Trastuzumab Emtansine: An Analysis of the ZEPHIR Clinical Trial

Mattia Rediti, Danai Fimereli, Magdalena Mileva, Zéna Wimana, David Venet, Patrick Flamen, Thomas Guiot, Elisabeth G.E. de Vries, Carolien P. Schröder, Catharina Willemien Menke-van der Houven van Oordt, Marion Maetens, Samira Majjaj, Denis Larsimont, Françoise Rothé, Christos Sotiriou, Géraldine Gebhart
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (1): 110–121.
https://doi.org/10.1158/1078-0432.CCR-24-1007
Published: 06 January 2025
View article titled, Integrating Molecular Imaging and Transcriptomic Profiling in Advanced HER2-Positive Breast Cancer Receiving Trastuzumab Emtansine: An Analysis of the ZEPHIR Clinical Trial
Open the PDF for Integrating Molecular Imaging and Transcriptomic Profiling in Advanced HER2-Positive Breast Cancer Receiving Trastuzumab Emtansine: An Analysis of the ZEPHIR Clinical Trial in another window
Includes: Supplementary data
Journal Articles

Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer

François Richard, Samira Majjaj, David Venet, Françoise Rothé, Julien Pingitore, Bram Boeckx, Caterina Marchio, Florian Clatot, François Bertucci, Odette Mariani, Christine Galant, Gert van den Eynden, Roberto Salgado, Elia Biganzoli, Diether Lambrechts, Anne Vincent-Salomon, Giancarlo Pruneri, Denis Larsimont, Christos Sotiriou, Christine Desmedt
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6254–6265.
https://doi.org/10.1158/1078-0432.CCR-20-2268
Published: 01 December 2020
View article titled, Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer
Open the PDF for Characterization of Stromal Tumor-infiltrating Lymphocytes and Genomic Alterations in Metastatic Lobular Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Association of p27 and Cyclin D1 Expression and Benefit from Adjuvant Trastuzumab Treatment in HER2-Positive Early Breast Cancer: A TransHERA Study

Martin Filipits, Urania Dafni, Michael Gnant, Varvara Polydoropoulou, Margaret Hills, Astrid Kiermaier, Evandro de Azambuja, Denis Larsimont, Federico Rojo, Giuseppe Viale, Masakazu Toi, Nadia Harbeck, Kathleen I. Prichard, Richard D. Gelber, Phuong Dinh, Dimitrios Zardavas, Brian Leyland-Jones, Martine J. Piccart-Gebhart, Mitch Dowsett
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (13): 3079–3086.
https://doi.org/10.1158/1078-0432.CCR-17-3473
Published: 01 July 2018
View article titled, Association of p27 and Cyclin D1 Expression and Benefit from Adjuvant Trastuzumab Treatment in HER2-Positive Early Breast Cancer: A TransHERA Study
Open the PDF for Association of p27 and Cyclin D1 Expression and Benefit from Adjuvant Trastuzumab Treatment in HER2-Positive Early Breast Cancer: A TransHERA Study in another window
Includes: Supplementary data
Journal Articles

Characterization and Clinical Evaluation of CD10+ Stroma Cells in the Breast Cancer Microenvironment

Christine Desmedt, Samira Majjaj, Naima Kheddoumi, Sandeep K. Singhal, Benjamin Haibe-Kains, Frank El Ouriaghli, Carole Chaboteaux, Stefan Michiels, Françoise Lallemand, Fabrice Journe, Hughes Duvillier, Sherene Loi, John Quackenbush, Sophie Dekoninck, Cédric Blanpain, Laurence Lagneaux, Nawal Houhou, Mauro Delorenzi, Denis Larsimont, Martine Piccart, Christos Sotiriou
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (4): 1004–1014.
https://doi.org/10.1158/1078-0432.CCR-11-0383
Published: 14 February 2012
View article titled, Characterization and Clinical Evaluation of CD10<sup>+</sup> Stroma Cells in the Breast Cancer Microenvironment
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Includes: Supplementary data
Journal Articles

Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes

Christine Desmedt, Benjamin Haibe-Kains, Pratyaksha Wirapati, Marc Buyse, Denis Larsimont, Gianluca Bontempi, Mauro Delorenzi, Martine Piccart, Christos Sotiriou
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5158–5165.
https://doi.org/10.1158/1078-0432.CCR-07-4756
Published: 12 August 2008
View article titled, Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes
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Includes: Supplementary data
Journal Articles

Class III β-Tubulin Isotype Predicts Response in Advanced Breast Cancer Patients Randomly Treated Either with Single-Agent Doxorubicin or Docetaxel

Carlos M. Galmarini, Isabelle Treilleux, Fatima Cardoso, Chantal Bernard-Marty, Virginie Durbecq, David Gancberg, Marie-Christine Bissery, Marianne Paesmans, Denis Larsimont, Martine J. Piccart, Angelo Di Leo, Charles Dumontet
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (14): 4511–4516.
https://doi.org/10.1158/1078-0432.CCR-07-4741
Published: 15 July 2008
View article titled, Class III β-Tubulin Isotype Predicts Response in Advanced Breast Cancer Patients Randomly Treated Either with Single-Agent Doxorubicin or Docetaxel
Open the PDF for Class III β-Tubulin Isotype Predicts Response in Advanced Breast Cancer Patients Randomly Treated Either with Single-Agent Doxorubicin or Docetaxel in another window
Includes: Supplementary data
Journal Articles

Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice

Yan Ma, Laurence Lespagnard, Virginie Durbecq, Marianne Paesmans, Christine Desmedt, Maria Gomez-Galdon, Isabelle Veys, Fatima Cardoso, Christos Sotiriou, Angelo Di Leo, Martine J. Piccart, Denis Larsimont
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (12): 4393–4399.
https://doi.org/10.1158/1078-0432.CCR-04-2256
Published: 15 June 2005
View article titled, Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice
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Journal Articles

HER-2 Amplification and Topoisomerase IIα Gene Aberrations as Predictive Markers in Node-positive Breast Cancer Patients Randomly Treated Either with an Anthracycline-based Therapy or with Cyclophosphamide, Methotrexate, and 5-Fluorouracil

Angelo Di Leo, David Gancberg, Denis Larsimont, Minna Tanner, Tero Jarvinen, Ghizlane Rouas, Stella Dolci, Jean-Yves Leroy, Marianne Paesmans, Jorma Isola, Martine J. Piccart
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (5): 1107–1116.
Published: 01 May 2002
View article titled, HER-2 Amplification and Topoisomerase IIα Gene Aberrations as Predictive Markers in Node-positive Breast Cancer Patients Randomly Treated Either with an Anthracycline-based Therapy or with Cyclophosphamide, Methotrexate, and 5-Fluorouracil
Open the PDF for HER-2 Amplification and Topoisomerase IIα Gene Aberrations as Predictive Markers in Node-positive Breast Cancer Patients Randomly Treated Either with an Anthracycline-based Therapy or with Cyclophosphamide, Methotrexate, and 5-Fluorouracil in another window