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Denis C. Talbot
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Journal Articles

Tumor Survivin Is Downregulated by the Antisense Oligonucleotide LY2181308: A Proof-of-Concept, First-in-Human Dose Study

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Denis C. Talbot, Malcolm Ranson, Joanna Davies, Michael Lahn, Sophie Callies, Valérie André, Sunil Kadam, Michael Burgess, Christopher Slapak, Anna L Olsen, Peter J. McHugh, Johann S. de Bono, Julian Matthews, Azeem Saleem, Patricia Price
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (24): 6150–6158.
https://doi.org/10.1158/1078-0432.CCR-10-1932
Published: 16 December 2010
View article titled, Tumor Survivin Is Downregulated by the Antisense Oligonucleotide LY2181308: A Proof-of-Concept, First-in-Human Dose Study
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Includes: Supplementary data
Journal Articles

A Randomized Phase II Pharmacokinetic and Pharmacodynamic Study of Indisulam as Second-Line Therapy in Patients with Advanced Non–Small Cell Lung Cancer

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Denis C. Talbot, Joachim von Pawel, Emma Cattell, S. Murray Yule, Claire Johnston, Anthe S. Zandvliet, Alwin D.R. Huitema, Chris J. Norbury, Paul Ellis, Leon Bosquee, Martin Reck
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (6): 1816–1822.
https://doi.org/10.1158/1078-0432.CCR-06-0249
Published: 15 March 2007
View article titled, A Randomized Phase II Pharmacokinetic and Pharmacodynamic Study of Indisulam as Second-Line Therapy in Patients with Advanced Non–Small Cell Lung Cancer
Open the PDF for A Randomized Phase II Pharmacokinetic and Pharmacodynamic Study of Indisulam as Second-Line Therapy in Patients with Advanced Non–Small Cell Lung Cancer in another window
Journal Articles

Phase I Study of MetXia-P450 Gene Therapy and Oral Cyclophosphamide for Patients with Advanced Breast Cancer or Melanoma

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Jeremy P. Braybrooke, Andrew Slade, Gael Deplanque, Richard Harrop, Srinivasan Madhusudan, Martin D. Forster, Rachel Gibson, Andreas Makris, Denis C. Talbot, Jan Steiner, Linda White, On Kan, Stuart Naylor, Miles W. Carroll, Sue M. Kingsman, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (4): 1512–1520.
https://doi.org/10.1158/1078-0432.CCR-04-0155
Published: 02 March 2005
View article titled, Phase I Study of MetXia-P450 Gene Therapy and Oral Cyclophosphamide for Patients with Advanced Breast Cancer or Melanoma
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Journal Articles

A Phase II Study of Etanercept (Enbrel), a Tumor Necrosis Factor α Inhibitor in Patients with Metastatic Breast Cancer

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Srinivasan Madhusudan, Martin Foster, Sethupathi R. Muthuramalingam, Jeremy P. Braybrooke, Susan Wilner, Kulwinder Kaur, Cheng Han, Susan Hoare, Frances Balkwill, Denis C. Talbot, Trivadi S. Ganesan, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (19): 6528–6534.
https://doi.org/10.1158/1078-0432.CCR-04-0730
Published: 08 October 2004
View article titled, A Phase II Study of Etanercept (Enbrel), a Tumor Necrosis Factor α Inhibitor in Patients with Metastatic Breast Cancer
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Journal Articles

Pharmacokinetic Study of Cisplatin and Infusional Etoposide Phosphate in Advanced Breast Cancer with Correlation of Response to Topoisomerase IIα Expression

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Jeremy P. Braybrooke, Nicola C. Levitt, Simon Joel, Theresa Davis, Srinivasan Madhusudan, Helen Turley, Sue Wilner, Adrian L. Harris, Denis C. Talbot
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (13): 4682–4688.
Published: 27 October 2003
View article titled, Pharmacokinetic Study of Cisplatin and Infusional Etoposide Phosphate in Advanced Breast Cancer with Correlation of Response to Topoisomerase IIα Expression
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Journal Articles

Low-Dose IFN-γ Induces Tumor MHC Expression in Metastatic Malignant Melanoma

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David J. Propper, David Chao, Jeremy P. Braybrooke, Pru Bahl, Parames Thavasu, Frances Balkwill, Helen Turley, Nicola Dobbs, Kevin Gatter, Denis C. Talbot, Adrian L. Harris, Trivadi S. Ganesan
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 84–92.
Published: 01 January 2003
View article titled, Low-Dose IFN-γ Induces Tumor MHC Expression in Metastatic Malignant Melanoma
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Journal Articles

Phase I and Pharmacological Study of the Oral Matrix Metalloproteinase Inhibitor, MMI270 (CGS27023A), in Patients with Advanced Solid Cancer

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Nicola C. Levitt, Ferry A. L. M. Eskens, Ken J. O’Byrne, David J. Propper, Louis J. Denis, Samantha J. Owen, Les Choi, John A. Foekens, Sue Wilner, Jeanette M. Wood, Motowo Nakajima, Denis C. Talbot, William P. Steward, Adrian L. Harris, Jaap Verweij
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (7): 1912–1922.
Published: 01 July 2001
View article titled, Phase I and Pharmacological Study of the Oral Matrix Metalloproteinase Inhibitor, MMI270 (CGS27023A), in Patients with Advanced Solid Cancer
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Journal Articles

A Phase II Study of Razoxane, an Antiangiogenic Topoisomerase II Inhibitor, in Renal Cell Cancer with Assessment of Potential Surrogate Markers of Angiogenesis

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Jeremy P. Braybrooke, Kenneth J. O’Byrne, David J. Propper, Andrew Blann, Mark Saunders, Nicola Dobbs, Cheng Han, Jane Woodhull, Karen Mitchell, Jeremy Crew, Kenneth Smith, Ross Stephens, Trivadi S. Ganesan, Denis C. Talbot, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (12): 4697–4704.
Published: 01 December 2000
View article titled, A Phase II Study of Razoxane, an Antiangiogenic Topoisomerase II Inhibitor, in Renal Cell Cancer with Assessment of Potential Surrogate Markers of Angiogenesis
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Journal Articles

Phase I Study of the Novel Cyclic AMP (cAMP) Analogue 8-Chloro-cAMP in Patients with Cancer: Toxicity, Hormonal, and Immunological Effects

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David J. Propper, Mark P. Saunders, Amanda J. Salisbury, Louise Long, Ken J. O’Byrne, Jeremy P. Braybrooke, Mitchell Dowsett, Marion Taylor, Denis C. Talbot, Trivadi S. Ganesan, Adrian L. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1682–1689.
Published: 01 July 1999
View article titled, Phase I Study of the Novel Cyclic AMP (cAMP) Analogue 8-Chloro-cAMP in Patients with Cancer: Toxicity, Hormonal, and Immunological Effects
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Journal Articles

Phase I Study of Intrapleural Batimastat (BB-94), a Matrix Metalloproteinase Inhibitor, in the Treatment of Malignant Pleural Effusions

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Valentine M. Macaulay, Ken J. O’Byrne, Mark P. Saunders, Jeremy P. Braybrooke, Louise Long, Fergus Gleeson, Clare S. Mason, Adrian L. Harris, Peter Brown, Denis C. Talbot
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (3): 513–520.
Published: 01 March 1999
View article titled, Phase I Study of Intrapleural Batimastat (BB-94), a Matrix Metalloproteinase Inhibitor, in the Treatment of Malignant Pleural Effusions
Open the PDF for Phase I Study of Intrapleural Batimastat (BB-94), a Matrix Metalloproteinase Inhibitor, in the Treatment of Malignant Pleural Effusions in another window