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Journal Articles

Pembrolizumab Monotherapy for Previously Untreated Advanced Hepatocellular Carcinoma: Data from the Open-Label, Phase II KEYNOTE-224 Trial

Gontran Verset, Ivan Borbath, Mark Karwal, Chris Verslype, Hans Van Vlierberghe, Adel Kardosh, Vittorina Zagonel, Per Stal, Debashis Sarker, Daniel H. Palmer, Arndt Vogel, Julien Edeline, Stephane Cattan, Masatoshi Kudo, Ann-Lii Cheng, Sadahisa Ogasawara, Bruno Daniele, Stephen L. Chan, Jennifer J. Knox, Shukui Qin, Abby B. Siegel, Michael Chisamore, Ken Hatogai, Anran Wang, Richard S. Finn, Andrew X. Zhu
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF8.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-3807
Published: 29 April 2022
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Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer

Ayumi Hashimoto, Debashis Sarker, Vikash Reebye, Sheba Jarvis, Mikael H. Sodergren, Andrew Kossenkov, Emilio Sanseviero, Nina Raulf, Jenni Vasara, Pinelopi Andrikakou, Tim Meyer, Kai-Wen Huang, Ruth Plummer, Cheng E. Chee, Duncan Spalding, Madhava Pai, Shahid Khan, David J. Pinato, Rohini Sharma, Bristi Basu, Daniel Palmer, Yuk-Ting Ma, Jeff Evans, Robert Habib, Anna Martirosyan, Naouel Elasri, Adeline Reynaud, John J. Rossi, Mark Cobbold, Nagy A. Habib, Dmitry I. Gabrilovich
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (21): 5961–5978.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-0986
Published: 01 November 2021
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Journal Articles

A Phase I, Open-Label, Dose-Finding Study of GSK2636771, a PI3Kβ Inhibitor, Administered with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer

Debashis Sarker, Nancy A. Dawson, Ana M. Aparicio, Tanya B. Dorff, Allan J. Pantuck, Ulka N. Vaishampayan, Lynn Henson, Lakshmi Vasist, Sumita Roy-Ghanta, Michele Gorczyca, Whitney York, Gopinath Ganji, Jerry Tolson, Johann S. de Bono
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (19): 5248–5257.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-1115
Published: 01 October 2021
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Journal Articles

MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial

Debashis Sarker, Ruth Plummer, Tim Meyer, Mikael H. Sodergren, Bristi Basu, Cheng Ean Chee, Kai-Wen Huang, Daniel H. Palmer, Yuk Ting Ma, T.R. Jeff Evans, Duncan R.C. Spalding, Madhava Pai, Rohini Sharma, David J. Pinato, James Spicer, Sarah Hunter, Vineet Kwatra, Joanna P. Nicholls, David Collin, Robert Nutbrown, Helen Glenny, Sonia Fairbairn, Vikash Reebye, Jon Voutila, Stephanie Dorman, Pinelopi Andrikakou, Peter Lloyd, Steve Felstead, Jenni Vasara, Robert Habib, Chris Wood, Pal Saetrom, Hans E. Huber, David C. Blakey, John J. Rossi, Nagy Habib
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (15): 3936–3946.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-0414
Published: 03 August 2020
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Journal Articles

First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan–Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors

Debashis Sarker, Joo Ern Ang, Richard Baird, Rebecca Kristeleit, Krunal Shah, Victor Moreno, Paul A. Clarke, Florence I. Raynaud, Gallia Levy, Joseph A. Ware, Kathryn Mazina, Ray Lin, Jenny Wu, Jill Fredrickson, Jill M. Spoerke, Mark R. Lackner, Yibing Yan, Lori S. Friedman, Stan B. Kaye, Mika K. Derynck, Paul Workman, Johann S. de Bono
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (1): 77–86.
DOI: https://doi.org/10.1158/1078-0432.CCR-14-0947
Published: 05 January 2015
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The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanced Cancer

Udai Banerji, D. Ross Camidge, Henk M.W. Verheul, Roshan Agarwal, Debashis Sarker, Stan B. Kaye, Ingrid M.E. Desar, Johanna N.H. Timmer-Bonte, S. Gail Eckhardt, Karl D. Lewis, Kathryn H. Brown, Mireille V. Cantarini, Clive Morris, Sarah M.A. George, Paul D. Smith, Carla M.L. van Herpen
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (5): 1613–1623.
DOI: https://doi.org/10.1158/1078-0432.CCR-09-2483
Published: 28 February 2010
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Includes: Supplementary data
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Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer

Debashis Sarker, Alison H.M. Reid, Timothy A. Yap, Johann S. de Bono
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (15): 4799–4805.
DOI: https://doi.org/10.1158/1078-0432.CCR-08-0125
Published: 29 July 2009
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Journal Articles

A Phase I Pharmacokinetic and Pharmacodynamic Study of TKI258, an Oral, Multitargeted Receptor Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

Debashis Sarker, Rhoda Molife, T.R. Jeffrey Evans, Maryon Hardie, Cheryl Marriott, Priska Butzberger-Zimmerli, Rosemary Morrison, Judith A. Fox, Carla Heise, Sharianne Louie, Natasha Aziz, Felix Garzon, Glenn Michelson, Ian R. Judson, Dalal Jadayel, Edgar Braendle, Johann S. de Bono
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (7): 2075–2081.
DOI: https://doi.org/10.1158/1078-0432.CCR-07-1466
Published: 01 April 2008
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