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David T. Curiel
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Journal Articles

Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies

Erik H.P. van Putten, Anne Kleijn, Victor W. van Beusechem, David Noske, Cor H.J. Lamers, Anna L. de Goede, Sander Idema, Daphna Hoefnagel, Jenneke J. Kloezeman, Juan Fueyo, Frederick F. Lang, Charlotte E. Teunissen, René M. Vernhout, Cathy Bakker, Winald Gerritsen, David T. Curiel, Arnold Vulto, Martine L.M. Lamfers, Clemens M.F. Dirven
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1572–1585.
https://doi.org/10.1158/1078-0432.CCR-21-3324
Published: 14 April 2022
View article titled, Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies
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Includes: Supplementary data
Journal Articles

Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma

Michael I. Chastkofsky, Katarzyna C. Pituch, Hiroaki Katagi, Markella Zannikou, Liliana Ilut, Ting Xiao, Yu Han, Adam M. Sonabend, David T. Curiel, Erin R. Bonner, Javad Nazarian, Craig M. Horbinski, C. David James, Amanda M. Saratsis, Rintaro Hashizume, Maciej S. Lesniak, Irina V. Balyasnikova
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1766–1777.
https://doi.org/10.1158/1078-0432.CCR-20-1499
Published: 15 March 2021
View article titled, Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma
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Includes: Supplementary data
Journal Articles

A Novel CDC25B Promoter–Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models

Helga L. Weber, Manuel Gidekel, Santiago Werbajh, Edgardo Salvatierra, Cecilia Rotondaro, Leonardo Sganga, Gabriela Acosta Haab, David T. Curiel, Eduardo G. Cafferata, Osvaldo L. Podhajcer
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (7): 1665–1674.
https://doi.org/10.1158/1078-0432.CCR-14-2316
Published: 31 March 2015
View article titled, A Novel <em>CDC25B</em> Promoter–Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models
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Includes: Supplementary data
Journal Articles

A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer

Kenneth H. Kim, Igor Dmitriev, Janis P. O'Malley, Minghui Wang, Souheil Saddekni, Zhiying You, Meredith A. Preuss, Raymond D. Harris, Rosemarie Aurigemma, Gene P. Siegal, Kurt R. Zinn, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3440–3451.
https://doi.org/10.1158/1078-0432.CCR-11-2852
Published: 14 June 2012
View article titled, A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer
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Includes: Supplementary data
Journal Articles

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases

Kristopher J. Kimball, Meredith A. Preuss, Mack N. Barnes, Minghui Wang, Gene P. Siegal, Wen Wan, Huichien Kuo, Souheil Saddekni, Cecil R. Stockard, William E. Grizzle, Raymond D. Harris, Rosemarie Aurigemma, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5277–5287.
https://doi.org/10.1158/1078-0432.CCR-10-0791
Published: 31 October 2010
View article titled, A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases
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Journal Articles

Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer

Kellie Matthews, Patricia E. Noker, Baohong Tian, Sheila D. Grimes, Ronna Fulton, Karen Schweikart, Raymond Harris, Rose Aurigemma, Minghui Wang, Mack N. Barnes, Gene P. Siegal, Akseli Hemminki, Kurt Zinn, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 4131–4137.
https://doi.org/10.1158/1078-0432.CCR-08-3354
Published: 15 June 2009
View article titled, Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer
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Journal Articles

Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation

Guo Zhang, Margaret A. Park, Clint Mitchell, Hossein Hamed, Mohamed Rahmani, Aditi Pandya Martin, David T. Curiel, Adly Yacoub, Martin Graf, Ray Lee, John D. Roberts, Paul B. Fisher, Steven Grant, Paul Dent
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (17): 5385–5399.
https://doi.org/10.1158/1078-0432.CCR-08-0469
Published: 02 September 2008
View article titled, Vorinostat and Sorafenib Synergistically Kill Tumor Cells via FLIP Suppression and CD95 Activation
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Includes: Supplementary data
Journal Articles

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Yuko Tsuruta, Larisa Pereboeva, Martina Breidenbach, Daniel T. Rein, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Paul Dent, Paul B. Fisher, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (11): 3582–3588.
https://doi.org/10.1158/1078-0432.CCR-07-5053
Published: 02 June 2008
View article titled, A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer
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Journal Articles

A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex vivo System via a Coxsackie and Adenovirus Receptor–Independent Pathway

Yuko Tsuruta, Larisa Pereboeva, Joel N. Glasgow, Daniel T. Rein, Yosuke Kawakami, Ronald D. Alvarez, Rodney P. Rocconi, Gene P. Siegal, Paul Dent, Paul B. Fisher, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (9): 2777–2783.
https://doi.org/10.1158/1078-0432.CCR-06-2706
Published: 01 May 2007
View article titled, A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer <em>Ex vivo</em> System via a Coxsackie and Adenovirus Receptor–Independent Pathway
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Journal Articles

Infectivity-Enhanced Adenoviruses Deliver Efficacy in Clinical Samples and Orthotopic Models of Disseminated Gastric Cancer

Lotta Kangasniemi, Tuula Kiviluoto, Anna Kanerva, Mari Raki, Tuuli Ranki, Merja Sarkioja, Hongju Wu, Frank Marini, Krister Höckerstedt, Helena Isoniemi, Henrik Alfthan, Ulf-Håkan Stenman, David T. Curiel, Akseli Hemminki
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (10): 3137–3144.
https://doi.org/10.1158/1078-0432.CCR-05-2576
Published: 17 May 2006
View article titled, Infectivity-Enhanced Adenoviruses Deliver Efficacy in Clinical Samples and Orthotopic Models of Disseminated Gastric Cancer
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Journal Articles

Advanced Generation Adenoviral Virotherapy Agents Embody Enhanced Potency Based upon CAR-Independent Tropism

J. Michael Mathis, Phoebe L. Stewart, Zheng B. Zhu, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (9): 2651–2656.
https://doi.org/10.1158/1078-0432.CCR-06-0497
Published: 04 May 2006
View article titled, Advanced Generation Adenoviral Virotherapy Agents Embody Enhanced Potency Based upon CAR-Independent Tropism
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Journal Articles

Delta-24 Increases the Expression and Activity of Topoisomerase I and Enhances the Antiglioma Effect of Irinotecan

Candelaria Gomez-Manzano, Marta M. Alonso, W.K. Alfred Yung, Frank McCormick, David T. Curiel, Frederick F. Lang, Hong Jiang, B. Nebiyou Bekele, Xian Zhou, Ramon Alemany, Juan Fueyo
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 556–562.
https://doi.org/10.1158/1078-0432.CCR-05-1892
Published: 20 January 2006
View article titled, Delta-24 Increases the Expression and Activity of Topoisomerase I and Enhances the Antiglioma Effect of Irinotecan
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Journal Articles

A Fiber-Modified, Secretory Leukoprotease Inhibitor Promoter-Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Daniel T. Rein, Martina Breidenbach, Tyler O. Kirby, Tie Han, Gene P. Siegal, Gerd J. Bauerschmitz, Minghui Wang, Dirk M. Nettelbeck, Yuko Tsuruta, Masato Yamamoto, Peter Dall, Akseli Hemminki, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1327–1335.
https://doi.org/10.1158/1078-0432.1327.11.3
Published: 11 February 2005
View article titled, A Fiber-Modified, Secretory Leukoprotease Inhibitor Promoter-Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer
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Journal Articles

A Novel Ex vivo Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity

Tyler O. Kirby, Angel Rivera, Daniel Rein, Minghui Wang, Ilya Ulasov, Martina Breidenbach, Manjula Kataram, Juan L. Contreras, Carlos Krumdieck, Masato Yamamoto, Marianne G. Rots, Hidde J. Haisma, Ronald D. Alvarez, Parameshwar J. Mahasreshti, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8697–8703.
https://doi.org/10.1158/1078-0432.CCR-04-1166
Published: 28 December 2004
View article titled, A Novel <em>Ex vivo</em> Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity
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Journal Articles

Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor

Meredith A. Preuss, John T. Lam, Minghui Wang, Charles A. Leath, III, Manjula Kataram, Parameshwar J. Mahasreshti, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (9): 3189–3194.
https://doi.org/10.1158/1078-0432.CCR-03-0802
Published: 06 May 2004
View article titled, Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor
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Journal Articles

Conditionally Replicative Adenovirus with Tropism Expanded towards Integrins Inhibits Osteosarcoma Tumor Growth in Vitro and in Vivo

Adhiambo M. Witlox, Victor W. van Beusechem, Bonnie Molenaar, Hans Bras, Gerard R. Schaap, Ramon Alemany, David T. Curiel, Herbert M. Pinedo, Paul I. J. M. Wuisman, Winald R. Gerritsen
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (1): 61–67.
https://doi.org/10.1158/1078-0432.CCR-0609-03
Published: 20 January 2004
View article titled, Conditionally Replicative Adenovirus with Tropism Expanded towards Integrins Inhibits Osteosarcoma Tumor Growth <em>in Vitro</em> and <em>in Vivo</em>
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Journal Articles

Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity

Parameshwar J. Mahasreshti, Manjula Kataram, Ming H. Wang, Cecil R. Stockard, William E. Grizzle, Delicia Carey, Gene P. Siegal, Hidde J. Haisma, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (7): 2701–2710.
Published: 01 July 2003
View article titled, Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity
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Journal Articles

CD40 Is Expressed on Ovarian Cancer Cells and Can Be Utilized for Targeting Adenoviruses

Tanja Hakkarainen, Akseli Hemminki, Alexander V. Pereboev, Shannon D. Barker, Clement K. Asiedu, Theresa V. Strong, Anna Kanerva, Jarmo Wahlfors, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 619–624.
Published: 01 February 2003
View article titled, CD40 Is Expressed on Ovarian Cancer Cells and Can Be Utilized for Targeting Adenoviruses
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Journal Articles

The Presence of the Adenovirus E3 Region Improves the Oncolytic Potency of Conditionally Replicative Adenoviruses

Kaori Suzuki, Ramón Alemany, Masato Yamamoto, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (11): 3348–3359.
Published: 01 November 2002
View article titled, The Presence of the Adenovirus E3 Region Improves the Oncolytic Potency of Conditionally Replicative Adenoviruses
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Journal Articles

Safety and Immunogenicity of a DNA Vaccine Encoding Carcinoembryonic Antigen and Hepatitis B Surface Antigen in Colorectal Carcinoma Patients

Robert M. Conry, David T. Curiel, Theresa V. Strong, Susan E. Moore, Karen O. Allen, Daunte L. Barlow, Denise R. Shaw, Albert F. LoBuglio
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (9): 2782–2787.
Published: 01 September 2002
View article titled, Safety and Immunogenicity of a DNA Vaccine Encoding Carcinoembryonic Antigen and Hepatitis B Surface Antigen in Colorectal Carcinoma Patients
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