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David Solit
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Journal Articles

Abstract A012: Kmt2c/d loss primes urothelium for tumorigenesis and redistributes Menin to bivalent promoters

Naitao Wang, Mohini Pachai, Dan Li, Cindy Lee, Sarah Warda, Makhzuna Khudoynazarova, Woo Hyun Cho, Guojia Xie, Fengshen Kuo, Sagar Shah, Li Yao, Cheng Qian, Elissa Wong, Juan Yan, Fanny Tomas, Wenhuo Hu, Sizhi Gao, Alison Smith, Ming Han, Dong Gao, Kai Ge, Haiyuan Yu, Sarat Chandarlapaty, Gopakumar Iyer, Jonathan Rosenberg, David Solit, Hikmat AI-Ahmadie, Ping Chi, Yu Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10_Supplement): A012.
https://doi.org/10.1158/1557-3265.BLADDER24-A012
Published: 17 May 2024
View article titled, Abstract A012: <em>Kmt2c/d</em> loss primes urothelium for tumorigenesis and redistributes Menin to bivalent promoters
Journal Articles

Abstract PR012: Targeted sequencing of 2,138 bone and soft tissue sarcomas reveals commonly altered pathways, subtype-independent genetic clusters, and potential therapeutic targets

Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh Smith, Cristina Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas Socci, Satshil Rana, Rodrigo Gularte-Merida, Ahmet Zehir, Mrinal Gounder, Timothy Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan Strong, Jake Stoller, Jason Chan, Ping Chi, Sandra D'Angelo, Mark Dickson, Ciara Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul Meyers, Leonard Wexler, Emily Slotkin, Julia Glade Bender, Neerav Shukla, Martee Hensley, John Healey, Michael La Quaglia, Kaled Alektiar, Aimee Crago, Sam Yoon, Brian Untch, Sarah Chiang, Narasimhan Agaram, Meera Hameed, Michael Berger, David Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer, William Tap
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): PR012.
https://doi.org/10.1158/1557-3265.SARCOMAS22-PR012
Published: 15 September 2022
View article titled, Abstract PR012: Targeted sequencing of 2,138 bone and soft tissue sarcomas reveals commonly altered pathways, subtype-independent genetic clusters, and potential therapeutic targets
Journal Articles

MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions

Hiroki Sato, Adam J. Schoenfeld, Evan Siau, Yue Christine Lu, Huichun Tai, Ken Suzawa, Daisuke Kubota, Allan J.W. Lui, Besnik Qeriqi, Marissa Mattar, Michael Offin, Masakiyo Sakaguchi, Shinichi Toyooka, Alexander Drilon, Neal X. Rosen, Mark G. Kris, David Solit, Elisa De Stanchina, Monika A. Davare, Gregory J. Riely, Marc Ladanyi, Romel Somwar
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12): 2932–2945.
https://doi.org/10.1158/1078-0432.CCR-19-3321
Published: 15 June 2020
View article titled, MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by <em>ROS1</em> Fusions
Open the PDF for MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by <em>ROS1</em> Fusions in another window
Includes: Supplementary data
Journal Articles

Abstract PR08: Validation and clinical implementation of MSK-ACCESS, an ultra-deep sequencing assay for noninvasive somatic mutation profiling

A. Rose Brannon, Gowtham Jayakumaran, Monica Diosdado, Yu Hu, Anna Razumova, Fanli Meng, Emily Lebow, Juber Patel, Ian Johnson, Preethi Srinivasan, Maysun Hasan, Jenna-marie Dix, Aijazuddin Syed, Brian Houck-Loomis, Bob T. Li, Charles Rudin, David Solit, Marc Ladanyi, Maria Arcila, Dana Tsui, Ahmet Zehir, Michael Berger, Ryma Benayed
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): PR08.
https://doi.org/10.1158/1557-3265.LiqBiop20-PR08
Published: 01 June 2020
View article titled, Abstract PR08: Validation and clinical implementation of MSK-ACCESS, an ultra-deep sequencing assay for noninvasive somatic mutation profiling
Journal Articles

A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2− Metastatic Breast Cancer

Ingrid A. Mayer, Vandana G. Abramson, Luigi Formisano, Justin M. Balko, Mónica V. Estrada, Melinda E. Sanders, Dejan Juric, David Solit, Michael F. Berger, Helen H. Won, Yisheng Li, Lewis C. Cantley, Eric Winer, Carlos L. Arteaga
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (1): 26–34.
https://doi.org/10.1158/1078-0432.CCR-16-0134
Published: 02 January 2017
View article titled, A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER<sup>+</sup>/HER2<sup>−</sup> Metastatic Breast Cancer
Open the PDF for A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER<sup>+</sup>/HER2<sup>−</sup> Metastatic Breast Cancer in another window
Journal Articles

Abstract 36: Functional characterization of ERBB2 mutations and response to targeted therapies

Hannah Johnsen, Aphrothiti Hanrahan, Alexis Jones, David Solit
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): 36.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-36
Published: 03 January 2016
View article titled, Abstract 36: Functional characterization of ERBB2 mutations and response to targeted therapies
Journal Articles

Abstract A22: Role of cap-dependent translation in response to upstream kinase-targeted therapy in colorectal cancer

Qing Ye, Weijia Cai, B. Mark Evers, David Solit, Neal Rosen, Qing-Bai She
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4_Supplement): A22.
https://doi.org/10.1158/1557-3265.PMS14-A22
Published: 13 February 2015
View article titled, Abstract A22: Role of cap-dependent translation in response to upstream kinase-targeted therapy in colorectal cancer
Journal Articles

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

Shanu Modi, Alison Stopeck, Hannah Linden, David Solit, Sarat Chandarlapaty, Neal Rosen, Gabriella D'Andrea, Maura Dickler, Mary E. Moynahan, Steven Sugarman, Weining Ma, Sujata Patil, Larry Norton, Alison L. Hannah, Clifford Hudis
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (15): 5132–5139.
https://doi.org/10.1158/1078-0432.CCR-11-0072
Published: 31 July 2011
View article titled, HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab
Open the PDF for HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab in another window
Includes: Supplementary data
Journal Articles

PIK3CA Mutation Associates with Improved Outcome in Breast Cancer

Kevin Kalinsky, Lindsay M. Jacks, Adriana Heguy, Sujata Patil, Marija Drobnjak, Umeshkumar K. Bhanot, Cyrus V. Hedvat, Tiffany A. Traina, David Solit, William Gerald, Mary Ellen Moynahan
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (16): 5049–5059.
https://doi.org/10.1158/1078-0432.CCR-09-0632
Published: 12 August 2009
View article titled, PIK3CA Mutation Associates with Improved Outcome in Breast Cancer
Open the PDF for PIK3CA Mutation Associates with Improved Outcome in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Pilot Trial of Unlabeled and Indium-111–Labeled Anti–Prostate-Specific Membrane Antigen Antibody J591 for Castrate Metastatic Prostate Cancer

Michael J. Morris, Chaitanya R. Divgi, Neeta Pandit-Taskar, Maria Batraki, Nyasha Warren, Angelo Nacca, Peter Smith-Jones, Lawrence Schwartz, W. Kevin Kelly, Susan Slovin, David Solit, Jennifer Halpern, Anthony Delacruz, Tracy Curley, Ronald Finn, Joseph A. O'Donoghue, Philip Livingston, Steven Larson, Howard I. Scher
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (20): 7454–7461.
https://doi.org/10.1158/1078-0432.CCR-05-0826
Published: 20 October 2005
View article titled, Pilot Trial of Unlabeled and Indium-111–Labeled Anti–Prostate-Specific Membrane Antigen Antibody J591 for Castrate Metastatic Prostate Cancer
Open the PDF for Pilot Trial of Unlabeled and Indium-111–Labeled Anti–Prostate-Specific Membrane Antigen Antibody J591 for Castrate Metastatic Prostate Cancer in another window
Journal Articles

Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3′-Kinase/Akt Pathway Signaling

Qing-Bai She, David Solit, Andrea Basso, Mark M. Moasser
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (12): 4340–4346.
Published: 10 October 2003
View article titled, Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3′-Kinase/Akt Pathway Signaling
Open the PDF for Resistance to Gefitinib in PTEN-Null HER-Overexpressing Tumor Cells Can Be Overcome through Restoration of PTEN Function or Pharmacologic Modulation of Constitutive Phosphatidylinositol 3′-Kinase/Akt Pathway Signaling in another window
Journal Articles

Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner: See The Biology Behind: E. A. Sausville, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters. Clin. Cancer Res., 7: 2155–2158, 2001.

Pamela N. Münster, Andrea Basso, David Solit, Larry Norton, Neal Rosen
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2228–2236.
Published: 01 August 2001
View article titled, Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner: <subtitle>See <em>The Biology Behind:</em> E. A. Sausville, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters. Clin. Cancer Res., <em>7:</em> 2155–2158, 2001.</subtitle>
Open the PDF for Modulation of Hsp90 Function by Ansamycins Sensitizes Breast Cancer Cells to Chemotherapy-induced Apoptosis in an RB- and Schedule-dependent Manner: <subtitle>See <em>The Biology Behind:</em> E. A. Sausville, Combining Cytotoxics and 17-Allylamino, 17-Demethoxygeldanamycin: Sequence and Tumor Biology Matters. Clin. Cancer Res., <em>7:</em> 2155–2158, 2001.</subtitle> in another window