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David Sidransky
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Journal Articles

Abstract B06: Repositioning the FDA-approved antiviral drug ribavirin as targeted therapy for nasopharyngeal carcinoma

Sakibul Huq, Joshua Casaos, Michael Peters, Yuanxuan Xia, Andy Ding, Manuel Morales, Noah Gorelick, Riccardo Serra, Tianna Zhao, Wataru Ishida, Alexander Perdomo-Pantoja, Arba Cecia, Chenchen Ji, Ian Suk, David Sidransky, Mariana Brait, Henry Brem, Nicolas Skuli, Betty Tyler
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_2): B06.
https://doi.org/10.1158/1557-3265.AACRAHNS19-B06
Published: 15 June 2020
View articletitled, Abstract B06: Repositioning the FDA-approved antiviral drug ribavirin as targeted therapy for nasopharyngeal carcinoma
Journal Articles

Abstract A25: Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma

Theresa Guo, Kristina D. A. Zambo, Fernando T. Zamuner, Tingting Ou, Christopher Hopkins, Dylan Z. Kelley, Hildegard A. Wulf, Ludmila V. Danilova, Michael Considine, David Sidransky, Alexander V. Favorov, Liliana Florea, Elana J. Fertig, Daria A. Gaykalova
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_2): A25.
https://doi.org/10.1158/1557-3265.AACRAHNS19-A25
Published: 15 June 2020
View articletitled, Abstract A25: Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma
Journal Articles

A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non–Small Cell Lung Cancer and Serum DNA

Akira Ooki, Zahra Maleki, Jun-Chieh J. Tsay, Chandra Goparaju, Mariana Brait, Nitesh Turaga, Hae-Seong Nam, William N. Rom, Harvey I. Pass, David Sidransky, Rafael Guerrero-Preston, Mohammad Obaidul Hoque
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 7141–7152.
https://doi.org/10.1158/1078-0432.CCR-17-1222
Published: 14 November 2017
View articletitled, A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non–Small Cell Lung Cancer and Serum DNA
Open the PDF for A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non–Small Cell Lung Cancer and Serum DNA in another window
Includes: Supplementary data
Journal Articles

SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells

Hiroyuki Ozawa, Ruchira S. Ranaweera, Evgeny Izumchenko, Eugene Makarev, Alex Zhavoronkov, Elana J. Fertig, Jason D. Howard, Ana Markovic, Atul Bedi, Rajani Ravi, Jimena Perez, Quynh-Thu Le, Christina S. Kong, Richard C. Jordan, Hao Wang, Hyunseok Kang, Harry Quon, David Sidransky, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 5162–5175.
https://doi.org/10.1158/1078-0432.CCR-16-1686
Published: 31 August 2017
View articletitled, SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells
Open the PDF for SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract IA03: Patient-derived xenografts as translational tools to predict patient responses to oncology therapy

Evgeny Izumchenko, David Sidransky
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): IA03.
https://doi.org/10.1158/1557-3265.PDX16-IA03
Published: 15 August 2016
View articletitled, Abstract IA03: Patient-derived xenografts as translational tools to predict patient responses to oncology therapy
Journal Articles

Abstract A40: The ImmunoGraftTM: A humanized mouse model for translational assessment of immunotherapy in solid tumors

Gilson Baia, David Vasquez, David Cerna, Daniel Ciznadija, David Sidransky, Jennifer Jaskowiak, Lindsay Ryland, Angela Davies, Amanda Katz, Keren Paz
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A40.
https://doi.org/10.1158/1557-3265.PDX16-A40
Published: 15 August 2016
View articletitled, Abstract A40: The ImmunoGraftTM: A humanized mouse model for translational assessment of immunotherapy in solid tumors
Journal Articles

Abstract A21: Accurate molecular fidelity of patient-derived xenograft (PDX) models to original human tumors and to The Cancer Genome Atlas (TCGA)

Ido Sloma, Ido Ben-zvi, Tin Khor, Daniel Ciznadija, Amanda Katz, David Vasquez, Jennifer Jaskowiak, Lindsay Ryland, Angela Davies, David Sidransky, Keren Paz
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A21.
https://doi.org/10.1158/1557-3265.PDX16-A21
Published: 15 August 2016
View articletitled, Abstract A21: Accurate molecular fidelity of patient-derived xenograft (PDX) models to original human tumors and to The Cancer Genome Atlas (TCGA)
Journal Articles

Abstract AS15: DNA promoter hypermethylation of HIST1H2BB as a diagnostic and prognostic biomarker for ovarian cancer

Blanca L. Valle, Elisabetta Kuhn, David Sidransky, Rafael Guerrero-Preston
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): AS15.
https://doi.org/10.1158/1557-3265.OVCASYMP14-AS15
Published: 15 August 2015
View articletitled, Abstract AS15: DNA promoter hypermethylation of HIST1H2BB as a diagnostic and prognostic biomarker for ovarian cancer
Journal Articles

Effect of different regimens of chemotherapy on stem-cell marker expression.

Vasyl Vasko, Phil Grimley, Michael Wick, David Sidransky
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): B32.
Published: 15 August 2014
View articletitled, Effect of different regimens of chemotherapy on stem-cell marker expression.
Journal Articles

Using a Novel Computer Technology for Tailoring Targeted and Chemotherapeutic Drug Schedules to the Individual Patient

Zvia Agur, Irit Ziv, Revital Shochat, Michael Wick, Craig Webb, David Hankins, Levon Arakelyan, David Sidransky
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): PL-29.
Published: 15 August 2014
View articletitled, Using a Novel Computer Technology for Tailoring Targeted and Chemotherapeutic Drug Schedules to the Individual Patient
Journal Articles

Detection of clonal mitochondrial DNA mutation in airway mucosa of follow-up lung cancer patients

Santanu Dasgupta, Rex Yung, William Westra, David Sidransky
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): A5.
Published: 15 August 2014
View articletitled, Detection of clonal mitochondrial DNA mutation in airway mucosa of follow-up lung cancer patients
Journal Articles

Towards personalized medicine: Establishment and in vivo characterization of a low passage tumor xenograft tumor predictive of clinical response

Wesley Lowell, David Sidransky, Eric Rowinsky, George Demetri, Chris Takimoto, Kuslima Shogen, Michael Wick
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): B22.
Published: 15 August 2014
View articletitled, Towards personalized medicine: Establishment and in vivo characterization of a low passage tumor xenograft tumor predictive of clinical response
Journal Articles

Moving towards clinically relevant preclinical models: Establishment, molecular characterization and in vivo evaluation of patient-derived low passage human tumor models

Michael Wick, Francis Nieves, Mitchell Moore, David Sidransky, Kyriakos Papadopoulos, Manuel Hidalgo
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (19_Supplement): A20.
Published: 15 August 2014
View articletitled, Moving towards clinically relevant preclinical models: Establishment, molecular characterization and in vivo evaluation of patient-derived low passage human tumor models
Journal Articles

Towards personalized medicine: Evaluation of blood and tissue biomarkers for drug sensitivity in a newly established human xenograft model

David Campos, Robert Streeper, Mario Sepulveda, Armando Diaz, Michael Wick, David Sidransky, George Demetri, Eric Rowinsky, Enrique Poradosu, Chris Takimoto, Elzbieta Izbicka
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): B14.
Published: 15 August 2014
View articletitled, Towards personalized medicine: Evaluation of blood and tissue biomarkers for drug sensitivity in a newly established human xenograft model
Journal Articles

Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment

Elena Garralda, Keren Paz, Pedro P. López-Casas, Siân Jones, Amanda Katz, Lisa M. Kann, Fernando López-Rios, Francesca Sarno, Fátima Al-Shahrour, David Vasquez, Elizabeth Bruckheimer, Samuel V. Angiuoli, Antonio Calles, Luis A. Diaz, Victor E. Velculescu, Alfonso Valencia, David Sidransky, Manuel Hidalgo
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (9): 2476–2484.
https://doi.org/10.1158/1078-0432.CCR-13-3047
Published: 30 April 2014
View articletitled, Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment
Open the PDF for Integrated Next-Generation Sequencing and Avatar Mouse Models for Personalized Cancer Treatment in another window
Includes: Supplementary data
Journal Articles

Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma

Wojciech Mydlarz, Mamoru Uemura, Sun Ahn, Patrick Hennessey, Steven Chang, Semra Demokan, Wenyue Sun, Chunbo Shao, Justin Bishop, Julie Krosting, Elizabeth Mambo, William Westra, Patrick Ha, David Sidransky, Joseph Califano
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 868–877.
https://doi.org/10.1158/1078-0432.CCR-13-2675
Published: 16 February 2014
View articletitled, Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Open the PDF for Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Clinical Correlates of Promoter Hypermethylation of Four Target Genes in Head and Neck Cancer: A Cooperative Group Correlative Study

Jong-Lyel Roh, Xin Victoria Wang, Judith Manola, David Sidransky, Arlene A. Forastiere, Wayne M. Koch
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (9): 2528–2540.
https://doi.org/10.1158/1078-0432.CCR-12-3047
Published: 30 April 2013
View articletitled, Clinical Correlates of Promoter Hypermethylation of Four Target Genes in Head and Neck Cancer: A Cooperative Group Correlative Study
Open the PDF for Clinical Correlates of Promoter Hypermethylation of Four Target Genes in Head and Neck Cancer: A Cooperative Group Correlative Study in another window
Journal Articles

Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites

Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks, Jennifer R. Grandis, David Sidransky, Nils Erik Heldin, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (23): 7248–7264.
https://doi.org/10.1158/1078-0432.CCR-11-0690
Published: 30 November 2011
View articletitled, Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites
Open the PDF for Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites in another window
Includes: Supplementary data
Journal Articles

Detection of Promoter Hypermethylation in Salivary Rinses as a Biomarker for Head and Neck Squamous Cell Carcinoma Surveillance

André Lopes Carvalho, Rui Henrique, Carmen Jeronimo, Chetan S. Nayak, Ashok N. Reddy, Mohammad O. Hoque, Steven Chang, Mariana Brait, Wei-Wen Jiang, Michael M. Kim, Quia Claybourne, David Goldenberg, Zubair Khan, Tanbir Khan, William H. Westra, David Sidransky, Wayne Koch, Joseph A. Califano
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4782–4789.
https://doi.org/10.1158/1078-0432.CCR-11-0324
Published: 17 July 2011
View articletitled, Detection of Promoter Hypermethylation in Salivary Rinses as a Biomarker for Head and Neck Squamous Cell Carcinoma Surveillance
Open the PDF for Detection of Promoter Hypermethylation in Salivary Rinses as a Biomarker for Head and Neck Squamous Cell Carcinoma Surveillance in another window
Includes: Supplementary data
Journal Articles

BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer

Sheetal Bhan, Sandeep S. Negi, Chunbo Shao, Chad A. Glazer, Alice Chuang, Daria A. Gaykalova, Wenyue Sun, David Sidransky, Patrick K. Ha, Joseph A. Califano
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (13): 4267–4276.
https://doi.org/10.1158/1078-0432.CCR-11-0653
Published: 05 July 2011
View articletitled, BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer
Open the PDF for BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer in another window