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David M. Nanus
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Journal Articles

The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide

Susan Halabi, Siyuan Guo, Joseph J. Park, David M. Nanus, Daniel J. George, Emmanuel S. Antonarakis, Daniel Costin Danila, Russell Zelig Szmulewitz, Donald P. McDonnell, John D. Norris, Changxue Lu, Jun Luo, Andrew J. Armstrong
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (6): 1152–1159.
https://doi.org/10.1158/1078-0432.CCR-23-3017
Published: 15 March 2024
View article titled, The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide
Open the PDF for The Impact of Circulating Tumor Cell HOXB13 RNA Detection in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide in another window
Includes: Supplementary data
Journal Articles

PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer

Santosh Gupta, Susan Halabi, Qian Yang, Akash Roy, Alisa Tubbs, Yamini Gore, Daniel J. George, David M. Nanus, Emmanuel S. Antonarakis, Daniel C. Danila, Russell Z. Szmulewitz, Richard Wenstrup, Andrew J. Armstrong
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (10): 1929–1937.
https://doi.org/10.1158/1078-0432.CCR-22-3233
Published: 15 May 2023
View article titled, PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer
Open the PDF for PSMA-positive Circulating Tumor Cell Detection and Outcomes with Abiraterone or Enzalutamide Treatment in Men with Metastatic Castrate-resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide

Landon C. Brown, Susan Halabi, Joseph D. Schonhoft, Qian Yang, Jun Luo, David M. Nanus, Paraskevi Giannakakou, Russell Z. Szmulewitz, Daniel C. Danila, Ethan S. Barnett, Emily A. Carbone, Jimmy L. Zhao, Patrick Healy, Monika Anand, Audrey Gill, Adam Jendrisak, William R. Berry, Santosh Gupta, Simon G. Gregory, Richard Wenstrup, Emmanuel S. Antonarakis, Daniel J. George, Howard I. Scher, Andrew J. Armstrong
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4077–4088.
https://doi.org/10.1158/1078-0432.CCR-20-3471
Published: 15 July 2021
View article titled, Circulating Tumor Cell Chromosomal Instability and Neuroendocrine Phenotype by Immunomorphology and Poor Outcomes in Men with mCRPC Treated with Abiraterone or Enzalutamide
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Includes: Supplementary data
Journal Articles

A Phase Ib/IIa Study of the Pan-BET Inhibitor ZEN-3694 in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer

Rahul R. Aggarwal, Michael T. Schweizer, David M. Nanus, Allan J. Pantuck, Elisabeth I. Heath, Eric Campeau, Sarah Attwell, Karen Norek, Margo Snyder, Lisa Bauman, Sanjay Lakhotia, Felix Y. Feng, Eric J. Small, Wassim Abida, Joshi J. Alumkal
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5338–5347.
https://doi.org/10.1158/1078-0432.CCR-20-1707
Published: 15 October 2020
View article titled, A Phase Ib/IIa Study of the Pan-BET Inhibitor ZEN-3694 in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Expression of AR-V7 and ARv567es in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY

Scott T. Tagawa, Emmanuel S. Antonarakis, Ada Gjyrezi, Giuseppe Galletti, Seaho Kim, Daniel Worroll, John Stewart, Atef Zaher, Ted P. Szatrowski, Karla V. Ballman, Katsuhiro Kita, Shinsuke Tasaki, Yang Bai, Luigi Portella, Brian J. Kirby, Fred Saad, Mario A. Eisenberger, David M. Nanus, Paraskevi Giannakakou
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (6): 1880–1888.
https://doi.org/10.1158/1078-0432.CCR-18-0320
Published: 15 March 2019
View article titled, Expression of AR-V7 and ARv<sup>567es</sup> in Circulating Tumor Cells Correlates with Outcomes to Taxane Therapy in Men with Metastatic Prostate Cancer Treated in TAXYNERGY
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Includes: Supplementary data
Journal Articles

A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers

Himisha Beltran, Clara Oromendia, Daniel C. Danila, Bruce Montgomery, Christopher Hoimes, Russell Z. Szmulewitz, Ulka Vaishampayan, Andrew J. Armstrong, Mark Stein, Jacek Pinski, Juan M. Mosquera, Verena Sailer, Rohan Bareja, Alessandro Romanel, Naveen Gumpeni, Andrea Sboner, Etienne Dardenne, Loredana Puca, Davide Prandi, Mark A. Rubin, Howard I. Scher, David S. Rickman, Francesca Demichelis, David M. Nanus, Karla V. Ballman, Scott T. Tagawa
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 43–51.
https://doi.org/10.1158/1078-0432.CCR-18-1912
Published: 03 January 2019
View article titled, A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers
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Includes: Supplementary data
Journal Articles

Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma

Denise R. Minton, Leiping Fu, Nigel P. Mongan, Maria M. Shevchuk, David M. Nanus, Lorraine J. Gudas
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (11): 2791–2801.
https://doi.org/10.1158/1078-0432.CCR-15-1511
Published: 31 May 2016
View article titled, Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer

Himisha Beltran, Adam Jendrisak, Mark Landers, Juan Miguel Mosquera, Myriam Kossai, Jessica Louw, Rachel Krupa, Ryon P. Graf, Nicole A. Schreiber, David M. Nanus, Scott T. Tagawa, Dena Marrinucci, Ryan Dittamore, Howard I. Scher
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (6): 1510–1519.
https://doi.org/10.1158/1078-0432.CCR-15-0137
Published: 14 March 2016
View article titled, The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer
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Includes: Supplementary data
Journal Articles

A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer

Neeta Pandit-Taskar, Joseph A. O'Donoghue, Jeremy C. Durack, Serge K. Lyashchenko, Sarah M. Cheal, Volkan Beylergil, Robert A. Lefkowitz, Jorge A. Carrasquillo, Danny F. Martinez, Alex Mak Fung, Stephen B. Solomon, Mithat Gönen, Glenn Heller, Massimo Loda, David M. Nanus, Scott T. Tagawa, Jarett L. Feldman, Joseph R. Osborne, Jason S. Lewis, Victor E. Reuter, Wolfgang A. Weber, Neil H. Bander, Howard I. Scher, Steven M. Larson, Michael J. Morris
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5277–5285.
https://doi.org/10.1158/1078-0432.CCR-15-0552
Published: 30 November 2015
View article titled, A Phase I/II Study for Analytic Validation of <sup>89</sup>Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer
Open the PDF for A Phase I/II Study for Analytic Validation of <sup>89</sup>Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Phase II Study of Lutetium-177–Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer

Scott T. Tagawa, Matthew I. Milowsky, Michael Morris, Shankar Vallabhajosula, Paul Christos, Naveed H. Akhtar, Joseph Osborne, Stanley J. Goldsmith, Steve Larson, Neeta Pandit Taskar, Howard I. Scher, Neil H. Bander, David M. Nanus
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (18): 5182–5191.
https://doi.org/10.1158/1078-0432.CCR-13-0231
Published: 16 September 2013
View article titled, Phase II Study of Lutetium-177–Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Radioimmunotherapy of Prostate Cancer Using 90Y- and 177Lu-Labeled J591 Monoclonal Antibodies: Effect of Multiple Treatments on Myelotoxicity

Shankar Vallabhajosula, Stanley J. Goldsmith, Lale Kostakoglu, Mathew I. Milowsky, David M. Nanus, Neil H. Bander
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (19): 7195s–7200s.
https://doi.org/10.1158/1078-0432.CCR-1004-0023
Published: 03 October 2005
View article titled, Radioimmunotherapy of Prostate Cancer Using <sup>90</sup>Y- and <sup>177</sup>Lu-Labeled J591 Monoclonal Antibodies: Effect of Multiple Treatments on Myelotoxicity
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Journal Articles

Retinoic Acid and the Histone Deacetylase Inhibitor Trichostatin A Inhibit the Proliferation of Human Renal Cell Carcinoma in a Xenograft Tumor Model

Sue Ellen Touma, Jonathan S. Goldberg, Paul Moench, Xiaojia Guo, Satish K. Tickoo, Lorraine J. Gudas, David M. Nanus
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (9): 3558–3566.
https://doi.org/10.1158/1078-0432.CCR-04-1155
Published: 02 May 2005
View article titled, Retinoic Acid and the Histone Deacetylase Inhibitor Trichostatin A Inhibit the Proliferation of Human Renal Cell Carcinoma in a Xenograft Tumor Model
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Journal Articles

Neutral Endopeptidase Protein Expression and Prognosis in Localized Prostate Cancer

Iman Osman, Herman Yee, Samir S. Taneja, Benjamin Levinson, Anne Zeleniuch-Jacquotte, Caroline Chang, Craig Nobert, David M. Nanus
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (12): 4096–4100.
https://doi.org/10.1158/1078-0432.CCR-04-0120
Published: 24 June 2004
View article titled, Neutral Endopeptidase Protein Expression and Prognosis in Localized Prostate Cancer
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Journal Articles

Reduced Lecithin: Retinol Acyltransferase Expression Correlates with Increased Pathologic Tumor Stage in Bladder Cancer

Stephen Boorjian, Satish K. Tickoo, Nigel P. Mongan, Huayin Yu, Dean Bok, Robert R. Rando, David M. Nanus, Douglas S. Scherr, Lorraine J. Gudas
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (10): 3429–3437.
https://doi.org/10.1158/1078-0432.CCR-03-0756
Published: 24 May 2004
View article titled, Reduced Lecithin: <subtitle>Retinol Acyltransferase Expression Correlates with Increased Pathologic Tumor Stage in Bladder Cancer</subtitle>
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Journal Articles

Chemosensitization of Androgen-Independent Prostate Cancer with Neutral Endopeptidase

Makoto Sumitomo, Tomohiko Asano, Junichi Asakuma, Takako Asano, David M. Nanus, Masamichi Hayakawa
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (1): 260–266.
https://doi.org/10.1158/1078-0432.CCR-0798-3
Published: 20 January 2004
View article titled, Chemosensitization of Androgen-Independent Prostate Cancer with Neutral Endopeptidase
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Journal Articles

Of Peptides and Peptidases: The Role of Cell Surface Peptidases in Cancer

David M. Nanus
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (17): 6307–6309.
Published: 24 December 2003
View article titled, Of Peptides and Peptidases: <subtitle>The Role of Cell Surface Peptidases in Cancer</subtitle>
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Journal Articles

Differential Expression of the Enzyme That Esterifies Retinol, Lecithin:Retinol Acyltransferase, in Subtypes of Human Renal Cancer and Normal Kidney

Hui Chun Zhan, Lorraine J. Gudas, Dean Bok, Robert Rando, David M. Nanus, Satish K. Tickoo
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (13): 4897–4905.
Published: 27 October 2003
View article titled, Differential Expression of the Enzyme That Esterifies Retinol, Lecithin:Retinol Acyltransferase, in Subtypes of Human Renal Cancer and Normal Kidney
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Journal Articles

Synergistic Activation of the Androgen Receptor by Bombesin and Low-Dose Androgen

Jie Dai, Ruoqian Shen, Makoto Sumitomo, Rosalyn Stahl, Daniel Navarro, Marvin C. Gershengorn, David M. Nanus
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (7): 2399–2405.
Published: 01 July 2002
View article titled, Synergistic Activation of the Androgen Receptor by Bombesin and Low-Dose Androgen
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Journal Articles

Tumor-Suppressive Effects of Neutral Endopeptidase in Androgen-independent Prostate Cancer Cells

Jie Dai, Ruoqian Shen, Makoto Sumitomo, Jonathan S. Goldberg, Yiping Geng, Daniel Navarro, Su Xu, Jason A. Koutcher, Mark Garzotto, C. Thomas Powell, David M. Nanus
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1370–1377.
Published: 01 May 2001
View article titled, Tumor-Suppressive Effects of Neutral Endopeptidase in Androgen-independent Prostate Cancer Cells
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Journal Articles

Methylation of the Neutral Endopeptidase Gene Promoter in Human Prostate Cancers

Badar A. Usmani, Ruoqian Shen, Michael Janeczko, Christos N. Papandreou, Wen-Hsiang Lee, William G. Nelson, Joel B. Nelson, David M. Nanus
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (5): 1664–1670.
Published: 01 May 2000
View article titled, Methylation of the Neutral Endopeptidase Gene Promoter in Human Prostate Cancers
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