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David L. Rimm
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Journal Articles

Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-Type Non-Small Cell Lung Cancer

Ioannis P. Trontzas, Mengni He, Anna Wurtz, Charles J. Robbins, Nathaniel Robinson, Katherine Bates, Matthew Liu, Thazin N. Aung, Liam Scott, Nay Chan, Sneha Burela, Jacob Schillo, Daniel C. Liebler, Salisha Hill, Ryan D. Morrison, Ioannis Vathiotis, Konstantinos N. Syrigos, Sarah B. Goldberg, Katerina Politi, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2025)
https://doi.org/10.1158/1078-0432.CCR-24-3347
Published: 06 March 2025
View article titled, Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-Type Non-Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Spatially Informed Gene Signatures for Response to Immunotherapy in Melanoma

Thazin N. Aung, Jonathan Warrell, Sandra Martinez-Morilla, Niki Gavrielatou, Ioannis Vathiotis, Vesal Yaghoobi, Harriet M. Kluger, Mark Gerstein, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (16): 3520–3532.
https://doi.org/10.1158/1078-0432.CCR-23-3932
Published: 15 August 2024
View article titled, Spatially Informed Gene Signatures for Response to Immunotherapy in Melanoma
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Includes: Supplementary data
Journal Articles

Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma

Brooke Horowitch, Daniel Y. Lee, Min Ding, Sandra Martinez-Morilla, Thazin Nwe Aung, Feriel Ouerghi, Xueting Wang, Wei Wei, William Damsky, Mario Sznol, Harriet Kluger, David L. Rimm, Jeffrey J. Ishizuka
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (15): 2908–2918.
https://doi.org/10.1158/1078-0432.CCR-23-0215
Published: 01 August 2023
View article titled, Subsets of IFN Signaling Predict Response to Immune Checkpoint Blockade in Patients with Melanoma
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Includes: Supplementary data
Journal Articles

Clinical Outcomes and Immune Markers by Race in a Phase I/II Clinical Trial of Durvalumab Concomitant with Neoadjuvant Chemotherapy in Early-Stage TNBC

Julia Foldi, Adriana Kahn, Andrea Silber, Tao Qing, Emily Reisenbichler, Neal Fischbach, Justin Persico, Kerin Adelson, Anamika Katoch, Anees Chagpar, Tristen Park, Adam Blanchard, Kim Blenman, David L. Rimm, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3720–3728.
https://doi.org/10.1158/1078-0432.CCR-22-0862
Published: 01 September 2022
View article titled, Clinical Outcomes and Immune Markers by Race in a Phase I/II Clinical Trial of Durvalumab Concomitant with Neoadjuvant Chemotherapy in Early-Stage TNBC
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Includes: Supplementary data
Journal Articles

Predictive Markers of Response to Neoadjuvant Durvalumab with Nab-Paclitaxel and Dose-Dense Doxorubicin/Cyclophosphamide in Basal-Like Triple-Negative Breast Cancer

Kim R.M. Blenman, Michal Marczyk, Thomas Karn, Tao Qing, Xiaotong Li, Vignesh Gunasekharan, Vesal Yaghoobi, Yalai Bai, Eiman Y. Ibrahim, Tristen Park, Andrea Silber, Denise M. Wolf, Emily Reisenbichler, Carsten Denkert, Bruno V. Sinn, Mariya Rozenblit, Julia Foldi, David L. Rimm, Sibylle Loibl, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (12): 2587–2597.
https://doi.org/10.1158/1078-0432.CCR-21-3215
Published: 13 June 2022
View article titled, Predictive Markers of Response to Neoadjuvant Durvalumab with Nab-Paclitaxel and Dose-Dense Doxorubicin/Cyclophosphamide in Basal-Like Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non–Small Cell Lung Cancer

Niki Gavrielatou, Yuting Liu, Ioannis Vathiotis, Jon Zugazagoitia, Thazin Nwe Aung, Saba Shafi, Aileen Fernandez, Kurt Schalper, Amanda Psyrri, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 360–367.
https://doi.org/10.1158/1078-0432.CCR-21-2649
Published: 19 January 2022
View article titled, Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Alpha-smooth Muscle Actin Expression in the Stroma Predicts Resistance to Trastuzumab in Patients with Early-stage HER2-positive Breast Cancer

Ioannis A. Vathiotis, Myrto K. Moutafi, Prajan Divakar, Thazin Nwe Aung, Tao Qing, Aileen Fernandez, Vesal Yaghoobi, Sarra El-Abed, Yingbo Wang, Sebastien Guillaume, Paolo Nuciforo, Jens Huober, Serena Di Cosimo, Sung-Bae Kim, Nadia Harbeck, Henry Gomez, Saba Shafi, Konstantinos N. Syrigos, George Fountzilas, Christos Sotiriou, Lajos Pusztai, Sarah Warren, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (22): 6156–6163.
https://doi.org/10.1158/1078-0432.CCR-21-2103
Published: 15 November 2021
View article titled, Alpha-smooth Muscle Actin Expression in the Stroma Predicts Resistance to Trastuzumab in Patients with Early-stage HER2-positive Breast Cancer
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Includes: Supplementary data
Journal Articles

An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer

Yalai Bai, Kimberly Cole, Sandra Martinez-Morilla, Fahad Shabbir Ahmed, Jon Zugazagoitia, Johan Staaf, Ana Bosch, Anna Ehinger, Emma Nimeus, Johan Hartman, Balazs Acs, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5557–5565.
https://doi.org/10.1158/1078-0432.CCR-21-0325
Published: 15 October 2021
View article titled, An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Putting the Microenvironment into the Immunotherapy Companion Diagnostic

Myrto Moutafi, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 3812–3814.
https://doi.org/10.1158/1078-0432.CCR-21-1238
Published: 15 July 2021
View article titled, Putting the Microenvironment into the Immunotherapy Companion Diagnostic
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Journal Articles

Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non–Small Cell Lung Cancer

Ila J. Datar, Sacha C. Hauc, Shruti Desai, Nicole Gianino, Brian Henick, Yuting Liu, Kostas Syrigos, David L. Rimm, Paula Kavathas, Soldano Ferrone, Kurt A. Schalper
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2837–2847.
https://doi.org/10.1158/1078-0432.CCR-20-3655
Published: 15 May 2021
View article titled, Spatial Analysis and Clinical Significance of HLA Class-I and Class-II Subunit Expression in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Biomarker Discovery in Patients with Immunotherapy-Treated Melanoma with Imaging Mass Cytometry

Sandra Martinez-Morilla, Franz Villarroel-Espindola, Pok Fai Wong, Maria I. Toki, Thazin Nwe Aung, Vasiliki Pelekanou, Brian Bourke-Martin, Kurt A. Schalper, Harriet M. Kluger, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (7): 1987–1996.
https://doi.org/10.1158/1078-0432.CCR-20-3340
Published: 01 April 2021
View article titled, Biomarker Discovery in Patients with Immunotherapy-Treated Melanoma with Imaging Mass Cytometry
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Includes: Supplementary data
Journal Articles

Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma

Paul Johannet, Nicolas Coudray, Douglas M. Donnelly, George Jour, Irineu Illa-Bochaca, Yuhe Xia, Douglas B. Johnson, Lee Wheless, James R. Patrinely, Sofia Nomikou, David L. Rimm, Anna C. Pavlick, Jeffrey S. Weber, Judy Zhong, Aristotelis Tsirigos, Iman Osman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 131–140.
https://doi.org/10.1158/1078-0432.CCR-20-2415
Published: 04 January 2021
View article titled, Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma
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Includes: Supplementary data
Journal Articles

PD-L1 Protein Expression on Both Tumor Cells and Macrophages are Associated with Response to Neoadjuvant Durvalumab with Chemotherapy in Triple-negative Breast Cancer

Fahad Shabbir Ahmed, Patricia Gaule, John McGuire, Katir Patel, Kim Blenman, Lajos Pusztai, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5456–5461.
https://doi.org/10.1158/1078-0432.CCR-20-1303
Published: 15 October 2020
View article titled, PD-L1 Protein Expression on Both Tumor Cells and Macrophages are Associated with Response to Neoadjuvant Durvalumab with Chemotherapy in Triple-negative Breast Cancer
Open the PDF for PD-L1 Protein Expression on Both Tumor Cells and Macrophages are Associated with Response to Neoadjuvant Durvalumab with Chemotherapy in Triple-negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Biomarkers Associated with Beneficial PD-1 Checkpoint Blockade in Non–Small Cell Lung Cancer (NSCLC) Identified Using High-Plex Digital Spatial Profiling

Jon Zugazagoitia, Swati Gupta, Yuting Liu, Kit Fuhrman, Scott Gettinger, Roy S. Herbst, Kurt A. Schalper, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (16): 4360–4368.
https://doi.org/10.1158/1078-0432.CCR-20-0175
Published: 14 August 2020
View article titled, Biomarkers Associated with Beneficial PD-1 Checkpoint Blockade in Non–Small Cell Lung Cancer (NSCLC) Identified Using High-Plex Digital Spatial Profiling
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Includes: Supplementary data
Journal Articles

Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death

Prathamesh M. Kulkarni, Eric J. Robinson, Jaya Sarin Pradhan, Robyn D. Gartrell-Corrado, Bethany R. Rohr, Megan H. Trager, Larisa J. Geskin, Harriet M. Kluger, Pok Fai Wong, Balazs Acs, Emanuelle M. Rizk, Chen Yang, Manas Mondal, Michael R. Moore, Iman Osman, Robert Phelps, Basil A. Horst, Zhe S. Chen, Tammie Ferringer, David L. Rimm, Jing Wang, Yvonne M. Saenger
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1126–1134.
https://doi.org/10.1158/1078-0432.CCR-19-1495
Published: 01 March 2020
View article titled, Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death
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Includes: Supplementary data
Journal Articles

Immune Cell PD-L1 Colocalizes with Macrophages and Is Associated with Outcome in PD-1 Pathway Blockade Therapy

Yuting Liu, Jon Zugazagoitia, Fahad Shabbir Ahmed, Brian S. Henick, Scott N. Gettinger, Roy S. Herbst, Kurt A. Schalper, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (4): 970–977.
https://doi.org/10.1158/1078-0432.CCR-19-1040
Published: 14 February 2020
View article titled, Immune Cell PD-L1 Colocalizes with Macrophages and Is Associated with Outcome in PD-1 Pathway Blockade Therapy
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Includes: Supplementary data
Journal Articles

High-Plex Predictive Marker Discovery for Melanoma Immunotherapy–Treated Patients Using Digital Spatial Profiling

Maria I. Toki, Christopher R. Merritt, Pok Fai Wong, James W. Smithy, Harriet M. Kluger, Konstantinos N. Syrigos, Giang T. Ong, Sarah E. Warren, Joseph M. Beechem, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5503–5512.
https://doi.org/10.1158/1078-0432.CCR-19-0104
Published: 13 September 2019
View article titled, High-Plex Predictive Marker Discovery for Melanoma Immunotherapy–Treated Patients Using Digital Spatial Profiling
Open the PDF for High-Plex Predictive Marker Discovery for Melanoma Immunotherapy–Treated Patients Using Digital Spatial Profiling in another window
Includes: Supplementary data
Journal Articles

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

Ila Datar, Miguel F. Sanmamed, Jun Wang, Brian S. Henick, Jungmin Choi, Ti Badri, Weilai Dong, Nikita Mani, Maria Toki, Luis D. Mejías, Maria D. Lozano, Jose Luis Perez-Gracia, Vamsidhar Velcheti, Matthew D. Hellmann, Justin F. Gainor, Kristen McEachern, David Jenkins, Konstantinos Syrigos, Katerina Politi, Scott Gettinger, David L. Rimm, Roy S. Herbst, Ignacio Melero, Lieping Chen, Kurt A. Schalper
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4663–4673.
https://doi.org/10.1158/1078-0432.CCR-18-4142
Published: 01 August 2019
View article titled, Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis
Open the PDF for Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non–Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis in another window
Includes: Supplementary data
Journal Articles

Immunotherapy in Non–Small Cell Lung Cancer: Facts and Hopes

Deborah B. Doroshow, Miguel F. Sanmamed, Katherine Hastings, Katerina Politi, David L. Rimm, Lieping Chen, Ignacio Melero, Kurt A. Schalper, Roy S. Herbst
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (15): 4592–4602.
https://doi.org/10.1158/1078-0432.CCR-18-1538
Published: 01 August 2019
View article titled, Immunotherapy in Non–Small Cell Lung Cancer: Facts and Hopes
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Journal Articles

Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry

Daniel E. Carvajal-Hausdorf, Jonathan Patsenker, Kelly P. Stanton, Franz Villarroel-Espindola, Amanda Esch, Ruth R. Montgomery, Amanda Psyrri, Konstantine T. Kalogeras, Vassiliki Kotoula, George Foutzilas, Kurt A. Schalper, Yuval Kluger, David L. Rimm
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 3054–3062.
https://doi.org/10.1158/1078-0432.CCR-18-2599
Published: 15 May 2019
View article titled, Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
Open the PDF for Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry in another window
Includes: Supplementary data