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David B. Solit
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Journal Articles

Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer

Andrew T. Lenis, Vignesh Ravichandran, Samantha Brown, Syed M. Alam, Andrew Katims, Hong Truong, Peter A. Reisz, Samantha Vasselman, Barbara Nweji, Karen A. Autio, Michael J. Morris, Susan F. Slovin, Dana Rathkopf, Daniel Danila, Sungmin Woo, Hebert A. Vargas, Vincent P. Laudone, Behfar Ehdaie, Victor Reuter, Maria Arcila, Michael F. Berger, Agnes Viale, Howard I. Scher, Nikolaus Schultz, Anuradha Gopalan, Mark T.A. Donoghue, Irina Ostrovnaya, Konrad H. Stopsack, David B. Solit, Wassim Abida
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3894–3903.
https://doi.org/10.1158/1078-0432.CCR-23-3403
Published: 03 September 2024
View article titled, Microsatellite Instability, Tumor Mutational Burden, and Response to Immune Checkpoint Blockade in Patients with Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract A029: Transcriptome analysis of variant histology bladder cancer reveals drug target heterogeneity

Jacob E. Tallman, Fenshen Kuo, Syed M. Alam, Florestan Koll, Jianqian Luo, Sizhi Paul Gao, Eugene J. Pietzak, Gopa Iyer, David B. Solit, Hikmat Al-Ahmadie
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10_Supplement): A029.
https://doi.org/10.1158/1557-3265.BLADDER24-A029
Published: 17 May 2024
View article titled, Abstract A029: Transcriptome analysis of variant histology bladder cancer reveals drug target heterogeneity
Journal Articles

Abstract A028: A living biobank of patient-derived organoids reveals a role for KMT2D in maintaining luminal identity in urothelial carcinoma

John R. Christin, Alana Nguyen, Talal Syed, Kwanghee Kim, Clementine Le Coz, Caroline J. Laplaca, Luis A. Pina, Reuben Akabas, Hanina Hibshoosh, Andrew T. Lenis, Guarionex J. Decastro, Christopher B. Anderson, James M. McKiernan, Chao Lu, Hikmat A. Al-Ahmadie, David B. Solit, Michael M. Shen
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10_Supplement): A028.
https://doi.org/10.1158/1557-3265.BLADDER24-A028
Published: 17 May 2024
View article titled, Abstract A028: A living biobank of patient-derived organoids reveals a role for KMT2D in maintaining luminal identity in urothelial carcinoma
Journal Articles

Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience

Brendan J. Guercio, Michal Sarfaty, Min Yuen Teo, Neha Ratna, Cihan Duzgol, Samuel A. Funt, Chung-Han Lee, David H. Aggen, Ashley M. Regazzi, Ziyu Chen, Michael Lattanzi, Hikmat A. Al-Ahmadie, A. Rose Brannon, Ronak Shah, Carissa Chu, Andrew T. Lenis, Eugene Pietzak, Bernard H. Bochner, Michael F. Berger, David B. Solit, Jonathan E. Rosenberg, Dean F. Bajorin, Gopa Iyer
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (22): 4586–4595.
https://doi.org/10.1158/1078-0432.CCR-23-1283
Published: 14 November 2023
View article titled, Clinical and Genomic Landscape of FGFR3-Altered Urothelial Carcinoma and Treatment Outcomes with Erdafitinib: A Real-World Experience
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Includes: Supplementary data
Journal Articles

Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets

Claire F. Friedman, Vignesh Ravichandran, Kathryn Miller, Chad Vanderbilt, Qin Zhou, Alexia Iasonos, Malavika Vivek, Pamela Mishra, Mario M. Leitao, Jr, Vance Broach, Yukio Sonoda, Chrisann Kyi, Dmitriy Zamarin, Roisin E. O'Cearbhaill, Jason Konner, Michael F. Berger, Britta Weigelt, Amir Momeni Boroujeni, Kay J. Park, Carol Aghajanian, David B. Solit, Mark T.A. Donoghue
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (22): 4660–4668.
https://doi.org/10.1158/1078-0432.CCR-23-1078
Published: 14 November 2023
View article titled, Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets
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Includes: Supplementary data
Journal Articles

Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer

Steven B. Maron, Walid Chatila, Henry Walch, Joanne F. Chou, Nicholas Ceglia, Ryan Ptashkin, Richard Kinh Gian Do, Viktoriya Paroder, Neeta Pandit-Taskar, Jason S. Lewis, Tiago Biachi De Castria, Shalom Sabwa, Fiona Socolow, Lara Feder, Jasmine Thomas, Isabell Schulze, Kwanghee Kim, Arijh Elzein, Viktoria Bojilova, Matthew Zatzman, Umesh Bhanot, Rebecca J. Nagy, Jeeyun Lee, Marc Simmons, Michal Segal, Geoffrey Yuyat Ku, David H. Ilson, Marinela Capanu, Jaclyn F. Hechtman, Taha Merghoub, Sohrab Shah, Nikolaus Schultz, David B. Solit, Yelena Y. Janjigian
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3633–3640.
https://doi.org/10.1158/1078-0432.CCR-22-3769
Published: 15 September 2023
View article titled, Determinants of Survival with Combined HER2 and PD-1 Blockade in Metastatic Esophagogastric Cancer
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Includes: Supplementary data
Journal Articles

Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach

Seyram A. Doe-Tetteh, Sabrina Y. Camp, Dalicia Reales, Jett Crowdis, Anne Marie Noronha, Bernadette Wolff, Tina Alano, Jesse Galle, S. Duygu Selcuklu, Agnes Viale, Nicholas D. Socci, Ying L. Liu, William P. Tew, Carol Aghajanian, Marc Ladanyi, Meng Xiao He, Saud H. AlDubayan, Roei David Mazor, Ofer Shpilberg, Oshrat Hershkovitz-Rokah, Jose A. Riancho, Jose L. Hernandez, M. Carmen Gonzalez-Vela, Justin J. Buthorn, Manda Wilson, Amy E. Webber, Mariko Yabe, Kseniya Petrova-Drus, Marc Rosenblum, Benjamin H. Durham, Omar Abdel-Wahab, Michael F. Berger, Mark T.A. Donoghue, Andrew L. Kung, Julia Glade Bender, Neerav N. Shukla, Samuel A. Funt, Ahmet Dogan, Robert A. Soslow, Hikmat Al-Ahmadie, Darren R. Feldman, Eliezer M. Van Allen, Eli L. Diamond, David B. Solit
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (13): 2445–2455.
https://doi.org/10.1158/1078-0432.CCR-22-3247
Published: 05 July 2023
View article titled, Overcoming Barriers to Tumor Genomic Profiling through Direct-to-Patient Outreach
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Includes: Supplementary data
Journal Articles

Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers

Felipe Batalini, Doga C. Gulhan, Victor Mao, Antuan Tran, Madeline Polak, Niya Xiong, Nabihah Tayob, Nadine M. Tung, Eric P. Winer, Erica L. Mayer, Stian Knappskog, Per E. Lønning, Ursula A. Matulonis, Panagiotis A. Konstantinopoulos, David B. Solit, Helen Won, Hans P. Eikesdal, Peter J. Park, Gerburg M. Wulf
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4714–4723.
https://doi.org/10.1158/1078-0432.CCR-22-0749
Published: 01 November 2022
View article titled, Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers
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Includes: Supplementary data
Journal Articles

Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non–Muscle-Invasive Bladder Cancer

Eugene J. Pietzak, Karissa Whiting, Preethi Srinivasan, Chaitanya Bandlamudi, Aliya Khurram, Vijai Joseph, Aleksandra Walasek, Emily Bochner, Timothy Clinton, Nima Almassi, Hong Truong, Manuel R. de Jesus Escano, Michal Wiseman, Diana Mandelker, Yelena Kemel, Liying Zhang, Michael F. Walsh, Karen A. Cadoo, Jonathan A. Coleman, Hikmat Al-Ahmadie, Jonathan E. Rosenberg, Gopakumar V. Iyer, David B. Solit, Irina Ostrovnaya, Kenneth Offit, Mark E. Robson, Zsofia K. Stadler, Michael F. Berger, Dean F. Bajorin, Maria Carlo, Bernard H. Bochner
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (19): 4267–4277.
https://doi.org/10.1158/1078-0432.CCR-22-1006
Published: 03 October 2022
View article titled, Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non–Muscle-Invasive Bladder Cancer
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Includes: Supplementary data
Journal Articles

The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma

Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Sergio De La Torre, Yelena Y. Janjigian, Steven B. Maron, Geoffrey Y. Ku, Laura H. Tang, Pari M. Shah, Abraham Wu, David R. Jones, David B. Solit, Nikolaus Schultz, Karuna Ganesh, Michael F. Berger, Daniela Molena
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (12): 2669–2678.
https://doi.org/10.1158/1078-0432.CCR-21-4016
Published: 13 June 2022
View article titled, The Role of the TP53 Pathway in Predicting Response to Neoadjuvant Therapy in Esophageal Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors

Konrad H. Stopsack, Subhiksha Nandakumar, Kanika Arora, Bastien Nguyen, Samantha E. Vasselman, Barbara Nweji, Sean M. McBride, Michael J. Morris, Dana E. Rathkopf, Susan F. Slovin, Daniel C. Danila, Karen A. Autio, Howard I. Scher, Lorelei A. Mucci, David B. Solit, Mithat Gönen, Yu Chen, Michael F. Berger, Nikolaus Schultz, Wassim Abida, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 318–326.
https://doi.org/10.1158/1078-0432.CCR-21-2577
Published: 15 January 2022
View article titled, Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
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Includes: Supplementary data
Journal Articles

Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non–Muscle-Invasive Bladder Cancer

Jeffrey S. Damrauer, Kyle R. Roell, Markia A. Smith, Xuezheng Sun, Erin L. Kirk, Katherine A. Hoadley, Halei C. Benefield, Gopakumar Iyer, David B. Solit, Matthew I. Milowsky, William Y. Kim, Matthew E. Nielsen, Sara E. Wobker, Guido Dalbagni, Hikmat A. Al-Ahmadie, Andrew F. Olshan, Bernard H. Bochner, Helena Furberg, Melissa A. Troester, Eugene J. Pietzak
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4599–4609.
https://doi.org/10.1158/1078-0432.CCR-21-0205
Published: 15 August 2021
View article titled, Identification of a Novel Inflamed Tumor Microenvironment Signature as a Predictive Biomarker of Bacillus Calmette-Guérin Immunotherapy in Non–Muscle-Invasive Bladder Cancer
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Journal Articles

Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways

Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Francisco Sanchez-Vega, Walid K. Chatila, Sergio A. De La Torre, Assem Patel, Yelena Y. Janjigian, Steven Maron, Geoffrey Y. Ku, Laura H. Tang, Jaclyn Hechtman, Pari M. Shah, Abraham J. Wu, David R. Jones, Daniela Molena, David B. Solit, Nikolaus Schultz, Michael F. Berger
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (12): 3491–3498.
https://doi.org/10.1158/1078-0432.CCR-20-4707
Published: 15 June 2021
View article titled, Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways
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Includes: Supplementary data
Journal Articles

Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas

Alexander N. Shoushtari, Walid K. Chatila, Arshi Arora, Francisco Sanchez-Vega, Havish S. Kantheti, Jorge A. Rojas Zamalloa, Penina Krieger, Margaret K. Callahan, Allison Betof Warner, Michael A. Postow, Parisa Momtaz, Suresh Nair, Charlotte E. Ariyan, Christopher A. Barker, Mary Susan Brady, Daniel G. Coit, Neal Rosen, Paul B. Chapman, Klaus J. Busam, David B. Solit, Katherine S. Panageas, Jedd D. Wolchok, Nikolaus Schultz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2226–2235.
https://doi.org/10.1158/1078-0432.CCR-20-4189
Published: 15 April 2021
View article titled, Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas
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Includes: Supplementary data
Journal Articles

Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer

Sabine Topka, Zoe Steinsnyder, Vignesh Ravichandran, Kaitlyn Tkachuk, Yelena Kemel, Chaitanya Bandlamudi, Mogens Winkel Madsen, Helena Furberg, Ouathek Ouerfelli, Charles M. Rudin, Gopa Iyer, Steven M. Lipkin, Semanti Mukherjee, David B. Solit, Michael F. Berger, Dean F. Bajorin, Jonathan E. Rosenberg, Barry S. Taylor, Elisa de Stanchina, Joseph Vijai, Kenneth Offit
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (7): 1997–2010.
https://doi.org/10.1158/1078-0432.CCR-20-3322
Published: 01 April 2021
View article titled, Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer
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Includes: Supplementary data
Journal Articles

Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer

Judit Börcsök, Zsofia Sztupinszki, Raie Bekele, Sizhi P. Gao, Miklos Diossy, Amruta S. Samant, Kasia M. Dillon, Viktoria Tisza, Sándor Spisák, Orsolya Rusz, Istvan Csabai, Helle Pappot, Zoë J. Frazier, David J. Konieczkowski, David Liu, Naresh Vasani, James A. Rodrigues, David B. Solit, Jean H. Hoffman-Censits, Elizabeth R. Plimack, Jonathan E. Rosenberg, Jean-Bernard Lazaro, Mary-Ellen Taplin, Gopa Iyer, Søren Brunak, Rita Lozsa, Eliezer M. Van Allen, Dávid Szüts, Kent W. Mouw, Zoltan Szallasi
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (7): 2011–2022.
https://doi.org/10.1158/1078-0432.CCR-20-3316
Published: 01 April 2021
View article titled, Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer
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Includes: Supplementary data
Journal Articles

The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas

Alvin P. Makohon-Moore, Evan J. Lipson, Jody E. Hooper, Amanda Zucker, Jungeui Hong, Craig M. Bielski, Akimasa Hayashi, Collin Tokheim, Priscilla Baez, Rajya Kappagantula, Zachary Kohutek, Vladimir Makarov, Nadeem Riaz, Michael A. Postow, Paul B. Chapman, Rachel Karchin, Nicholas D. Socci, David B. Solit, Timothy A. Chan, Barry S. Taylor, Suzanne L. Topalian, Christine A. Iacobuzio-Donahue
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1516–1525.
https://doi.org/10.1158/1078-0432.CCR-20-2984
Published: 01 March 2021
View article titled, The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas
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Includes: Supplementary data
Journal Articles

Abstract A14: Next-generation sequencing of Bacille Calmette-Guerin (BCG)-unresponsive tumors identifies actionable alterations for potential targeted therapy in non-muscle invasive bladder cancer

Aleksandra Walasek, Nima Almassi, Victor McPherson, Shawn Dason, Nicole Benfante, Tanya Klein, Michael F. Berger, Nikolaus Schultz, Guido Dalbagni, Dean F. Bajorin, Jonathan E. Rosenberg, Hikmat Al-Ahmadie, Bernard H. Bochner, David B. Solit, Gopakumar Iyer, Eugene J. Pietzak
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (15_Supplement): A14.
https://doi.org/10.1158/1557-3265.BLADDER19-A14
Published: 03 August 2020
View article titled, Abstract A14: Next-generation sequencing of Bacille Calmette-Guerin (BCG)-unresponsive tumors identifies actionable alterations for potential targeted therapy in non-muscle invasive bladder cancer
Journal Articles

Abstract B20: Characterization of tumor mutational landscape in smokers and nonsmokers with urothelial carcinoma

Aleksandra Walasek, Nima Almassi, Min Yuen Teo, Samuel Funt, Nikolaus Schultz, Guido Dalbagni, Wenhu Hu, Hikmat Al-Ahmadie, Dean F Bajorin, Jonathan E Rosenberg, Gopakumar Iyer, Bernard H. Bochner, David B. Solit, Eugene J. Pietzak
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (15_Supplement): B20.
https://doi.org/10.1158/1557-3265.BLADDER19-B20
Published: 03 August 2020
View article titled, Abstract B20: Characterization of tumor mutational landscape in smokers and nonsmokers with urothelial carcinoma
Journal Articles

Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing

Martee L. Hensley, Shweta S. Chavan, David B. Solit, Rajmohan Murali, Robert Soslow, Sarah Chiang, Achim A. Jungbluth, Chaitanya Bandlamudi, Preethi Srinivasan, William D. Tap, Evan Rosenbaum, Barry S. Taylor, Mark T.A. Donoghue, David M. Hyman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3881–3888.
https://doi.org/10.1158/1078-0432.CCR-19-3959
Published: 15 July 2020
View article titled, Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing
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Includes: Supplementary data