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David A. Braun
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Journal Articles

PD-1 Expression on Intratumoral Regulatory T Cells Is Associated with Lack of Benefit from Anti–PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients

Thomas Denize, Opeyemi A. Jegede, Sayed Matar, Nourhan El Ahmar, Destiny J. West, Emily Walton, Aseman Sheshdeh Bagheri, Varunika Savla, Yasmin Nabil Laimon, Saurabh Gupta, Sai Vikram Vemula, David A. Braun, Kelly P. Burke, Paul J. Catalano, Gordon J. Freeman, Robert J. Motzer, Michael B. Atkins, David F. McDermott, Arlene H. Sharpe, Toni K. Choueiri, Sabina Signoretti
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 803–813.
https://doi.org/10.1158/1078-0432.CCR-23-2274
Published: 16 February 2024
View article titled, PD-1 Expression on Intratumoral Regulatory T Cells Is Associated with Lack of Benefit from Anti–PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients
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Includes: Supplementary data
Journal Articles

Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma

Thomas Denize, Yue Hou, Jean-Christophe Pignon, Emily Walton, Destiny J. West, Gordon J. Freeman, David A. Braun, Catherine J. Wu, Saurabh Gupta, Robert J. Motzer, Michael B. Atkins, David McDermott, Toni K. Choueiri, Sachet A. Shukla, Sabina Signoretti
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18): 4045–4055.
https://doi.org/10.1158/1078-0432.CCR-22-0923
Published: 15 September 2022
View article titled, Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit

Toni K. Choueiri, Laurence Albiges, Michael B. Atkins, Ziad Bakouny, Gennady Bratslavsky, David A. Braun, Naomi B. Haas, John B.A.G. Haanen, A. Ari Hakimi, Michael A.S. Jewett, Eric Jonasch, William G. Kaelin, Jr, Payal Kapur, Chris Labaki, Bryan Lewis, David F. McDermott, Sumanta K. Pal, Kevin Pels, Susan Poteat, Thomas Powles, W. Kimryn Rathmell, Brian I. Rini, Sabina Signoretti, Nizar M. Tannir, Robert G. Uzzo, Hans J. Hammers
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (5): 831–839.
https://doi.org/10.1158/1078-0432.CCR-21-3238
Published: 03 March 2022
View article titled, From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit
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Journal Articles

Biomarkers of Angiogenesis and Clinical Outcomes to Cabozantinib and Everolimus in Patients with Metastatic Renal Cell Carcinoma from the Phase III METEOR Trial

Thomas Denize, Subrina Farah, Alessia Cimadamore, Abdallah Flaifel, Emily Walton, Maura A. Sticco-Ivins, Chris Labaki, David A. Braun, Maxine Sun, Evelyn Wang, Wanling Xie, Toni K. Choueiri, Sabina Signoretti
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 748–755.
https://doi.org/10.1158/1078-0432.CCR-21-3088
Published: 15 February 2022
View article titled, Biomarkers of Angiogenesis and Clinical Outcomes to Cabozantinib and Everolimus in Patients with Metastatic Renal Cell Carcinoma from the Phase III METEOR Trial
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Includes: Supplementary data
Journal Articles

CDKN2A Alterations and Response to Immunotherapy in Solid Tumors

Elio Adib, Amin H. Nassar, Elie W. Akl, Sarah Abou Alaiwi, Pier Vitale Nuzzo, Tarek H. Mouhieddine, Guru Sonpavde, Robert I. Haddad, Kent W. Mouw, Marios Giannakis, F. Stephen Hodi, Sachet A. Shukla, Alexander Gusev, David A. Braun, Toni K. Choueiri, David J. Kwiatkowski
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4025–4035.
https://doi.org/10.1158/1078-0432.CCR-21-0575
Published: 15 July 2021
View article titled, <em>CDKN2A</em> Alterations and Response to Immunotherapy in Solid Tumors
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Includes: Supplementary data
Journal Articles

Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma

Miriam Ficial, Opeyemi A. Jegede, Miriam Sant'Angelo, Yue Hou, Abdallah Flaifel, Jean-Christophe Pignon, David A. Braun, Megan Wind-Rotolo, Maura A. Sticco-Ivins, Paul J. Catalano, Gordon J. Freeman, Arlene H. Sharpe, F. Stephen Hodi, Robert J. Motzer, Catherine J. Wu, Michael B. Atkins, David F. McDermott, Sachet A. Shukla, Toni K. Choueiri, Sabina Signoretti
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1371–1380.
https://doi.org/10.1158/1078-0432.CCR-20-3084
Published: 01 March 2021
View article titled, Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN

Abdallah Flaifel, Wanling Xie, David A. Braun, Miriam Ficial, Ziad Bakouny, Amin H. Nassar, Rebecca B. Jennings, Bernard Escudier, Daniel J. George, Robert J. Motzer, Michael J. Morris, Thomas Powles, Evelyn Wang, Ying Huang, Gordon J. Freeman, Toni K. Choueiri, Sabina Signoretti
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (20): 6080–6088.
https://doi.org/10.1158/1078-0432.CCR-19-1135
Published: 15 October 2019
View article titled, PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN
Open the PDF for PD-L1 Expression and Clinical Outcomes to Cabozantinib, Everolimus, and Sunitinib in Patients with Metastatic Renal Cell Carcinoma: Analysis of the Randomized Clinical Trials METEOR and CABOSUN in another window
Includes: Supplementary data
Journal Articles

irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial

Jean-Christophe Pignon, Opeyemi Jegede, Sachet A. Shukla, David A. Braun, Christine E. Horak, Megan Wind-Rotolo, Yuko Ishii, Paul J. Catalano, Jonian Grosha, Abdallah Flaifel, Jesse S. Novak, Kathleen M. Mahoney, Gordon J. Freeman, Arlene H. Sharpe, F. Stephen Hodi, Robert J. Motzer, Toni K. Choueiri, Catherine J. Wu, Michael B. Atkins, David F. McDermott, Sabina Signoretti
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2174–2184.
https://doi.org/10.1158/1078-0432.CCR-18-3206
Published: 01 April 2019
View article titled, irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial
Open the PDF for irRECIST for the Evaluation of Candidate Biomarkers of Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma: Analysis of a Phase II Prospective Clinical Trial in another window
Includes: Supplementary data
Journal Articles

Genomic Approaches to Understanding Response and Resistance to Immunotherapy

David A. Braun, Kelly P. Burke, Eliezer M. Van Allen
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (23): 5642–5650.
https://doi.org/10.1158/1078-0432.CCR-16-0066
Published: 30 November 2016
View article titled, Genomic Approaches to Understanding Response and Resistance to Immunotherapy
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