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Daniel B. Longley
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Journal Articles

In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer

Sudhir B. Malla, David J. Fisher, Enric Domingo, Andrew Blake, Sylvana Hassanieh, Keara L. Redmond, Susan D. Richman, Michael Youdell, Steven M. Walker, Gemma E. Logan, Aikaterina Chatzipli, Raheleh Amirkhah, Matthew P. Humphries, Stephanie G. Craig, Ultan McDermott, Matthew T. Seymour, Dion G. Morton, Philip Quirke, Nicholas P. West, Manuel Salto-Tellez, Richard D. Kennedy, Patrick G. Johnston, Ian Tomlinson, Viktor H. Koelzer, Letitia Campo, Richard S. Kaplan, Daniel B. Longley, Mark Lawler, Timothy S. Maughan, Louise C. Brown, Philip D. Dunne
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 288–300.
https://doi.org/10.1158/1078-0432.CCR-20-3237
Published: 04 January 2021
View article titled, In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

Manuela Salvucci, Maximilian L. Würstle, Clare Morgan, Sarah Curry, Mattia Cremona, Andreas U. Lindner, Orna Bacon, Alexa J. Resler, Áine C. Murphy, Robert O'Byrne, Lorna Flanagan, Sonali Dasgupta, Nadege Rice, Camilla Pilati, Elisabeth Zink, Lisa M. Schöller, Sinead Toomey, Mark Lawler, Patrick G. Johnston, Richard Wilson, Sophie Camilleri-Broët, Manuel Salto-Tellez, Deborah A. McNamara, Elaine W. Kay, Pierre Laurent-Puig, Sandra Van Schaeybroeck, Bryan T. Hennessy, Daniel B. Longley, Markus Rehm, Jochen H.M. Prehn
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (5): 1200–1212.
https://doi.org/10.1158/1078-0432.CCR-16-1084
Published: 28 February 2017
View article titled, A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer

Philip D. Dunne, Darragh G. McArt, Conor A. Bradley, Paul G. O'Reilly, Helen L. Barrett, Robert Cummins, Tony O'Grady, Ken Arthur, Maurice B. Loughrey, Wendy L. Allen, Simon S. McDade, David J. Waugh, Peter W. Hamilton, Daniel B. Longley, Elaine W. Kay, Patrick G. Johnston, Mark Lawler, Manuel Salto-Tellez, Sandra Van Schaeybroeck
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16): 4095–4104.
https://doi.org/10.1158/1078-0432.CCR-16-0032
Published: 14 August 2016
View article titled, Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

Robbie Carson, Basak Celtikci, Cathy Fenning, Arman Javadi, Nyree Crawford, Lucia Perez-Carbonell, Mark Lawler, Daniel B. Longley, Patrick G. Johnston, Sandra Van Schaeybroeck
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (14): 3230–3240.
https://doi.org/10.1158/1078-0432.CCR-14-2701
Published: 14 July 2015
View article titled, HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in <em>BRAF</em>-Mutant Colorectal Cancer by Downregulation of c-FLIP<sub>L</sub>
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Includes: Supplementary data
Journal Articles

AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer

Philip D. Dunne, Darragh G. McArt, Jaine K. Blayney, Murugan Kalimutho, Samanda Greer, Tingting Wang, Supriya Srivastava, Chee Wee Ong, Ken Arthur, Maurice Loughrey, Keara Redmond, Daniel B. Longley, Manuel Salto-Tellez, Patrick G. Johnston, Sandra Van Schaeybroeck
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (1): 164–175.
https://doi.org/10.1158/1078-0432.CCR-13-1354
Published: 05 January 2014
View article titled, AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer
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Includes: Supplementary data
Journal Articles

Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer

Leanne Stevenson, Wendy L. Allen, Richard Turkington, Puthen V. Jithesh, Irina Proutski, Gail Stewart, Heinz-Josef Lenz, Sandra Van Schaeybroeck, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5412–5426.
https://doi.org/10.1158/1078-0432.CCR-12-1780
Published: 30 September 2012
View article titled, Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor–Targeted Therapy

Clare McCourt, Pamela Maxwell, Roberta Mazzucchelli, Rodolfo Montironi, Marina Scarpelli, Manuel Salto-Tellez, Joe M. O'Sullivan, Daniel B. Longley, David J.J. Waugh
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (14): 3822–3833.
https://doi.org/10.1158/1078-0432.CCR-11-3277
Published: 15 July 2012
View article titled, Elevation of c-FLIP in Castrate-Resistant Prostate Cancer Antagonizes Therapeutic Response to Androgen Receptor–Targeted Therapy
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Includes: Supplementary data
Journal Articles

Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer

Donal P. McLornan, Helen L. Barrett, Robert Cummins, Ultan McDermott, Cliona McDowell, Susie J. Conlon, Victoria M. Coyle, Sandra Van Schaeybroeck, Richard Wilson, Elaine W. Kay, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (13): 3442–3451.
https://doi.org/10.1158/1078-0432.CCR-10-0052
Published: 30 June 2010
View article titled, Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer

Joan N. Kyula, Sandra Van Schaeybroeck, Joanne Doherty, Catherine S. Fenning, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (13): 3378–3389.
https://doi.org/10.1158/1078-0432.CCR-10-0014
Published: 30 June 2010
View article titled, Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Wendy L. Allen, Vicky M. Coyle, Puthen V. Jithesh, Irina Proutski, Leanne Stevenson, Cathy Fenning, Daniel B. Longley, Richard H. Wilson, Michael Gordon, Heinz-Josef Lenz, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (20): 6647–6655.
https://doi.org/10.1158/1078-0432.CCR-08-0452
Published: 16 October 2008
View article titled, Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models
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Includes: Supplementary data
Journal Articles

Characterization of p53 Wild-Type and Null Isogenic Colorectal Cancer Cell Lines Resistant to 5-Fluorouracil, Oxaliplatin, and Irinotecan

John Boyer, Estelle G. McLean, Somaiah Aroori, Peter Wilson, Andrea McCulla, P. Declan Carey, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (6): 2158–2167.
https://doi.org/10.1158/1078-0432.CCR-03-0362
Published: 24 March 2004
View article titled, Characterization of p53 Wild-Type and Null Isogenic Colorectal Cancer Cell Lines Resistant to 5-Fluorouracil, Oxaliplatin, and Irinotecan
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Journal Articles

Characterization of a Thymidylate Synthase (TS)-inducible Cell Line: A Model System for Studying Sensitivity to TS- and non-TS-targeted Chemotherapies

Daniel B. Longley, Paul R. Ferguson, John Boyer, Tariq Latif, Maria Lynch, Pamela Maxwell, D. Paul Harkin, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (11): 3533–3539.
Published: 01 November 2001
View article titled, Characterization of a Thymidylate Synthase (TS)-inducible Cell Line: <subtitle>A Model System for Studying Sensitivity to TS- and non-TS-targeted Chemotherapies</subtitle>
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