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Dan Theodorescu
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Journal Articles

Abstract IA005: Y chromosome loss in cancer drives growth by evasion of adaptive immunity

Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10_Supplement): IA005.
https://doi.org/10.1158/1557-3265.BLADDER24-IA005
Published: 17 May 2024
View article titled, Abstract IA005: Y chromosome loss in cancer drives growth by evasion of adaptive immunity
Journal Articles

Association of Molecular Subtypes with Pathologic Response, PFS, and OS in a Phase II Study of COXEN with Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer

Seth P. Lerner, David J. McConkey, Catherine M. Tangen, Joshua J. Meeks, Thomas W. Flaig, Xing Hua, Siamak Daneshmand, Ajjai Shivaram Alva, M. Scott Lucia, Dan Theodorescu, Amir Goldkorn, Matthew I. Milowsky, Woonyoung Choi, Rick Bangs, Daniel L. Gustafson, Melissa Plets, Ian M. Thompson, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (2): 444–449.
https://doi.org/10.1158/1078-0432.CCR-23-0602
Published: 17 January 2024
View article titled, Association of Molecular Subtypes with Pathologic Response, PFS, and OS in a Phase II Study of COXEN with Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer
Open the PDF for Association of Molecular Subtypes with Pathologic Response, PFS, and OS in a Phase II Study of COXEN with Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer in another window
Includes: Supplementary data
Journal Articles

A Randomized Phase II Study of Coexpression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Bladder Cancer (SWOG S1314; NCT02177695)

Thomas W. Flaig, Catherine M. Tangen, Siamak Daneshmand, Ajjai Alva, Seth P. Lerner, M. Scott Lucia, David J. McConkey, Dan Theodorescu, Amir Goldkorn, Matthew I. Milowsky, Rick Bangs, Gary R. MacVicar, Bruno R. Bastos, Jared S. Fowles, Daniel L. Gustafson, Melissa Plets, Ian M. Thompson, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2435–2441.
https://doi.org/10.1158/1078-0432.CCR-20-2409
Published: 01 May 2021
View article titled, A Randomized Phase II Study of Coexpression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Bladder Cancer (SWOG S1314; NCT02177695)
Open the PDF for A Randomized Phase II Study of Coexpression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Bladder Cancer (SWOG S1314; NCT02177695) in another window
Includes: Supplementary data
Journal Articles

Abstract IA10: Developing rational combination therapy with checkpoint inhibitors

Megan M. Tu, Francis Y. F. Lee, Robert T. Jones, Abigail K. Kimball, Elizabeth Saravia, Robert F. Graziano, Brianne Coleman, Krista Menard, Jun Yan, Erin Michaud, Han Chang, Hany A. Abdel-Hafiz, Andrii I. Rozhok, Jason E. Duex, Neeraj Agarwal, Ana Chauca-Diaz, Linda K. Johnson, Terry L. Ng, John C. Cambier, Eric T. Clambey, James C. Costello, Alan J. Korman, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (15_Supplement): IA10.
https://doi.org/10.1158/1557-3265.BLADDER19-IA10
Published: 03 August 2020
View article titled, Abstract IA10: Developing rational combination therapy with checkpoint inhibitors
Journal Articles

Abstract B11: Multi-omic interrogation of gemcitabine and cisplatin-resistant bladder cancer cell lines identifies unique and shared mediators of chemosensitivity and resistance

Robert T. Jones, Tahlita C. M. Zuiverloon, Hedvig Vekony, Andrew Goodspeed, Teemu D. Laajala, Molishree Joshi, Colin Sempeck, Annie Jean, Megan Tu, Julia D. Wulfkuhle, Emanuel F. Petricoin, James C. Costello, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (15_Supplement): B11.
https://doi.org/10.1158/1557-3265.BLADDER19-B11
Published: 03 August 2020
View article titled, Abstract B11: Multi-omic interrogation of gemcitabine and cisplatin-resistant bladder cancer cell lines identifies unique and shared mediators of chemosensitivity and resistance
Journal Articles

Development and Validation of Urine-based Peptide Biomarker Panels for Detecting Bladder Cancer in a Multi-center Study

Maria Frantzi, Kim E. van Kessel, Ellen C. Zwarthoff, Mirari Marquez, Marta Rava, Núria Malats, Axel S. Merseburger, Ioannis Katafigiotis, Konstantinos Stravodimos, William Mullen, Jerome Zoidakis, Manousos Makridakis, Martin Pejchinovski, Elena Critselis, Ralph Lichtinghagen, Korbinian Brand, Mohammed Dakna, Maria G. Roubelakis, Dan Theodorescu, Antonia Vlahou, Harald Mischak, Nicholas P. Anagnou
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16): 4077–4086.
https://doi.org/10.1158/1078-0432.CCR-15-2715
Published: 14 August 2016
View article titled, Development and Validation of Urine-based Peptide Biomarker Panels for Detecting Bladder Cancer in a Multi-center Study
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Includes: Supplementary data
Journal Articles

Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis

Sunny Guin, Yuanbin Ru, Neeraj Agarwal, Carolyn R. Lew, Charles Owens, Giacomo P. Comi, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (5): 1274–1283.
https://doi.org/10.1158/1078-0432.CCR-15-1706
Published: 29 February 2016
View article titled, Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis
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Includes: Supplementary data
Journal Articles

Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer

Michael L. Nickerson, Garrett M. Dancik, Kate M. Im, Michael G. Edwards, Sevilay Turan, Joseph Brown, Christina Ruiz-Rodriguez, Charles Owens, James C. Costello, Guangwu Guo, Shirley X. Tsang, Yingrui Li, Quan Zhou, Zhiming Cai, Lee E. Moore, M. Scott Lucia, Michael Dean, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (18): 4935–4948.
https://doi.org/10.1158/1078-0432.CCR-14-0330
Published: 14 September 2014
View article titled, Concurrent Alterations in <em>TERT</em>, <em>KDM6A</em>, and the BRCA Pathway in Bladder Cancer
Open the PDF for Concurrent Alterations in <em>TERT</em>, <em>KDM6A</em>, and the BRCA Pathway in Bladder Cancer in another window
Includes: Supplementary data
Journal Articles

Cancer chemosensitivity prediction of drug combinations using single drug responses and microarray profiling data

Dmytro M. Havaleshko, HyungJun Cho, Jae K. Lee, Garret Hampton, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): B46.
Published: 15 August 2014
View article titled, Cancer chemosensitivity prediction of drug combinations using single drug responses and microarray profiling data
Journal Articles

Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization

Hong Wang, Yuanbin Ru, Marta Sanchez-Carbayo, Xuejiao Wang, Jeffrey S. Kieft, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 2850–2860.
https://doi.org/10.1158/1078-0432.CCR-12-3084
Published: 30 May 2013
View article titled, Translation Initiation Factor eIF3b Expression in Human Cancer and Its Role in Tumor Growth and Lung Colonization
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Includes: Supplementary data
Journal Articles

Prospective Comparison of Clinical and Genomic Multivariate Predictors of Response to Neoadjuvant Chemotherapy in Breast Cancer

Jae K. Lee, Charles Coutant, Young-Chul Kim, Yuan Qi, Dan Theodorescu, W. Fraser Symmans, Keith Baggerly, Roman Rouzier, Lajos Pusztai
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 711–718.
https://doi.org/10.1158/1078-0432.CCR-09-2247
Published: 14 January 2010
View article titled, Prospective Comparison of Clinical and Genomic Multivariate Predictors of Response to Neoadjuvant Chemotherapy in Breast Cancer
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Includes: Supplementary data
Journal Articles

Prediction of Muscle-invasive Bladder Cancer Using Urinary Proteomics

Eric Schiffer, Antonia Vlahou, Andreas Petrolekas, Konstantinos Stravodimos, Robert Tauber, Jürgen E. Geschwend, Jochen Neuhaus, Jens-Uwe Stolzenburg, Mark R. Conaway, Harald Mischak, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (15): 4935–4943.
https://doi.org/10.1158/1078-0432.CCR-09-0226
Published: 29 July 2009
View article titled, Prediction of Muscle-invasive Bladder Cancer Using Urinary Proteomics
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Includes: Supplementary data
Journal Articles

Preclinical Drug Development Must Consider the Impact on Metastasis

Patricia S. Steeg, Robin L. Anderson, Menashe Bar-Eli, Ann F. Chambers, Suzanne A. Eccles, Kent Hunter, Kazuyuki Itoh, Yibin Kang, Lynn M. Matrisian, Jonathan P. Sleeman, Dan Theodorescu, Erik W. Thompson, Danny R. Welch
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (14): 4529–4530.
https://doi.org/10.1158/1078-0432.CCR-09-1363
Published: 15 July 2009
View article titled, Preclinical Drug Development Must Consider the Impact on Metastasis
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Journal Articles

Integrin Agonists as Adjuvants in Chemotherapy for Melanoma

Martin A. Schwartz, Kevin McRoberts, Matthew Coyner, Kumari L. Andarawewa, Henry F. Frierson, Jr., John M. Sanders, Stephen Swenson, Frank Markland, Mark R. Conaway, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (19): 6193–6197.
https://doi.org/10.1158/1078-0432.CCR-08-1285
Published: 30 September 2008
View article titled, Integrin Agonists as Adjuvants in Chemotherapy for Melanoma
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Journal Articles

Sensitivity to Epidermal Growth Factor Receptor Inhibitor Requires E-Cadherin Expression in Urothelial Carcinoma Cells

Peter C. Black, Gordon A. Brown, Teruo Inamoto, Marissa Shrader, Ameeta Arora, Arlene O. Siefker-Radtke, Liana Adam, Dan Theodorescu, Xifeng Wu, Mark F. Munsell, Menashe Bar-Eli, David J. McConkey, Colin P.N. Dinney
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (5): 1478–1486.
https://doi.org/10.1158/1078-0432.CCR-07-1593
Published: 03 March 2008
View article titled, Sensitivity to Epidermal Growth Factor Receptor Inhibitor Requires E-Cadherin Expression in Urothelial Carcinoma Cells
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Journal Articles

Expression of Ral GTPases, Their Effectors, and Activators in Human Bladder Cancer

Steven Christopher Smith, Gary Oxford, Alexander S. Baras, Charles Owens, Dmytro Havaleshko, David L. Brautigan, Martin K. Safo, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (13): 3803–3813.
https://doi.org/10.1158/1078-0432.CCR-06-2419
Published: 02 July 2007
View article titled, Expression of Ral GTPases, Their Effectors, and Activators in Human Bladder Cancer
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Journal Articles

Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical Application

Carrie W. Rinker-Schaeffer, James P. O'Keefe, Danny R. Welch, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 3882–3889.
https://doi.org/10.1158/1078-0432.CCR-06-1014
Published: 03 July 2006
View article titled, Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical Application
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Journal Articles

Combination Antiangiogenic and Androgen Deprivation Therapy for Prostate Cancer: A Promising Therapeutic Approach

Brian Nicholson, Kathryn Gulding, Mark Conaway, Stephen R. Wedge, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8728–8734.
https://doi.org/10.1158/1078-0432.CCR-04-0902
Published: 28 December 2004
View article titled, Combination Antiangiogenic and Androgen Deprivation Therapy for Prostate Cancer: <subtitle>A Promising Therapeutic Approach</subtitle>
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Journal Articles

Reduced Expression of Metastasis Suppressor RhoGDI2 Is Associated with Decreased Survival for Patients with Bladder Cancer

Dan Theodorescu, L. M. Sapinoso, M. R. Conaway, G. Oxford, G. M. Hampton, H. F. Frierson, Jr.
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (11): 3800–3806.
https://doi.org/10.1158/1078-0432.CCR-03-0653
Published: 01 June 2004
View article titled, Reduced Expression of Metastasis Suppressor RhoGDI2 Is Associated with Decreased Survival for Patients with Bladder Cancer
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Journal Articles

Molecular Determination of Perivesical and Lymph Node Metastasis after Radical Cystectomy for Urothelial Carcinoma of the Bladder

M. Jabed Seraj, Alexander R. Thomas, Joseph L. Chin, Dan Theodorescu
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (6): 1516–1522.
Published: 01 June 2001
View article titled, Molecular Determination of Perivesical and Lymph Node Metastasis after Radical Cystectomy for Urothelial Carcinoma of the Bladder
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