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Cristina R. Antonescu
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Journal Articles

Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma

Caroline E. Gleason, Mark A. Dickson, Mary E. Klein (Dooley), Cristina R. Antonescu, Rodrigo Gularte-Mérida, Marimar Benitez, Juliana I. Delgado, Raghu P. Kataru, Mark Wei Yi Tan, Martina Bradic, Travis E. Adamson, Kenneth Seier, Allison L. Richards, Marta Palafox, Eric Chan, Sandra P. D'Angelo, Mrinal M. Gounder, Mary Louise Keohan, Ciara M. Kelly, Ping Chi, Sujana Movva, Jonathan Landa, Aimee M. Crago, Mark T.A. Donoghue, Li-Xuan Qin, Violetta Serra, Mesruh Turkekul, Afsar Barlas, Daniel M. Firester, Katia Manova-Todorova, Babak J. Mehrara, Marta Kovatcheva, Nguan Soon Tan, Samuel Singer, William D. Tap, Andrew Koff
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF16.
https://doi.org/10.1158/1078-0432.CCR-23-2378
Published: 27 September 2023
View article titled, Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
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Includes: Supplementary data
Journal Articles

Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era

Josephine K. Dermawan, Ciara Kelly, Zhidong Gao, Shaleigh Smith, Bhumika Jadeja, Samuel Singer, William D. Tap, Ping Chi, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF12.
https://doi.org/10.1158/1078-0432.CCR-23-1184
Published: 22 August 2023
View article titled, Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era
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Includes: Supplementary data
Journal Articles

A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma

Ciara M. Kelly, Li-Xuan Qin, Karissa A. Whiting, Allison L. Richards, Viswatej Avutu, Jason E. Chan, Ping Chi, Mark A. Dickson, Mrinal M. Gounder, Mary Louise Keohan, Sujana Movva, Benjamin A. Nacev, Evan Rosenbaum, Travis Adamson, Samuel Singer, Edmund K. Bartlett, Aimee M. Crago, Sam S. Yoon, Sinchun Hwang, Joseph P. Erinjeri, Cristina R. Antonescu, William D. Tap, Sandra P. D'Angelo
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (11): 2043–2051.
https://doi.org/10.1158/1078-0432.CCR-22-3911
Published: 01 June 2023
View article titled, A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma
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Includes: Supplementary data
Journal Articles

Myosin Light-Chain Kinase Inhibition Potentiates the Antitumor Effects of Avapritinib in PDGFRA D842V-Mutant Gastrointestinal Stromal Tumor

Ferdinand Rossi, Mengyuan Liu, Andrew Tieniber, Mark S. Etherington, Andrew Hanna, Gerardo A. Vitiello, Nesteene J. Param, Kevin Do, Laura Wang, Cristina R. Antonescu, Shan Zeng, Jennifer Q. Zhang, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (11): 2144–2157.
https://doi.org/10.1158/1078-0432.CCR-22-0533
Published: 01 June 2023
View article titled, Myosin Light-Chain Kinase Inhibition Potentiates the Antitumor Effects of Avapritinib in <em>PDGFRA D842V</em>-Mutant Gastrointestinal Stromal Tumor
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Includes: Supplementary data
Journal Articles

Abstract PR005: PRC2 inactivating mutations amplify cell death in response to DNMT1-targeted therapy through enhanced viral mimicry in malignant peripheral nerve sheath tumor

Ping Chi, Amish J. Patel, Sarah Warda, Jesper L.V. Maag, Rohan Misra, Miguel A. Miranda-Román, Mohini R. Pachai, Cindy J. Lee, Dan Li, Naitao Wang, Gabriella Bayshtok, Eve Fishinevich, Yinuo Meng, Elissa W.P. Wong, Juan Yan, Emily Giff, Jonathan Fletcher, Joseph M. Scandura, Richard Koche, Jacob L. Glass, Cristina R. Antonescu, Deyou Zheng, Yu Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): PR005.
https://doi.org/10.1158/1557-3265.SARCOMAS22-PR005
Published: 15 September 2022
View article titled, Abstract PR005: PRC2 inactivating mutations amplify cell death in response to DNMT1-targeted therapy through enhanced viral mimicry in malignant peripheral nerve sheath tumor
Journal Articles

Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors

Ping Chi, Li-Xuan Qin, Niedzica Camacho, Ciara M. Kelly, Sandra P. D'Angelo, Mark A. Dickson, Mrinal M. Gounder, Mary L. Keohan, Sujana Movva, Benjamin A. Nacev, Evan Rosenbaum, Katherine A. Thornton, Aimee M. Crago, Jasmine H. Francis, Moriah Martindale, Haley T. Phelan, Matthew D. Biniakewitz, Cindy J. Lee, Samuel Singer, Sinchun Hwang, Michael F. Berger, Yu Chen, Cristina R. Antonescu, William D. Tap
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1507–1517.
https://doi.org/10.1158/1078-0432.CCR-21-3909
Published: 14 April 2022
View article titled, Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors
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Includes: Supplementary data
Journal Articles

A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma

Mrinal M. Gounder, Evan Rosenbaum, Nian Wu, Mark A. Dickson, Tahir N. Sheikh, Sandra P. D'Angelo, Ping Chi, Mary Lou Keohan, Joseph P. Erinjeri, Cristina R. Antonescu, Narasimhan Agaram, Meera R. Hameed, Moriah Martindale, Robert A. Lefkowitz, Aimee M. Crago, Sam Singer, William D. Tap, Naoko Takebe, Li-Xuan Qin, Gary K. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1586–1594.
https://doi.org/10.1158/1078-0432.CCR-21-3874
Published: 14 April 2022
View article titled, A Phase Ib/II Randomized Study of RO4929097, a Gamma-Secretase or Notch Inhibitor with or without Vismodegib, a Hedgehog Inhibitor, in Advanced Sarcoma
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Includes: Supplementary data
Journal Articles

HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome

Evan Rosenbaum, Kenneth Seier, Chaitanya Bandlamudi, Mark Dickson, Mrinal Gounder, Mary L. Keohan, Ping Chi, Ciara Kelly, Sujana Movva, Benjamin Nacev, Noemi Simeone, Mark Donoghue, Emily K. Slotkin, Li-Xuan Qin, Cristina R. Antonescu, William D. Tap, Sandra P. D'Angelo
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5448–5455.
https://doi.org/10.1158/1078-0432.CCR-20-0832
Published: 15 October 2020
View article titled, HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome
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Includes: Supplementary data
Journal Articles

Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor

Gerardo A. Vitiello, Benjamin D. Medina, Shan Zeng, Timothy G. Bowler, Jennifer Q. Zhang, Jennifer K. Loo, Nesteene J. Param, Mengyuan Liu, Alec J. Moral, Julia N. Zhao, Ferdinand Rossi, Cristina R. Antonescu, Vinod P. Balachandran, Justin R. Cross, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 972–984.
https://doi.org/10.1158/1078-0432.CCR-17-2697
Published: 14 February 2018
View article titled, Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor
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Includes: Supplementary data
Journal Articles

Abstract A15: Modeling sporadic gastrointestinal stromal tumor with BRAFV600E mutation

Leili Ran, Devan Murphy, Jessica Sher, Zhen Cao, Shangqian Wang, Edward Walczak, Youxin Guan, Yuanyuan Xie, Shipra Shukla, Yu Zhan, Cristina R. Antonescu, Yu Chen, Ping Chi
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): A15.
https://doi.org/10.1158/1557-3265.SARCOMAS17-A15
Published: 15 January 2018
View article titled, Abstract A15: Modeling sporadic gastrointestinal stromal tumor with BRAFV600E mutation
Journal Articles

In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets

Elsa Arbajian, Florian Puls, Cristina R. Antonescu, Fernanda Amary, Raf Sciot, Maria Debiec-Rychter, Vaiyapuri P. Sumathi, Marcus Järås, Linda Magnusson, Jenny Nilsson, Jakob Hofvander, Fredrik Mertens
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23): 7426–7434.
https://doi.org/10.1158/1078-0432.CCR-17-1856
Published: 30 November 2017
View article titled, In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets
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Includes: Supplementary data
Journal Articles

PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors

Adrian M. Seifert, Shan Zeng, Jennifer Q. Zhang, Teresa S. Kim, Noah A. Cohen, Michael J. Beckman, Benjamin D. Medina, Joanna H. Maltbaek, Jennifer K. Loo, Megan H. Crawley, Ferdinand Rossi, Peter Besmer, Cristina R. Antonescu, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (2): 454–465.
https://doi.org/10.1158/1078-0432.CCR-16-1163
Published: 15 January 2017
View article titled, PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors
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Includes: Supplementary data
Journal Articles

CCR 20th Anniversary Commentary: A Genetic Mechanism of Imatinib Resistance in Gastrointestinal Stromal Tumor—Where Are We a Decade Later?

Cristina R. Antonescu, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3363–3365.
https://doi.org/10.1158/1078-0432.CCR-14-3120
Published: 02 August 2015
View article titled, <em>CCR</em> 20<sup>th</sup> Anniversary Commentary: A Genetic Mechanism of Imatinib Resistance in Gastrointestinal Stromal Tumor—Where Are We a Decade Later?
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Journal Articles

Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition

Richard D. Carvajal, Donald P. Lawrence, Jeffrey S. Weber, Thomas F. Gajewski, Rene Gonzalez, Jose Lutzky, Steven J. O'Day, Omid Hamid, Jedd D. Wolchok, Paul B. Chapman, Ryan J. Sullivan, Jerrold B. Teitcher, Nikhil Ramaiya, Anita Giobbie-Hurder, Cristina R. Antonescu, Michael C. Heinrich, Boris C. Bastian, Christopher L. Corless, Jonathan A. Fletcher, F. Stephen Hodi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (10): 2289–2296.
https://doi.org/10.1158/1078-0432.CCR-14-1630
Published: 14 May 2015
View article titled, Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition
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Includes: Supplementary data
Journal Articles

Correlation of KIT and PDGFRA mutation status with sunitinib activity in imatinib-resistant GIST

Michael C. Heinrich, Robert G. Maki, Christopher L. Corless, Cristina R. Antonescu, Jonathan A. Fletcher, Christopher D. Fletcher, Xin Huang, Charles M. Baum, George D. Demetri
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): B56.
Published: 15 August 2014
View article titled, Correlation of <em>KIT</em> and <em>PDGFRA</em> mutation status with sunitinib activity in imatinib-resistant GIST
Journal Articles

Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor

Teresa S. Kim, Michael J. Cavnar, Noah A. Cohen, Eric C. Sorenson, Jonathan B. Greer, Adrian M. Seifert, Megan H. Crawley, Benjamin L. Green, Rachel Popow, Nagavarakishore Pillarsetty, Darren R. Veach, Anson T. Ku, Ferdinand Rossi, Peter Besmer, Cristina R. Antonescu, Shan Zeng, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (9): 2350–2362.
https://doi.org/10.1158/1078-0432.CCR-13-3033
Published: 30 April 2014
View article titled, Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor
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Includes: Supplementary data
Journal Articles

Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability

Aimee M. Crago, Nicholas D. Socci, Penelope DeCarolis, Rachael O'Connor, Barry S. Taylor, Li-Xuan Qin, Cristina R. Antonescu, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (5): 1334–1340.
https://doi.org/10.1158/1078-0432.CCR-11-2820
Published: 01 March 2012
View article titled, Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability
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Includes: Supplementary data
Journal Articles

Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis

Mrinal M. Gounder, Robert A. Lefkowitz, Mary Louise Keohan, David R. D'Adamo, Meera Hameed, Cristina R. Antonescu, Samuel Singer, Katherine Stout, Linda Ahn, Robert G. Maki
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 4082–4090.
https://doi.org/10.1158/1078-0432.CCR-10-3322
Published: 15 June 2011
View article titled, Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis
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Journal Articles

Comprehensive Genomic Analysis Reveals Clinically Relevant Molecular Distinctions between Thymic Carcinomas and Thymomas

Nicolas Girard, Ronglai Shen, Tianhua Guo, Maureen F. Zakowski, Adriana Heguy, Gregory J. Riely, James Huang, Christopher Lau, Alex E. Lash, Marc Ladanyi, Agnes Viale, Cristina R. Antonescu, William D. Travis, Valerie W. Rusch, Mark G. Kris, William Pao
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6790–6799.
https://doi.org/10.1158/1078-0432.CCR-09-0644
Published: 11 November 2009
View article titled, Comprehensive Genomic Analysis Reveals Clinically Relevant Molecular Distinctions between Thymic Carcinomas and Thymomas
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Includes: Supplementary data
Journal Articles

Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance

Tianhua Guo, Mihai Hajdu, Narasimhan P. Agaram, Hiroko Shinoda, Darren Veach, Bayard D. Clarkson, Robert G. Maki, Samuel Singer, Ronald P. DeMatteo, Peter Besmer, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6862–6870.
https://doi.org/10.1158/1078-0432.CCR-09-1315
Published: 11 November 2009
View article titled, Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring <em>KIT</em><sup>AY502-3ins</sup> Mutation: An <em>In vitro</em> Mutagenesis Screen for Drug Resistance
Open the PDF for Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring <em>KIT</em><sup>AY502-3ins</sup> Mutation: An <em>In vitro</em> Mutagenesis Screen for Drug Resistance in another window