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Cornelis J.M. Melief
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Journal Articles

Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men

Karien C.M. Gosens, Sjoerd H. van der Burg, Marij J.P. Welters, Sanne Boekestijn, Nikki M. Loof, Wim G.V. Quint, Carel J.M. van Noesel, Allard C. van der Wal, Olivier Richel, Wilhelmus J.T.A. Krebber, Cornelis J.M. Melief, Henry J.C. de Vries, Jan M. Prins
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (20): 4109–4117.
https://doi.org/10.1158/1078-0432.CCR-22-3361
Published: 13 October 2023
View article titled, Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV<sup>+</sup> Men
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Includes: Supplementary data
Journal Articles

Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Mariëtte I.E. van Poelgeest, Marij J.P. Welters, Renee Vermeij, Linda F.M. Stynenbosch, Nikki M. Loof, Dorien M.A. Berends-van der Meer, Margriet J.G. Löwik, Ineke L.E. Hamming, Edith M.G. van Esch, Bart W.J. Hellebrekers, Marc van Beurden, Henk W. Schreuder, Marjolein J. Kagie, J. Baptist M.Z. Trimbos, Lorraine M. Fathers, Toos Daemen, Harry Hollema, A. Rob P.M. Valentijn, Jaap Oostendorp, J. Hanneke N.G. Oude Elberink, Gertjan J. Fleuren, Tjalling Bosse, Gemma G. Kenter, Theo Stijnen, Hans W. Nijman, Cornelis J.M. Melief, Sjoerd H. van der Burg
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (10): 2342–2350.
https://doi.org/10.1158/1078-0432.CCR-15-2594
Published: 12 May 2016
View article titled, Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response
Open the PDF for Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response in another window
Includes: Supplementary data
Journal Articles

Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

Maartje C.A. Wouters, Fenne L. Komdeur, Hagma H. Workel, Harry G. Klip, Annechien Plat, Neeltje M. Kooi, G. Bea A. Wisman, Marian J.E. Mourits, Henriette J.G. Arts, Maaike H.M. Oonk, Refika Yigit, Steven de Jong, Cornelis J.M. Melief, Harry Hollema, Evelien W. Duiker, Toos Daemen, Marco de Bruyn, Hans W. Nijman
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 714–724.
https://doi.org/10.1158/1078-0432.CCR-15-1617
Published: 31 January 2016
View article titled, Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Vaccine-Induced Tumor Necrosis Factor–Producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death

Tetje C. van der Sluis, Suzanne van Duikeren, Suzanna Huppelschoten, Ekaterina S. Jordanova, Elham Beyranvand Nejad, Arjen Sloots, Louis Boon, Vincent T.H.B.M. Smit, Marij J.P. Welters, Ferry Ossendorp, Bob van de Water, Ramon Arens, Sjoerd H. van der Burg, Cornelis J.M. Melief
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4): 781–794.
https://doi.org/10.1158/1078-0432.CCR-14-2142
Published: 16 February 2015
View article titled, Vaccine-Induced Tumor Necrosis Factor–Producing T Cells Synergize with Cisplatin to Promote Tumor Cell Death
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Includes: Multimedia, Supplementary data
Journal Articles

Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell–Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

Marieke F. Fransen, Tetje C. van der Sluis, Ferry Ossendorp, Ramon Arens, Cornelis J.M. Melief
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19): 5381–5389.
https://doi.org/10.1158/1078-0432.CCR-12-0781
Published: 01 October 2013
View article titled, Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8<sup>+</sup> T-Cell–Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects
Open the PDF for Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8<sup>+</sup> T-Cell–Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects in another window
Includes: Supplementary data
Journal Articles

“License to Kill” Reflects Joint Action of CD4 and CD8 T Cells

Cornelis J.M. Melief
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (16): 4295–4296.
https://doi.org/10.1158/1078-0432.CCR-13-1432
Published: 13 August 2013
View article titled, “License to Kill” Reflects Joint Action of CD4 and CD8 T Cells
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Includes: Supplementary data
Journal Articles

T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy

Esther P.M. Tjin, Debby Konijnenberg, Gabrielle Krebbers, Henk Mallo, Jan W. Drijfhout, Kees L.M.C. Franken, Chantal M.A.M. van der Horst, Jan D. Bos, Omgo E. Nieweg, Bin B.R. Kroon, John B.A.G. Haanen, Cornelis J.M. Melief, Florry A. Vyth-Dreese, Rosalie M. Luiten
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5736–5747.
https://doi.org/10.1158/1078-0432.CCR-11-0230
Published: 01 September 2011
View article titled, T-Cell Immune Function in Tumor, Skin, and Peripheral Blood of Advanced Stage Melanoma Patients: Implications for Immunotherapy
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Includes: Supplementary data
Journal Articles

Local Activation of CD8 T Cells and Systemic Tumor Eradication without Toxicity via Slow Release and Local Delivery of Agonistic CD40 Antibody

Marieke F. Fransen, Marjolein Sluijter, Hans Morreau, Ramon Arens, Cornelis J.M. Melief
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2270–2280.
https://doi.org/10.1158/1078-0432.CCR-10-2888
Published: 14 April 2011
View article titled, Local Activation of CD8 T Cells and Systemic Tumor Eradication without Toxicity via Slow Release and Local Delivery of Agonistic CD40 Antibody
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Includes: Supplementary data
Journal Articles

Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer

Frank M. Speetjens, Peter J.K. Kuppen, Marij J.P. Welters, Farah Essahsah, Anne Marie E.G. Voet van den Brink, M. Graziella Kallenberg Lantrua, A. Rob P.M. Valentijn, Jaap Oostendorp, Lorraine M. Fathers, Hans W. Nijman, Jan W. Drijfhout, Cornelis J.H. van de Velde, Cornelis J.M. Melief, Sjoerd H. van der Burg
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (3): 1086–1095.
https://doi.org/10.1158/1078-0432.CCR-08-2227
Published: 02 February 2009
View article titled, Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer
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Journal Articles

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

Marij J.P. Welters, Gemma G. Kenter, Sytse J. Piersma, Annelies P.G. Vloon, Margriet J.G. Löwik, Dorien M.A. Berends-van der Meer, Jan W. Drijfhout, A. Rob P.M. Valentijn, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Cornelis J.M. Melief, Sjoerd H. van der Burg
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 178–187.
https://doi.org/10.1158/1078-0432.CCR-07-1880
Published: 02 January 2008
View article titled, Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine
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Journal Articles

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

Gemma G. Kenter, Marij J.P. Welters, A.Rob P.M. Valentijn, Margriet J.G. Löwik, Dorien M.A. Berends-van der Meer, Annelies P.G. Vloon, Jan W. Drijfhout, Amon R. Wafelman, Jaap Oostendorp, Gert Jan Fleuren, Rienk Offringa, Sjoerd H. van der Burg, Cornelis J.M. Melief
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 169–177.
https://doi.org/10.1158/1078-0432.CCR-07-1881
Published: 02 January 2008
View article titled, Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity
Open the PDF for Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity in another window
Journal Articles

Expression of Cellular FLICE Inhibitory Protein, Caspase-8, and Protease Inhibitor-9 in Ewing Sarcoma and Implications for Susceptibility to Cytotoxic Pathways

Alfons S.K. de Hooge, Dagmar Berghuis, Susy Justo Santos, Esther Mooiman, Salvatore Romeo, J. Alain Kummer, R. Maarten Egeler, Maarten J.D. van Tol, Cornelis J.M. Melief, Pancras C.W. Hogendoorn, Arjan C. Lankester
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (1): 206–214.
https://doi.org/10.1158/1078-0432.CCR-06-1457
Published: 02 January 2007
View article titled, Expression of Cellular FLICE Inhibitory Protein, Caspase-8, and Protease Inhibitor-9 in Ewing Sarcoma and Implications for Susceptibility to Cytotoxic Pathways
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Journal Articles

Detection and Functional Analysis of CD8+ T Cells Specific for PRAME: a Target for T-Cell Therapy

Marieke Griffioen, Jan H. Kessler, Martina Borghi, Ronald A. van Soest, Caroline E. van der Minne, Jan Nouta, Sjoerd H. van der Burg, Jan Paul Medema, Peter I. Schrier, J.H. Frederik Falkenburg, Susanne Osanto, Cornelis J.M. Melief
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (10): 3130–3136.
https://doi.org/10.1158/1078-0432.CCR-05-2578
Published: 17 May 2006
View article titled, Detection and Functional Analysis of CD8<sup>+</sup> T Cells Specific for PRAME: a Target for T-Cell Therapy
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Journal Articles

Detection of Human Papillomavirus (HPV) 16-Specific CD4+ T-cell Immunity in Patients with Persistent HPV16-Induced Vulvar Intraepithelial Neoplasia in Relation to Clinical Impact of Imiquimod Treatment

Mariëtte I.E. van Poelgeest, Manon van Seters, Marc van Beurden, Kitty M.C. Kwappenberg, Claudia Heijmans-Antonissen, Jan W. Drijfhout, Cornelis J.M. Melief, Gemma G. Kenter, Theo J.M. Helmerhorst, Rienk Offringa, Sjoerd H. van der Burg
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (14): 5273–5280.
https://doi.org/10.1158/1078-0432.CCR-05-0616
Published: 20 July 2005
View article titled, Detection of Human Papillomavirus (HPV) 16-Specific CD4+ T-cell Immunity in Patients with Persistent HPV16-Induced Vulvar Intraepithelial Neoplasia in Relation to Clinical Impact of Imiquimod Treatment
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Journal Articles

Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization

Maro H. Sandel, Alisher R. Dadabayev, Anand G. Menon, Hans Morreau, Cornelis J.M. Melief, Rienk Offringa, Sjoerd H. van der Burg, Connie M. Janssen-van Rhijn, N. Geeske Ensink, Rob A.E.M. Tollenaar, Cornelis J.H. van de Velde, Peter J.K. Kuppen
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (7): 2576–2582.
https://doi.org/10.1158/1078-0432.CCR-04-1448
Published: 06 April 2005
View article titled, Prognostic Value of Tumor-Infiltrating Dendritic Cells in Colorectal Cancer: Role of Maturation Status and Intratumoral Localization
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