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Clinton F. Stewart
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Journal Articles

A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study

Mariko D. DeWire, Christine Fuller, Olivia Campagne, Tong Lin, Haitao Pan, Tina Young Poussaint, Patricia A. Baxter, Eugene I. Hwang, Andrew Bukowinski, Kathleen Dorris, Lindsey Hoffman, Angela J. Waanders, Matthias A. Karajannis, Clinton F. Stewart, Arzu Onar-Thomas, Maryam Fouladi, Ira J. Dunkel
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2442–2451.
https://doi.org/10.1158/1078-0432.CCR-20-4078
Published: 01 May 2021
View article titled, A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study
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Includes: Supplementary data
Journal Articles

Exposure–Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing

Olivia Campagne, Bo Zhong, Sreenath Nair, Tong Lin, Jie Huang, Arzu Onar-Thomas, Giles Robinson, Amar Gajjar, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1563–1573.
https://doi.org/10.1158/1078-0432.CCR-19-2685
Published: 01 April 2020
View article titled, Exposure–Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing
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Includes: Supplementary data
Journal Articles

Establishing a Preclinical Multidisciplinary Board for Brain Tumors

Birgit V. Nimmervoll, Nidal Boulos, Brandon Bianski, Jason Dapper, Michael DeCuypere, Anang Shelat, Sabrina Terranova, Hope E. Terhune, Amar Gajjar, Yogesh T. Patel, Burgess B. Freeman, Arzu Onar-Thomas, Clinton F. Stewart, Martine F. Roussel, R. Kipling Guy, Thomas E. Merchant, Christopher Calabrese, Karen D. Wright, Richard J. Gilbertson
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (7): 1654–1666.
https://doi.org/10.1158/1078-0432.CCR-17-2168
Published: 02 April 2018
View article titled, Establishing a Preclinical Multidisciplinary Board for Brain Tumors
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Includes: Supplementary data
Journal Articles

Population Pharmacokinetics of Bevacizumab in Children with Osteosarcoma: Implications for Dosing

David C. Turner, Fariba Navid, Najat C. Daw, Shenghua Mao, Jianrong Wu, Victor M. Santana, Michael Neel, Bhaskar Rao, Jennifer Reikes Willert, David M. Loeb, K. Elaine Harstead, Stacy L. Throm, Burgess B. Freeman, III, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (10): 2783–2792.
https://doi.org/10.1158/1078-0432.CCR-13-2364
Published: 14 May 2014
View article titled, Population Pharmacokinetics of Bevacizumab in Children with Osteosarcoma: Implications for Dosing
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Includes: Supplementary data
Journal Articles

Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study

Amar Gajjar, Clinton F. Stewart, David W. Ellison, Sue Kaste, Larry E. Kun, Roger J. Packer, Stewart Goldman, Murali Chintagumpala, Dana Wallace, Naoko Takebe, James M. Boyett, Richard J. Gilbertson, Tom Curran
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (22): 6305–6312.
https://doi.org/10.1158/1078-0432.CCR-13-1425
Published: 14 November 2013
View article titled, Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study
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Includes: Supplementary data
Journal Articles

Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Alberto Broniscer, Sharyn D. Baker, Cynthia Wetmore, Atmaram S. Pai Panandiker, Jie Huang, Andrew M. Davidoff, Arzu Onar-Thomas, John C. Panetta, Thomas K. Chin, Thomas E. Merchant, Justin N. Baker, Sue C. Kaste, Amar Gajjar, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 3050–3058.
https://doi.org/10.1158/1078-0432.CCR-13-0306
Published: 30 May 2013
View article titled, Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
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Includes: Supplementary data
Journal Articles

Phase I and Clinical Pharmacology Study of Bevacizumab, Sorafenib, and Low-Dose Cyclophosphamide in Children and Young Adults with Refractory/Recurrent Solid Tumors

Fariba Navid, Sharyn D. Baker, M. Beth McCarville, Clinton F. Stewart, Catherine A. Billups, Jianrong Wu, Andrew M. Davidoff, Sheri L. Spunt, Wayne L. Furman, Lisa M. McGregor, Shuiying Hu, John C. Panetta, David Turner, Demba Fofana, Wilburn E. Reddick, Wing Leung, Victor M. Santana
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 236–246.
https://doi.org/10.1158/1078-0432.CCR-12-1897
Published: 02 January 2013
View article titled, Phase I and Clinical Pharmacology Study of Bevacizumab, Sorafenib, and Low-Dose Cyclophosphamide in Children and Young Adults with Refractory/Recurrent Solid Tumors
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Journal Articles

Role of ATP-Binding Cassette and Solute Carrier Transporters in Erlotinib CNS Penetration and Intracellular Accumulation

Mohamed A. Elmeliegy, Angel M. Carcaboso, Michael Tagen, Feng Bai, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (1): 89–99.
https://doi.org/10.1158/1078-0432.CCR-10-1934
Published: 04 January 2011
View article titled, Role of ATP-Binding Cassette and Solute Carrier Transporters in Erlotinib CNS Penetration and Intracellular Accumulation
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Includes: Supplementary data
Journal Articles

Clinical Pharmacokinetics of Amifostine and WR1065 in Pediatric Patients with Medulloblastoma

Trevor McKibbin, John C. Panetta, Maryam Fouladi, Amar Gajjar, Feng Bai, M. Fatih Okcu, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (3): 1049–1057.
https://doi.org/10.1158/1078-0432.CCR-09-1997
Published: 01 February 2010
View article titled, Clinical Pharmacokinetics of Amifostine and WR1065 in Pediatric Patients with Medulloblastoma
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Includes: Supplementary data
Journal Articles

Phase I and Pharmacokinetic Studies of Erlotinib Administered Concurrently with Radiotherapy for Children, Adolescents, and Young Adults with High-Grade Glioma

Alberto Broniscer, Suzanne J. Baker, Clinton F. Stewart, Thomas E. Merchant, Fred H. Laningham, Paula Schaiquevich, Mehmet Kocak, E. Brannon Morris, Raelene Endersby, David W. Ellison, Amar Gajjar
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (2): 701–707.
https://doi.org/10.1158/1078-0432.CCR-08-1923
Published: 15 January 2009
View article titled, Phase I and Pharmacokinetic Studies of Erlotinib Administered Concurrently with Radiotherapy for Children, Adolescents, and Young Adults with High-Grade Glioma
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Journal Articles

Phase I Trial of VNP40101M (Cloretazine) in Children with Recurrent Brain Tumors: A Pediatric Brain Tumor Consortium Study

Sridharan Gururangan, Christopher D. Turner, Clinton F. Stewart, Melinda O'Shaughnessy, Mehmet Kocak, Tina Young Poussaint, Peter C. Phillips, Stewart Goldman, Roger Packer, Ian F. Pollack, Susan M. Blaney, Verena Karsten, Stanton L. Gerson, James M. Boyett, Henry S. Friedman, Larry E. Kun
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (4): 1124–1130.
https://doi.org/10.1158/1078-0432.CCR-07-4242
Published: 15 February 2008
View article titled, Phase I Trial of VNP40101M (Cloretazine) in Children with Recurrent Brain Tumors: A Pediatric Brain Tumor Consortium Study
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Journal Articles

Using Pharmacokinetic and Pharmacodynamic Modeling and Simulation to Evaluate Importance of Schedule in Topotecan Therapy for Pediatric Neuroblastoma

John C. Panetta, Paula Schaiquevich, Victor M. Santana, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 318–325.
https://doi.org/10.1158/1078-0432.CCR-07-1243
Published: 02 January 2008
View article titled, Using Pharmacokinetic and Pharmacodynamic Modeling and Simulation to Evaluate Importance of Schedule in Topotecan Therapy for Pediatric Neuroblastoma
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Journal Articles

Population Pharmacokinetic Analysis of Topotecan in Pediatric Cancer Patients

Paula Schaiquevich, John C. Panetta, Lisa C. Iacono, Burgess B. Freeman, III, Victor M. Santana, Amar Gajjar, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22): 6703–6711.
https://doi.org/10.1158/1078-0432.CCR-07-1376
Published: 15 November 2007
View article titled, Population Pharmacokinetic Analysis of Topotecan in Pediatric Cancer Patients
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Includes: Supplementary data
Journal Articles

Phase I Trial of Single-Dose Temozolomide and Continuous Administration of O6-Benzylguanine in Children with Brain Tumors: a Pediatric Brain Tumor Consortium Report

Alberto Broniscer, Sridharan Gururangan, Tobey J. MacDonald, Stewart Goldman, Roger J. Packer, Clinton F. Stewart, Dana Wallace, Mary K. Danks, Henry S. Friedman, Tina Y. Poussaint, Larry E. Kun, James M. Boyett, Amar Gajjar, for the Pediatric Brain Tumor Consortium
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22): 6712–6718.
https://doi.org/10.1158/1078-0432.CCR-07-1016
Published: 15 November 2007
View article titled, Phase I Trial of Single-Dose Temozolomide and Continuous Administration of <em>O</em><sup>6</sup>-Benzylguanine in Children with Brain Tumors: a Pediatric Brain Tumor Consortium Report
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Includes: Supplementary data
Journal Articles

Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy

Paxton V. Dickson, John B. Hamner, Thomas L. Sims, Charles H. Fraga, Catherine Y.C. Ng, Surender Rajasekeran, Nikolaus L. Hagedorn, M. Beth McCarville, Clinton F. Stewart, Andrew M. Davidoff
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (13): 3942–3950.
https://doi.org/10.1158/1078-0432.CCR-07-0278
Published: 02 July 2007
View article titled, Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy
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Journal Articles

Plasma and Cerebrospinal Fluid Pharmacokinetics of Erlotinib and Its Active Metabolite OSI-420

Alberto Broniscer, John C. Panetta, Melinda O'Shaughnessy, Charles Fraga, Feng Bai, Matthew J. Krasin, Amar Gajjar, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (5): 1511–1515.
https://doi.org/10.1158/1078-0432.CCR-06-2372
Published: 01 March 2007
View article titled, Plasma and Cerebrospinal Fluid Pharmacokinetics of Erlotinib and Its Active Metabolite OSI-420
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Journal Articles

Evaluation of the Antitumor Efficacy, Pharmacokinetics, and Pharmacodynamics of the Histone Deacetylase Inhibitor Depsipeptide in Childhood Cancer Models In vivo

Claire Graham, Chandra Tucker, Jeremy Creech, Edward Favours, Catherine A. Billups, Tiebin Liu, Maryam Fouladi, Burgess B. Freeman, III, Clinton F. Stewart, Peter J. Houghton
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (1): 223–234.
https://doi.org/10.1158/1078-0432.CCR-05-1225
Published: 05 January 2006
View article titled, Evaluation of the Antitumor Efficacy, Pharmacokinetics, and Pharmacodynamics of the Histone Deacetylase Inhibitor Depsipeptide in Childhood Cancer Models <em>In vivo</em>
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Journal Articles

Phase I Trial of Temozolomide and Protracted Irinotecan in Pediatric Patients with Refractory Solid Tumors

Lars M. Wagner, Kristine R. Crews, Lisa C. Iacono, Peter J. Houghton, Christine E. Fuller, M. Beth McCarville, Robert E. Goldsby, Karen Albritton, Clinton F. Stewart, Victor M. Santana
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (3): 840–848.
https://doi.org/10.1158/1078-0432.CCR-03-0175
Published: 10 February 2004
View article titled, Phase I Trial of Temozolomide and Protracted Irinotecan in Pediatric Patients with Refractory Solid Tumors
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Journal Articles

The Importance of Pharmacokinetic Limited Sampling Models for Childhood Cancer Drug Development

J. Carl Panetta, Lisa C. Iacono, Peter C. Adamson, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (14): 5068–5077.
Published: 12 November 2003
View article titled, The Importance of Pharmacokinetic Limited Sampling Models for Childhood Cancer Drug Development
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Journal Articles

A Pilot Study of Protracted Topotecan Dosing Using a Pharmacokinetically Guided Dosing Approach in Children with Solid Tumors

Victor M. Santana, William C. Zamboni, Mark N. Kirstein, Ming Tan, Tiebin Liu, Amar Gajjar, Peter J. Houghton, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 633–640.
Published: 01 February 2003
View article titled, A Pilot Study of Protracted Topotecan Dosing Using a Pharmacokinetically Guided Dosing Approach in Children with Solid Tumors
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