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Christopher J. Sweeney
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Journal Articles

Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer

Christopher J. Sweeney, Russell Petry, Chang Xu, Merrida Childress, Jie He, David Fabrizio, Ole Gjoerup, Samantha Morley, Timothy Catlett, Zoe J. Assaf, Kobe Yuen, Matthew Wongchenko, Kalpit Shah, Pratyush Gupta, Priti Hegde, Lincoln W. Pasquina, Sanjeev Mariathasan, Ryon P. Graf, Thomas Powles
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (18): 4115–4122.
https://doi.org/10.1158/1078-0432.CCR-24-1096
Published: 13 September 2024
View article titled, Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Phase Ib/II Study of Enzalutamide with Samotolisib (LY3023414) or Placebo in Patients with Metastatic Castration-Resistant Prostate Cancer

Christopher J. Sweeney, Ivor J. Percent, Sunil Babu, Jennifer L. Cultrera, Bryan A. Mehlhaff, Oscar B. Goodman, David S. Morris, Ian D. Schnadig, Costantine Albany, Neal D. Shore, Paul R. Sieber, Susan C. Guba, Wei Zhang, Volker Wacheck, Gregory P. Donoho, Anna M. Szpurka, Sophie Callies, Boris Kin Lin, Johanna C. Bendell
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2237–2247.
https://doi.org/10.1158/1078-0432.CCR-21-2326
Published: 01 June 2022
View article titled, Phase Ib/II Study of Enzalutamide with Samotolisib (LY3023414) or Placebo in Patients with Metastatic Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Dual Blockade of c-MET and the Androgen Receptor in Metastatic Castration-resistant Prostate Cancer: A Phase I Study of Concurrent Enzalutamide and Crizotinib

Abhishek Tripathi, Jeffrey G. Supko, Kathryn P. Gray, Zachary J. Melnick, Meredith M. Regan, Mary-Ellen Taplin, Atish D. Choudhury, Mark M. Pomerantz, Joaquim Bellmunt, Channing Yu, Zijie Sun, Sandy Srinivas, Philip W. Kantoff, Christopher J. Sweeney, Lauren C. Harshman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6122–6131.
https://doi.org/10.1158/1078-0432.CCR-20-2306
Published: 01 December 2020
View article titled, Dual Blockade of c-MET and the Androgen Receptor in Metastatic Castration-resistant Prostate Cancer: A Phase I Study of Concurrent Enzalutamide and Crizotinib
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Includes: Supplementary data
Journal Articles

Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer

Emma H. Allott, Ericka M. Ebot, Konrad H. Stopsack, Amparo G. Gonzalez-Feliciano, Sarah C. Markt, Kathryn M. Wilson, Thomas U. Ahearn, Travis A. Gerke, Mary K. Downer, Jennifer R. Rider, Stephen J. Freedland, Tamara L. Lotan, Philip W. Kantoff, Elizabeth A. Platz, Massimo Loda, Meir J. Stampfer, Edward Giovannucci, Christopher J. Sweeney, Stephen P. Finn, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1086–1093.
https://doi.org/10.1158/1078-0432.CCR-19-2853
Published: 02 March 2020
View article titled, Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup

David P. Labbé, Christopher J. Sweeney, Myles Brown, Phillip Galbo, Spencer Rosario, Kristine M. Wadosky, Sheng-Yu Ku, Martin Sjöström, Mohammed Alshalalfa, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Edward M. Schaeffer, Robert B. Jenkins, Robert B. Den, Ashley E. Ross, Michaela Bowden, Ying Huang, Kathryn P. Gray, Felix Y. Feng, Daniel E. Spratt, David W. Goodrich, Kevin H. Eng, Leigh Ellis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 7072–7083.
https://doi.org/10.1158/1078-0432.CCR-17-0413
Published: 14 November 2017
View article titled, TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup
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Includes: Supplementary data
Journal Articles

Association of AR-V7 and Prostate-Specific Antigen RNA Levels in Blood with Efficacy of Abiraterone Acetate and Enzalutamide Treatment in Men with Prostate Cancer

Fangfang Qu, Wanling Xie, Mari Nakabayashi, Haitao Zhang, Seong Ho Jeong, Xiaodong Wang, Kazumasa Komura, Christopher J. Sweeney, Oliver Sartor, Gwo-Shu Mary Lee, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (3): 726–734.
https://doi.org/10.1158/1078-0432.CCR-16-1070
Published: 31 January 2017
View article titled, Association of AR-V7 and Prostate-Specific Antigen RNA Levels in Blood with Efficacy of Abiraterone Acetate and Enzalutamide Treatment in Men with Prostate Cancer
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Includes: Supplementary data
Journal Articles

Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors

Gregory V. Kryukov, Craig M. Bielski, Kaitlin Samocha, Menachem Fromer, Sara Seepo, Carleen Gentry, Benjamin Neale, Levi A. Garraway, Christopher J. Sweeney, Mary-Ellen Taplin, Eliezer M. Van Allen
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (9): 2183–2189.
https://doi.org/10.1158/1078-0432.CCR-15-2317
Published: 01 May 2016
View article titled, Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors
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Includes: Supplementary data
Journal Articles

Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer

Donghao Lu, Jennifer A. Sinnott, Unnur Valdimarsdóttir, Fang Fang, Travis Gerke, Svitlana Tyekucheva, Michelangelo Fiorentino, Mats Lambe, Howard D. Sesso, Christopher J. Sweeney, Kathryn M. Wilson, Edward L. Giovannucci, Massimo Loda, Lorelei A. Mucci, Katja Fall
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 765–772.
https://doi.org/10.1158/1078-0432.CCR-15-0101
Published: 31 January 2016
View article titled, Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

Cabozantinib Inhibits Abiraterone's Upregulation of IGFIR Phosphorylation and Enhances Its Anti–Prostate Cancer Activity

Xiaodong Wang, Ying Huang, Amanda Christie, Michaela Bowden, Gwo-Shu Mary Lee, Philip W. Kantoff, Christopher J. Sweeney
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (24): 5578–5587.
https://doi.org/10.1158/1078-0432.CCR-15-0824
Published: 14 December 2015
View article titled, Cabozantinib Inhibits Abiraterone's Upregulation of IGFIR Phosphorylation and Enhances Its Anti–Prostate Cancer Activity
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Includes: Supplementary data
Journal Articles

A Phase I/II Trial of BNC105P with Everolimus in Metastatic Renal Cell Carcinoma

Sumanta Pal, Arun Azad, Shailender Bhatia, Harry Drabkin, Brian Costello, John Sarantopoulos, Ravindran Kanesvaran, Richard Lauer, Alexander Starodub, Ralph Hauke, Christopher J. Sweeney, Noah M. Hahn, Guru Sonpavde, Stephen Richey, Timothy Breen, Gabriel Kremmidiotis, Annabell Leske, Elizabeth Doolin, David C. Bibby, Jeremy Simpson, Jose Iglesias, Thomas Hutson
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3420–3427.
https://doi.org/10.1158/1078-0432.CCR-14-3370
Published: 02 August 2015
View article titled, A Phase I/II Trial of BNC105P with Everolimus in Metastatic Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Phase I and Pharmacokinetic Study of CT-322 (BMS-844203), a Targeted Adnectin Inhibitor of VEGFR-2 Based on a Domain of Human Fibronectin

Anthony W. Tolcher, Christopher J. Sweeney, Kyri Papadopoulos, Amita Patnaik, Elena G. Chiorean, Alain C. Mita, Kamalesh Sankhala, Eric Furfine, Jochem Gokemeijer, Lisa Iacono, Cheryl Eaton, Bruce A. Silver, Monica Mita
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (2): 363–371.
https://doi.org/10.1158/1078-0432.CCR-10-1411
Published: 16 January 2011
View article titled, Phase I and Pharmacokinetic Study of CT-322 (BMS-844203), a Targeted Adnectin Inhibitor of VEGFR-2 Based on a Domain of Human Fibronectin
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Includes: Supplementary data
Journal Articles

A Phase Ib Study of AMG 102 in Combination with Bevacizumab or Motesanib in Patients with Advanced Solid Tumors

Peter J. Rosen, Christopher J. Sweeney, Dorothy J. Park, Darrin M. Beaupre, Hongjie Deng, Ian M. Leitch, Poornima Shubhakar, Min Zhu, Kelly S. Oliner, Abraham Anderson, Lorrin K. Yee
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (9): 2677–2687.
https://doi.org/10.1158/1078-0432.CCR-09-2862
Published: 28 April 2010
View article titled, A Phase Ib Study of AMG 102 in Combination with Bevacizumab or Motesanib in Patients with Advanced Solid Tumors
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Journal Articles

Safety, Pharmacokinetics, and Pharmacodynamics of AMG 102, a Fully Human Hepatocyte Growth Factor–Neutralizing Monoclonal Antibody, in a First-in-Human Study of Patients with Advanced Solid Tumors

Michael S. Gordon, Christopher J. Sweeney, David S. Mendelson, S. Gail Eckhardt, Abraham Anderson, Darrin M. Beaupre, Daniel Branstetter, Teresa L. Burgess, Angela Coxon, Hongjie Deng, Paula Kaplan-Lefko, Ian M. Leitch, Kelly S. Oliner, Lucy Yan, Min Zhu, Lia Gore
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 699–710.
https://doi.org/10.1158/1078-0432.CCR-09-1365
Published: 14 January 2010
View article titled, Safety, Pharmacokinetics, and Pharmacodynamics of AMG 102, a Fully Human Hepatocyte Growth Factor–Neutralizing Monoclonal Antibody, in a First-in-Human Study of Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

A Phase I and Pharmacokinetic Trial of Erlotinib in Combination with Weekly Docetaxel in Patients with Taxane-Naive Malignancies

E. Gabriela Chiorean, Jennifer M. Porter, Anne E. Foster, Amal S.H. Al Omari, Christy A. Yoder, Karen L. Fife, R. Matthew Strother, Daryl J. Murry, Menggang Yu, David R. Jones, Christopher J. Sweeney
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (4): 1131–1137.
https://doi.org/10.1158/1078-0432.CCR-07-0437
Published: 15 February 2008
View article titled, A Phase I and Pharmacokinetic Trial of Erlotinib in Combination with Weekly Docetaxel in Patients with Taxane-Naive Malignancies
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Journal Articles

Hoosier Oncology Group Randomized Phase II Study of Docetaxel, Vinorelbine, and Estramustine in Combination in Hormone-Refractory Prostate Cancer with Pharmacogenetic Survival Analysis

Noah M. Hahn, Sharon Marsh, William Fisher, Robert Langdon, Robin Zon, Mark Browning, Cynthia S. Johnson, Tiffany J. Scott-Horton, Lang Li, Howard L. McLeod, Christopher J. Sweeney
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (20): 6094–6099.
https://doi.org/10.1158/1078-0432.CCR-06-1188
Published: 24 October 2006
View article titled, Hoosier Oncology Group Randomized Phase II Study of Docetaxel, Vinorelbine, and Estramustine in Combination in Hormone-Refractory Prostate Cancer with Pharmacogenetic Survival Analysis
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Journal Articles

Two Drug Interaction Studies Evaluating the Pharmacokinetics and Toxicity of Pemetrexed When Coadministered with Aspirin or Ibuprofen in Patients with Advanced Cancer

Christopher J. Sweeney, Chris H. Takimoto, Jane E. Latz, Sharyn D. Baker, Daryl J. Murry, James H. Krull, Karen Fife, Linda Battiato, Ann Cleverly, Ajai K. Chaudhary, Tuhin Chaudhuri, Alan Sandler, Alain C. Mita, Eric K. Rowinsky
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 536–542.
https://doi.org/10.1158/1078-0432.CCR-05-1834
Published: 20 January 2006
View article titled, Two Drug Interaction Studies Evaluating the Pharmacokinetics and Toxicity of Pemetrexed When Coadministered with Aspirin or Ibuprofen in Patients with Advanced Cancer
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Journal Articles

PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma

Chong-Xian Pan, Michael S. Kinch, Peter A. Kiener, Solomon Langermann, Ginette Serrero, Le Sun, Joseph Corvera, Christopher J. Sweeney, Lang Li, Shaobo Zhang, Lee Ann Baldridge, Timothy D. Jones, Michael O. Koch, Thomas M. Ulbright, John N. Eble, Liang Cheng
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (4): 1333–1337.
https://doi.org/10.1158/1078-0432.CCR-1123-03
Published: 20 February 2004
View article titled, PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma
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