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Christopher J. Logothetis
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Journal Articles

A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration–Resistant Prostate Cancer

Available to Purchase
Ana M. Aparicio, Rebecca S.S. Tidwell, Shalini S. Yadav, Jiun-Sheng Chen, Miao Zhang, Jingjing Liu, Shuai Guo, Patrick G. Pilié, Yao Yu, Xingzhi Song, Haswanth Vundavilli, Sonali Jindal, Keyi Zhu, Paul V. Viscuse, Justin M. Lebenthal, Andrew W. Hahn, Rama Soundararajan, Paul G. Corn, Amado Zurita-Saavedra, Sumit K. Subudhi, Jianhua Zhang, Wenyi Wang, Chad Huff, Patricia Troncoso, James P. Allison, Padmanee Sharma, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (13): 2751–2763.
https://doi.org/10.1158/1078-0432.CCR-23-3740
Published: 01 July 2024
View articletitled, A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration–Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series

Open Access
Nicolas Anselmino, Estefania Labanca, Peter D.A. Shepherd, Jiabin Dong, Jun Yang, Xiaofei Song, Subhiksha Nandakumar, Ritika Kundra, Cindy Lee, Nikolaus Schultz, Jianhua Zhang, John C. Araujo, Ana M. Aparicio, Sumit K. Subudhi, Paul G. Corn, Louis L. Pisters, John F. Ward, John W. Davis, Elba S. Vazquez, Geraldine Gueron, Christopher J. Logothetis, Andrew Futreal, Patricia Troncoso, Yu Chen, Nora M. Navone
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10): 2272–2285.
https://doi.org/10.1158/1078-0432.CCR-23-2438
Published: 15 May 2024
View articletitled, Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series
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Includes: Supplementary data
Journal Articles

Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Progressing on Enzalutamide

Available to Purchase
Wassim Abida, Andrew W. Hahn, Neal Shore, Neeraj Agarwal, Paul Sieber, Matthew R. Smith, Tanya Dorff, Paul Monk, Matthew Rettig, Rupal Patel, Anne Page, Maureen Duff, Rongda Xu, Jian Wang, Shravani Barkund, Aleksandr Pankov, Amber Wang, Melissa R. Junttila, Pratik S. Multani, Anneleen Daemen, Edna Chow Maneval, Christopher J. Logothetis, Michael J. Morris
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (6): 1111–1120.
https://doi.org/10.1158/1078-0432.CCR-23-3508
Published: 15 March 2024
View articletitled, Phase I Study of ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Progressing on Enzalutamide
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Includes: Supplementary data
Journal Articles

Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment

Available to Purchase
Ioulia Vardaki, Paul Corn, Emanuela Gentile, Jian H. Song, Namrata Madan, Anh Hoang, Nila Parikh, Leah Guerra, Yu-Chen Lee, Song-Chang Lin, Guoyu Yu, Elmer Santos, Marites P. Melancon, Patricia Troncoso, Nora Navone, Gary E. Gallick, Eleni Efstathiou, Sumit K. Subudhi, Sue-Hwa Lin, Christopher J. Logothetis, Theocharis Panaretakis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3253–3264.
https://doi.org/10.1158/1078-0432.CCR-20-4790
Published: 01 June 2021
View articletitled, Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment
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Includes: Supplementary data
Journal Articles

The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development

Free
Nallasivam Palanisamy, Jun Yang, Peter D.A. Shepherd, Elsa M. Li-Ning-Tapia, Estefania Labanca, Ganiraju C. Manyam, Murali K. Ravoori, Vikas Kundra, John C. Araujo, Eleni Efstathiou, Louis L. Pisters, Xinhai Wan, Xuemei Wang, Elba S. Vazquez, Ana M. Aparicio, Shannon L. Carskadon, Scott A. Tomlins, Lakshmi P. Kunju, Arul M. Chinnaiyan, Bradley M. Broom, Christopher J. Logothetis, Patricia Troncoso, Nora M. Navone
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (18): 4933–4946.
https://doi.org/10.1158/1078-0432.CCR-20-0479
Published: 15 September 2020
View articletitled, The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development
Open the PDF for The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development in another window
Includes: Supplementary data
Journal Articles

Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer

Free
Wei Zhang, Bo Liu, Wenhui Wu, Likun Li, Bradley M. Broom, Spyridon P. Basourakos, Dimitrios Korentzelos, Yang Luan, Jianxiang Wang, Guang Yang, Sanghee Park, Abul Kalam Azad, Xuhong Cao, Jeri Kim, Paul G. Corn, Christopher J. Logothetis, Ana M. Aparicio, Arul M. Chinnaiyan, Nora Navone, Patricia Troncoso, Timothy C. Thompson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (3): 696–707.
https://doi.org/10.1158/1078-0432.CCR-17-1872
Published: 31 January 2018
View articletitled, Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer
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Includes: Supplementary data
Journal Articles

Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters

Free
Anders Carlsson, Peter Kuhn, Madelyn S. Luttgen, Kevin Keomanee-Dizon, Patricia Troncoso, Paul G. Corn, Anand Kolatkar, James B. Hicks, Christopher J. Logothetis, Amado J. Zurita
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (7): 1722–1732.
https://doi.org/10.1158/1078-0432.CCR-16-1355
Published: 02 April 2017
View articletitled, Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters
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Journal Articles

Abstract A03: Analyses of a prostate cancer patient-derived xenografts series, a resource for translational research

Free
Nallasivam Palanisamy, Jun Yang, Xinhai Wan, Elsa M. li Ning Tapia, John C. Araujo, Eleni Efstathiou, Estefania Labanca, Louis Pisters, Ana Aparicio, Ritu Bhalla, Scott Tomlins, Lakshmi P. Kunju, Arul Chinnaiyan, Christopher J. Logothetis, Patricia Troncoso, Nora M. Navone
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A03.
https://doi.org/10.1158/1557-3265.PDX16-A03
Published: 15 August 2016
View articletitled, Abstract A03: Analyses of a prostate cancer patient-derived xenografts series, a resource for translational research
Journal Articles

Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers

Free
Ana M. Aparicio, Li Shen, Elsa Li Ning Tapia, Jing-Fang Lu, Hsiang-Chun Chen, Jiexin Zhang, Guanglin Wu, Xuemei Wang, Patricia Troncoso, Paul Corn, Timothy C. Thompson, Bradley Broom, Keith Baggerly, Sankar N. Maity, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (6): 1520–1530.
https://doi.org/10.1158/1078-0432.CCR-15-1259
Published: 14 March 2016
View articletitled, Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers
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Includes: Supplementary data
Journal Articles

Integrating Murine and Clinical Trials with Cabozantinib to Understand Roles of MET and VEGFR2 as Targets for Growth Inhibition of Prostate Cancer

Free
Andreas Varkaris, Paul G. Corn, Nila U. Parikh, Eleni Efstathiou, Jian H. Song, Yu-Chen Lee, Ana Aparicio, Anh G. Hoang, Sanchaika Gaur, Lynnelle Thorpe, Sankar N. Maity, Menashe Bar Eli, Bogdan A. Czerniak, Yiping Shao, Mian Alauddin, Sue-Hwa Lin, Christopher J. Logothetis, Gary E. Gallick
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1): 107–121.
https://doi.org/10.1158/1078-0432.CCR-15-0235
Published: 03 January 2016
View articletitled, Integrating Murine and Clinical Trials with Cabozantinib to Understand Roles of MET and VEGFR2 as Targets for Growth Inhibition of Prostate Cancer
Open the PDF for Integrating Murine and Clinical Trials with Cabozantinib to Understand Roles of MET and VEGFR2 as Targets for Growth Inhibition of Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate

Free
Gerhardt Attard, Johann S. de Bono, Christopher J. Logothetis, Karim Fizazi, Som D. Mukherjee, Anthony M. Joshua, Dirk Schrijvers, Alfons J.M. van den Eertwegh, Weimin Li, Arturo Molina, Thomas W. Griffin, Thian Kheoh, Deborah S. Ricci, Kathy Zelinsky, Dana E. Rathkopf, Howard I. Scher, Charles J. Ryan
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (7): 1621–1627.
https://doi.org/10.1158/1078-0432.CCR-14-1961
Published: 31 March 2015
View articletitled, Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate
Open the PDF for Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate in another window
Includes: Supplementary data
Journal Articles

The Prostate Cancer Susceptibility Variant rs2735839 Near KLK3 Gene Is Associated with Aggressive Prostate Cancer and Can Stratify Gleason Score 7 Patients

Free
Yonggang He, Jian Gu, Sara Strom, Christopher J. Logothetis, Jeri Kim, Xifeng Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19): 5133–5139.
https://doi.org/10.1158/1078-0432.CCR-14-0661
Published: 30 September 2014
View articletitled, The Prostate Cancer Susceptibility Variant rs2735839 Near KLK3 Gene Is Associated with Aggressive Prostate Cancer and Can Stratify Gleason Score 7 Patients
Open the PDF for The Prostate Cancer Susceptibility Variant rs2735839 Near KLK3 Gene Is Associated with Aggressive Prostate Cancer and Can Stratify Gleason Score 7 Patients in another window
Includes: Supplementary data
Journal Articles

Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer

Free
Ana M. Aparicio, Andrea L. Harzstark, Paul G. Corn, Sijin Wen, John C. Araujo, Shi-Ming Tu, Lance C. Pagliaro, Jeri Kim, Randall E. Millikan, Charles Ryan, Nizar M. Tannir, Amado J. Zurita, Paul Mathew, Wadih Arap, Patricia Troncoso, Peter F. Thall, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (13): 3621–3630.
https://doi.org/10.1158/1078-0432.CCR-12-3791
Published: 30 June 2013
View articletitled, Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features

Free
Vassiliki Tzelepi, Jiexin Zhang, Jing-Fang Lu, Brittany Kleb, Guanglin Wu, Xinhai Wan, Anh Hoang, Eleni Efstathiou, Kanishka Sircar, Nora M. Navone, Patricia Troncoso, Shoudan Liang, Christopher J. Logothetis, Sankar N. Maity, Ana M. Aparicio
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 666–677.
https://doi.org/10.1158/1078-0432.CCR-11-1867
Published: 31 January 2012
View articletitled, Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features
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Includes: Supplementary data
Journal Articles

Phase II Study of Abiraterone Acetate in Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer Displaying Bone Flare Discordant with Serologic Response

Free
Charles J. Ryan, Shreya Shah, Eleni Efstathiou, Matthew R. Smith, Mary-Ellen Taplin, Glenn J. Bubley, Christopher J. Logothetis, Thian Kheoh, Christine Kilian, Christopher M. Haqq, Arturo Molina, Eric J. Small
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4854–4861.
https://doi.org/10.1158/1078-0432.CCR-11-0815
Published: 17 July 2011
View articletitled, Phase II Study of Abiraterone Acetate in Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer Displaying Bone Flare Discordant with Serologic Response
Open the PDF for Phase II Study of Abiraterone Acetate in Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer Displaying Bone Flare Discordant with Serologic Response in another window
Journal Articles

Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial

Free
Bradley C. Carthon, Jedd D. Wolchok, Jianda Yuan, Ashish Kamat, Derek S. Ng Tang, Jingjing Sun, Geoffrey Ku, Patricia Troncoso, Christopher J. Logothetis, James P. Allison, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (10): 2861–2871.
https://doi.org/10.1158/1078-0432.CCR-10-0569
Published: 13 May 2010
View articletitled, Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial
Open the PDF for Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial in another window
Includes: Supplementary data
Journal Articles

A New Therapy Paradigm for Prostate Cancer Founded on Clinical Observations

Free
Eleni Efstathiou, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (4): 1100–1107.
https://doi.org/10.1158/1078-0432.CCR-09-1215
Published: 15 February 2010
View articletitled, A New Therapy Paradigm for Prostate Cancer Founded on Clinical Observations
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Journal Articles

NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells

Free
Sacha Gnjatic, Nasser K. Altorki, Derek Ng Tang, Shi-Ming Tu, Vikas Kundra, Gerd Ritter, Lloyd J. Old, Christopher J. Logothetis, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (6): 2130–2139.
https://doi.org/10.1158/1078-0432.CCR-08-2632
Published: 16 March 2009
View articletitled, NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells
Open the PDF for NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells in another window
Includes: Supplementary data
Journal Articles

Soluble ErbB3 Levels in Bone Marrow and Plasma of Men with Prostate Cancer

Free
Sue-Hwa Lin, Yu-Chen Lee, Michel B. Choueiri, Sijin Wen, Paul Mathew, Xiangcang Ye, Kim-Anh Do, Nora M. Navone, Jeri Kim, Shi-Ming Tu, Li-Yuan Yu-Lee, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (12): 3729–3736.
https://doi.org/10.1158/1078-0432.CCR-08-0472
Published: 16 June 2008
View articletitled, Soluble ErbB3 Levels in Bone Marrow and Plasma of Men with Prostate Cancer
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Journal Articles

Understanding the Biology of Bone Metastases: Key to the Effective Treatment of Prostate Cancer

Free
Christopher J. Logothetis, Nora M. Navone, Sue-Hwa Lin
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (6): 1599–1602.
https://doi.org/10.1158/1078-0432.CCR-07-4603
Published: 17 March 2008
View articletitled, Understanding the Biology of Bone Metastases: Key to the Effective Treatment of Prostate Cancer
Open the PDF for Understanding the Biology of Bone Metastases: Key to the Effective Treatment of Prostate Cancer in another window