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Christine M. Lovly
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Journal Articles

Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types

Pashtoon M. Kasi, Jessica K. Lee, Lincoln W. Pasquina, Brennan Decker, Pierre Vanden Borre, Dean C. Pavlick, Justin M. Allen, Christine Parachoniak, Julia C. F. Quintanilha, Ryon P. Graf, Alexa B. Schrock, Geoffrey R. Oxnard, Christine M. Lovly, Hanna Tukachinsky, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 836–848.
https://doi.org/10.1158/1078-0432.CCR-23-2693
Published: 16 February 2024
View article titled, Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types
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Includes: Supplementary data
Journal Articles

Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer

Lavanya Sivapalan, Wade T. Iams, Zineb Belcaid, Susan C. Scott, Noushin Niknafs, Archana Balan, James R. White, Prasad Kopparapu, Christopher Cann, Blair V. Landon, Gavin Pereira, Victor E. Velculescu, Christine L. Hann, Christine M. Lovly, Valsamo Anagnostou
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (12): 2310–2323.
https://doi.org/10.1158/1078-0432.CCR-22-2242
Published: 13 June 2023
View article titled, Dynamics of Sequence and Structural Cell-Free DNA Landscapes in Small-Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non–Small Cell Lung Cancer

Jia Luo, Victoria L. Martucci, Zoe Quandt, Stefan Groha, Megan H. Murray, Christine M. Lovly, Hira Rizvi, Jacklynn V. Egger, Andrew J. Plodkowski, Mohsen Abu-Akeel, Isabell Schulze, Taha Merghoub, Eduardo Cardenas, Scott Huntsman, Min Li, Donglei Hu, Matthew A. Gubens, Alexander Gusev, Melinda C. Aldrich, Matthew D. Hellmann, Elad Ziv
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (18): 5131–5140.
https://doi.org/10.1158/1078-0432.CCR-21-0921
Published: 15 September 2021
View article titled, Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract B20: Prolonged time to clearance of circulating-tumor DNA from patients with limited-stage small-cell lung cancer is associated with inferior progression-free and overall survival

Christopher Cann, Prasad Kopparapu, Yingjun Yan, Anel Muterspaugh, Heidi Chen, Zhiguo Zhao, Sally York, Leora Horn, Kristen Ancell, Kenneth Wyman, Caterina Bertucci, Tristan Shaffer, Lauren Hodson, Kavita Garg, Seyed Ali Hosseini, Lee Lim, Christine M. Lovly, Wade Iams
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): B20.
https://doi.org/10.1158/1557-3265.LiqBiop20-B20
Published: 01 June 2020
View article titled, Abstract B20: Prolonged time to clearance of circulating-tumor DNA from patients with limited-stage small-cell lung cancer is associated with inferior progression-free and overall survival
Journal Articles

On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation

Benjamin P. Brown, Yun-Kai Zhang, David Westover, Yingjun Yan, Huan Qiao, Vincent Huang, Zhenfang Du, Jarrod A. Smith, Jeffrey S. Ross, Vincent A. Miller, Siraj Ali, Lyudmila Bazhenova, Alexa B. Schrock, Jens Meiler, Christine M. Lovly
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (11): 3341–3351.
https://doi.org/10.1158/1078-0432.CCR-18-3829
Published: 03 June 2019
View article titled, On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation
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Includes: Multimedia, Supplementary data
Journal Articles

Ensartinib (X-396) in ALK-Positive Non–Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study

Leora Horn, Jeffrey R. Infante, Karen L. Reckamp, George R. Blumenschein, Ticiana A. Leal, Saiama N. Waqar, Barbara J. Gitlitz, Rachel E. Sanborn, Jennifer G. Whisenant, Liping Du, Joel W. Neal, Jon P. Gockerman, Gary Dukart, Kimberly Harrow, Chris Liang, James J. Gibbons, Allison Holzhausen, Christine M. Lovly, Heather A. Wakelee
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2771–2779.
https://doi.org/10.1158/1078-0432.CCR-17-2398
Published: 14 June 2018
View article titled, Ensartinib (X-396) in ALK-Positive Non–Small Cell Lung Cancer: Results from a First-in-Human Phase I/II, Multicenter Study
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Includes: Supplementary data
Journal Articles

Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors

Sandra Ortiz-Cuaran, Matthias Scheffler, Dennis Plenker, llona Dahmen, Andreas H. Scheel, Lynnette Fernandez-Cuesta, Lydia Meder, Christine M. Lovly, Thorsten Persigehl, Sabine Merkelbach-Bruse, Marc Bos, Sebastian Michels, Rieke Fischer, Kerstin Albus, Katharina König, Hans-Ulrich Schildhaus, Jana Fassunke, Michaela A. Ihle, Helen Pasternack, Carina Heydt, Christian Becker, Janine Altmüller, Hongbin Ji, Christian Müller, Alexandra Florin, Johannes M. Heuckmann, Peter Nuernberg, Sascha Ansén, Lukas C. Heukamp, Johannes Berg, William Pao, Martin Peifer, Reinhard Buettner, Jürgen Wolf, Roman K. Thomas, Martin L. Sos
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19): 4837–4847.
https://doi.org/10.1158/1078-0432.CCR-15-1915
Published: 02 October 2016
View article titled, Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors
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Includes: Supplementary data
Journal Articles

Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade

Wade T. Iams, Christine M. Lovly
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (19): 4270–4277.
https://doi.org/10.1158/1078-0432.CCR-14-2518
Published: 30 September 2015
View article titled, Molecular Pathways: Clinical Applications and Future Direction of Insulin-like Growth Factor-1 Receptor Pathway Blockade
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Journal Articles

Therapeutic Targeting of Anaplastic Lymphoma Kinase in Lung Cancer: A Paradigm for Precision Cancer Medicine

Ryohei Katayama, Christine M. Lovly, Alice T. Shaw
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (10): 2227–2235.
https://doi.org/10.1158/1078-0432.CCR-14-2791
Published: 14 May 2015
View article titled, Therapeutic Targeting of Anaplastic Lymphoma Kinase in Lung Cancer: A Paradigm for Precision Cancer Medicine
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Journal Articles

MAP2K1 (MEK1) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking

Maria E. Arcila, Alexander Drilon, Brooke E. Sylvester, Christine M. Lovly, Laetitia Borsu, Boris Reva, Mark G. Kris, David B. Solit, Marc Ladanyi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (8): 1935–1943.
https://doi.org/10.1158/1078-0432.CCR-14-2124
Published: 14 April 2015
View article titled, <em>MAP2K1</em> (<em>MEK1</em>) Mutations Define a Distinct Subset of Lung Adenocarcinoma Associated with Smoking
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Includes: Supplementary data
Journal Articles

Therapeutic Strategies Utilized in the Setting of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors

Helena A. Yu, Gregory J. Riely, Christine M. Lovly
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (23): 5898–5907.
https://doi.org/10.1158/1078-0432.CCR-13-2437
Published: 30 November 2014
View article titled, Therapeutic Strategies Utilized in the Setting of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors
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Journal Articles

Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies

Catherine B. Meador, Christine M. Micheel, Mia A. Levy, Christine M. Lovly, Leora Horn, Jeremy L. Warner, Douglas B. Johnson, Zhongming Zhao, Ingrid A. Anderson, Jeffrey A. Sosman, Cindy L. Vnencak-Jones, Kimberly B. Dahlman, William Pao
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (9): 2264–2275.
https://doi.org/10.1158/1078-0432.CCR-13-1591
Published: 30 April 2014
View article titled, Beyond Histology: Translating Tumor Genotypes into Clinically Effective Targeted Therapies
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Journal Articles

Molecular Pathways: Resistance to Kinase Inhibitors and Implications for Therapeutic Strategies

Christine M. Lovly, Alice T. Shaw
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (9): 2249–2256.
https://doi.org/10.1158/1078-0432.CCR-13-1610
Published: 30 April 2014
View article titled, Molecular Pathways: Resistance to Kinase Inhibitors and Implications for Therapeutic Strategies
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Journal Articles

Characteristics of Lung Cancers Harboring NRAS Mutations

Kadoaki Ohashi, Lecia V. Sequist, Maria E. Arcila, Christine M. Lovly, Xi Chen, Charles M. Rudin, Teresa Moran, David Ross Camidge, Cindy L. Vnencak-Jones, Lynne Berry, Yumei Pan, Hidefumi Sasaki, Jeffrey A. Engelman, Edward B. Garon, Steven M. Dubinett, Wilbur A. Franklin, Gregory J. Riely, Martin L. Sos, Mark G. Kris, Dora Dias-Santagata, Marc Ladanyi, Paul A. Bunn, Jr, William Pao
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (9): 2584–2591.
https://doi.org/10.1158/1078-0432.CCR-12-3173
Published: 30 April 2013
View article titled, Characteristics of Lung Cancers Harboring <em>NRAS</em> Mutations
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Includes: Supplementary data
Journal Articles

Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

Johannes M. Heuckmann, Hyatt Balke-Want, Florian Malchers, Martin Peifer, Martin L. Sos, Mirjam Koker, Lydia Meder, Christine M. Lovly, Lukas C. Heukamp, William Pao, Ralf Küppers, Roman K. Thomas
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (17): 4682–4690.
https://doi.org/10.1158/1078-0432.CCR-11-3260
Published: 30 August 2012
View article titled, Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants
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Includes: Supplementary data
Journal Articles

ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors

Johannes M. Heuckmann, Michael Hölzel, Martin L. Sos, Stefanie Heynck, Hyatt Balke-Want, Mirjam Koker, Martin Peifer, Jonathan Weiss, Christine M. Lovly, Christian Grütter, Daniel Rauh, William Pao, Roman K. Thomas
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (23): 7394–7401.
https://doi.org/10.1158/1078-0432.CCR-11-1648
Published: 30 November 2011
View article titled, ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors
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Includes: Supplementary data