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Christine H. Chung
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Journal Articles

Neoadjuvant Chemotherapy and Surgery versus Surgery for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma: ECOG-ACRIN EA3163

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Nabil F. Saba, Yael Flamand, Derrick T. Lin, Christine H. Chung, Mark W. McDonald, Styliani Flampouri, Saad A. Khan, Carl H. Snyderman, Ehab Y. Hanna, Ivan H. El-Sayed, Clementino A. Solares, Christopher H. Le, Maged Ghaly, Peter H. Hwang, Dong M. Shin, Rita S. Axelrod, Chukwuemeka V. Ikpeazu, Douglas R. Adkins, Fenghai Duan, Marc Cohen, Michael A. Samuels, Paul L. Swiecicki, Rathan M. Subramaniam, A. Bapsi Chakravarthy, Barbara A. Burtness
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12): 2339–2346.
https://doi.org/10.1158/1078-0432.CCR-24-4085
Published: 13 June 2025
View articletitled, Neoadjuvant Chemotherapy and Surgery versus Surgery for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma: ECOG-ACRIN EA3163
Open the PDF for Neoadjuvant Chemotherapy and Surgery versus Surgery for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma: ECOG-ACRIN EA3163 in another window
Includes: Supplementary data
Journal Articles

Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis

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Nabil F. Saba, Ritu Chaudhary, Kedar Kirtane, Angelo Marra, Asari Ekpenyong, Ashley McCook-Veal, Nicole C. Schmitt, Jennifer H. Gross, Mihir R. Patel, Jill Remick, James E. Bates, Mark W. McDonald, Soumon F. Rudra, William A. Stokes, Maria Biernacki, Xiaofei Song, Robbert J.C. Slebos, Yuan Liu, Conor E. Steuer, Dong M. Shin, Yong Teng, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4601–4608.
https://doi.org/10.1158/1078-0432.CCR-24-1202
Published: 15 October 2024
View articletitled, Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis
Open the PDF for Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis in another window
Includes: Supplementary data
Journal Articles

Abstract IA09: Characterization of hypoxic tumor microenvironment in HPV-negative HNSCC

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Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18_Supplement): IA09.
https://doi.org/10.1158/1557-3265.AACRAHNS23-IA09
Published: 15 September 2023
View articletitled, Abstract IA09: Characterization of hypoxic tumor microenvironment in HPV-negative HNSCC
Journal Articles

Phase II Multi-institutional Clinical Trial Result of Concurrent Cetuximab and Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma

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Christine H. Chung, Jiannong Li, Conor E. Steuer, Priyanka Bhateja, Matthew Johnson, Jude Masannat, Maria I. Poole, Feifei Song, Juan C. Hernandez-Prera, Helen Molina, Bruce M. Wenig, Sunil Kumar, Charlotte Kuperwasser, Philip J. Stephens, Joaquim M. Farinhas, Dong M. Shin, Julie A. Kish, Jameel Muzaffar, Kedar Kirtane, James W. Rocco, Michael J. Schell, Nabil F. Saba, Marcelo Bonomi
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2329–2338.
https://doi.org/10.1158/1078-0432.CCR-21-3849
Published: 01 June 2022
View articletitled, Phase II Multi-institutional Clinical Trial Result of Concurrent Cetuximab and Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma
Open the PDF for Phase II Multi-institutional Clinical Trial Result of Concurrent Cetuximab and Nivolumab in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Correction: Effects of Tobacco Smoking On the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma

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Janis V. de la Iglesia, Robbert J.C. Slebos, Laura Martin-Gomez, Xuefeng Wang, Jamie K. Teer, Aik Choon Tan, Travis A. Gerke, Garrick Aden-Buie, Tessa van Veen, Jude Masannat, Ritu Chaudhary, Feifei Song, Michelle Fournier, Erin M. Siegel, Matthew B. Schabath, J. Trad Wadsworth, Jimmy Caudell, Louis Harrison, Bruce M. Wenig, Jose Conejo-Garcia, Juan C. Hernandez-Prera, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (17): 4941.
https://doi.org/10.1158/1078-0432.CCR-21-2432
Published: 01 September 2021
View articletitled, Correction: Effects of Tobacco Smoking On the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma
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Journal Articles

Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma

Available to Purchase
Janis V. de la Iglesia, Robbert J.C. Slebos, Laura Martin-Gomez, Xuefeng Wang, Jamie K. Teer, Aik Choon Tan, Travis A. Gerke, Garrick Aden-Buie, Tessa van Veen, Jude Masannat, Ritu Chaudhary, Feifei Song, Michelle Fournier, Erin M. Siegel, Matthew B. Schabath, J. Trad Wadsworth, Jimmy Caudell, Louis Harrison, Bruce M. Wenig, Jose Conejo-Garcia, Juan C. Hernandez-Prera, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1474–1485.
https://doi.org/10.1158/1078-0432.CCR-19-1769
Published: 13 March 2020
View articletitled, Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma
Open the PDF for Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 05: Untangling the gene-epigenome networks: Timing of epigenetic regulation of gene expression in acquired cetuximab resistance gene programs

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Genevieve Stein-O'Brien, Luciane T. Kagohara, Sijia Li, Manjusha Thakar, Ruchira Ranaweera, Michael Considine, Ludmila V. Danilova, Hiroyuki Ozawa, Joseph A. Califano, Daria A. Gaykalova, Michael F. Ochs, Christine H. Chung, Elana J. Fertig
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23_Supplement): 05.
https://doi.org/10.1158/1557-3265.AACRAHNS17-05
Published: 30 November 2017
View articletitled, Abstract 05: Untangling the gene-epigenome networks: Timing of epigenetic regulation of gene expression in acquired cetuximab resistance gene programs
Journal Articles

SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells

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Hiroyuki Ozawa, Ruchira S. Ranaweera, Evgeny Izumchenko, Eugene Makarev, Alex Zhavoronkov, Elana J. Fertig, Jason D. Howard, Ana Markovic, Atul Bedi, Rajani Ravi, Jimena Perez, Quynh-Thu Le, Christina S. Kong, Richard C. Jordan, Hao Wang, Hyunseok Kang, Harry Quon, David Sidransky, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 5162–5175.
https://doi.org/10.1158/1078-0432.CCR-16-1686
Published: 31 August 2017
View articletitled, SMAD4 Loss Is Associated with Cetuximab Resistance and Induction of MAPK/JNK Activation in Head and Neck Cancer Cells
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Includes: Supplementary data
Journal Articles

Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations

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Zachary S. Zumsteg, Natasha Morse, Gabriel Krigsfeld, Gaorav Gupta, Daniel S. Higginson, Nancy Y. Lee, Luc Morris, Ian Ganly, Stephan L. Shiao, Simon N. Powell, Christine H. Chung, Maurizio Scaltriti, José Baselga
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (8): 2009–2019.
https://doi.org/10.1158/1078-0432.CCR-15-2245
Published: 14 April 2016
View articletitled, Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
Open the PDF for Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations in another window
Includes: Supplementary data
Journal Articles

Novel Targets in Head and Neck Cancer: Should We Be Optimistic?

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Gabriel S. Krigsfeld, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (3): 495–497.
https://doi.org/10.1158/1078-0432.CCR-14-1776
Published: 01 February 2015
View articletitled, Novel Targets in Head and Neck Cancer: Should We Be Optimistic?
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Journal Articles

CHK It Out! Blocking WEE Kinase Routs TP53 Mutant Cancer

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Julie E. Bauman, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (16): 4173–4175.
https://doi.org/10.1158/1078-0432.CCR-14-0720
Published: 13 August 2014
View articletitled, CHK It Out! Blocking WEE Kinase Routs TP53 Mutant Cancer
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Journal Articles

Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements

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D. Neil Hayes, Amy S. Lucas, Tawee Tanvetyanon, Monika K. Krzyzanowska, Christine H. Chung, Barbara A. Murphy, Jill Gilbert, Ranee Mehra, Dominic T. Moore, Arif Sheikh, Janelle Hoskins, Michele C. Hayward, Ni Zhao, Wendi O'Connor, Karen E. Weck, Roger B. Cohen, Ezra E.W. Cohen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (7): 2056–2065.
https://doi.org/10.1158/1078-0432.CCR-11-0563
Published: 01 April 2012
View articletitled, Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements
Open the PDF for Phase II Efficacy and Pharmacogenomic Study of Selumetinib (AZD6244; ARRY-142886) in Iodine-131 Refractory Papillary Thyroid Carcinoma with or without Follicular Elements in another window
Includes: Supplementary data
Journal Articles

Human Papillomavirus in Head and Neck Cancer: Its Role in Pathogenesis and Clinical Implications

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Christine H. Chung, Maura L. Gillison
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6758–6762.
https://doi.org/10.1158/1078-0432.CCR-09-0784
Published: 11 November 2009
View articletitled, Human Papillomavirus in Head and Neck Cancer: Its Role in Pathogenesis and Clinical Implications
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Journal Articles

Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma

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Robbert J.C. Slebos, Yajun Yi, Kim Ely, Jesse Carter, Amy Evjen, Xueqiong Zhang, Yu Shyr, Barbara M. Murphy, Anthony J. Cmelak, Brian B. Burkey, James L. Netterville, Shawn Levy, Wendell G. Yarbrough, Christine H. Chung
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (3): 701–709.
https://doi.org/10.1158/1078-0432.CCR-05-2017
Published: 07 February 2006
View articletitled, Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data