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Christian Klein
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Journal Articles

Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies

Gabrielle Leclercq-Cohen, Nathalie Steinhoff, Llucia Albertí Servera, Sina Nassiri, Sabrina Danilin, Emily Piccione, Emilio Yángüez, Tamara Hüsser, Sylvia Herter, Stephan Schmeing, Petra Gerber, Petra Schwalie, Johannes Sam, Stefanie Briner, Sylvia Jenni, Roberta Bianchi, Marlene Biehl, Floriana Cremasco, Katerina Apostolopoulou, Hélène Haegel, Christian Klein, Pablo Umaña, Marina Bacac
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4449–4463.
https://doi.org/10.1158/1078-0432.CCR-22-3667
Published: 01 November 2023
View article titled, Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
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Includes: Supplementary data
Journal Articles

Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy

Clara H. Karches, Mohamed-Reda Benmebarek, Moritz L. Schmidbauer, Mathias Kurzay, Richard Klaus, Martina Geiger, Felicitas Rataj, Bruno L. Cadilha, Stefanie Lesch, Constanze Heise, Ramona Murr, Johannes vom Berg, Martin Jastroch, Daniel Lamp, Jian Ding, Peter Duewell, Gerhard Niederfellner, Claudio Sustmann, Stefan Endres, Christian Klein, Sebastian Kobold
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 5890–5900.
https://doi.org/10.1158/1078-0432.CCR-18-3927
Published: 01 October 2019
View article titled, Bispecific Antibodies Enable Synthetic Agonistic Receptor-Transduced T Cells for Tumor Immunotherapy
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Includes: Supplementary data
Journal Articles

Prognostic Impact of Natural Killer Cell Count in Follicular Lymphoma and Diffuse Large B-cell Lymphoma Patients Treated with Immunochemotherapy

Magdalena Klanova, Mikkel Z. Oestergaard, Marek Trněný, Wolfgang Hiddemann, Robert Marcus, Laurie H. Sehn, Umberto Vitolo, Alexandra Bazeos, Valentin Goede, Harald Zeuner, Andrea Knapp, Deniz Sahin, Nathalie Spielewoy, Christopher R. Bolen, Andres Cardona, Christian Klein, Jeffrey M. Venstrom, Tina Nielsen, Günter Fingerle-Rowson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (15): 4634–4643.
https://doi.org/10.1158/1078-0432.CCR-18-3270
Published: 01 August 2019
View article titled, Prognostic Impact of Natural Killer Cell Count in Follicular Lymphoma and Diffuse Large B-cell Lymphoma Patients Treated with Immunochemotherapy
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Includes: Supplementary data
Journal Articles

CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies

Marina Bacac, Sara Colombetti, Sylvia Herter, Johannes Sam, Mario Perro, Stanford Chen, Roberta Bianchi, Marine Richard, Anne Schoenle, Valeria Nicolini, Sarah Diggelmann, Florian Limani, Ramona Schlenker, Tamara Hüsser, Wolfgang Richter, Katharine Bray-French, Heather Hinton, Anna Maria Giusti, Anne Freimoser-Grundschober, Laurent Lariviere, Christiane Neumann, Christian Klein, Pablo Umaña
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (19): 4785–4797.
https://doi.org/10.1158/1078-0432.CCR-18-0455
Published: 01 October 2018
View article titled, CD20-TCB with Obinutuzumab Pretreatment as Next-Generation Treatment of Hematologic Malignancies
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Includes: Multimedia, Supplementary data
Journal Articles

Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy

Benjamin Ribba, Christophe Boetsch, Tapan Nayak, Hans Peter Grimm, Jehad Charo, Stefan Evers, Christian Klein, Jean Tessier, Jean Eric Charoin, Alex Phipps, Pavel Pisa, Volker Teichgräber
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (14): 3325–3333.
https://doi.org/10.1158/1078-0432.CCR-17-2953
Published: 15 July 2018
View article titled, Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy
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Includes: Supplementary data
Journal Articles

In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell–Mediated Tumor Killing

Steffi Lehmann, Ramanil Perera, Hans-Peter Grimm, Johannes Sam, Sara Colombetti, Tanja Fauti, Linda Fahrni, Teilo Schaller, Anne Freimoser-Grundschober, Jörg Zielonka, Szymon Stoma, Markus Rudin, Christian Klein, Pablo Umana, Christian Gerdes, Marina Bacac
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (17): 4417–4427.
https://doi.org/10.1158/1078-0432.CCR-15-2622
Published: 31 August 2016
View article titled, <em>In Vivo</em> Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell–Mediated Tumor Killing
Open the PDF for <em>In Vivo</em> Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell–Mediated Tumor Killing in another window
Includes: Multimedia, Supplementary data
Journal Articles

A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors

Marina Bacac, Tanja Fauti, Johannes Sam, Sara Colombetti, Tina Weinzierl, Djamila Ouaret, Walter Bodmer, Steffi Lehmann, Thomas Hofer, Ralf J. Hosse, Ekkehard Moessner, Oliver Ast, Peter Bruenker, Sandra Grau-Richards, Teilo Schaller, Annette Seidl, Christian Gerdes, Mario Perro, Valeria Nicolini, Nathalie Steinhoff, Sherri Dudal, Sebastian Neumann, Thomas von Hirschheydt, Christiane Jaeger, Jose Saro, Vaios Karanikas, Christian Klein, Pablo Umaña
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (13): 3286–3297.
https://doi.org/10.1158/1078-0432.CCR-15-1696
Published: 30 June 2016
View article titled, A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
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Includes: Multimedia, Supplementary data
Journal Articles

Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy

Yvonne Kienast, Christian Klein, Werner Scheuer, Romi Raemsch, Erica Lorenzon, Dirk Bernicke, Frank Herting, Sidney Yu, Huynh Hung The, Laurent Martarello, Christian Gassner, Kay-Gunnar Stubenrauch, Kate Munro, Hellmut G. Augustin, Markus Thomas
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2013) 19 (24): 6730–6740.
https://doi.org/10.1158/1078-0432.CCR-13-0081
Published: 16 December 2013
View article titled, Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy
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Includes: Supplementary data
Journal Articles

Candidate Biomarkers of Response to an Experimental Cancer Drug Identified through a Large-scale RNA Interference Genetic Screen

Jasper Mullenders, Wolfgang von der Saal, Miranda M.W. van Dongen, Ulrike Reiff, Rogier van Willigen, Roderick L. Beijersbergen, Georg Tiefenthaler, Christian Klein, René Bernards
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (18): 5811–5819.
https://doi.org/10.1158/1078-0432.CCR-09-0261
Published: 14 September 2009
View article titled, Candidate Biomarkers of Response to an Experimental Cancer Drug Identified through a Large-scale RNA Interference Genetic Screen
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Includes: Supplementary data