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Chris Twelves
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Journal Articles

A Phase I Clinical Trial of Intrahepatic Artery Delivery of TG6002 in Combination with Oral 5-Fluorocytosine in Patients with Liver-Dominant Metastatic Colorectal Cancer

Open Access
Emma J. West, Alain Sadoun, Kaidre Bendjama, Philippe Erbs, Cristina Smolenschi, Philippe A. Cassier, Thierry de Baere, Sophie Sainte-Croix, Maud Brandely, Alan A. Melcher, Fay Ismail, Karen J. Scott, Angela Bennett, Emma Banks, Ewa Gasior, Sarah Kent, Marta Kurzawa, Christopher Hammond, Jai V. Patel, Fiona J. Collinson, Chris Twelves, D. Alan Anthoney, Dan Swinson, Adel Samson
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (7): 1243–1256.
https://doi.org/10.1158/1078-0432.CCR-24-2498
Published: 01 April 2025
View articletitled, A Phase I Clinical Trial of Intrahepatic Artery Delivery of TG6002 in Combination with Oral 5-Fluorocytosine in Patients with Liver-Dominant Metastatic Colorectal Cancer
Open the PDF for A Phase I Clinical Trial of Intrahepatic Artery Delivery of TG6002 in Combination with Oral 5-Fluorocytosine in Patients with Liver-Dominant Metastatic Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Change in Topoisomerase 1–Positive Circulating Tumor Cells Affects Overall Survival in Patients with Advanced Breast Cancer after Treatment with Etirinotecan Pegol

Free
Hope S. Rugo, Javier Cortes, Ahmad Awada, Joyce O'Shaughnessy, Chris Twelves, Seock-Ah Im, Alison Hannah, Lin Lu, Sherwin Sy, Katie Caygill, Deborah A. Zajchowski, Darren W. Davis, Mary Tagliaferri, Ute Hoch, Edith A. Perez
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (14): 3348–3357.
https://doi.org/10.1158/1078-0432.CCR-17-3059
Published: 15 July 2018
View articletitled, Change in Topoisomerase 1–Positive Circulating Tumor Cells Affects Overall Survival in Patients with Advanced Breast Cancer after Treatment with Etirinotecan Pegol
Open the PDF for Change in Topoisomerase 1–Positive Circulating Tumor Cells Affects Overall Survival in Patients with Advanced Breast Cancer after Treatment with Etirinotecan Pegol in another window
Includes: Supplementary data
Journal Articles

First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer

Free
Sarah Blagden, Aurelius Olmin, Debra Josephs, Chara Stavraka, Andrea Zivi, David J. Pinato, Alan Anthoney, Shaun Decordova, Karen Swales, Ruth Riisnaes, Lorna Pope, Kohei Noguchi, Rie Shiokawa, Michiyasu Inatani, Jenny Prince, Keith Jones, Chris Twelves, James Spicer, Udai Banerji
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (23): 5908–5917.
https://doi.org/10.1158/1078-0432.CCR-14-1315
Published: 30 November 2014
View articletitled, First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer
Open the PDF for First-in-Human Study of CH5132799, an Oral Class I PI3K Inhibitor, Studying Toxicity, Pharmacokinetics, and Pharmacodynamics, in Patients with Metastatic Cancer in another window
Includes: Supplementary data
Journal Articles

Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients

Free
Liane M. McGlynn, Tove Kirkegaard, Joanne Edwards, Sian Tovey, David Cameron, Chris Twelves, John M.S. Bartlett, Timothy G. Cooke
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (4): 1487–1495.
https://doi.org/10.1158/1078-0432.CCR-07-4967
Published: 19 February 2009
View articletitled, Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients
Open the PDF for Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Phase I Study of OSI-7904L, a Novel Liposomal Thymidylate Synthase Inhibitor in Patients with Refractory Solid Tumors

Free
Gernot Beutel, Hilary Glen, Patrick Schöffski, Jon Chick, Stan Gill, James Cassidy, Chris Twelves
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5487–5495.
https://doi.org/10.1158/1078-0432.CCR-05-0104
Published: 01 August 2005
View articletitled, Phase I Study of OSI-7904L, a Novel Liposomal Thymidylate Synthase Inhibitor in Patients with Refractory Solid Tumors
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Journal Articles

A Phase I Clinical and Pharmacokinetic Study of Ro 31-7453 Given as a 7- or 14-Day Oral Twice Daily Schedule Every 4 Weeks in Patients with Solid Tumors

Free
Ramon Salazar, Donald Bissett, Chris Twelves, Lars Breimer, Mark DeMario, Sophia Campbell, Jay Zhi, Steve Ritland, Jim Cassidy
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (13): 4374–4382.
https://doi.org/10.1158/1078-0432.CCR-04-0135
Published: 06 July 2004
View articletitled, A Phase I Clinical and Pharmacokinetic Study of Ro 31-7453 Given as a 7- or 14-Day Oral Twice Daily Schedule Every 4 Weeks in Patients with Solid Tumors
Open the PDF for A Phase I Clinical and Pharmacokinetic Study of Ro 31-7453 Given as a 7- or 14-Day Oral Twice Daily Schedule Every 4 Weeks in Patients with Solid Tumors in another window
Journal Articles

Phase I Pharmacological and Bioavailability Study of Oral Diflomotecan (BN80915), a Novel E-Ring-modified Camptothecin Analogue in Adults with Solid Tumors

Free
Hans Gelderblom, Ramon Salazar, Jaap Verweij, George Pentheroudakis, Maja J. A. de Jonge, Martin Devlin, Christel van Hooije, Francis Seguy, Rosendo Obach, Joan Pruñonosa, Paola Principe, Chris Twelves
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (11): 4101–4107.
Published: 30 September 2003
View articletitled, Phase I Pharmacological and Bioavailability Study of Oral Diflomotecan (BN80915), a Novel E-Ring-modified Camptothecin Analogue in Adults with Solid Tumors
Open the PDF for Phase I Pharmacological and Bioavailability Study of Oral Diflomotecan (BN80915), a Novel E-Ring-modified Camptothecin Analogue in Adults with Solid Tumors in another window
Journal Articles

Effect of Hepatic Dysfunction due to Liver Metastases on the Pharmacokinetics of Capecitabine and Its Metabolites

Free
Chris Twelves, Robert Glynne-Jones, Jim Cassidy, Johannes Schüller, Timothy Goggin, Brigitte Roos, Ludger Banken, Masahiro Utoh, Erhard Weidekamm, Bruno Reigner
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1696–1702.
Published: 01 July 1999
View articletitled, Effect of Hepatic Dysfunction due to Liver Metastases on the Pharmacokinetics of Capecitabine and Its Metabolites
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Journal Articles

Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates

Free
Paul A. Vasey, Stan B. Kaye, Rosemary Morrison, Chris Twelves, Peter Wilson, Ruth Duncan, Alison H. Thomson, Lilian S. Murray, Tom E. Hilditch, Tom Murray, Sally Burtles, D. Fraier, E. Frigerio, Jim Cassidy, on behalf of the Cancer Research Campaign Phase I/II Committee
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (1): 83–94.
Published: 01 January 1999
View articletitled, Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates
Open the PDF for Phase I Clinical and Pharmacokinetic Study of PK1 [N-(2-Hydroxypropyl)methacrylamide Copolymer Doxorubicin]: First Member of a New Class of Chemotherapeutic Agents—Drug-Polymer Conjugates in another window