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Chris Takimoto
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Journal Articles

Towards personalized medicine: Evaluation of blood and tissue biomarkers for drug sensitivity in a newly established human xenograft model

David Campos, Robert Streeper, Mario Sepulveda, Armando Diaz, Michael Wick, David Sidransky, George Demetri, Eric Rowinsky, Enrique Poradosu, Chris Takimoto, Elzbieta Izbicka
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): B14.
Published: 15 August 2014
View article titled, Towards personalized medicine: Evaluation of blood and tissue biomarkers for drug sensitivity in a newly established human xenograft model
Journal Articles

Development of biomarkers in Phase I trials of targeted therapies: The reality of the clinical research forefront

Jordi Rodon, Andrew Hsu, Chris Takimoto, Robert Geller, Anthony Tolcher
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): B74.
Published: 15 August 2014
View article titled, Development of biomarkers in Phase I trials of targeted therapies: The reality of the clinical research forefront
Journal Articles

Towards personalized medicine: Establishment and in vivo characterization of a low passage tumor xenograft tumor predictive of clinical response

Wesley Lowell, David Sidransky, Eric Rowinsky, George Demetri, Chris Takimoto, Kuslima Shogen, Michael Wick
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): B22.
Published: 15 August 2014
View article titled, Towards personalized medicine: Establishment and <em>in vivo</em> characterization of a low passage tumor xenograft tumor predictive of clinical response
Journal Articles

A Phase 1, Dose-Escalation, Pharmacokinetic and Pharmacodynamic Study of BIIB021 Administered Orally in Patients with Advanced Solid Tumors

Muhammad Wasif Saif, Chris Takimoto, Monica Mita, Udai Banerji, Nicole Lamanna, Januario Castro, Susan O'Brien, Christopher Stogard, Daniel Von Hoff
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2): 445–455.
https://doi.org/10.1158/1078-0432.CCR-13-1257
Published: 16 January 2014
View article titled, A Phase 1, Dose-Escalation, Pharmacokinetic and Pharmacodynamic Study of BIIB021 Administered Orally in Patients with Advanced Solid Tumors
Open the PDF for A Phase 1, Dose-Escalation, Pharmacokinetic and Pharmacodynamic Study of BIIB021 Administered Orally in Patients with Advanced Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Phase I Study of E7820, an Oral Inhibitor of Integrin α-2 Expression with Antiangiogenic Properties, in Patients with Advanced Malignancies

Monica Mita, Kevin R. Kelly, Alain Mita, Alejandro D. Ricart, Ofelia Romero, Anthony Tolcher, Laurel Hook, Chukwuemeka Okereke, Ilya Krivelevich, Daniel P. Rossignol, Francis J. Giles, Eric K. Rowinsky, Chris Takimoto
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (1): 193–200.
https://doi.org/10.1158/1078-0432.CCR-10-0010
Published: 04 January 2011
View article titled, Phase I Study of E7820, an Oral Inhibitor of Integrin α-2 Expression with Antiangiogenic Properties, in Patients with Advanced Malignancies
Open the PDF for Phase I Study of E7820, an Oral Inhibitor of Integrin α-2 Expression with Antiangiogenic Properties, in Patients with Advanced Malignancies in another window
Journal Articles

A Phase II, Pharmacokinetic, and Biological Correlative Study of Oblimersen Sodium and Docetaxel in Patients with Hormone-Refractory Prostate Cancer

Anthony W. Tolcher, Kim Chi, John Kuhn, Martin Gleave, Amita Patnaik, Chris Takimoto, Garry Schwartz, Ian Thompson, Kristin Berg, Susan D'Aloisio, Nevin Murray, Stanley R. Frankel, Elzbieta Izbicka, Eric Rowinsky
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (10): 3854–3861.
https://doi.org/10.1158/1078-0432.CCR-04-2145
Published: 16 May 2005
View article titled, A Phase II, Pharmacokinetic, and Biological Correlative Study of Oblimersen Sodium and Docetaxel in Patients with Hormone-Refractory Prostate Cancer
Open the PDF for A Phase II, Pharmacokinetic, and Biological Correlative Study of Oblimersen Sodium and Docetaxel in Patients with Hormone-Refractory Prostate Cancer in another window
Journal Articles

ING-1, a Monoclonal Antibody Targeting Ep-CAM in Patients with Advanced Adenocarcinomas

Johann S. de Bono, Anthony W. Tolcher, Andre Forero, Gertrude F. A. Vanhove, Chris Takimoto, Robert J. Bauer, Lisa A. Hammond, Amita Patnaik, Mark L. White, Sui Shen, Muhammad B. Khazaeli, Eric K. Rowinsky, Albert F. LoBuglio
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (22): 7555–7565.
https://doi.org/10.1158/1078-0432.CCR-04-0729
Published: 29 November 2004
View article titled, ING-1, a Monoclonal Antibody Targeting Ep-CAM in Patients with Advanced Adenocarcinomas
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Journal Articles

A Phase I and Pharmacokinetic Study of Col-3 (Metastat), an Oral Tetracycline Derivative with Potent Matrix Metalloproteinase and Antitumor Properties

Samira Syed, Chris Takimoto, Manuel Hidalgo, Jinee Rizzo, John G. Kuhn, Lisa A. Hammond, Garry Schwartz, Anthony Tolcher, Amita Patnaik, S. Gail Eckhardt, Eric K. Rowinsky
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (19): 6512–6521.
https://doi.org/10.1158/1078-0432.CCR-04-0804
Published: 08 October 2004
View article titled, A Phase I and Pharmacokinetic Study of Col-3 (Metastat), an Oral Tetracycline Derivative with Potent Matrix Metalloproteinase and Antitumor Properties
Open the PDF for A Phase I and Pharmacokinetic Study of Col-3 (Metastat), an Oral Tetracycline Derivative with Potent Matrix Metalloproteinase and Antitumor Properties in another window
Journal Articles

A Pilot Study of Interferon α-2a, Fluorouracil, and Leucovorin Given with Granulocyte-Macrophage Colony Stimulating Factor in Advanced Gastrointestinal Adenocarcinoma

Jeremy D. Shapiro, Nancy Harold, Chris Takimoto, J. Michael Hamilton, David Vaughn, Alice Chen, Seth M. Steinberg, David Liewehr, Carmen Allegra, Brian Monahan, Alex Lash, Frank Grollman, Donald Flemming, Katherine Behan, Patrick G. Johnston, Daniel Haller, Mary Quinn, Geraldine Morrison, Jean L. Grem
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (9): 2399–2408.
Published: 01 September 1999
View article titled, A Pilot Study of Interferon α-2a, Fluorouracil, and Leucovorin Given with Granulocyte-Macrophage Colony Stimulating Factor in Advanced Gastrointestinal Adenocarcinoma
Open the PDF for A Pilot Study of Interferon α-2a, Fluorouracil, and Leucovorin Given with Granulocyte-Macrophage Colony Stimulating Factor in Advanced Gastrointestinal Adenocarcinoma in another window