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Chien-Tsun Kuan
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Journal Articles

A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

Patrick C. Gedeon, Teilo H. Schaller, Satish K. Chitneni, Bryan D. Choi, Chien-Tsun Kuan, Carter M. Suryadevara, David J. Snyder, Robert J. Schmittling, Scott E. Szafranski, Xiuyu Cui, Patrick N. Healy, James E. Herndon, II, Roger E. McLendon, Stephen T. Keir, Gary E. Archer, Elizabeth A. Reap, Luis Sanchez-Perez, Darell D. Bigner, John H. Sampson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (15): 3611–3631.
https://doi.org/10.1158/1078-0432.CCR-17-0126
Published: 31 July 2018
View article titled, A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma
Open the PDF for A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma in another window
Includes: Supplementary data
Journal Articles

Recombinant antibody-based molecular therapeutics for brain tumor immunotherapy

Chien-Tsun Kuan, Kenji Wakiya, Jianjun Li, Stephen Keir, James Herndon, Carol Wikstrand, Michael Zalutsky, Ira Pastan, Darell Bigner
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22_Supplement): A28.
Published: 15 August 2014
View article titled, Recombinant antibody-based molecular therapeutics for brain tumor immunotherapy
Journal Articles

EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss

John H. Sampson, Bryan D. Choi, Luis Sanchez-Perez, Carter M. Suryadevara, David J. Snyder, Catherine T. Flores, Robert J. Schmittling, Smita K. Nair, Elizabeth A. Reap, Pamela K. Norberg, James E. Herndon, II, Chien-Tsun Kuan, Richard A. Morgan, Steven A. Rosenberg, Laura A. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 972–984.
https://doi.org/10.1158/1078-0432.CCR-13-0709
Published: 16 February 2014
View article titled, EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss
Open the PDF for EGFRvIII mCAR-Modified T-Cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity against Tumor-Antigen Loss in another window
Journal Articles

Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

Vidyalakshmi Chandramohan, Xuhui Bao, Stephen T. Keir, Charles N. Pegram, Scott E. Szafranski, Hailan Piao, Carol J. Wikstrand, Roger E. McLendon, Chien-Tsun Kuan, Ira H. Pastan, Darell D. Bigner
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (17): 4717–4727.
https://doi.org/10.1158/1078-0432.CCR-12-3891
Published: 02 September 2013
View article titled, Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy
Open the PDF for Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy in another window
Includes: Supplementary data
Journal Articles

Glycoprotein Nonmetastatic Melanoma Protein B, a Potential Molecular Therapeutic Target in Patients with Glioblastoma Multiforme

Chien-Tsun Kuan, Kenji Wakiya, Jeannette M. Dowell, James E. Herndon, II, David A. Reardon, Michael W. Graner, Gregory J. Riggins, Carol J. Wikstrand, Darell D. Bigner
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (7): 1970–1982.
https://doi.org/10.1158/1078-0432.CCR-05-2797
Published: 11 April 2006
View article titled, Glycoprotein Nonmetastatic Melanoma Protein B, a Potential Molecular Therapeutic Target in Patients with Glioblastoma Multiforme
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Journal Articles

Regional Treatment of Epidermal Growth Factor Receptor vIII-expressing Neoplastic Meningitis with a Single-Chain Immunotoxin, MR-1

Gary E. Archer, John H. Sampson, Ian A. J. Lorimer, Roger E. McLendon, Chien-Tsun Kuan, Allan H. Friedman, Henry S. Friedman, Ira H. Pastan, Darell D. Bigner
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (9): 2646–2652.
Published: 01 September 1999
View article titled, Regional Treatment of Epidermal Growth Factor Receptor vIII-expressing Neoplastic Meningitis with a Single-Chain Immunotoxin, MR-1
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Journal Articles

125I-labeled Anti-Epidermal Growth Factor Receptor-vIII Single-Chain Fv Exhibits Specific and High-Level Targeting of Glioma Xenografts

Chien-Tsun Kuan, Craig J. Reist, Catherine F. Foulon, Ian A. J. Lorimer, Gary Archer, Charles N. Pegram, Ira Pastan, Michael R. Zalutsky, Darell D. Bigner
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (6): 1539–1549.
Published: 01 June 1999
View article titled, <sup>125</sup>I-labeled Anti-Epidermal Growth Factor Receptor-vIII Single-Chain Fv Exhibits Specific and High-Level Targeting of Glioma Xenografts
Open the PDF for <sup>125</sup>I-labeled Anti-Epidermal Growth Factor Receptor-vIII Single-Chain Fv Exhibits Specific and High-Level Targeting of Glioma Xenografts in another window