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Chiara Cremolini
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Journal Articles

Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors

Claire Gallois, Matteo Landi, Julien Taieb, Marine Sroussi, Bahar Saberzadeh-Ardestani, Antoine Cazelles, Sara Lonardi, Francesca Bergamo, Rossana Intini, Giulia Maddalena, Filippo Pietrantonio, Francesca Corti, Margherita Ambrosini, Antonia Martinetti, Marco Maria Germani, Chiara Boccaccio, Guglielmo Vetere, Sophie Mouillet-Richard, Aurélien de Reynies, Frank A. Sinicrope, Chiara Cremolini, Pierre Laurent-Puig
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3771–3778.
https://doi.org/10.1158/1078-0432.CCR-22-3964
Published: 15 September 2023
View article titled, Transcriptomic Signatures of MSI-High Metastatic Colorectal Cancer Predict Efficacy of Immune Checkpoint Inhibitors
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Includes: Supplementary data
Journal Articles

Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study

Giovanni Randon, Yoshiaki Nakamura, Rona Yaeger, Sara Lonardi, Chiara Cremolini, Elena Elez, Federico Nichetti, Filippo Ghelardi, Vincenzo Nasca, Francesca Bergamo, Veronica Conca, Javier Ros, Hideaki Bando, Giulia Maddalena, Simone Oldani, Michele Prisciandaro, Alessandra Raimondi, Alexa B. Schrock, Luca Agnelli, Henry Walch, Takayuki Yoshino, Filippo Pietrantonio
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF8.
https://doi.org/10.1158/1078-0432.CCR-23-1379
Published: 07 September 2023
View article titled, Negative Hyperselection of Patients with HER2<sup>+</sup> and <em>RAS</em> Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study
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Includes: Supplementary data
Journal Articles

An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal Cancer

Carlotta Antoniotti, Alessandra Boccaccino, Robert Seitz, Mirella Giordano, Aurélie Catteau, Daniele Rossini, Filippo Pietrantonio, Lisa Salvatore, Kimberly McGregor, Francesca Bergamo, Veronica Conca, Simone Leonetti, Federica Morano, Giorgio Papiani, Emiliano Tamburini, Maria Bensi, Sabina Murgioni, Douglas Teller Ross, Alessandro Passardi, Isabelle Boquet, Tyler J. Nielsen, Jérôme Galon, Matthew Gordon Varga, Brock L. Schweitzer, Chiara Cremolini
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (12): 2291–2298.
https://doi.org/10.1158/1078-0432.CCR-22-3878
Published: 13 June 2023
View article titled, An Immune-Related Gene Expression Signature Predicts Benefit from Adding Atezolizumab to FOLFOXIRI plus Bevacizumab in Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study

Joleen M. Hubbard, Enikő R. Tőke, Roberto Moretto, Rondell P. Graham, Hagop Youssoufian, Orsolya Lőrincz, Levente Molnár, Zsolt Csiszovszki, Jessica L. Mitchell, Jaclynn Wessling, József Tóth, Chiara Cremolini
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2818–2829.
https://doi.org/10.1158/1078-0432.CCR-22-0112
Published: 01 July 2022
View article titled, Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study
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Includes: Supplementary data
Journal Articles

The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer

Hiroyuki Arai, Andrew Elliott, Joanne Xiu, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Davendra Sohal, Richard M. Goldberg, Michael J. Hall, Aaron J. Scott, Moh'd Khushman, Jimmy J. Hwang, Emil Lou, Benjamin A. Weinberg, John L. Marshall, Albert C. Lockhart, Phillip Stafford, Jian Zhang, Roberto Moretto, Chiara Cremolini, W. Michael Korn, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3234–3242.
https://doi.org/10.1158/1078-0432.CCR-20-3635
Published: 01 June 2021
View article titled, The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer

Jim P. Abraham, Daniel Magee, Chiara Cremolini, Carlotta Antoniotti, David D. Halbert, Joanne Xiu, Phillip Stafford, Donald A. Berry, Matthew J. Oberley, Anthony F. Shields, John L. Marshall, Mohamed E. Salem, Alfredo Falcone, Axel Grothey, Michael J. Hall, Alan P. Venook, Heinz-Josef Lenz, Anthony Helmstetter, W. Michael Korn, David B. Spetzler
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (4): 1174–1183.
https://doi.org/10.1158/1078-0432.CCR-20-3286
Published: 15 February 2021
View article titled, Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Class 1, 2, and 3 BRAF-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization

Marta Schirripa, Paola Biason, Sara Lonardi, Nicoletta Pella, Maria Simona Pino, Federica Urbano, Carlotta Antoniotti, Chiara Cremolini, Salvatore Corallo, Filippo Pietrantonio, Fabio Gelsomino, Stefano Cascinu, Armando Orlandi, Giada Munari, Umberto Malapelle, Serena Saggio, Gabriella Fontanini, Massimo Rugge, Claudia Mescoli, Stefano Lazzi, Luca Reggiani Bonetti, Giovanni Lanza, Angelo Paolo Dei Tos, Giovanna De Maglio, Maurizio Martini, Francesca Bergamo, Vittorina Zagonel, Fotios Loupakis, Matteo Fassan
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 3954–3961.
https://doi.org/10.1158/1078-0432.CCR-19-0311
Published: 01 July 2019
View article titled, Class 1, 2, and 3 <em>BRAF</em>-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization
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Includes: Supplementary data
Journal Articles

Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study

Filippo Pietrantonio, Giovanni Fucà, Federica Morano, Annunziata Gloghini, Simona Corso, Giuseppe Aprile, Federica Perrone, Ferdinando De Vita, Elena Tamborini, Gianluca Tomasello, Ambra Vittoria Gualeni, Elena Ongaro, Adele Busico, Elisa Giommoni, Chiara Costanza Volpi, Maria Maddalena Laterza, Salvatore Corallo, Michele Prisciandaro, Maria Antista, Alessandro Pellegrinelli, Lorenzo Castagnoli, Serenella M. Pupa, Giancarlo Pruneri, Filippo de Braud, Silvia Giordano, Chiara Cremolini, Maria Di Bartolomeo
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (5): 1082–1089.
https://doi.org/10.1158/1078-0432.CCR-17-2781
Published: 28 February 2018
View article titled, Biomarkers of Primary Resistance to Trastuzumab in HER2-Positive Metastatic Gastric Cancer Patients: the AMNESIA Case-Control Study
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Includes: Supplementary data
Journal Articles

A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab

Martin D. Berger, Sebastian Stintzing, Volker Heinemann, Shu Cao, Dongyun Yang, Yu Sunakawa, Satoshi Matsusaka, Yan Ning, Satoshi Okazaki, Yuji Miyamoto, Mitsukuni Suenaga, Marta Schirripa, Diana L. Hanna, Shivani Soni, Alberto Puccini, Wu Zhang, Chiara Cremolini, Alfredo Falcone, Fotios Loupakis, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 784–793.
https://doi.org/10.1158/1078-0432.CCR-17-1663
Published: 14 February 2018
View article titled, A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab
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Includes: Supplementary data
Journal Articles

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients

Carmine Carbone, Geny Piro, Francesca Simionato, Francesca Ligorio, Chiara Cremolini, Fotios Loupakis, Greta Alì, Daniele Rossini, Valeria Merz, Raffaela Santoro, Camilla Zecchetto, Marco Zanotto, Federica Di Nicolantonio, Alberto Bardelli, Gabriella Fontanini, Giampaolo Tortora, Davide Melisi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4312–4322.
https://doi.org/10.1158/1078-0432.CCR-16-3153
Published: 01 August 2017
View article titled, Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients
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Includes: Supplementary data
Journal Articles

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer

Filippo Pietrantonio, Claudio Vernieri, Giulia Siravegna, Alessia Mennitto, Rosa Berenato, Federica Perrone, Annunziata Gloghini, Elena Tamborini, Sara Lonardi, Federica Morano, Benedetta Picciani, Adele Busico, Chiara Costanza Volpi, Antonia Martinetti, Francesca Battaglin, Ilaria Bossi, Alessio Pellegrinelli, Massimo Milione, Chiara Cremolini, Maria Di Bartolomeo, Alberto Bardelli, Filippo de Braud
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (10): 2414–2422.
https://doi.org/10.1158/1078-0432.CCR-16-1863
Published: 14 May 2017
View article titled, Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Biomarkers and Response to Bevacizumab—Letter

Chiara Cremolini, Fotios Loupakis, Guido Bocci, Alfredo Falcone
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 1056–1057.
https://doi.org/10.1158/1078-0432.CCR-13-2763
Published: 16 February 2014
View article titled, Biomarkers and Response to Bevacizumab—Letter
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