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Journal Articles

Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance)

Andrew B. Nixon, Alexander B. Sibley, Yingmiao Liu, Ace J. Hatch, Chen Jiang, Flora Mulkey, Mark D. Starr, John C. Brady, Donna Niedzwiecki, Alan P. Venook, Luis Baez-Diaz, Heinz-Josef Lenz, Bert H. O'Neil, Federico Innocenti, Jeffrey A. Meyerhardt, Eileen M. O'Reilly, Kouros Owzar, Herbert I. Hurwitz
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2779–2788.
DOI: https://doi.org/10.1158/1078-0432.CCR-21-2389
Published: 01 July 2022
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Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance)

Federico Innocenti, Alexander B. Sibley, Sushant A. Patil, Amy S. Etheridge, Chen Jiang, Fang-Shu Ou, Stefanie D. Howell, Sarah J. Plummer, Graham Casey, Monica M. Bertagnolli, Howard L. McLeod, James T. Auman, Charles D. Blanke, Yoichi Furukawa, Alan P. Venook, Michiaki Kubo, Heinz-Josef Lenz, Joel S. Parker, Mark J. Ratain, Kouros Owzar
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 267–275.
DOI: https://doi.org/10.1158/1078-0432.CCR-20-2021
Published: 04 January 2021
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Includes: Supplementary data
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Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance)

Megan Li, Flora Mulkey, Chen Jiang, Bert H. O’Neil, Bryan P. Schneider, Fei Shen, Paula N. Friedman, Yukihide Momozawa, Michiaki Kubo, Donna Niedzwiecki, Howard S. Hochster, Heinz-Josef Lenz, James N. Atkins, Hope S. Rugo, Susan Halabi, William Kevin Kelly, Howard L. McLeod, Federico Innocenti, Mark J. Ratain, Alan P. Venook, Kouros Owzar, Deanna L. Kroetz
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (19): 4734–4744.
DOI: https://doi.org/10.1158/1078-0432.CCR-17-1523
Published: 01 October 2018
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Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy

Daniel L. Hertz, Kouros Owzar, Sherrie Lessans, Claudia Wing, Chen Jiang, William Kevin Kelly, Jai Patel, Susan Halabi, Yoichi Furukawa, Heather E. Wheeler, Alexander B. Sibley, Cameron Lassiter, Lois Weisman, Dorothy Watson, Stefanie D. Krens, Flora Mulkey, Cynthia L. Renn, Eric J. Small, Phillip G. Febbo, Ivo Shterev, Deanna L. Kroetz, Paula N. Friedman, John F. Mahoney, Michael A. Carducci, Michael J. Kelley, Yusuke Nakamura, Michiaki Kubo, Susan G. Dorsey, M. Eileen Dolan, Michael J. Morris, Mark J. Ratain, Howard L. McLeod
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19): 4890–4900.
DOI: https://doi.org/10.1158/1078-0432.CCR-15-2823
Published: 02 October 2016
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Includes: Supplementary data
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Gene Expression Markers of Efficacy and Resistance to Cetuximab Treatment in Metastatic Colorectal Cancer: Results from CALGB 80203 (Alliance)

Stephanie M. Cushman, Chen Jiang, Ace J. Hatch, Ivo Shterev, Alexander B. Sibley, Donna Niedzwiecki, Alan P. Venook, Kouros Owzar, Herbert I. Hurwitz, Andrew B. Nixon
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (5): 1078–1086.
DOI: https://doi.org/10.1158/1078-0432.CCR-14-2313
Published: 01 March 2015
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Includes: Supplementary data
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Integration of Cell Line and Clinical Trial Genome-Wide Analyses Supports a Polygenic Architecture of Paclitaxel-Induced Sensory Peripheral Neuropathy

Heather E. Wheeler, Eric R. Gamazon, Claudia Wing, Uchenna O. Njiaju, Chidiamara Njoku, Robert Michael Baldwin, Kouros Owzar, Chen Jiang, Dorothy Watson, Ivo Shterev, Michiaki Kubo, Hitoshi Zembutsu, Eric P. Winer, Clifford A. Hudis, Lawrence N. Shulman, Yusuke Nakamura, Mark J. Ratain, Deanna L. Kroetz, Nancy J. Cox, Mary Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (2): 491–499.
DOI: https://doi.org/10.1158/1078-0432.CCR-12-2618
Published: 16 January 2013
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Includes: Supplementary data
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A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101

R. Michael Baldwin, Kouros Owzar, Hitoshi Zembutsu, Aparna Chhibber, Michiaki Kubo, Chen Jiang, Dorothy Watson, Rachel J. Eclov, Joel Mefford, Howard L. McLeod, Paula N. Friedman, Clifford A. Hudis, Eric P. Winer, Eric M. Jorgenson, John S. Witte, Lawrence N. Shulman, Yusuke Nakamura, Mark J. Ratain, Deanna L. Kroetz
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (18): 5099–5109.
DOI: https://doi.org/10.1158/1078-0432.CCR-12-1590
Published: 16 September 2012
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A Genome-Wide Association Study of Overall Survival in Pancreatic Cancer Patients Treated with Gemcitabine in CALGB 80303

Federico Innocenti, Kouros Owzar, Nancy L. Cox, Patrick Evans, Michiaki Kubo, Hitoshi Zembutsu, Chen Jiang, Donna Hollis, Taisei Mushiroda, Liang Li, Paula Friedman, Liewei Wang, Dylan Glubb, Herbert Hurwitz, Kathleen M. Giacomini, Howard L. McLeod, Richard M. Goldberg, Richard L. Schilsky, Hedy L. Kindler, Yusuke Nakamura, Mark J. Ratain
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 577–584.
DOI: https://doi.org/10.1158/1078-0432.CCR-11-1387
Published: 16 January 2012
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Includes: Supplementary data
Journal Articles

Comparison of Genomics and Functional Imaging from Canine Sarcomas Treated with Thermoradiotherapy Predicts Therapeutic Response and Identifies Combination Therapeutics

Jen-Tsan Chi, Donald E. Thrall, Chen Jiang, Stacey Snyder, Diane Fels, Chelsea Landon, Linda McCall, Lan Lan, Marlene Hauck, James R. MacFall, Benjamin L. Viglianti, Mark W. Dewhirst
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2549–2560.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-2583
Published: 14 April 2011
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MEK-Independent Survival of B-RAFV600E Melanoma Cells Selected for Resistance to Apoptosis Induced by the RAF Inhibitor PLX4720

Chen Chen Jiang, Fritz Lai, Rick F. Thorne, Fan Yang, Hao Liu, Peter Hersey, Xu Dong Zhang
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 721–730.
DOI: https://doi.org/10.1158/1078-0432.CCR-10-2225
Published: 15 February 2011
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Apoptosis Induction in Human Melanoma Cells by Inhibition of MEK Is Caspase-Independent and Mediated by the Bcl-2 Family Members PUMA, Bim, and Mcl-1

Yu Fang Wang, Chen Chen Jiang, Kelly Anne Kiejda, Susan Gillespie, Xu Dong Zhang, Peter Hersey
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4934–4942.
DOI: https://doi.org/10.1158/1078-0432.CCR-07-0665
Published: 15 August 2007
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Docetaxel-Induced Apoptosis of Human Melanoma Is Mediated by Activation of c-Jun NH2-Terminal Kinase and Inhibited by the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 Pathway

Nizar M. Mhaidat, Xu Dong Zhang, Chen Chen Jiang, Peter Hersey
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (4): 1308–1314.
DOI: https://doi.org/10.1158/1078-0432.CCR-06-2216
Published: 22 February 2007
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