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Charles S. Fuchs
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Journal Articles

Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)

Qiao-Li Wang, Chao Ma, Chen Yuan, Qian Shi, Brian M. Wolpin, Yin Zhang, Charles S. Fuchs, Jeffrey Meyer, Tyler Zemla, En Cheng, Priya Kumthekar, Katherine A. Guthrie, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Richard M. Goldberg, Alan Venook, Charles Blanke, Anthony F. Shields, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Kimmie Ng
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (14): 2621–2630.
https://doi.org/10.1158/1078-0432.CCR-23-0447
Published: 14 July 2023
View article titled, Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
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Includes: Supplementary data
Journal Articles

Association of Tumor Mutational Burden with Efficacy of Pembrolizumab±Chemotherapy as First-Line Therapy for Gastric Cancer in the Phase III KEYNOTE-062 Study

Keun-Wook Lee, Eric Van Cutsem, Yung-Jue Bang, Charles S. Fuchs, Iveta Kudaba, Marcelo Garrido, Hyun Cheol Chung, Jeeyun Lee, Hugo R. Castro, Joseph Chao, Zev A. Wainberg, Z. Alexander Cao, Deepti Aurora-Garg, Julie Kobie, Razvan Cristescu, Pooja Bhagia, Sukrut Shah, Josep Tabernero, Kohei Shitara, Lucjan Wyrwicz
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (16): 3489–3498.
https://doi.org/10.1158/1078-0432.CCR-22-0121
Published: 15 August 2022
View article titled, Association of Tumor Mutational Burden with Efficacy of Pembrolizumab±Chemotherapy as First-Line Therapy for Gastric Cancer in the Phase III KEYNOTE-062 Study
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Includes: Supplementary data
Journal Articles

Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment

Jennifer Borowsky, Koichiro Haruki, Mai Chan Lau, Andressa Dias Costa, Juha P. Väyrynen, Tomotaka Ugai, Kota Arima, Annacarolina da Silva, Kristen D. Felt, Melissa Zhao, Carino Gurjao, Tyler S. Twombly, Kenji Fujiyoshi, Sara A. Väyrynen, Tsuyoshi Hamada, Kosuke Mima, Susan Bullman, Tabitha A. Harrison, Amanda I. Phipps, Ulrike Peters, Kimmie Ng, Jeffrey A. Meyerhardt, Mingyang Song, Edward L. Giovannucci, Kana Wu, Xuehong Zhang, Gordon J. Freeman, Curtis Huttenhower, Wendy S. Garrett, Andrew T. Chan, Barbara A. Leggett, Vicki L.J. Whitehall, Neal Walker, Ian Brown, Mark Bettington, Reiko Nishihara, Charles S. Fuchs, Jochen K. Lennerz, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2816–2826.
https://doi.org/10.1158/1078-0432.CCR-20-4009
Published: 15 May 2021
View article titled, Association of <em>Fusobacterium nucleatum</em> with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment
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Includes: Supplementary data
Journal Articles

Efficacy of Pembrolizumab Monotherapy for Advanced Gastric/Gastroesophageal Junction Cancer with Programmed Death Ligand 1 Combined Positive Score ≥10

Zev A. Wainberg, Charles S. Fuchs, Josep Tabernero, Kohei Shitara, Kei Muro, Eric Van Cutsem, Yung-Jue Bang, Hyun Cheol Chung, Kensei Yamaguchi, Eniko Varga, Jen-Shi Chen, Daniel Hochhauser, Peter Thuss-Patience, Salah-Eddin Al-Batran, Marcelo Garrido, Uma Kher, Chie-Schin Shih, Sukrut Shah, Pooja Bhagia, Joseph Chao
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (7): 1923–1931.
https://doi.org/10.1158/1078-0432.CCR-20-2980
Published: 01 April 2021
View article titled, Efficacy of Pembrolizumab Monotherapy for Advanced Gastric/Gastroesophageal Junction Cancer with Programmed Death Ligand 1 Combined Positive Score ≥10
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Journal Articles

Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer

Sara A. Väyrynen, Jinming Zhang, Chen Yuan, Juha P. Väyrynen, Andressa Dias Costa, Hannah Williams, Vicente Morales-Oyarvide, Mai Chan Lau, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Wenjia Wang, Diana Agostini-Vulaj, Michael G. Drage, Lauren Brais, Emma Reilly, Osama Rahma, Thomas Clancy, Jiping Wang, David C. Linehan, Andrew J. Aguirre, Charles S. Fuchs, Lisa M. Coussens, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, Shuji Ogino, Jonathan A. Nowak, Brian M. Wolpin
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (4): 1069–1081.
https://doi.org/10.1158/1078-0432.CCR-20-3141
Published: 15 February 2021
View article titled, Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin–Stained Sections

Juha P. Väyrynen, Mai Chan Lau, Koichiro Haruki, Sara A. Väyrynen, Andressa Dias Costa, Jennifer Borowsky, Melissa Zhao, Kenji Fujiyoshi, Kota Arima, Tyler S. Twombly, Junko Kishikawa, Simeng Gu, Saina Aminmozaffari, Shanshan Shi, Yoshifumi Baba, Naohiko Akimoto, Tomotaka Ugai, Annacarolina Da Silva, Mingyang Song, Kana Wu, Andrew T. Chan, Reiko Nishihara, Charles S. Fuchs, Jeffrey A. Meyerhardt, Marios Giannakis, Shuji Ogino, Jonathan A. Nowak
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (16): 4326–4338.
https://doi.org/10.1158/1078-0432.CCR-20-0071
Published: 14 August 2020
View article titled, Prognostic Significance of Immune Cell Populations Identified by Machine Learning in Colorectal Cancer Using Routine Hematoxylin and Eosin–Stained Sections
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Includes: Supplementary data
Journal Articles

Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance)

Chen Yuan, Kaori Sato, Bruce W. Hollis, Sui Zhang, Donna Niedzwiecki, Fang-Shu Ou, I-Wen Chang, Bert H. O'Neil, Federico Innocenti, Heinz-Josef Lenz, Charles D. Blanke, Richard M. Goldberg, Alan P. Venook, Robert J. Mayer, Charles S. Fuchs, Jeffrey A. Meyerhardt, Kimmie Ng
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (24): 7497–7505.
https://doi.org/10.1158/1078-0432.CCR-19-0877
Published: 13 December 2019
View article titled, Plasma 25-Hydroxyvitamin D Levels and Survival in Patients with Advanced or Metastatic Colorectal Cancer: Findings from CALGB/SWOG 80405 (Alliance)
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Includes: Supplementary data
Journal Articles

A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer

James J. Harding, Andrew X. Zhu, Todd M. Bauer, Toni K. Choueiri, Alexander Drilon, Martin H. Voss, Charles S. Fuchs, Ghassan K. Abou-Alfa, Sameera R. Wijayawardana, Xuejing Aimee Wang, Brian A. Moser, Arantxa Uruñuela, Volker Wacheck, Johanna C. Bendell
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (17): 5202–5211.
https://doi.org/10.1158/1078-0432.CCR-18-4010
Published: 03 September 2019
View article titled, A Phase Ib/II Study of Ramucirumab in Combination with Emibetuzumab in Patients with Advanced Cancer
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Includes: Supplementary data
Journal Articles

Calcium Intake and Survival after Colorectal Cancer Diagnosis

Wanshui Yang, Yanan Ma, Stephanie Smith-Warner, Mingyang Song, Kana Wu, Molin Wang, Andrew T. Chan, Shuji Ogino, Charles S. Fuchs, Vitaliy Poylin, Kimmie Ng, Jeffrey A. Meyerhardt, Edward L. Giovannucci, Xuehong Zhang
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (6): 1980–1988.
https://doi.org/10.1158/1078-0432.CCR-18-2965
Published: 15 March 2019
View article titled, Calcium Intake and Survival after Colorectal Cancer Diagnosis
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Includes: Supplementary data
Journal Articles

Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma

Kent W. Mouw, James M. Cleary, Brendan Reardon, Jonathan Pike, Lior Z. Braunstein, Jaegil Kim, Ali Amin-Mansour, Diana Miao, Alexis Damish, Joanna Chin, Patrick A. Ott, Charles S. Fuchs, Neil E. Martin, Gad Getz, Scott Carter, Harvey J. Mamon, Jason L. Hornick, Eliezer M. Van Allen, Alan D. D'Andrea
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): 3214–3222.
https://doi.org/10.1158/1078-0432.CCR-16-2017
Published: 14 June 2017
View article titled, Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract B13: Human pancreatic cancer organoids for functional dependency profiling

Srivatsan Raghavan, Shubhroz Gill, Andrew J. Aguirre, Yuen-Yi M. Tseng, Anson Peng, Paula Keskula, Xiaoyun Wu, Coyin Oh, Jamie Cheah, Gregory Kryukov, Ewa Sicinska, Brian M. Wolpin, Matthew H. Kulke, Charles S. Fuchs, Paul Clemons, Todd R. Golub, Stuart Schreiber, Jesse S. Boehm, William C. Hahn
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): B13.
https://doi.org/10.1158/1557-3265.PDX16-B13
Published: 15 August 2016
View article titled, Abstract B13: Human pancreatic cancer organoids for functional dependency profiling
Journal Articles

MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival

Kosuke Mima, Reiko Nishihara, Juhong Yang, Ruoxu Dou, Yohei Masugi, Yan Shi, Annacarolina da Silva, Yin Cao, Mingyang Song, Jonathan Nowak, Mancang Gu, Wanwan Li, Teppei Morikawa, Xuehong Zhang, Kana Wu, Hideo Baba, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Andrew T. Chan, Charles S. Fuchs, Zhi Rong Qian, Shuji Ogino
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (15): 3841–3848.
https://doi.org/10.1158/1078-0432.CCR-15-2173
Published: 31 July 2016
View article titled, MicroRNA <em>MIR21</em> (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival
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Includes: Supplementary data
Journal Articles

Prognostic Utility of Molecular Factors by Age at Diagnosis of Colorectal Cancer

Nadine J. McCleary, Kaori Sato, Reiko Nishihara, Kentaro Inamura, Teppei Morikawa, Xuehong Zhang, Kana Wu, Mai Yamauchi, Sun A. Kim, Yasutaka Sukawa, Kosuke Mima, Zhi Rong Qian, Charles S. Fuchs, Shuji Ogino, Jeffrey A. Meyerhardt
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (6): 1489–1498.
https://doi.org/10.1158/1078-0432.CCR-15-0946
Published: 14 March 2016
View article titled, Prognostic Utility of Molecular Factors by Age at Diagnosis of Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Putative Predictive Biomarkers of Survival in Patients with Metastatic Pancreatic Adenocarcinoma Treated with Gemcitabine and Ganitumab, an IGF1R Inhibitor

Ian McCaffery, Yanyan Tudor, Hongjie Deng, Rui Tang, Samuel Suzuki, Sunita Badola, Hedy L. Kindler, Charles S. Fuchs, Elwyn Loh, Scott D. Patterson, Li Chen, Jennifer L. Gansert
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (15): 4282–4289.
https://doi.org/10.1158/1078-0432.CCR-12-1840
Published: 31 July 2013
View article titled, Putative Predictive Biomarkers of Survival in Patients with Metastatic Pancreatic Adenocarcinoma Treated with Gemcitabine and Ganitumab, an IGF1R Inhibitor
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Includes: Supplementary data
Journal Articles

Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens

Kimmie Ng, Josep Tabernero, Jimmy Hwang, Emilio Bajetta, Sunil Sharma, Salvatore A. Del Prete, Edward R. Arrowsmith, David P. Ryan, Michaela Sedova, Jin Jin, Kamel Malek, Charles S. Fuchs
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (14): 3987–3995.
https://doi.org/10.1158/1078-0432.CCR-13-0027
Published: 15 July 2013
View article titled, Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens
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Journal Articles

Efficacy, Safety, Pharmacokinetics, and Biomarkers of Cediranib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study

Andrew X. Zhu, Marek Ancukiewicz, Jeffrey G. Supko, Dushyant V. Sahani, Lawrence S. Blaszkowsky, Jeffrey A. Meyerhardt, Thomas A. Abrams, Nadine Jackson McCleary, Pankaj Bhargava, Alona Muzikansky, Susan Sheehan, Eileen Regan, Eamala Vasudev, Michelle Knowles, Charles S. Fuchs, David P. Ryan, Rakesh K. Jain, Dan G. Duda
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1557–1566.
https://doi.org/10.1158/1078-0432.CCR-12-3041
Published: 14 March 2013
View article titled, Efficacy, Safety, Pharmacokinetics, and Biomarkers of Cediranib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study
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Includes: Supplementary data
Journal Articles

Expression Profiling of Archival Tumors for Long-term Health Studies

Levi Waldron, Shuji Ogino, Yujin Hoshida, Kaori Shima, Amy E. McCart Reed, Peter T. Simpson, Yoshifumi Baba, Katsuhiko Nosho, Nicola Segata, Ana Cristina Vargas, Margaret C. Cummings, Sunil R. Lakhani, Gregory J. Kirkner, Edward Giovannucci, John Quackenbush, Todd R. Golub, Charles S. Fuchs, Giovanni Parmigiani, Curtis Huttenhower
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (22): 6136–6146.
https://doi.org/10.1158/1078-0432.CCR-12-1915
Published: 14 November 2012
View article titled, Expression Profiling of Archival Tumors for Long-term Health Studies
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Includes: Supplementary data
Journal Articles

Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers

Yu Imamura, Teppei Morikawa, Xiaoyun Liao, Paul Lochhead, Aya Kuchiba, Mai Yamauchi, Zhi Rong Qian, Reiko Nishihara, Jeffrey A. Meyerhardt, Kevin M. Haigis, Charles S. Fuchs, Shuji Ogino
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (17): 4753–4763.
https://doi.org/10.1158/1078-0432.CCR-11-3210
Published: 30 August 2012
View article titled, Specific Mutations in <em>KRAS</em> Codons 12 and 13, and Patient Prognosis in 1075 <em>BRAF</em> Wild-Type Colorectal Cancers
Open the PDF for Specific Mutations in <em>KRAS</em> Codons 12 and 13, and Patient Prognosis in 1075 <em>BRAF</em> Wild-Type Colorectal Cancers in another window
Includes: Supplementary data
Journal Articles

Prognostic Role of PIK3CA Mutation in Colorectal Cancer: Cohort Study and Literature Review

Xiaoyun Liao, Teppei Morikawa, Paul Lochhead, Yu Imamura, Aya Kuchiba, Mai Yamauchi, Katsuhiko Nosho, Zhi Rong Qian, Reiko Nishihara, Jeffrey A. Meyerhardt, Charles S. Fuchs, Shuji Ogino
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (8): 2257–2268.
https://doi.org/10.1158/1078-0432.CCR-11-2410
Published: 16 April 2012
View article titled, Prognostic Role of <em>PIK3CA</em> Mutation in Colorectal Cancer: Cohort Study and Literature Review
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Includes: Supplementary data
Journal Articles

Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

Shuji Ogino, Kaori Shima, Jeffrey A. Meyerhardt, Nadine J. McCleary, Kimmie Ng, Donna Hollis, Leonard B. Saltz, Robert J. Mayer, Paul Schaefer, Renaud Whittom, Alexander Hantel, Al B. Benson, III, Donna Spiegelman, Richard M. Goldberg, Monica M. Bertagnolli, Charles S. Fuchs
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 890–900.
https://doi.org/10.1158/1078-0432.CCR-11-2246
Published: 31 January 2012
View article titled, Predictive and Prognostic Roles of <em>BRAF</em> Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803
Open the PDF for Predictive and Prognostic Roles of <em>BRAF</em> Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803 in another window
Includes: Supplementary data