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Charles M. Rudin
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Journal Articles

A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer

Noura J. Choudhury, W. Victoria Lai, Alex Makhnin, Glenn Heller, Juliana Eng, Bob Li, Isabel Preeshagul, Fernando C. Santini, Michael Offin, Kenneth Ng, Paul Paik, Christina Larsen, Michelle S. Ginsberg, Yvonne Lau, Xinyuan Zhang, Marina K. Baine, Natasha Rekhtman, Charles M. Rudin
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3697–3703.
https://doi.org/10.1158/1078-0432.CCR-23-3383
Published: 03 September 2024
View article titled, A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer

Rohit Thummalapalli, Biagio Ricciuti, Chaitanya Bandlamudi, Daniel Muldoon, Hira Rizvi, Arielle Elkrief, Jia Luo, Joao V. Alessi, Federica Pecci, Giuseppe Lamberti, Alessandro Di Federico, Lingzhi Hong, Jianjun Zhang, John V. Heymach, Don L. Gibbons, Andrew J. Plodkowski, Vignesh Ravichandran, Mark T.A. Donoghue, Chad Vanderbilt, Marc Ladanyi, Charles M. Rudin, Mark G. Kris, Gregory J. Riely, Jamie E. Chaft, Matthew D. Hellmann, Natalie I. Vokes, Mark M. Awad, Adam J. Schoenfeld
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4408–4418.
https://doi.org/10.1158/1078-0432.CCR-23-1207
Published: 01 November 2023
View article titled, Clinical and Molecular Features of Long-term Response to Immune Checkpoint Inhibitors in Patients with Advanced Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

De Novo and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways

Subhamoy Chakraborty, Charles Coleman, Parvathy Manoj, Deniz Demircioglu, Nisargbhai Shah, Elisa de Stanchina, Charles M. Rudin, Dan Hasson, Triparna Sen
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3526–3540.
https://doi.org/10.1158/1078-0432.CCR-23-0471
Published: 01 September 2023
View article titled, <em>De Novo</em> and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways
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Includes: Supplementary data
Journal Articles

Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset

Christopher A. Febres-Aldana, Jason C. Chang, Ryan Ptashkin, Yuhan Wang, Erika Gedvilaite, Marina K. Baine, William D. Travis, Katia Ventura, Francis Bodd, Helena A. Yu, Alvaro Quintanal-Villalonga, W. Victoria Lai, Jacklynn V. Egger, Michael Offin, Marc Ladanyi, Charles M. Rudin, Natasha Rekhtman
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4702–4713.
https://doi.org/10.1158/1078-0432.CCR-22-1115
Published: 01 November 2022
View article titled, Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset
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Includes: Supplementary data
Journal Articles

Systemic and Oligo-Acquired Resistance to PD-(L)1 Blockade in Lung Cancer

Adam J. Schoenfeld, Hira A. Rizvi, Danish Memon, Narek Shaverdian, Matthew J. Bott, Jennifer L. Sauter, C. Jillian Tsai, Jayon Lihm, David Hoyos, Andrew J. Plodkowski, Rocio Perez-Johnston, Peter Sawan, Jacklynn V. Egger, Benjamin D. Greenbaum, Andreas Rimner, Gregory J. Riely, Charles M. Rudin, Valerie W. Rusch, Daniel R. Gomez, Matthew D. Hellmann
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3797–3803.
https://doi.org/10.1158/1078-0432.CCR-22-0657
Published: 01 September 2022
View article titled, Systemic and Oligo-Acquired Resistance to PD-(L)1 Blockade in Lung Cancer
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Includes: Supplementary data
Journal Articles

Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma

Virginia Aragon-Sanabria, Anusha Aditya, Li Zhang, Feng Chen, Barney Yoo, Tianye Cao, Brian Madajewski, Rachel Lee, Melik Z. Turker, Kai Ma, Sebastien Monette, Peiming Chen, Jing Wu, Shutian Ruan, Michael Overholtzer, Pat Zanzonico, Charles M. Rudin, Cameron Brennan, Ulrich Wiesner, Michelle S. Bradbury
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2938–2952.
https://doi.org/10.1158/1078-0432.CCR-21-4053
Published: 01 July 2022
View article titled, Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma
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Includes: Supplementary data
Journal Articles

Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity

Kathryn M. Tully, Salomon Tendler, Lukas M. Carter, Sai Kiran Sharma, Zachary V. Samuels, Komal Mandleywala, Joshua A. Korsen, Avelyn Mae Delos Reyes, Alessandra Piersigilli, William D. Travis, Triparna Sen, Nagavarakishore Pillarsetty, John T. Poirier, Charles M. Rudin, Jason S. Lewis
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (7): 1391–1401.
https://doi.org/10.1158/1078-0432.CCR-21-1533
Published: 01 April 2022
View article titled, Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity
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Includes: Supplementary data
Journal Articles

Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions

Noura J. Choudhury, Adam J. Schoenfeld, Jessica Flynn, Christina J. Falcon, Hira Rizvi, Charles M. Rudin, Mark G. Kris, Maria E. Arcila, Glenn Heller, Helena A. Yu, Marc Ladanyi, Gregory J. Riely
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (10): 2920–2927.
https://doi.org/10.1158/1078-0432.CCR-20-4650
Published: 15 May 2021
View article titled, Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with <em>EGFR</em> Exon 20 Insertions
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Includes: Supplementary data
Journal Articles

KRASG12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma

Gregory D. Jones, Raul Caso, Kay See Tan, Brooke Mastrogiacomo, Francisco Sanchez-Vega, Yuan Liu, James G. Connolly, Yonina R. Murciano-Goroff, Matthew J. Bott, Prasad S. Adusumilli, Daniela Molena, Gaetano Rocco, Valerie W. Rusch, Smita Sihag, Sandra Misale, Rona Yaeger, Alexander Drilon, Kathryn C. Arbour, Gregory J. Riely, Neal Rosen, Piro Lito, Haiying Zhang, David C. Lyden, Charles M. Rudin, David R. Jones, Bob T. Li, James M. Isbell
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2604–2612.
https://doi.org/10.1158/1078-0432.CCR-20-4772
Published: 01 May 2021
View article titled, <em>KRAS</em><sup>G12C</sup> Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer

Kathryn C. Arbour, Hira Rizvi, Andrew J. Plodkowski, Matthew D. Hellmann, Andrea Knezevic, Glenn Heller, Helena A. Yu, Marc Ladanyi, Mark G. Kris, Maria E. Arcila, Charles M. Rudin, Piro Lito, Gregory J. Riely
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2209–2215.
https://doi.org/10.1158/1078-0432.CCR-20-4023
Published: 15 April 2021
View article titled, Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C–Mutant Non–Small Cell Lung Cancer
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Journal Articles

Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer

Sabine Topka, Zoe Steinsnyder, Vignesh Ravichandran, Kaitlyn Tkachuk, Yelena Kemel, Chaitanya Bandlamudi, Mogens Winkel Madsen, Helena Furberg, Ouathek Ouerfelli, Charles M. Rudin, Gopa Iyer, Steven M. Lipkin, Semanti Mukherjee, David B. Solit, Michael F. Berger, Dean F. Bajorin, Jonathan E. Rosenberg, Barry S. Taylor, Elisa de Stanchina, Joseph Vijai, Kenneth Offit
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (7): 1997–2010.
https://doi.org/10.1158/1078-0432.CCR-20-3322
Published: 01 April 2021
View article titled, Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer
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Includes: Supplementary data
Journal Articles

MET Exon 14–altered Lung Cancers and MET Inhibitor Resistance

Robin Guo, Michael Offin, A. Rose Brannon, Jason Chang, Andrew Chow, Lukas Delasos, Jeffrey Girshman, Olivia Wilkins, Caroline G. McCarthy, Alex Makhnin, Christina Falcon, Kerry Scott, Yuan Tian, Fabiola Cecchi, Todd Hembrough, Deepu Alex, Ronglai Shen, Ryma Benayed, Bob T. Li, Charles M. Rudin, Mark G. Kris, Maria E. Arcila, Natasha Rekhtman, Paul Paik, Ahmet Zehir, Alexander Drilon
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3): 799–806.
https://doi.org/10.1158/1078-0432.CCR-20-2861
Published: 01 February 2021
View article titled, <em>MET</em> Exon 14–altered Lung Cancers and MET Inhibitor Resistance
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Includes: Supplementary data
Journal Articles

A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy

Brian H. Santich, Sarah M. Cheal, Mahiuddin Ahmed, Michael R. McDevitt, Ouathek Ouerfelli, Guangbin Yang, Darren R. Veach, Edward K. Fung, Mitesh Patel, Daniela Burnes Vargas, Aiza A. Malik, Hong-Fen Guo, Pat B. Zanzonico, Sebastien Monette, Adam O. Michel, Charles M. Rudin, Steven M. Larson, Nai K. Cheung
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (2): 532–541.
https://doi.org/10.1158/1078-0432.CCR-20-2150
Published: 19 January 2021
View article titled, A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy
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Includes: Multimedia, Supplementary data
Journal Articles

The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer

Adam J. Schoenfeld, Chai Bandlamudi, Jessica A. Lavery, Joseph Montecalvo, Azadeh Namakydoust, Hira Rizvi, Jacklynn Egger, Carla P. Concepcion, Sonal Paul, Maria E. Arcila, Yahya Daneshbod, Jason Chang, Jennifer L. Sauter, Amanda Beras, Marc Ladanyi, Tyler Jacks, Charles M. Rudin, Barry S. Taylor, Mark T.A. Donoghue, Glenn Heller, Matthew D. Hellmann, Natasha Rekhtman, Gregory J. Riely
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (21): 5701–5708.
https://doi.org/10.1158/1078-0432.CCR-20-1825
Published: 02 November 2020
View article titled, The Genomic Landscape of <em>SMARCA4</em> Alterations and Associations with Outcomes in Patients with Lung Cancer
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Includes: Supplementary data
Journal Articles

Molecular Engineering of Ultrasmall Silica Nanoparticle–Drug Conjugates as Lung Cancer Therapeutics

Brian Madajewski, Feng Chen, Barney Yoo, Melik Z. Turker, Kai Ma, Li Zhang, Pei-Ming Chen, Rupa Juthani, Virginia Aragon-Sanabria, Mithat Gonen, Charles M. Rudin, Ulrich Wiesner, Michelle S. Bradbury, Cameron Brennan
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (20): 5424–5437.
https://doi.org/10.1158/1078-0432.CCR-20-0851
Published: 15 October 2020
View article titled, Molecular Engineering of Ultrasmall Silica Nanoparticle–Drug Conjugates as Lung Cancer Therapeutics
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Includes: Supplementary data
Journal Articles

Abstract 12: Characterizing KRAS G12C and other mutations in plasma ctDNA from patients with lung cancer

Yonina R. Murciano-Goroff, Emily S. Lebow, Hai-Yan Tu, Mark Li, Lee P. Lim, Kathryn C. Arbour, William Travis, David B. Solit, Marc Ladanyi, David R. Jones, Charles M. Rudin, Andres Martinez, Mackenzie L. Myers, Alexander Makhnin, Pedram Razavi, Michael D. Offin, James W. Isbell, Gregory J. Riely, David M. Hyman, Piro Lito, Bob T. Li
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_1): 12.
https://doi.org/10.1158/1557-3265.ADVPRECMED20-12
Published: 15 June 2020
View article titled, Abstract 12: Characterizing KRAS G12C and other mutations in plasma ctDNA from patients with lung cancer
Journal Articles

Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC

Matthew D. Hellmann, Barzin Y. Nabet, Hira Rizvi, Aadel A. Chaudhuri, Daniel K. Wells, Mark P.S. Dunphy, Jacob J. Chabon, Chih Long Liu, Angela B. Hui, Kathryn C. Arbour, Jia Luo, Isabel R. Preeshagul, Everett J. Moding, Diego Almanza, Rene F. Bonilla, Jennifer L. Sauter, Hyejin Choi, Megan Tenet, Mohsen Abu-Akeel, Andrew J. Plodkowski, Rocio Perez Johnston, Christopher H. Yoo, Ryan B. Ko, Henning Stehr, Linda Gojenola, Heather A. Wakelee, Sukhmani K. Padda, Joel W. Neal, Jamie E. Chaft, Mark G. Kris, Charles M. Rudin, Taha Merghoub, Bob T. Li, Ash A. Alizadeh, Maximilian Diehn
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12): 2849–2858.
https://doi.org/10.1158/1078-0432.CCR-19-3418
Published: 15 June 2020
View article titled, Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC
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Includes: Supplementary data
Journal Articles

A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers

Paul K. Paik, Rachel K. Kim, Linda Ahn, Andrew J. Plodkowski, Ai Ni, Mark T.A. Donoghue, Philip Jonsson, Miguel Villalona-Calero, Kenneth Ng, Daniel McFarland, John J. Fiore, Afsheen Iqbal, Juliana Eng, Mark G. Kris, Charles M. Rudin
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 1796–1802.
https://doi.org/10.1158/1078-0432.CCR-19-3060
Published: 15 April 2020
View article titled, A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers
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Includes: Supplementary data
Journal Articles

Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model

Rupa Juthani, Brian Madajewski, Barney Yoo, Li Zhang, Pei-Ming Chen, Feng Chen, Melik Z. Turker, Kai Ma, Michael Overholtzer, Valerie A. Longo, Sean Carlin, Virginia Aragon-Sanabria, Jason Huse, Mithat Gonen, Pat Zanzonico, Charles M. Rudin, Ulrich Wiesner, Michelle S. Bradbury, Cameron W. Brennan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (1): 147–158.
https://doi.org/10.1158/1078-0432.CCR-19-1834
Published: 03 January 2020
View article titled, Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model
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Includes: Multimedia, Supplementary data
Journal Articles

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance

Himisha Beltran, Andrew Hruszkewycz, Howard I. Scher, Jeffrey Hildesheim, Jennifer Isaacs, Evan Y. Yu, Kathleen Kelly, Daniel Lin, Adam Dicker, Julia Arnold, Toby Hecht, Max Wicha, Rosalie Sears, David Rowley, Richard White, James L. Gulley, John Lee, Maria Diaz Meco, Eric J. Small, Michael Shen, Karen Knudsen, David W. Goodrich, Tamara Lotan, Amina Zoubeidi, Charles L. Sawyers, Charles M. Rudin, Massimo Loda, Timothy Thompson, Mark A. Rubin, Abdul Tawab-Amiri, William Dahut, Peter S. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 6916–6924.
https://doi.org/10.1158/1078-0432.CCR-19-1423
Published: 02 December 2019
View article titled, The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
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Includes: Supplementary data