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Charles L. Sawyers
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Journal Articles

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance

Himisha Beltran, Andrew Hruszkewycz, Howard I. Scher, Jeffrey Hildesheim, Jennifer Isaacs, Evan Y. Yu, Kathleen Kelly, Daniel Lin, Adam Dicker, Julia Arnold, Toby Hecht, Max Wicha, Rosalie Sears, David Rowley, Richard White, James L. Gulley, John Lee, Maria Diaz Meco, Eric J. Small, Michael Shen, Karen Knudsen, David W. Goodrich, Tamara Lotan, Amina Zoubeidi, Charles L. Sawyers, Charles M. Rudin, Massimo Loda, Timothy Thompson, Mark A. Rubin, Abdul Tawab-Amiri, William Dahut, Peter S. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 6916–6924.
https://doi.org/10.1158/1078-0432.CCR-19-1423
Published: 02 December 2019
View article titled, The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
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Includes: Supplementary data
Journal Articles

SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance

Isaac Wasserman, Lik Hang Lee, Shuji Ogino, Michael R. Marco, Chao Wu, Xi Chen, Jashodeep Datta, Eran Sadot, Bryan Szeglin, Jose G. Guillem, Philip B. Paty, Martin R. Weiser, Garrett M. Nash, Leonard Saltz, Afsar Barlas, Katia Manova-Todorova, Srijaya Prakash Babu Uppada, Arthur E. Elghouayel, Peter Ntiamoah, Jonathan N. Glickman, Tsuyoshi Hamada, Keisuke Kosumi, Kentaro Inamura, Andrew T. Chan, Reiko Nishihara, Andrea Cercek, Karuna Ganesh, Nancy E. Kemeny, Punita Dhawan, Rona Yaeger, Charles L. Sawyers, Julio Garcia-Aguilar, Marios Giannakis, Jinru Shia, J. Joshua Smith
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (6): 1948–1956.
https://doi.org/10.1158/1078-0432.CCR-18-1726
Published: 15 March 2019
View article titled, SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance
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Includes: Supplementary data
Journal Articles

Abstract IA22: Reflections on precision medicine

Charles L. Sawyers
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): IA22.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-IA22
Published: 03 January 2016
View article titled, Abstract IA22: Reflections on precision medicine
Journal Articles

Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: A Policy Statement from the American Association for Cancer Research

Charles L. Sawyers, Laura J. van ‘t Veer
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (19): 4978–4981.
https://doi.org/10.1158/1078-0432.CCR-14-2295
Published: 30 September 2014
View article titled, Reliable and Effective Diagnostics Are Keys to Accelerating Personalized Cancer Medicine and Transforming Cancer Care: A Policy Statement from the American Association for Cancer Research
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Journal Articles

AACR Cancer Progress Report 2013

Charles L. Sawyers, Cory Abate-Shen, Kenneth C. Anderson, Anna Barker, Jose Baselga, Nathan A. Berger, Margaret Foti, Ahmedin Jemal, Theodore S. Lawrence, Christopher I. Li, Elaine R. Mardis, Peter J. Neumann, Drew M. Pardoll, George C. Prendergast, John C. Reed, George J. Weiner
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20_Supplement): S1–S98.
https://doi.org/10.1158/1078-0432.CCR-13-2107
Published: 15 October 2013
View article titled, AACR Cancer Progress Report 2013
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Includes: Supplementary data
Journal Articles

Developing Standards for Breakthrough Therapy Designation in Oncology

Sandra J. Horning, Daniel A. Haber, Wendy K.D. Selig, S. Percy Ivy, Samantha A. Roberts, Jeff D. Allen, Ellen V. Sigal, Charles L. Sawyers
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (16): 4297–4304.
https://doi.org/10.1158/1078-0432.CCR-13-0523
Published: 13 August 2013
View article titled, Developing Standards for Breakthrough Therapy Designation in Oncology
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Includes: Supplementary data
Journal Articles

Pretreatment EGFR T790M Mutation and BRCA1 mRNA Expression in Erlotinib-Treated Advanced Non–Small-Cell Lung Cancer Patients with EGFR Mutations

Rafael Rosell, Miguel Angel Molina, Carlota Costa, Sara Simonetti, Ana Gimenez-Capitan, Jordi Bertran-Alamillo, Clara Mayo, Teresa Moran, Pedro Mendez, Felipe Cardenal, Dolores Isla, Mariano Provencio, Manuel Cobo, Amelia Insa, Rosario Garcia-Campelo, Noemi Reguart, Margarita Majem, Santiago Viteri, Enric Carcereny, Ruth Porta, Bartomeu Massuti, Cristina Queralt, Itziar de Aguirre, Jose Miguel Sanchez, Maria Sanchez-Ronco, Jose Luis Mate, Aurelio Ariza, Susana Benlloch, Jose Javier Sanchez, Trever G Bivona, Charles L Sawyers, Miquel Taron
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (5): 1160–1168.
https://doi.org/10.1158/1078-0432.CCR-10-2158
Published: 01 March 2011
View article titled, Pretreatment EGFR T790M Mutation and BRCA1 mRNA Expression in Erlotinib-Treated Advanced Non–Small-Cell Lung Cancer Patients with EGFR Mutations
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Includes: Supplementary data
Journal Articles

Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer

George V. Thomas, Steve Horvath, Bradley L. Smith, Katherine Crosby, Lori A. Lebel, Matthew Schrage, Jonathan Said, Jean De Kernion, Robert E. Reiter, Charles L. Sawyers
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8351–8356.
https://doi.org/10.1158/1078-0432.CCR-04-0130
Published: 28 December 2004
View article titled, Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer
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Includes: Supplementary data
Journal Articles

A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and Is Effective against STI571-resistant Bcr-abl Mutants

David R. Huron, Mercedes E. Gorre, Alan J. Kraker, Charles L. Sawyers, Neal Rosen, Mark M. Moasser
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1267–1273.
Published: 01 April 2003
View article titled, A Novel Pyridopyrimidine Inhibitor of Abl Kinase Is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and Is Effective against STI571-resistant Bcr-abl Mutants
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