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Charles G. Mullighan
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Journal Articles

Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Jonathan Paolino, Boris Dimitrov, Beth Apsel Winger, Angelica Sandoval-Perez, Amith Vikram Rangarajan, Nicole Ocasio-Martinez, Harrison K. Tsai, Yuting Li, Amanda L. Robichaud, Delan Khalid, Charlie Hatton, Riaz Gillani, Petri Polonen, Anthony Dilig, Giacomo Gotti, Julia Kavanagh, Asmani A. Adhav, Sean Gow, Jonathan Tsai, Yen Der Li, Benjamin L. Ebert, Eliezer M. Van Allen, Jacob Bledsoe, Annette S. Kim, Sarah K. Tasian, Stacy L. Cooper, Todd M. Cooper, Nobuko Hijiya, Maria Luisa Sulis, Neerav N. Shukla, Jeffrey A. Magee, Charles G. Mullighan, Michael J. Burke, Marlise R. Luskin, Brenton G. Mar, Matthew P. Jacobson, Marian H. Harris, Kimberly Stegmaier, Andrew E. Place, Yana Pikman
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (22): 4613–4626.
https://doi.org/10.1158/1078-0432.CCR-22-2562
Published: 14 November 2023
View article titled, Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Open the PDF for Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma in another window
Includes: Supplementary data
Journal Articles

OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL

Kathryn Evans, JianXin Duan, Tara Pritchard, Connor D. Jones, Lisa McDermott, Zhaohui Gu, Cara E. Toscan, Narimanne El-Zein, Chelsea Mayoh, Stephen W. Erickson, Yuelong Guo, Fanying Meng, Donald Jung, Komal S. Rathi, Kathryn G. Roberts, Charles G. Mullighan, Chi-Sheng Shia, Tillman Pearce, Beverly A. Teicher, Malcolm A. Smith, Richard B. Lock
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4493–4503.
https://doi.org/10.1158/1078-0432.CCR-19-0551
Published: 15 July 2019
View article titled, OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL
Open the PDF for OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL in another window
Includes: Supplementary data
Journal Articles

Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL+ B-Lineage Acute Lymphoblastic Leukemia

Amit Budhraja, Meghan E. Turnis, Michelle L. Churchman, Anisha Kothari, Xue Yang, Haiyan Xu, Ewa Kaminska, John C. Panetta, David Finkelstein, Charles G. Mullighan, Joseph T. Opferman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (24): 7558–7568.
https://doi.org/10.1158/1078-0432.CCR-17-1231
Published: 14 December 2017
View article titled, Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL<sup>+</sup> B-Lineage Acute Lymphoblastic Leukemia
Open the PDF for Modulation of Navitoclax Sensitivity by Dihydroartemisinin-Mediated MCL-1 Repression in BCR-ABL<sup>+</sup> B-Lineage Acute Lymphoblastic Leukemia in another window
Includes: Supplementary data
Journal Articles

Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome

Christian P. Kratz, Maria Isabel Achatz, Laurence Brugières, Thierry Frebourg, Judy E. Garber, Mary-Louise C. Greer, Jordan R. Hansford, Katherine A. Janeway, Wendy K. Kohlmann, Rose McGee, Charles G. Mullighan, Kenan Onel, Kristian W. Pajtler, Stefan M. Pfister, Sharon A. Savage, Joshua D. Schiffman, Katherine A. Schneider, Louise C. Strong, D. Gareth R. Evans, Jonathan D. Wasserman, Anita Villani, David Malkin
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11): e38–e45.
https://doi.org/10.1158/1078-0432.CCR-17-0408
Published: 31 May 2017
View article titled, Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome
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Journal Articles

Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group

Ariadne H.A.G. Ooms, Samantha Gadd, Daniela S. Gerhard, Malcolm A. Smith, Jaime M. Guidry Auvil, Daoud Meerzaman, Qing-Rong Chen, Chih Hao Hsu, Chunhua Yan, Cu Nguyen, Ying Hu, Yussanne Ma, Zusheng Zong, Andrew J. Mungall, Richard A. Moore, Marco A. Marra, Vicki Huff, Jeffrey S. Dome, Yueh-Yun Chi, Jing Tian, James I. Geller, Charles G. Mullighan, Jing Ma, David A. Wheeler, Oliver A. Hampton, Amy L. Walz, Marry M. van den Heuvel-Eibrink, Ronald R. de Krijger, Nicole Ross, Julie M. Gastier-Foster, Elizabeth J. Perlman
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (22): 5582–5591.
https://doi.org/10.1158/1078-0432.CCR-16-0985
Published: 14 November 2016
View article titled, Significance of <em>TP53</em> Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group
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Includes: Supplementary data
Journal Articles

Abstract IA02: Precision medicine in acute lymphoblastic leukemia

Charles G. Mullighan
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): IA02.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-IA02
Published: 03 January 2016
View article titled, Abstract IA02: Precision medicine in acute lymphoblastic leukemia
Journal Articles

Abstract B04: Investigating the use of tyrosine kinase inhibitors in Ph-like ALL.

Kathryn G. Roberts, Yung-Li Yang, Debbie Payne-Turner, Richard C. Harvey, I-Ming Chen, Julie M. Gastier-Foster, Mignon L. Loh, Cheryl L. Willman, Stephen P. Hunger, Charles G. Mullighan
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): B04.
https://doi.org/10.1158/1557-3265.HEMMAL14-B04
Published: 19 August 2015
View article titled, Abstract B04: Investigating the use of tyrosine kinase inhibitors in Ph-like ALL.
Journal Articles

Abstract PR02: Investigating the use of tyrosine kinase inhibitors in Ph-like ALL.

Kathryn G. Roberts, Yung-Li Yang, Debbie Payne-Turner, Richard C. Harvey, I-Ming Chen, Julie M. Gastier-Foster, Mignon L. Loh, Cheryl L. Willman, Stephen P. Hunger, Charles G. Mullighan
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): PR02.
https://doi.org/10.1158/1557-3265.HEMMAL14-PR02
Published: 19 August 2015
View article titled, Abstract PR02: Investigating the use of tyrosine kinase inhibitors in Ph-like ALL.
Journal Articles

Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia

Sharyn D. Baker, Eric I. Zimmerman, Yong-Dong Wang, Shelley Orwick, Douglas S. Zatechka, Jassada Buaboonnam, Geoffrey A. Neale, Scott R. Olsen, Eric J. Enemark, Sheila Shurtleff, Jeffrey E. Rubnitz, Charles G. Mullighan, Hiroto Inaba
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5758–5768.
https://doi.org/10.1158/1078-0432.CCR-13-1323
Published: 14 October 2013
View article titled, Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia
Open the PDF for Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Advances in the Genetics of High-Risk Childhood B-Progenitor Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia: Implications for Therapy

Mignon L. Loh, Charles G. Mullighan
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10): 2754–2767.
https://doi.org/10.1158/1078-0432.CCR-11-1936
Published: 14 May 2012
View article titled, Advances in the Genetics of High-Risk Childhood B-Progenitor Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia: Implications for Therapy
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Journal Articles

New Strategies in Acute Lymphoblastic Leukemia: Translating Advances in Genomics into Clinical Practice

Charles G. Mullighan
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (3): 396–400.
https://doi.org/10.1158/1078-0432.CCR-10-1203
Published: 01 February 2011
View article titled, New Strategies in Acute Lymphoblastic Leukemia: Translating Advances in Genomics into Clinical Practice
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