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Journal Articles

Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs

Amy K. LeBlanc, Christina N. Mazcko, Aswini Cherukuri, Erika P. Berger, William C. Kisseberth, Megan E. Brown, Susan E. Lana, Kristen Weishaar, Brian K. Flesner, Jeffrey N. Bryan, David M. Vail, Jenna H. Burton, Jennifer L. Willcox, Anthony J. Mutsaers, J. Paul Woods, Nicole C. Northrup, Corey Saba, Kaitlin M. Curran, Haley Leeper, Heather Wilson-Robles, Brandan G. Wustefeld-Janssens, Stephanie Lindley, Annette N. Smith, Nikolaos Dervisis, Shawna Klahn, Mary Lynn Higginbotham, Raelene M. Wouda, Erika Krick, Jennifer A. Mahoney, Cheryl A. London, Lisa G. Barber, Cheryl E. Balkman, Angela L. McCleary-Wheeler, Steven E. Suter, Olya Martin, Antonella Borgatti, Kristine Burgess, Michael O. Childress, Janean L. Fidel, Sara D. Allstadt, Daniel L. Gustafson, Laura E. Selmic, Chand Khanna, Timothy M. Fan
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (11): 3005–3016.
https://doi.org/10.1158/1078-0432.CCR-21-0315
Published: 01 June 2021
View articletitled, Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs
Open the PDF for Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs in another window
Includes: Supplementary data
Journal Articles

NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma

Jenna H. Burton, Christina Mazcko, Amy LeBlanc, Joseph M. Covey, Jiuping Ji, Robert J. Kinders, Ralph E. Parchment, Chand Khanna, Melissa Paoloni, Sue Lana, Kristen Weishaar, Cheryl London, William Kisseberth, Erika Krick, David Vail, Michael Childress, Jeffrey N. Bryan, Lisa Barber, E.J. Ehrhart, Michael Kent, Timothy Fan, Kelvin Kow, Nicole Northup, Heather Wilson-Robles, Joseph Tomaszewski, Julianne L. Holleran, Miguel Muzzio, Julie Eiseman, Jan H. Beumer, James H. Doroshow, Yves Pommier
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 5830–5840.
https://doi.org/10.1158/1078-0432.CCR-18-1498
Published: 03 December 2018
View articletitled, NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma
Open the PDF for NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma in another window
Includes: Supplementary data
Journal Articles

mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo

James J. Morrow, Arnulfo Mendoza, Allyson Koyen, Michael M. Lizardo, Ling Ren, Timothy J. Waybright, Ryan J. Hansen, Daniel L. Gustafson, Ming Zhou, Timothy M. Fan, Peter C. Scacheri, Chand Khanna
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (24): 6129–6141.
https://doi.org/10.1158/1078-0432.CCR-16-0326
Published: 15 December 2016
View articletitled, mTOR Inhibition Mitigates Enhanced mRNA Translation Associated with the Metastatic Phenotype of Osteosarcoma Cells In Vivo
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Includes: Supplementary data
Journal Articles

Defining the Value of a Comparative Approach to Cancer Drug Development

Amy K. LeBlanc, Christina N. Mazcko, Chand Khanna
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (9): 2133–2138.
https://doi.org/10.1158/1078-0432.CCR-15-2347
Published: 01 May 2016
View articletitled, Defining the Value of a Comparative Approach to Cancer Drug Development
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Journal Articles

Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

Chand Khanna, Timothy M. Fan, Richard Gorlick, Lee J. Helman, Eugenie S. Kleinerman, Peter C. Adamson, Peter J. Houghton, William D. Tap, Danny R. Welch, Patricia S. Steeg, Glenn Merlino, Poul H.B. Sorensen, Paul Meltzer, David G. Kirsch, Katherine A. Janeway, Brenda Weigel, Lor Randall, Stephen J Withrow, Melissa Paoloni, Rosandra Kaplan, Beverly A. Teicher, Nita L. Seibel, Malcolm Smith, Aykut Üren, Shreyaskumar R. Patel, Jeffrey Trent, Sharon A. Savage, Lisa Mirabello, Denise Reinke, Donald A. Barkaukas, Mark Krailo, Mark Bernstein
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (16): 4200–4209.
https://doi.org/10.1158/1078-0432.CCR-13-2574
Published: 13 August 2014
View articletitled, Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma
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Journal Articles

Guiding the Optimal Translation of New Cancer Treatments From Canine to Human Cancer Patients

Chand Khanna, Cheryl London, David Vail, Christina Mazcko, Steven Hirschfeld
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (18): 5671–5677.
https://doi.org/10.1158/1078-0432.CCR-09-0719
Published: 14 September 2009
View articletitled, Guiding the Optimal Translation of New Cancer Treatments From Canine to Human Cancer Patients
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Journal Articles

Catching Cancer by the Tail: New Perspectives on the Use of Kinase Inhibitors

Chand Khanna, Ira Gordon
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (11): 3645–3647.
https://doi.org/10.1158/1078-0432.CCR-09-0132
Published: 01 June 2009
View articletitled, Catching Cancer by the Tail: New Perspectives on the Use of Kinase Inhibitors
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Includes: Supplementary data
Journal Articles

Corruption of the Fas Pathway Delays the Pulmonary Clearance of Murine Osteosarcoma Cells, Enhances Their Metastatic Potential, and Reduces the Effect of Aerosol Gemcitabine

Nancy Gordon, Nadezhda V. Koshkina, Shu-Fang Jia, Chand Khanna, Arnulfo Mendoza, Laura L. Worth, Eugenie S. Kleinerman
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (15): 4503–4510.
https://doi.org/10.1158/1078-0432.CCR-07-0313
Published: 01 August 2007
View articletitled, Corruption of the Fas Pathway Delays the Pulmonary Clearance of Murine Osteosarcoma Cells, Enhances Their Metastatic Potential, and Reduces the Effect of Aerosol Gemcitabine
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Journal Articles

Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma

Anthony Rusk, Elizabeth Cozzi, Marty Stebbins, David Vail, Joanne Graham, Victor Valli, Jack Henkin, Rick Sharpee, Chand Khanna
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (24): 7456–7464.
https://doi.org/10.1158/1078-0432.CCR-06-0110
Published: 22 December 2006
View articletitled, Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma
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Includes: Supplementary data
Journal Articles

Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers

Anthony Rusk, Evelyn McKeegan, Fortuna Haviv, Sandra Majest, Jack Henkin, Chand Khanna
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (24): 7444–7455.
https://doi.org/10.1158/1078-0432.CCR-06-0109
Published: 22 December 2006
View articletitled, Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers
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Journal Articles

Biology of Childhood Osteogenic Sarcoma and Potential Targets for Therapeutic Development: Meeting Summary

Richard Gorlick, Peter Anderson, Irene Andrulis, Carola Arndt, G. Peter Beardsley, Mark Bernstein, Julia Bridge, Nai-Kong Cheung, Jeffrey S. Dome, David Ebb, Thomas Gardner, Mark Gebhardt, Holcombe Grier, Marc Hansen, John Healey, Lee Helman, Janet Hock, Janet Houghton, Peter Houghton, Andrew Huvos, Chand Khanna, Mark Kieran, Eugenie Kleinerman, Marc Ladanyi, Ching Lau, David Malkin, Neyssa Marina, Paul Meltzer, Paul Meyers, Deborah Schofield, Cindy Schwartz, Malcolm A. Smith, Jeffrey Toretsky, Maria Tsokos, Leonard Wexler, Jon Wigginton, Stephen Withrow, Mason Schoenfeldt, Barry Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (15): 5442–5453.
Published: 03 December 2003
View articletitled, Biology of Childhood Osteogenic Sarcoma and Potential Targets for Therapeutic Development: Meeting Summary
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Journal Articles

A Randomized Controlled Trial of Octreotide Pamoate Long-acting Release and Carboplatin versus Carboplatin Alone in Dogs with Naturally Occurring Osteosarcoma: Evaluation of Insulin-like Growth Factor Suppression and Chemotherapy

Chand Khanna, Jennifer Prehn, David Hayden, Ryan D. Cassaday, Jana Caylor, Shevin Jacob, Seuli M. Bose, Sung-Hyeok Hong, Stephen M. Hewitt, Lee J. Helman
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (7): 2406–2412.
Published: 01 July 2002
View articletitled, A Randomized Controlled Trial of Octreotide Pamoate Long-acting Release and Carboplatin versus Carboplatin Alone in Dogs with Naturally Occurring Osteosarcoma: Evaluation of Insulin-like Growth Factor Suppression and Chemotherapy
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Journal Articles

Pretreatment with a Monoclonal Antibody/Interleukin-2 Fusion Protein Directed against DNA Enhances the Delivery of Therapeutic Molecules to Solid Tumors

Jason L. Hornick, Leslie A. Khawli, Peisheng Hu, Jahangir Sharifi, Chand Khanna, Alan L. Epstein
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (1): 51–60.
Published: 01 January 1999
View articletitled, Pretreatment with a Monoclonal Antibody/Interleukin-2 Fusion Protein Directed against DNA Enhances the Delivery of Therapeutic Molecules to Solid Tumors
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