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Celestia S. Higano
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Journal Articles

A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors

Atish D. Choudhury, Celestia S. Higano, Johann S. de Bono, Natalie Cook, Dana E. Rathkopf, Kari B. Wisinski, Juan Martin-Liberal, Mark Linch, Elisabeth I. Heath, Richard D. Baird, Javier García-Carbacho, Miguel Quintela-Fandino, Simon T. Barry, Elza C. de Bruin, Steve Colebrook, George Hawkins, Teresa Klinowska, Brijesh Maroj, Ganesh Moorthy, Peter G. Mortimer, Michele Moschetta, Myria Nikolaou, Liz Sainsbury, Geoffrey I. Shapiro, Lillian L. Siu, Aaron R. Hansen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2257–2269.
https://doi.org/10.1158/1078-0432.CCR-21-3087
Published: 01 June 2022
View article titled, A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Response to Rucaparib in BRCA-Mutant Metastatic Castration-Resistant Prostate Cancer Identified by Genomic Testing in the TRITON2 Study

Andrea Loehr, Akash Patnaik, David Campbell, Jeremy Shapiro, Alan H. Bryce, Ray McDermott, Brieuc Sautois, Nicholas J. Vogelzang, Richard M. Bambury, Eric Voog, Jingsong Zhang, Josep M. Piulats, Arif Hussain, Charles J. Ryan, Axel S. Merseburger, Gedske Daugaard, Axel Heidenreich, Karim Fizazi, Celestia S. Higano, Laurence E. Krieger, Cora N. Sternberg, Simon P. Watkins, Darrin Despain, Andrew D. Simmons, Melanie Dowson, Tony Golsorkhi, Simon Chowdhury, Wassim Abida
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (24): 6677–6686.
https://doi.org/10.1158/1078-0432.CCR-21-2199
Published: 15 December 2021
View article titled, Response to Rucaparib in BRCA-Mutant Metastatic Castration-Resistant Prostate Cancer Identified by Genomic Testing in the TRITON2 Study
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Includes: Supplementary data
Journal Articles

A Phase Ib Study of Atezolizumab with Radium-223 Dichloride in Men with Metastatic Castration-Resistant Prostate Cancer

Lawrence Fong, Michael J. Morris, Oliver Sartor, Celestia S. Higano, Lance Pagliaro, Ajjai Alva, Leonard J. Appleman, Winston Tan, Ulka Vaishampayan, Raphaelle Porcu, Darren Tayama, Edward E. Kadel, III, Kobe C. Yuen, Asim Datye, Andrew J. Armstrong, Daniel P. Petrylak
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (17): 4746–4756.
https://doi.org/10.1158/1078-0432.CCR-21-0063
Published: 01 September 2021
View article titled, A Phase Ib Study of Atezolizumab with Radium-223 Dichloride in Men with Metastatic Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study

Wassim Abida, David Campbell, Akash Patnaik, Jeremy D. Shapiro, Brieuc Sautois, Nicholas J. Vogelzang, Eric G. Voog, Alan H. Bryce, Ray McDermott, Francesco Ricci, Julie Rowe, Jingsong Zhang, Josep Maria Piulats, Karim Fizazi, Axel S. Merseburger, Celestia S. Higano, Laurence E. Krieger, Charles J. Ryan, Felix Y. Feng, Andrew D. Simmons, Andrea Loehr, Darrin Despain, Melanie Dowson, Foad Green, Simon P. Watkins, Tony Golsorkhi, Simon Chowdhury
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (11): 2487–2496.
https://doi.org/10.1158/1078-0432.CCR-20-0394
Published: 01 June 2020
View article titled, Non-BRCA DNA Damage Repair Gene Alterations and Response to the PARP Inhibitor Rucaparib in Metastatic Castration-Resistant Prostate Cancer: Analysis From the Phase II TRITON2 Study
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Includes: Supplementary data
Journal Articles

SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer

Xiaotun Zhang, Ilsa M. Coleman, Lisha G. Brown, Lawrence D. True, Lori Kollath, Jared M. Lucas, Hung-Ming Lam, Ruth Dumpit, Eva Corey, Lisly Chéry, Bryce Lakely, Celestia S. Higano, Bruce Montgomery, Martine Roudier, Paul H. Lange, Peter S. Nelson, Robert L. Vessella, Colm Morrissey
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (20): 4698–4708.
https://doi.org/10.1158/1078-0432.CCR-15-0157
Published: 14 October 2015
View article titled, SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome

Debraj GuhaThakurta, Nadeem A. Sheikh, Li-Qun Fan, Harini Kandadi, T. Craig Meagher, Simon J. Hall, Philip W. Kantoff, Celestia S. Higano, Eric J. Small, Thomas A. Gardner, Kate Bailey, Tuyen Vu, Todd DeVries, James B. Whitmore, Mark W. Frohlich, James B. Trager, Charles G. Drake
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (16): 3619–3630.
https://doi.org/10.1158/1078-0432.CCR-14-2334
Published: 13 August 2015
View article titled, Humoral Immune Response against Nontargeted Tumor Antigens after Treatment with Sipuleucel-T and Its Association with Improved Clinical Outcome
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Includes: Supplementary data
Journal Articles

Genetic Profiling to Determine Risk of Relapse-Free Survival in High-Risk Localized Prostate Cancer

Christine M. Barnett, Michael C. Heinrich, Jeong Lim, Dylan Nelson, Carol Beadling, Andrea Warrick, Tanaya Neff, Celestia S. Higano, Mark Garzotto, David Qian, Christopher L. Corless, George V. Thomas, Tomasz M. Beer
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (5): 1306–1312.
https://doi.org/10.1158/1078-0432.CCR-13-1775
Published: 02 March 2014
View article titled, Genetic Profiling to Determine Risk of Relapse-Free Survival in High-Risk Localized Prostate Cancer
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Includes: Supplementary data
Journal Articles

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

Martin A. Cheever, Celestia S. Higano
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (11): 3520–3526.
https://doi.org/10.1158/1078-0432.CCR-10-3126
Published: 01 June 2011
View article titled, PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine
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Journal Articles

Prostate Cancer–Associated Gene Expression Alterations Determined from Needle Biopsies

David Z. Qian, Chung-Ying Huang, Catherine A. O'Brien, Ilsa M. Coleman, Mark Garzotto, Lawrence D. True, Celestia S. Higano, Robert Vessella, Paul H. Lange, Peter S. Nelson, Tomasz M. Beer
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (9): 3135–3142.
https://doi.org/10.1158/1078-0432.CCR-08-1982
Published: 30 April 2009
View article titled, Prostate Cancer–Associated Gene Expression Alterations Determined from Needle Biopsies
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Includes: Supplementary data
Journal Articles

Molecular Alterations in Prostate Carcinomas that Associate with In vivo Exposure to Chemotherapy: Identification of a Cytoprotective Mechanism Involving Growth Differentiation Factor 15

Chung-Ying Huang, Tomasz M. Beer, Celestia S. Higano, Lawrence D. True, Robert Vessella, Paul H. Lange, Mark Garzotto, Peter S. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19): 5825–5833.
https://doi.org/10.1158/1078-0432.CCR-07-1037
Published: 01 October 2007
View article titled, Molecular Alterations in Prostate Carcinomas that Associate with <em>In vivo</em> Exposure to Chemotherapy: Identification of a Cytoprotective Mechanism Involving Growth Differentiation Factor 15
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Includes: Supplementary data
Journal Articles

Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer

Celestia S. Higano, Nicholas J. Vogelzang, Jeffrey A. Sosman, Anyang Feng, Dania Caron, Eric J Small
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (4): 1219–1225.
https://doi.org/10.1158/1078-0432.CCR-1404-02
Published: 20 February 2004
View article titled, Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer
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Journal Articles

Phase I Study of Weekly Mitoxantrone and Docetaxel before Prostatectomy in Patients with High-Risk Localized Prostate Cancer

Tomasz M. Beer, Mark Garzotto, Bruce A. Lowe, William J. Ellis, Michelle A. Montalto, Paul H. Lange, Celestia S. Higano
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (4): 1306–1311.
https://doi.org/10.1158/1078-0432.CCR-1021-03
Published: 20 February 2004
View article titled, Phase I Study of Weekly Mitoxantrone and Docetaxel before Prostatectomy in Patients with High-Risk Localized Prostate Cancer
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Journal Articles

Zoledronic Acid Exhibits Inhibitory Effects on Osteoblastic and Osteolytic Metastases of Prostate Cancer

Eva Corey, Lisha G. Brown, Janna E. Quinn, Martin Poot, Martine P. Roudier, Celestia S. Higano, Robert L. Vessella
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 295–306.
Published: 01 January 2003
View article titled, Zoledronic Acid Exhibits Inhibitory Effects on Osteoblastic and Osteolytic Metastases of Prostate Cancer
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