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Journal Articles

Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC

Pedro Rocha, Jiexin Zhang, Raquel Laza-Briviesca, Alberto Cruz-Bermúdez, Neus Bota-Rabassedas, Beatriz Sanchez-Espiridon, Katsuhiro Yoshimura, Carmen Behrens, Wei Lu, Ximing Tang, Apar Pataer, Edwin R. Parra, Cara Haymaker, Junya Fujimoto, Stephen G. Swisher, John V. Heymach, Don L. Gibbons, J. Jack Lee, Boris Sepesi, Tina Cascone, Luisa M. Solis, Mariano Provencio, Ignacio I. Wistuba, Humam Kadara
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2461–2473.
https://doi.org/10.1158/1078-0432.CCR-21-3207
Published: 01 June 2022
View article titled, Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC
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Includes: Supplementary data
Journal Articles

A Phase I/II Study of Neoadjuvant Cisplatin, Docetaxel, and Nintedanib for Resectable Non–Small Cell Lung Cancer

Tina Cascone, Boris Sepesi, Heather Y. Lin, Neda Kalhor, Edwin R. Parra, Mei Jiang, Myrna C.B. Godoy, Jianjun Zhang, Frank V. Fossella, Anne S. Tsao, Vincent K. Lam, Charles Lu, Frank E. Mott, George R. Simon, Mara B. Antonoff, Reza J. Mehran, David C. Rice, Carmen Behrens, Annikka Weissferdt, Cesar Moran, Ara A. Vaporciyan, J. Jack Lee, Stephen G. Swisher, Don L. Gibbons, Ignacio I. Wistuba, William N. William, Jr., John V. Heymach
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (14): 3525–3536.
https://doi.org/10.1158/1078-0432.CCR-19-4180
Published: 15 July 2020
View article titled, A Phase I/II Study of Neoadjuvant Cisplatin, Docetaxel, and Nintedanib for Resectable Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer

Yang Xie, Wei Lu, Shidan Wang, Ximing Tang, Hao Tang, Yunyun Zhou, Cesar Moran, Carmen Behrens, Jack A. Roth, Qinghua Zhou, David H. Johnson, Stephen G. Swisher, John V. Heymach, Vassiliki A. Papadimitrakopoulou, Guanghua Xiao, John D. Minna, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 150–157.
https://doi.org/10.1158/1078-0432.CCR-17-2543
Published: 03 January 2019
View article titled, Validation of the 12-gene Predictive Signature for Adjuvant Chemotherapy Response in Lung Cancer
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Includes: Supplementary data
Journal Articles

Image Analysis–based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non–small Cell Lung Carcinoma Patients

Edwin R. Parra, Carmen Behrens, Jaime Rodriguez-Canales, Heather Lin, Barbara Mino, Jorge Blando, Jianjun Zhang, Don L. Gibbons, John V. Heymach, Boris Sepesi, Stephen G. Swisher, Annikka Weissferdt, Neda Kalhor, Julie Izzo, Humam Kadara, Cesar Moran, Jack J. Lee, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (24): 6278–6289.
https://doi.org/10.1158/1078-0432.CCR-15-2443
Published: 15 December 2016
View article titled, Image Analysis–based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non–small Cell Lung Carcinoma Patients
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Includes: Supplementary data
Journal Articles

An Expression Signature as an Aid to the Histologic Classification of Non–Small Cell Lung Cancer

Luc Girard, Jaime Rodriguez-Canales, Carmen Behrens, Debrah M. Thompson, Ihab W. Botros, Hao Tang, Yang Xie, Natasha Rekhtman, William D. Travis, Ignacio I. Wistuba, John D. Minna, Adi F. Gazdar
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19): 4880–4889.
https://doi.org/10.1158/1078-0432.CCR-15-2900
Published: 02 October 2016
View article titled, An Expression Signature as an Aid to the Histologic Classification of Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

Yanyan Lou, Lixia Diao, Edwin Roger Parra Cuentas, Warren L. Denning, Limo Chen, You Hong Fan, Lauren A. Byers, Jing Wang, Vassiliki A. Papadimitrakopoulou, Carmen Behrens, Jaime Canales Rodriguez, Patrick Hwu, Ignacio I. Wistuba, John V. Heymach, Don L. Gibbons
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (14): 3630–3642.
https://doi.org/10.1158/1078-0432.CCR-15-1434
Published: 14 July 2016
View article titled, Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2

Robert J.G. Cardnell, Carmen Behrens, Lixia Diao, YouHong Fan, Ximing Tang, Pan Tong, John D. Minna, Gordon B. Mills, John V. Heymach, Ignacio I. Wistuba, Jing Wang, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3480–3491.
https://doi.org/10.1158/1078-0432.CCR-14-3286
Published: 02 August 2015
View article titled, An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2
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Includes: Supplementary data
Journal Articles

Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non–Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway

Chunli Shao, James P. Sullivan, Luc Girard, Alexander Augustyn, Paul Yenerall, Jaime Rodriguez-Canales, Hui Liu, Carmen Behrens, Jerry W. Shay, Ignacio I. Wistuba, John D. Minna
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (15): 4154–4166.
https://doi.org/10.1158/1078-0432.CCR-13-3292
Published: 31 July 2014
View article titled, Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non–Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway
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Includes: Supplementary data
Journal Articles

VEGF/VEGFR-2 Upregulates EZH2 Expression in Lung Adenocarcinoma Cells and EZH2 Depletion Enhances the Response to Platinum-Based and VEGFR-2–Targeted Therapy

Erick Riquelme, Milind Suraokar, Carmen Behrens, Heather Y. Lin, Luc Girard, Monique B. Nilsson, George Simon, Jing Wang, Kevin R. Coombes, J. Jack Lee, Waun Ki Hong, John Heymach, John D. Minna, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (14): 3849–3861.
https://doi.org/10.1158/1078-0432.CCR-13-1916
Published: 14 July 2014
View article titled, VEGF/VEGFR-2 Upregulates EZH2 Expression in Lung Adenocarcinoma Cells and EZH2 Depletion Enhances the Response to Platinum-Based and VEGFR-2–Targeted Therapy
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Includes: Supplementary data
Journal Articles

Prediction of Survival in Resected Non–Small Cell Lung Cancer Using a Protein Expression–Based Risk Model: Implications for Personalized Chemoprevention and Therapy

Kathryn A. Gold, Edward S. Kim, Diane D. Liu, Ping Yuan, Carmen Behrens, Luisa M. Solis, Humam Kadara, David C. Rice, Ignacio I. Wistuba, Stephen G. Swisher, Wayne L. Hofstetter, J. Jack Lee, Waun K. Hong
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (7): 1946–1954.
https://doi.org/10.1158/1078-0432.CCR-13-1959
Published: 31 March 2014
View article titled, Prediction of Survival in Resected Non–Small Cell Lung Cancer Using a Protein Expression–Based Risk Model: Implications for Personalized Chemoprevention and Therapy
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Includes: Supplementary data
Journal Articles

Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer

Oliver Delgado, Kimberly G. Batten, James A. Richardson, Xian-Jin Xie, Adi F. Gazdar, Aadil A. Kaisani, Luc Girard, Carmen Behrens, Milind Suraokar, Gail Fasciani, Woodring E. Wright, Michael D. Story, Ignacio I. Wistuba, John D. Minna, Jerry W. Shay
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (6): 1610–1622.
https://doi.org/10.1158/1078-0432.CCR-13-2589
Published: 13 March 2014
View article titled, Radiation-Enhanced Lung Cancer Progression in a Transgenic Mouse Model of Lung Cancer Is Predictive of Outcomes in Human Lung and Breast Cancer
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Includes: Supplementary data
Journal Articles

Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma

Marie Cumberbatch, Ximing Tang, Garry Beran, Sonia Eckersley, Xin Wang, Rebecca P.A. Ellston, Simon Dearden, Sabina Cosulich, Paul D. Smith, Carmen Behrens, Edward S. Kim, Xinying Su, Shuqiong Fan, Neil Gray, David P. Blowers, Ignacio I. Wistuba, Chris Womack
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (3): 595–603.
https://doi.org/10.1158/1078-0432.CCR-13-1638
Published: 02 February 2014
View article titled, Identification of a Subset of Human Non–Small Cell Lung Cancer Patients with High PI3Kβ and Low PTEN Expression, More Prevalent in Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract B24: A systematic search for cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets.

Ayumu Taguchi, Allen D. Taylor, Jaime Rodriguez, Muge Celiktas, Hui Liu, Xiaotu Ma, Qing Zhang, Chee-Hong Wong, Alice Chin, Luc Girard, Carmen Behrens, Wan Lam, Stephen Lam, John D. Minna, Ignacio I. Wistuba, Adi F. Gazdar, Samir M. Hanash
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2_Supplement): B24.
https://doi.org/10.1158/1078-0432.14AACRIASLC-B24
Published: 16 January 2014
View article titled, Abstract B24: A systematic search for cancer/testis antigens in lung cancer identifies VCX/Y genes expanding the repertoire of potential immunotherapeutic targets.
Journal Articles

Abstract IA21: Developing a new functional classification of lung cancer based on tumor acquired vulnerabilities.

John D. Minna, Adi Gazdar, Alexander Augustyn, Rebecca Britt, Ryan Carstens, Patrick Dospoy, Boning Gao, Luc Girard, Suzie Hight, Kenneth Huffman, Jill Larsen, Michael Peyton, Chunli Shao, David Mangelsdorf, Rolf Brekken, Ralph Deberardinis, Pei-Hsuan Chen, Carmen Behrens, Lauren Byers, John Heymach, Jack Roth, Ignacio Wistuba, Yang Xie, Caleb Davis, David Wheeler, Richard Gibbs, Edward Marcotte, Joseph Ready, Deepak Nijhawan, Noelle Williams, Steven McKnight, Bruce Posner, John MacMillan, Michael Roth, Michael White
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2_Supplement): IA21.
https://doi.org/10.1158/1078-0432.14AACRIASLC-IA21
Published: 16 January 2014
View article titled, Abstract IA21: Developing a new functional classification of lung cancer based on tumor acquired vulnerabilities.
Journal Articles

EZH2 Protein Expression Associates with the Early Pathogenesis, Tumor Progression, and Prognosis of Non–Small Cell Lung Carcinoma

Carmen Behrens, Luisa M. Solis, Heather Lin, Ping Yuan, Ximing Tang, Humam Kadara, Erick Riquelme, Hector Galindo, Cesar A. Moran, Neda Kalhor, Stephen G. Swisher, George R. Simon, David J. Stewart, J. Jack Lee, Ignacio I. Wistuba
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (23): 6556–6565.
https://doi.org/10.1158/1078-0432.CCR-12-3946
Published: 01 December 2013
View article titled, EZH2 Protein Expression Associates with the Early Pathogenesis, Tumor Progression, and Prognosis of Non–Small Cell Lung Carcinoma
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Includes: Supplementary data
Journal Articles

Validation of a Proliferation-Based Expression Signature as Prognostic Marker in Early Stage Lung Adenocarcinoma

Ignacio I. Wistuba, Carmen Behrens, Francesca Lombardi, Susanne Wagner, Junya Fujimoto, M. Gabriela Raso, Lorenzo Spaggiari, Domenico Galetta, Robyn Riley, Elisha Hughes, Julia Reid, Zaina Sangale, Steven G. Swisher, Neda Kalhor, Cesar A. Moran, Alexander Gutin, Jerry S. Lanchbury, Massimo Barberis, Edward S. Kim
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (22): 6261–6271.
https://doi.org/10.1158/1078-0432.CCR-13-0596
Published: 14 November 2013
View article titled, Validation of a Proliferation-Based Expression Signature as Prognostic Marker in Early Stage Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

ETS2 Mediated Tumor Suppressive Function and MET Oncogene Inhibition in Human Non–Small Cell Lung Cancer

Mohamed Kabbout, Melinda M. Garcia, Junya Fujimoto, Diane D. Liu, Denise Woods, Chi-Wan Chow, Gabriela Mendoza, Amin A. Momin, Brian P. James, Luisa Solis, Carmen Behrens, J. Jack Lee, Ignacio I. Wistuba, Humam Kadara
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (13): 3383–3395.
https://doi.org/10.1158/1078-0432.CCR-13-0341
Published: 30 June 2013
View article titled, ETS2 Mediated Tumor Suppressive Function and MET Oncogene Inhibition in Human Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients

Hao Tang, Guanghua Xiao, Carmen Behrens, Joan Schiller, Jeffrey Allen, Chi-Wan Chow, Milind Suraokar, Alejandro Corvalan, Jianhua Mao, Michael A. White, Ignacio I. Wistuba, John D. Minna, Yang Xie
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1577–1586.
https://doi.org/10.1158/1078-0432.CCR-12-2321
Published: 14 March 2013
View article titled, A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients
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Includes: Supplementary data
Journal Articles

Abstract B42: The lineage-specific transcription factor ASCL1 defines a subtype of neuroendocrine non-small cell lung cancers with poor prognosis and points to potential therapeutic targets

Alexander Augustyn, John Minna, Christopher Tan, James Sullivan, Mark Borromeo, Luc Girard, Jane Johnson, Carmen Behrens, Ignacio Wistuba, Yang Xie
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): B42.
https://doi.org/10.1158/1078-0432.12AACRIASLC-B42
Published: 01 February 2012
View article titled, Abstract B42: The lineage-specific transcription factor ASCL1 defines a subtype of neuroendocrine non-small cell lung cancers with poor prognosis and points to potential therapeutic targets
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Journal Articles

Abstract IA3: Lung cancer stem cells, acquired vulnerabilities, and molecular portraits: Translation to the clinic

John D. Minna, Chunli Shao, Amit Das, Chris Desevo, Patrick Dospoy, Boning Gao, Rachel Greer, Suzie Hight, Kenneth Huffman, Jill Larsen, Michael Peyton, Misty Shields, James P. Sullivan, Laura Sullivan, David Gerber, David Mangelsdorf, Joan Schiller, Jerry Shay, Alexander Pertsemlidis, Kevin Coombes, John V. Heymach, Jonathan Kurie, Jack Roth, Luc Girard, Xifeng Wu, Carmen Behrens, Heidi Erickson, Ignacio Wistuba, Bruce Posner, Michael Roth, Adi Gazdar, Michael White, Yang Xie, Alex Augustyn, Rolf Brekken, Rebecca Britt, Robin Frink, Ryan Carstens
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3_Supplement): IA3.
https://doi.org/10.1158/1078-0432.12AACRIASLC-IA3
Published: 01 February 2012
View article titled, Abstract IA3: Lung cancer stem cells, acquired vulnerabilities, and molecular portraits: Translation to the clinic
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