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Brigitte C. Widemann
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Journal Articles

Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies

Melissa R. Perrino, Anirban Das, Sarah R. Scollon, Sarah G. Mitchell, Mary-Louise C. Greer, Marielle E. Yohe, Jordan R. Hansford, Jennifer M. Kalish, Kris Ann P. Schultz, Suzanne P. MacFarland, Wendy K. Kohlmann, Philip J. Lupo, Kara N. Maxwell, Stefan M. Pfister, Rosanna Weksberg, Orli Michaeli, Marjolijn C.J. Jongmans, Gail E. Tomlinson, Jack Brzezinski, Uri Tabori, Gina M. Ney, Karen W. Gripp, Andrea M. Gross, Brigitte C. Widemann, Douglas R. Stewart, Emma R. Woodward, Christian P. Kratz
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21): 4834–4843.
https://doi.org/10.1158/1078-0432.CCR-24-1611
Published: 01 November 2024
View article titled, Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies
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Journal Articles

Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics

R. Taylor Sundby, Jeffrey J. Szymanski, Alexander C. Pan, Paul A. Jones, Sana Z. Mahmood, Olivia H. Reid, Divya Srihari, Amy E. Armstrong, Stacey Chamberlain, Sanita Burgic, Kara Weekley, Béga Murray, Sneh Patel, Faridi Qaium, Andrea N. Lucas, Margaret Fagan, Anne Dufek, Christian F. Meyer, Natalie B. Collins, Christine A. Pratilas, Eva Dombi, Andrea M. Gross, AeRang Kim, John S.A. Chrisinger, Carina A. Dehner, Brigitte C. Widemann, Angela C. Hirbe, Aadel A. Chaudhuri, Jack F. Shern
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (19): 4363–4376.
https://doi.org/10.1158/1078-0432.CCR-24-0797
Published: 01 October 2024
View article titled, Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
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Includes: Supplementary data
Journal Articles

Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma

Srivandana Akshintala, R. Taylor Sundby, Donna Bernstein, John W. Glod, Rosandra N. Kaplan, Marielle E. Yohe, Andrea M. Gross, Joanne Derdak, Haiyan Lei, Alexander Pan, Eva Dombi, Isabel Palacio-Yance, Kailey R. Herrera, Markku M. Miettinen, Helen X. Chen, Seth M. Steinberg, Lee J. Helman, Leo Mascarenhas, Brigitte C. Widemann, Fariba Navid, Jack F. Shern, Christine M. Heske
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (17): 3329–3339.
https://doi.org/10.1158/1078-0432.CCR-23-0709
Published: 01 September 2023
View article titled, Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
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Includes: Supplementary data
Journal Articles

MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

Dana C. Borcherding, Neha V. Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A. Pratilas, Kai Pollard, Taylor Sundby, Brigitte C. Widemann, Angela C. Hirbe
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (8): 1592–1604.
https://doi.org/10.1158/1078-0432.CCR-22-3722
Published: 14 April 2023
View article titled, MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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Includes: Supplementary data
Journal Articles

Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I–Related Plexiform Neurofibromas

Lauren H. Boal, John Glod, Melissa Spencer, Miki Kasai, Joanne Derdak, Eva Dombi, Mark Ahlman, Daniel W. Beury, Melinda S. Merchant, Christianne Persenaire, David J. Liewehr, Seth M. Steinberg, Brigitte C. Widemann, Rosandra N. Kaplan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6112–6121.
https://doi.org/10.1158/1078-0432.CCR-20-1696
Published: 01 December 2020
View article titled, Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I–Related Plexiform Neurofibromas
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Includes: Supplementary data
Journal Articles

A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor

John Glod, Fernanda I. Arnaldez, Lori Wiener, Melissa Spencer, J. Keith Killian, Paul Meltzer, Eva Dombi, Claudia Derse-Anthony, Joanne Derdak, Ramaprasad Srinivasan, W. Marston Linehan, Markku Miettinen, Seth M. Steinberg, Lee Helman, Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (21): 6302–6308.
https://doi.org/10.1158/1078-0432.CCR-19-0986
Published: 01 November 2019
View article titled, A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase–Deficient Gastrointestinal Stromal Tumor
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Journal Articles

Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib

Ira L. Kraft, Srivandana Akshintala, Yuelin Zhu, Haiyan Lei, Claudia Derse-Anthony, Eva Dombi, Seth M. Steinberg, Maya Lodish, Steven G. Waguespack, Oxana Kapustina, Elizabeth Fox, Frank M. Balis, Maria J. Merino, Paul S. Meltzer, John W. Glod, Jack F. Shern, Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 753–765.
https://doi.org/10.1158/1078-0432.CCR-17-2101
Published: 14 February 2018
View article titled, Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib
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Includes: Supplementary data
Journal Articles

Abstract IA16: Natural history of peripheral nerve sheath tumors in NF1: Identification and characterization of malignant precursor lesions

Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): IA16.
https://doi.org/10.1158/1557-3265.SARCOMAS17-IA16
Published: 15 January 2018
View article titled, Abstract IA16: Natural history of peripheral nerve sheath tumors in NF1: Identification and characterization of malignant precursor lesions
Journal Articles

Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer

Jung-Min Lee, Cody J. Peer, Minshu Yu, Lauren Amable, Nicolas Gordon, Christina M. Annunziata, Nicole Houston, Andrew K.L. Goey, Tristan M. Sissung, Bernard Parker, Lori Minasian, Victoria L. Chiou, Robert F. Murphy, Brigitte C. Widemann, William D. Figg, Elise C. Kohn
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1397–1406.
https://doi.org/10.1158/1078-0432.CCR-16-1546
Published: 14 March 2017
View article titled, Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer
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Includes: Supplementary data
Journal Articles

MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research

Wendy Chang, Andrew S. Brohl, Rajesh Patidar, Sivasish Sindiri, Jack F. Shern, Jun S. Wei, Young K. Song, Marielle E. Yohe, Berkley Gryder, Shile Zhang, Kathleen A. Calzone, Nityashree Shivaprasad, Xinyu Wen, Thomas C. Badgett, Markku Miettinen, Kip R. Hartman, James C. League-Pascual, Toby N. Trahair, Brigitte C. Widemann, Melinda S. Merchant, Rosandra N. Kaplan, Jimmy C. Lin, Javed Khan
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (15): 3810–3820.
https://doi.org/10.1158/1078-0432.CCR-15-2717
Published: 31 July 2016
View article titled, MultiDimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research
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Includes: Supplementary data
Journal Articles

Vandetanib in Children and Adolescents with Multiple Endocrine Neoplasia Type 2B Associated Medullary Thyroid Carcinoma

Elizabeth Fox, Brigitte C. Widemann, Meredith K. Chuk, Leigh Marcus, Alberta Aikin, Patricia O. Whitcomb, Maria J. Merino, Maya Lodish, Eva Dombi, Seth M. Steinberg, Samuel A. Wells, Frank M. Balis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (15): 4239–4248.
https://doi.org/10.1158/1078-0432.CCR-13-0071
Published: 31 July 2013
View article titled, Vandetanib in Children and Adolescents with Multiple Endocrine Neoplasia Type 2B Associated Medullary Thyroid Carcinoma
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Includes: Supplementary data
Journal Articles

A Phase I Trial and Pharmacokinetic Study of Sorafenib in Children with Refractory Solid Tumors or Leukemias: A Children's Oncology Group Phase I Consortium Report

Brigitte C. Widemann, AeRang Kim, Elizabeth Fox, Sylvain Baruchel, Peter C. Adamson, Ashish M. Ingle, Julia Glade Bender, Michael Burke, Brenda Weigel, Diana Stempak, Frank M. Balis, Susan M. Blaney
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (21): 6011–6022.
https://doi.org/10.1158/1078-0432.CCR-11-3284
Published: 06 November 2012
View article titled, A Phase I Trial and Pharmacokinetic Study of Sorafenib in Children with Refractory Solid Tumors or Leukemias: A Children's Oncology Group Phase I Consortium Report
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Includes: Supplementary data
Journal Articles

Automated Volumetric Growth Plate Measurement Using Magnetic Resonance Imaging for Monitoring Skeletal Toxicity in Children Treated on Investigational Drug Trials

AeRang Kim, Eva Dombi, Jeffrey Solomon, Elizabeth Fox, Frank M. Balis, Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (18): 5982–5990.
https://doi.org/10.1158/1078-0432.CCR-10-2259
Published: 14 September 2011
View article titled, Automated Volumetric Growth Plate Measurement Using Magnetic Resonance Imaging for Monitoring Skeletal Toxicity in Children Treated on Investigational Drug Trials
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Journal Articles

Phase II Trial of Ixabepilone Administered Daily for Five Days in Children and Young Adults with Refractory Solid Tumors: A Report from the Children's Oncology Group

Shana Jacobs, Elizabeth Fox, Mark Krailo, Gwen Hartley, Fariba Navid, Leonard Wexler, Susan M. Blaney, Anne Goodwin, Wendy Goodspeed, Frank M. Balis, Peter C. Adamson, Brigitte C. Widemann
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 750–754.
https://doi.org/10.1158/1078-0432.CCR-09-1906
Published: 14 January 2010
View article titled, Phase II Trial of Ixabepilone Administered Daily for Five Days in Children and Young Adults with Refractory Solid Tumors: A Report from the Children's Oncology Group
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Journal Articles

Randomized Trial and Pharmacokinetic Study of Pegfilgrastim versus Filgrastim after Dose-Intensive Chemotherapy in Young Adults and Children with Sarcomas

Elizabeth Fox, Brigitte C. Widemann, Douglas S. Hawkins, Nalini Jayaprakash, Ramzi Dagher, Alberta A. Aikin, Donna Bernstein, Lauren Long, Crystal Mackall, Lee Helman, Seth M. Steinberg, Frank M. Balis
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (23): 7361–7367.
https://doi.org/10.1158/1078-0432.CCR-09-0761
Published: 30 November 2009
View article titled, Randomized Trial and Pharmacokinetic Study of Pegfilgrastim versus Filgrastim after Dose-Intensive Chemotherapy in Young Adults and Children with Sarcomas
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Journal Articles

A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors

Elizabeth Fox, John M. Maris, Brigitte C. Widemann, Wendy Goodspeed, Anne Goodwin, Marie Kromplewski, Molly E. Fouts, Diane Medina, Susan L. Cohn, Andrew Krivoshik, Anne E. Hagey, Peter C. Adamson, Frank M. Balis
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (4): 1111–1115.
https://doi.org/10.1158/1078-0432.CCR-07-4097
Published: 15 February 2008
View article titled, A Phase I Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 21 Days Every 28 Days in Pediatric Patients with Solid Tumors
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Journal Articles

A Phase 1 Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 7 Days Every 21 Days in Pediatric Patients with Solid Tumors

Elizabeth Fox, John M. Maris, Brigitte C. Widemann, Kysa Meek, Anne Goodwin, Wendy Goodspeed, Marie Kromplewski, Molly E. Fouts, Diane Medina, Steve Y. Cho, Susan L. Cohn, Andrew Krivoshik, Anne E. Hagey, Peter C. Adamson, Frank M. Balis
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (16): 4882–4887.
https://doi.org/10.1158/1078-0432.CCR-06-0534
Published: 16 August 2006
View article titled, A Phase 1 Study of ABT-751, an Orally Bioavailable Tubulin Inhibitor, Administered Daily for 7 Days Every 21 Days in Pediatric Patients with Solid Tumors
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Journal Articles

A Phase I Trial and Pharmacokinetic Study of Tipifarnib, a Farnesyltransferase Inhibitor, and Tamoxifen in Metastatic Breast Cancer

Peter F. Lebowitz, Jennifer Eng-Wong, Brigitte C. Widemann, Frank M. Balis, Nalini Jayaprakash, Catherine Chow, Geoff Clark, Susan B. Gantz, David Venzon, JoAnne Zujewski
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1247–1252.
https://doi.org/10.1158/1078-0432.1247.11.3
Published: 11 February 2005
View article titled, A Phase I Trial and Pharmacokinetic Study of Tipifarnib, a Farnesyltransferase Inhibitor, and Tamoxifen in Metastatic Breast Cancer
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Journal Articles

A Phase I Trial and Pharmacokinetic Study of 9- cis -Retinoic Acid (ALRT1057) in Pediatric Patients with Refractory Cancer: A Joint Pediatric Oncology Branch, National Cancer Institute, and Children’s Cancer Group Study

Peter C. Adamson, Brigitte C. Widemann, Gregory H. Reaman, Nita L. Seibel, Robert F. Murphy, Andrea F. Gillespie, Frank M. Balis
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (10): 3034–3039.
Published: 01 October 2001
View article titled, A Phase I Trial and Pharmacokinetic Study of 9- <em>cis</em> -Retinoic Acid (ALRT1057) in Pediatric Patients with Refractory Cancer: <subtitle>A Joint Pediatric Oncology Branch, National Cancer Institute, and Children’s Cancer Group Study</subtitle>
Open the PDF for A Phase I Trial and Pharmacokinetic Study of 9- <em>cis</em> -Retinoic Acid (ALRT1057) in Pediatric Patients with Refractory Cancer: <subtitle>A Joint Pediatric Oncology Branch, National Cancer Institute, and Children’s Cancer Group Study</subtitle> in another window