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Journal Articles

NXP800 activates the unfolded protein response, altering AR and E2F function to impact castration-resistant prostate cancer growth

Jonathan Welti, Denisa Bogdan, Ines Figueiredo, Ilsa Coleman, Juan Jiménez Vacas, Kate Liodaki, Franziska Weigl, Lorenzo Buroni, Wanting Zeng, Ilona Bernett, Claudia Bertan, Theodoros I. Roumeliotis, Amandeep Bhamra, Jan Rekowski, Bora Gurel, Antje J. Neeb, Jian Ning, Dapei Li, Veronica S. Gil, Ruth Riisnaes, Susana Miranda, Mateus Crespo, Ana Ferreira, Nina Tunariu, Elisa Pasqua, Nicola Chessum, Matthew Cheeseman, Robert te Poele, Marissa Powers, Suzanne Carreira, Jyoti Choudhary, Paul Clarke, Udai Banerji, Amanda Swain, Keith Jones, Wei Yuan, Paul Workman, Peter S. Nelson, Johann S. de Bono, Adam Sharp
Journal: Clinical Cancer Research
Clin Cancer Res (2025)
https://doi.org/10.1158/1078-0432.CCR-24-2386
Published: 09 January 2025
View article titled, NXP800 activates the unfolded protein response, altering AR and E2F function to impact castration-resistant prostate cancer growth
Open the PDF for NXP800 activates the unfolded protein response, altering AR and E2F function to impact castration-resistant prostate cancer growth in another window
Includes: Supplementary data
Journal Articles

CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors

Sophie Archer, Phillip M. Brailey, Minjung Song, Phillip D. Bartlett, Ines Figueiredo, Bora Gurel, Christina Guo, Verena Brucklacher-Waldert, H. Lorraine Thompson, Jude Akinwale, Samantha E. Boyle, Christine Rossant, Neil R. Birkett, Julia Pizzey, Mark Maginn, James Legg, Richard Williams, Colette M. Johnston, Philip Bland-Ward, Johann S. de Bono, Andrew J. Pierce
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (8): 1595–1606.
https://doi.org/10.1158/1078-0432.CCR-23-3052
Published: 15 April 2024
View article titled, CB307: A Dual Targeting Costimulatory Humabody V<sub>H</sub> Therapeutic for Treating PSMA-Positive Tumors
Open the PDF for CB307: A Dual Targeting Costimulatory Humabody V<sub>H</sub> Therapeutic for Treating PSMA-Positive Tumors in another window
Includes: Multimedia, Supplementary data
Journal Articles

Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010)

Alistair Ring, Lucy S. Kilburn, Alex Pearson, Laura Moretti, Angelica Afshari-Mehr, Andrew M. Wardley, Bora Gurel, Iain R. Macpherson, Ruth Riisnaes, Richard D. Baird, Sue Martin, Rebecca Roylance, Hannah Johnson, Ana Ferreira, Matthew C. Winter, Kathryn Dunne, Ellen Copson, Tamas Hickish, Russell Burcombe, Kat Randle, Violeta Serra, Alba Llop-Guevara, Judith M. Bliss, Nicolas C. Turner
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (23): 4751–4759.
https://doi.org/10.1158/1078-0432.CCR-23-1696
Published: 01 December 2023
View article titled, Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010)
Open the PDF for Olaparib and Ceralasertib (AZD6738) in Patients with Triple-Negative Advanced Breast Cancer: Results from Cohort E of the plasmaMATCH Trial (CRUK/15/010) in another window
Includes: Supplementary data
Journal Articles

A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer

Susana Banerjee, Vasiliki Michalarea, Joo Ern Ang, Alvaro Ingles Garces, Andrea Biondo, Ionut-Gabriel Funingana, Martin Little, Ruth Ruddle, Florence Raynaud, Ruth Riisnaes, Bora Gurel, Sue Chua, Nina Tunariu, Joanna C. Porter, Toby Prout, Mona Parmar, Anna Zachariou, Alison Turner, Ben Jenkins, Stuart McIntosh, Ed Ainscow, Anna Minchom, Juanita Lopez, Johann de Bono, Robert Jones, Emma Hall, Natalie Cook, Bristi Basu, Udai Banerji
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4634–4641.
https://doi.org/10.1158/1078-0432.CCR-22-1268
Published: 01 November 2022
View article titled, A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer
Open the PDF for A Phase I Trial of CT900, a Novel α-Folate Receptor–Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer

Adam G. Sowalsky, Ines Figueiredo, Rosina T. Lis, Ilsa Coleman, Bora Gurel, Denisa Bogdan, Wei Yuan, Joshua W. Russo, John R. Bright, Nichelle C. Whitlock, Shana Y. Trostel, Anson T. Ku, Radhika A. Patel, Lawrence D. True, Jonathan Welti, Juan M. Jimenez-Vacas, Daniel Nava Rodrigues, Ruth Riisnaes, Antje Neeb, Cynthia T. Sprenger, Amanda Swain, Scott Wilkinson, Fatima Karzai, William L. Dahut, Steven P. Balk, Eva Corey, Peter S. Nelson, Michael C. Haffner, Stephen R. Plymate, Johann S. de Bono, Adam Sharp
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (16): 3509–3525.
https://doi.org/10.1158/1078-0432.CCR-22-0851
Published: 15 August 2022
View article titled, Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer
Open the PDF for Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer

Beshara Sheehan, Antje Neeb, Lorenzo Buroni, Alec Paschalis, Ruth Riisnaes, Bora Gurel, Veronica Gil, Susana Miranda, Mateus Crespo, Christina Guo, Juan Jiménez Vacas, Ines Figueiredo, Ana Ferreira, Jon Welti, Wei Yuan, Suzanne Carreira, Adam Sharp, Johann de Bono
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (14): 3104–3115.
https://doi.org/10.1158/1078-0432.CCR-21-4531
Published: 15 July 2022
View article titled, Prostate-Specific Membrane Antigen Expression and Response to DNA Damaging Agents in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies

Yi Liang, Sujeeve Jeganathan, Stefano Marastoni, Adam Sharp, Ines Figueiredo, Richard Marcellus, Amanda Mawson, Zvi Shalev, Aleksandra Pesic, Joan Sweet, Haiyang Guo, David Uehling, Bora Gurel, Antje Neeb, Housheng Hansen He, Bruce Montgomery, Marianne Koritzinsky, Samantha Oakes, Johann S. de Bono, Martin Gleave, Amina Zoubeidi, Bradly G. Wouters, Anthony M. Joshua
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2340–2351.
https://doi.org/10.1158/1078-0432.CCR-20-3260
Published: 15 April 2021
View article titled, Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies
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Includes: Supplementary data
Journal Articles

Characterizing CDK12-Mutated Prostate Cancers

Pasquale Rescigno, Bora Gurel, Rita Pereira, Mateus Crespo, Jan Rekowski, Mattia Rediti, Maialen Barrero, Joaquin Mateo, Diletta Bianchini, Carlo Messina, Maria D. Fenor de la Maza, Khobe Chandran, Juliet Carmichael, Christina Guo, Alec Paschalis, Adam Sharp, George Seed, Ines Figueiredo, Maryou Lambros, Susana Miranda, Ana Ferreira, Claudia Bertan, Ruth Riisnaes, Nuria Porta, Wei Yuan, Suzanne Carreira, Johann S. de Bono
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (2): 566–574.
https://doi.org/10.1158/1078-0432.CCR-20-2371
Published: 19 January 2021
View article titled, Characterizing CDK12-Mutated Prostate Cancers
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Includes: Supplementary data
Journal Articles

PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients

Tamara L. Lotan, Bora Gurel, Siobhan Sutcliffe, David Esopi, Wennuan Liu, Jianfeng Xu, Jessica L. Hicks, Ben H. Park, Elizabeth Humphreys, Alan W. Partin, Misop Han, George J. Netto, William B. Isaacs, Angelo M. De Marzo
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (20): 6563–6573.
https://doi.org/10.1158/1078-0432.CCR-11-1244
Published: 14 October 2011
View article titled, PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients
Open the PDF for PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients in another window
Includes: Supplementary data