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Journal Articles

Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia

Catherine C. Smith, Aaron D. Viny, Evan Massi, Cyriac Kandoth, Nicholas D. Socci, Franck Rapaport, Matthieu Najm, Juan S. Medina-Martinez, Elli Papaemmanuil, Theodore C. Tarver, Henry H. Hsu, Mai H. Le, Brian West, Gideon Bollag, Barry S. Taylor, Ross L. Levine, Neil P. Shah
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4003–4011.
https://doi.org/10.1158/1078-0432.CCR-20-3458
Published: 15 July 2021
View article titled, Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer

Sabine Topka, Zoe Steinsnyder, Vignesh Ravichandran, Kaitlyn Tkachuk, Yelena Kemel, Chaitanya Bandlamudi, Mogens Winkel Madsen, Helena Furberg, Ouathek Ouerfelli, Charles M. Rudin, Gopa Iyer, Steven M. Lipkin, Semanti Mukherjee, David B. Solit, Michael F. Berger, Dean F. Bajorin, Jonathan E. Rosenberg, Barry S. Taylor, Elisa de Stanchina, Joseph Vijai, Kenneth Offit
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (7): 1997–2010.
https://doi.org/10.1158/1078-0432.CCR-20-3322
Published: 01 April 2021
View article titled, Targeting Germline- and Tumor-Associated Nucleotide Excision Repair Defects in Cancer
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Includes: Supplementary data
Journal Articles

The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas

Alvin P. Makohon-Moore, Evan J. Lipson, Jody E. Hooper, Amanda Zucker, Jungeui Hong, Craig M. Bielski, Akimasa Hayashi, Collin Tokheim, Priscilla Baez, Rajya Kappagantula, Zachary Kohutek, Vladimir Makarov, Nadeem Riaz, Michael A. Postow, Paul B. Chapman, Rachel Karchin, Nicholas D. Socci, David B. Solit, Timothy A. Chan, Barry S. Taylor, Suzanne L. Topalian, Christine A. Iacobuzio-Donahue
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1516–1525.
https://doi.org/10.1158/1078-0432.CCR-20-2984
Published: 01 March 2021
View article titled, The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas
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Includes: Supplementary data
Journal Articles

Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma

Tyler D. Hitchman, Gabriella Bayshtok, Emilie Ceraudo, Amanda R. Moore, Cindy Lee, Ruobing Jia, Naitao Wang, Mohini R. Pachai, Alexander N. Shoushtari, Jasmine H. Francis, Youxin Guan, Juliet Chen, Matthew T. Chang, Barry S. Taylor, Thomas P. Sakmar, Thomas Huber, Ping Chi, Yu Chen
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1476–1490.
https://doi.org/10.1158/1078-0432.CCR-20-2860
Published: 01 March 2021
View article titled, Combined Inhibition of Gα<sub>q</sub> and MEK Enhances Therapeutic Efficacy in Uveal Melanoma
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Includes: Supplementary data
Journal Articles

Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib

Ezra Y. Rosen, Melissa L. Johnson, Sarah E. Clifford, Romel Somwar, Jennifer F. Kherani, Jieun Son, Arrien A. Bertram, Monika A. Davare, Eric Gladstone, Elena V. Ivanova, Dahlia N. Henry, Elaine M. Kelley, Mika Lin, Marina S.D. Milan, Binoj C. Nair, Elizabeth A. Olek, Jenna E. Scanlon, Morana Vojnic, Kevin Ebata, Jaclyn F. Hechtman, Bob T. Li, Lynette M. Sholl, Barry S. Taylor, Marc Ladanyi, Pasi A. Jänne, S. Michael Rothenberg, Alexander Drilon, Geoffrey R. Oxnard
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 34–42.
https://doi.org/10.1158/1078-0432.CCR-20-2278
Published: 04 January 2021
View article titled, Overcoming MET-Dependent Resistance to Selective RET Inhibition in Patients with RET Fusion–Positive Lung Cancer by Combining Selpercatinib with Crizotinib
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Includes: Supplementary data
Journal Articles

The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer

Adam J. Schoenfeld, Chai Bandlamudi, Jessica A. Lavery, Joseph Montecalvo, Azadeh Namakydoust, Hira Rizvi, Jacklynn Egger, Carla P. Concepcion, Sonal Paul, Maria E. Arcila, Yahya Daneshbod, Jason Chang, Jennifer L. Sauter, Amanda Beras, Marc Ladanyi, Tyler Jacks, Charles M. Rudin, Barry S. Taylor, Mark T.A. Donoghue, Glenn Heller, Matthew D. Hellmann, Natasha Rekhtman, Gregory J. Riely
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (21): 5701–5708.
https://doi.org/10.1158/1078-0432.CCR-20-1825
Published: 02 November 2020
View article titled, The Genomic Landscape of <em>SMARCA4</em> Alterations and Associations with Outcomes in Patients with Lung Cancer
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Includes: Supplementary data
Journal Articles

Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer

Lillian M. Smyth, Kenji Tamura, Mafalda Oliveira, Eva M. Ciruelos, Ingrid A. Mayer, Marie-Paule Sablin, Laura Biganzoli, Helen J. Ambrose, Jack Ashton, Alan Barnicle, Des D. Cashell, Claire Corcoran, Elza C. de Bruin, Andrew Foxley, Joana Hauser, Justin P.O. Lindemann, Rhiannon Maudsley, Robert McEwen, Michele Moschetta, Martin Pass, Vicky Rowlands, Gaia Schiavon, Udai Banerji, Maurizio Scaltriti, Barry S. Taylor, Sarat Chandarlapaty, José Baselga, David M. Hyman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (15): 3947–3957.
https://doi.org/10.1158/1078-0432.CCR-19-3953
Published: 03 August 2020
View article titled, Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with <em>AKT1</em><sup>E17K</sup>-Mutant, ER-Positive Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing

Martee L. Hensley, Shweta S. Chavan, David B. Solit, Rajmohan Murali, Robert Soslow, Sarah Chiang, Achim A. Jungbluth, Chaitanya Bandlamudi, Preethi Srinivasan, William D. Tap, Evan Rosenbaum, Barry S. Taylor, Mark T.A. Donoghue, David M. Hyman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3881–3888.
https://doi.org/10.1158/1078-0432.CCR-19-3959
Published: 15 July 2020
View article titled, Genomic Landscape of Uterine Sarcomas Defined Through Prospective Clinical Sequencing
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Includes: Supplementary data
Journal Articles

Abstract 16: Landscape and outcome of TRK fusion-positive Cancers

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_1): 16.
https://doi.org/10.1158/1557-3265.ADVPRECMED20-16
Published: 15 June 2020
View article titled, Abstract 16: Landscape and outcome of TRK fusion-positive Cancers
Journal Articles

TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations

Ezra Y. Rosen, Debra A. Goldman, Jaclyn F. Hechtman, Ryma Benayed, Alison M. Schram, Emiliano Cocco, Sophie Shifman, Yixiao Gong, Ritika Kundra, James P. Solomon, Alberto Bardelli, Maurizio Scaltriti, Alexander Drilon, Alexia Iasonos, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (7): 1624–1632.
https://doi.org/10.1158/1078-0432.CCR-19-3165
Published: 01 April 2020
View article titled, TRK Fusions Are Enriched in Cancers with Uncommon Histologies and the Absence of Canonical Driver Mutations
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Includes: Supplementary data
Journal Articles

Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer

Jashodeep Datta, J. Joshua Smith, Walid K. Chatila, John C. McAuliffe, Cyriac Kandoth, Efsevia Vakiani, Timothy L. Frankel, Karuna Ganesh, Isaac Wasserman, Marla Lipsyc-Sharf, Jose Guillem, Garrett M. Nash, Philip B. Paty, Martin R. Weiser, Leonard B. Saltz, Michael F. Berger, William R. Jarnagin, Vinod Balachandran, T. Peter Kingham, Nancy E. Kemeny, Andrea Cercek, Julio Garcia-Aguilar, Barry S. Taylor, Agnes Viale, Rona Yaeger, David B. Solit, Nikolaus Schultz, Michael I. D'Angelica
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1077–1085.
https://doi.org/10.1158/1078-0432.CCR-19-2390
Published: 02 March 2020
View article titled, Coaltered <em>Ras/B-raf</em> and <em>TP53</em> Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas

Philip Jonsson, Andrew L. Lin, Robert J. Young, Natalie M. DiStefano, David M. Hyman, Bob T. Li, Michael F. Berger, Ahmet Zehir, Marc Ladanyi, David B. Solit, Angela G. Arnold, Zsofia K. Stadler, Diana Mandelker, Michael E. Goldberg, Juliann Chmielecki, Maryam Pourmaleki, Shahiba Q. Ogilvie, Shweta S. Chavan, Andrew T. McKeown, Malbora Manne, Allison Hyde, Kathryn Beal, T. Jonathan Yang, Craig P. Nolan, Elena Pentsova, Antonio Omuro, Igor T. Gavrilovic, Thomas J. Kaley, Eli L. Diamond, Jacqueline B. Stone, Christian Grommes, Adrienne Boire, Mariza Daras, Anna F. Piotrowski, Alexandra M. Miller, Philip H. Gutin, Timothy A. Chan, Viviane S. Tabar, Cameron W. Brennan, Marc Rosenblum, Lisa M. DeAngelis, Ingo K. Mellinghoff, Barry S. Taylor
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (18): 5537–5547.
https://doi.org/10.1158/1078-0432.CCR-19-0032
Published: 13 September 2019
View article titled, Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas
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Includes: Supplementary data
Journal Articles

Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma

François Audenet, Sumit Isharwal, Eugene K. Cha, Mark T.A. Donoghue, Esther N. Drill, Irina Ostrovnaya, Eugene J. Pietzak, John P. Sfakianos, Aditya Bagrodia, Paari Murugan, Guido Dalbagni, Timothy F. Donahue, Jonathan E. Rosenberg, Dean F. Bajorin, Maria E. Arcila, Jaclyn F. Hechtman, Michael F. Berger, Barry S. Taylor, Hikmat Al-Ahmadie, Gopa Iyer, Bernard H. Bochner, Jonathan A. Coleman, David B. Solit
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (3): 967–976.
https://doi.org/10.1158/1078-0432.CCR-18-2039
Published: 01 February 2019
View article titled, Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma
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Includes: Supplementary data
Journal Articles

Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer

Tara E. Soumerai, Mark T.A. Donoghue, Chaitanya Bandlamudi, Preethi Srinivasan, Matthew T. Chang, Dmitriy Zamarin, Karen A. Cadoo, Rachel N. Grisham, Roisin E. O'Cearbhaill, William P. Tew, Jason A. Konner, Martee L. Hensley, Vicky Makker, Paul Sabbatini, David R. Spriggs, Tiffany A. Troso-Sandoval, Alexandra Snyder Charen, Claire Friedman, Mila Gorsky, Sarah J. Schweber, Sumit Middha, Rajmohan Murali, Sarah Chiang, Kay J. Park, Robert A. Soslow, Marc Ladanyi, Bob T. Li, Jennifer Mueller, Britta Weigelt, Ahmet Zehir, Michael F. Berger, Nadeem R. Abu-Rustum, Carol Aghajanian, Deborah F. DeLair, David B. Solit, Barry S. Taylor, David M. Hyman
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 5939–5947.
https://doi.org/10.1158/1078-0432.CCR-18-0412
Published: 03 December 2018
View article titled, Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer
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Includes: Supplementary data
Journal Articles

Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis

Matthew T. Chang, Alexander Penson, Neil B. Desai, Nicholas D. Socci, Ronglai Shen, Venkatraman E. Seshan, Ritika Kundra, Adam Abeshouse, Agnes Viale, Eugene K. Cha, Xueli Hao, Victor E. Reuter, Charles M. Rudin, Bernard H. Bochner, Jonathan E. Rosenberg, Dean F. Bajorin, Nikolaus Schultz, Michael F. Berger, Gopa Iyer, David B. Solit, Hikmat A. Al-Ahmadie, Barry S. Taylor
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (8): 1965–1973.
https://doi.org/10.1158/1078-0432.CCR-17-2655
Published: 12 April 2018
View article titled, Small-Cell Carcinomas of the Bladder and Lung Are Characterized by a Convergent but Distinct Pathogenesis
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Includes: Supplementary data
Journal Articles

Transcriptional Mechanisms of Resistance to Anti–PD-1 Therapy

Maria L. Ascierto, Alvin Makohon-Moore, Evan J. Lipson, Janis M. Taube, Tracee L. McMiller, Alan E. Berger, Jinshui Fan, Genevieve J. Kaunitz, Tricia R. Cottrell, Zachary A. Kohutek, Alexander Favorov, Vladimir Makarov, Nadeem Riaz, Timothy A. Chan, Leslie Cope, Ralph H. Hruban, Drew M. Pardoll, Barry S. Taylor, David B. Solit, Christine A. Iacobuzio-Donahue, Suzanne L. Topalian
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (12): 3168–3180.
https://doi.org/10.1158/1078-0432.CCR-17-0270
Published: 14 June 2017
View article titled, Transcriptional Mechanisms of Resistance to Anti–PD-1 Therapy
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Includes: Supplementary data
Journal Articles

Abstract IA05: Clinical genomics alters care, informs new science

Barry S. Taylor
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1_Supplement): IA05.
https://doi.org/10.1158/1557-3265.PMSCLINGEN15-IA05
Published: 03 January 2016
View article titled, Abstract IA05: Clinical genomics alters care, informs new science
Journal Articles

Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability

Aimee M. Crago, Nicholas D. Socci, Penelope DeCarolis, Rachael O'Connor, Barry S. Taylor, Li-Xuan Qin, Cristina R. Antonescu, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (5): 1334–1340.
https://doi.org/10.1158/1078-0432.CCR-11-2820
Published: 01 March 2012
View article titled, Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability
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Includes: Supplementary data