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Axel Grothey
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Journal Articles

Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Andreas Seeber, Francesca Battaglin, Kai Zimmer, Florian Kocher, Yasmine Baca, Joanne Xiu, Gilbert Spizzo, Veronica Novotny-Diermayr, Dietmar Rieder, Alberto Puccini, Jeff Swensen, Michelle Ellis, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, John L. Marshall, Benjamin A. Weinberg, Paul E. Sackstein, Kiat Hon Lim, Gek San Tan, Chadi Nabhan, W. Michael Korn, Arno Amann, Zlatko Trajanoski, Martin D. Berger, Emil Lou, Dominik Wolf, Heinz-Josef Lenz
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1863–1870.
https://doi.org/10.1158/1078-0432.CCR-21-3018
Published: 02 May 2022
View article titled, Comprehensive Analysis of R-Spondin Fusions and <em>RNF43</em> Mutations Implicate Novel Therapeutic Options in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

Jonathan M. Loree, Yucai Wang, Muddassir A. Syed, Alexey V. Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A. Weinberg, Ari M. Vanderwalde, Anteneh Tesfaye, Victoria M. Raymond, Benjamin Miron, Gabi Tarcic, Ori Zelichov, Russell R. Broaddus, Patrick Kwok Shing Ng, Kang Jin Jeong, Yiu Huen Tsang, Gordon B. Mills, Michael J. Overman, Axel Grothey, John L. Marshall, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4587–4598.
https://doi.org/10.1158/1078-0432.CCR-21-0180
Published: 15 August 2021
View article titled, Clinical and Functional Characterization of Atypical <em>KRAS</em>/<em>NRAS</em> Mutations in Metastatic Colorectal Cancer
Open the PDF for Clinical and Functional Characterization of Atypical <em>KRAS</em>/<em>NRAS</em> Mutations in Metastatic Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer

Jim P. Abraham, Daniel Magee, Chiara Cremolini, Carlotta Antoniotti, David D. Halbert, Joanne Xiu, Phillip Stafford, Donald A. Berry, Matthew J. Oberley, Anthony F. Shields, John L. Marshall, Mohamed E. Salem, Alfredo Falcone, Axel Grothey, Michael J. Hall, Alan P. Venook, Heinz-Josef Lenz, Anthony Helmstetter, W. Michael Korn, David B. Spetzler
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (4): 1174–1183.
https://doi.org/10.1158/1078-0432.CCR-20-3286
Published: 15 February 2021
View article titled, Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer

Axel Grothey, Jonathan R. Strosberg, Lindsay A. Renfro, Herbert I. Hurwitz, John L. Marshall, Howard Safran, Michael J. Guarino, George P. Kim, J.R. Hecht, Susan C. Weil, John Heyburn, Wenquan Wang, Charles Schweizer, Daniel J. O'Shannessy, Luis Alberto Diaz, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2): 316–325.
https://doi.org/10.1158/1078-0432.CCR-17-1558
Published: 15 January 2018
View article titled, A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer
Open the PDF for A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer in another window
Journal Articles

Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas

Harry H. Yoon, Qian Shi, William R. Sukov, Anne E. Wiktor, Maliha Khan, Christopher A. Sattler, Axel Grothey, Tsung-Teh Wu, Robert B. Diasio, Robert B. Jenkins, Frank A. Sinicrope
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 546–554.
https://doi.org/10.1158/1078-0432.CCR-11-2272
Published: 16 January 2012
View article titled, Association of HER2/ErbB2 Expression and Gene Amplification with Pathologic Features and Prognosis in Esophageal Adenocarcinomas
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Includes: Supplementary data
Journal Articles

Does Stage II Colorectal Cancer Need to Be Redefined?

Axel Grothey
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3053–3055.
https://doi.org/10.1158/1078-0432.CCR-11-0574
Published: 15 May 2011
View article titled, Does Stage II Colorectal Cancer Need to Be Redefined?
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Includes: Supplementary data
Journal Articles

Biomarkers of Resistance to Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer

Michaela S. Banck, Axel Grothey
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (24): 7492–7501.
https://doi.org/10.1158/1078-0432.CCR-09-0188
Published: 14 December 2009
View article titled, Biomarkers of Resistance to Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer
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Journal Articles

Biological Therapy and Other Novel Therapies in Early-Stage Disease: Are They Appropriate?

Axel Grothey
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22): 6909s–6912s.
https://doi.org/10.1158/1078-0432.CCR-07-1125
Published: 15 November 2007
View article titled, Biological Therapy and Other Novel Therapies in Early-Stage Disease: Are They Appropriate?
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Journal Articles

New Approaches to Assessing and Treating Early-Stage Colon and Rectal Cancer: Summary Statement from 2007 Santa Monica Conference

Lee S. Rosen, Anton J. Bilchik, Robert W. Beart, Jr., Al B. Benson, III, Kenneth J. Chang, Carolyn C. Compton, Axel Grothey, Daniel G. Haller, Clifford Y. Ko, Patrick M. Lynch, Heidi Nelson, Michael J. Stamos, Roderick R. Turner, Christopher G. Willett
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22): 6853s–6856s.
https://doi.org/10.1158/1078-0432.CCR-07-1629
Published: 15 November 2007
View article titled, New Approaches to Assessing and Treating Early-Stage Colon and Rectal Cancer: Summary Statement from 2007 Santa Monica Conference
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