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Anna M. Varghese
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Journal Articles

Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma

Brett L. Ecker, Alice J. Tao, Quisette P. Janssen, Henry S. Walch, Colin M. Court, Vinod P. Balachandran, Christopher H. Crane, Michael I. D'Angelica, Jeffrey A. Drebin, T. Peter Kingham, Kevin C. Soares, Christine A. Iacobuzio-Donahue, Efsevia Vakiani, Mithat Gonen, Eileen M. O'Reilly, Anna M. Varghese, William R. Jarnagin, Alice C. Wei
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1368–1374.
https://doi.org/10.1158/1078-0432.CCR-22-3089
Published: 03 April 2023
View article titled, Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma
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Journal Articles

Clinico-genomic Characterization of ATM and HRD in Pancreas Cancer: Application for Practice

Wungki Park, Catherine A. O'Connor, Chaitanya Bandlamudi, Daniella Forman, Joanne F. Chou, Shigeaki Umeda, Marsha Reyngold, Anna M. Varghese, Fergus Keane, Fiyinfolu Balogun, Kenneth H. Yu, David P. Kelsen, Christopher Crane, Marinela Capanu, Christine Iacobuzio-Donahue, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4782–4792.
https://doi.org/10.1158/1078-0432.CCR-22-1483
Published: 01 November 2022
View article titled, Clinico-genomic Characterization of <em>ATM</em> and HRD in Pancreas Cancer: Application for Practice
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Includes: Supplementary data
Journal Articles

Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer

Neil H. Segal, Andrea Cercek, Geoffrey Ku, Abraham J. Wu, Andreas Rimner, Danny N. Khalil, Diane Reidy-Lagunes, John Cuaron, T. Jonathan Yang, Martin R. Weiser, Paul B. Romesser, Zsofia K. Stadler, Anna M. Varghese, Karuna Ganesh, Rona Yaeger, Louise C. Connell, David Faleck, Ghassan K. Abou-Alfa, Kathleen C. Mcauliffe, Pamela Vaiskauskas, Mark L. Solter, Martinique Ogle, Matthew J. Adamow, Aliya Holland, Pallavi Vedantam, Phillip Wong, Taha Merghoub, Efsevia Vakiani, Travis J. Hollmann, Krishna Juluru, Joanne F. Chou, Marinela Capanu, Joseph Erinjeri, Stephen Solomon, Yoshiya Yamada, Nancy Kemeny, Christopher H. Crane, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2200–2208.
https://doi.org/10.1158/1078-0432.CCR-20-2474
Published: 15 April 2021
View article titled, Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer
Open the PDF for Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection

Wungki Park, Jiapeng Chen, Joanne F. Chou, Anna M. Varghese, Kenneth H. Yu, Winston Wong, Marinela Capanu, Vinod Balachandran, Caitlin A. McIntyre, Imane El Dika, Danny N. Khalil, James J. Harding, Nima Ghalehsari, Zoe McKinnell, Sree B. Chalasani, Vladimir Makarov, Pier Selenica, Xin Pei, Nicolas Lecomte, David P. Kelsen, Ghassan K. Abou-Alfa, Mark E. Robson, Liying Zhang, Michael F. Berger, Nikolaus Schultz, Timothy A. Chan, Simon N. Powell, Jorge S. Reis-Filho, Christine A. Iacobuzio-Donahue, Nadeem Riaz, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3239–3247.
https://doi.org/10.1158/1078-0432.CCR-20-0418
Published: 01 July 2020
View article titled, Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection
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Includes: Supplementary data
Journal Articles

Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy

Andrea Cercek, Gustavo Dos Santos Fernandes, Campbell S. Roxburgh, Karuna Ganesh, Shu Ng, Francisco Sanchez-Vega, Rona Yaeger, Neil H. Segal, Diane L. Reidy-Lagunes, Anna M. Varghese, Arnold Markowitz, Chao Wu, Bryan Szeglin, Charles-Etienne Gabriel Sauvé, Erin Salo-Mullen, Christina Tran, Zalak Patel, Asha Krishnan, Kaitlyn Tkachuk, Garrett M. Nash, Jose Guillem, Philip B. Paty, Jinru Shia, Nikolaus Schultz, Julio Garcia-Aguilar, Luis A. Diaz, Karyn Goodman, Leonard B. Saltz, Martin R. Weiser, J. Joshua Smith, Zsofia K. Stadler
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3271–3279.
https://doi.org/10.1158/1078-0432.CCR-19-3728
Published: 01 July 2020
View article titled, Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
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Includes: Supplementary data
Journal Articles

Phase I Study of Trifluridine/Tipiracil Plus Irinotecan and Bevacizumab in Advanced Gastrointestinal Tumors

Anna M. Varghese, Dana B. Cardin, Jonathan Hersch, Al B. Benson, Howard S. Hochster, Lukas Makris, Kensuke Hamada, Jordan D. Berlin, Leonard B. Saltz
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (7): 1555–1562.
https://doi.org/10.1158/1078-0432.CCR-19-2743
Published: 01 April 2020
View article titled, Phase I Study of Trifluridine/Tipiracil Plus Irinotecan and Bevacizumab in Advanced Gastrointestinal Tumors
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Includes: Supplementary data
Journal Articles

A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer

Johanna C. Bendell, Anna M. Varghese, David M. Hyman, Todd M. Bauer, Shubham Pant, Sophie Callies, Ji Lin, Ricardo Martinez, Enaksha Wickremsinhe, Aaron Fink, Volker Wacheck, Kathleen N. Moore
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (14): 3253–3262.
https://doi.org/10.1158/1078-0432.CCR-17-3421
Published: 15 July 2018
View article titled, A First-in-Human Phase 1 Study of LY3023414, an Oral PI3K/mTOR Dual Inhibitor, in Patients with Advanced Cancer
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Includes: Supplementary data
Journal Articles

Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations

Zishuo I. Hu, Jinru Shia, Zsofia K. Stadler, Anna M. Varghese, Marinela Capanu, Erin Salo-Mullen, Maeve A. Lowery, Luis A. Diaz, Jr, Diana Mandelker, Kenneth H. Yu, Alice Zervoudakis, David P. Kelsen, Christine A. Iacobuzio-Donahue, David S. Klimstra, Leonard B. Saltz, Ibrahim H. Sahin, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (6): 1326–1336.
https://doi.org/10.1158/1078-0432.CCR-17-3099
Published: 14 March 2018
View article titled, Evaluating Mismatch Repair Deficiency in Pancreatic Adenocarcinoma: Challenges and Recommendations
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Journal Articles

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype

Maeve A. Lowery, Emmet J. Jordan, Olca Basturk, Ryan N. Ptashkin, Ahmet Zehir, Michael F. Berger, Tanisha Leach, Brian Herbst, Gokce Askan, Hannah Maynard, Danielle Glassman, Christina Covington, Nikolaus Schultz, Ghassan K. Abou-Alfa, James J. Harding, David S. Klimstra, Jaclyn F. Hechtman, David M. Hyman, Peter J. Allen, William R. Jarnagin, Vinod P. Balachandran, Anna M. Varghese, Mark A. Schattner, Kenneth H. Yu, Leonard B. Saltz, David B. Solit, Christine A. Iacobuzio-Donahue, Steven D. Leach, Eileen M. O'Reilly
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6094–6100.
https://doi.org/10.1158/1078-0432.CCR-17-0899
Published: 12 October 2017
View article titled, Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype
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Journal Articles

ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer

Justin F. Gainor, Anna M. Varghese, Sai-Hong Ignatius Ou, Sheheryar Kabraji, Mark M. Awad, Ryohei Katayama, Amanda Pawlak, Mari Mino-Kenudson, Beow Y. Yeap, Gregory J. Riely, A. John Iafrate, Maria E. Arcila, Marc Ladanyi, Jeffrey A. Engelman, Dora Dias-Santagata, Alice T. Shaw
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (15): 4273–4281.
https://doi.org/10.1158/1078-0432.CCR-13-0318
Published: 31 July 2013
View article titled, <em>ALK</em> Rearrangements Are Mutually Exclusive with Mutations in <em>EGFR</em> or <em>KRAS</em>: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer
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