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Journal Articles

Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial

Melissa L. Abel, Nobuyuki Takahashi, Cody Peer, Christophe E. Redon, Samantha Nichols, Rasa Vilimas, Min-Jung Lee, Sunmin Lee, Meenakshi Shelat, Robbie Kattappuram, Linda Sciuto, Danielle Pinkiert, Chante Graham, Donna Butcher, Baktiar Karim, Ajit Kumar Sharma, Justin Malin, Rajesh Kumar, Christopher W. Schultz, Shubhank Goyal, Jaydira del Rivero, Manan Krishnamurthy, Deep Upadhyay, Brett Schroeder, Tristan Sissung, Manoj Tyagi, Jung Kim, Yves Pommier, Mirit Aladjem, Mark Raffeld, William Douglas Figg, Jane Trepel, Liqiang Xi, Parth Desai, Anish Thomas
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18): 3603–3611.
https://doi.org/10.1158/1078-0432.CCR-23-0536
Published: 15 September 2023
View article titled, Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial
Open the PDF for Targeting Replication Stress and Chemotherapy Resistance with a Combination of Sacituzumab Govitecan and Berzosertib: A Phase I Clinical Trial in another window
Includes: Supplementary data
Journal Articles

New Life of Topoisomerase I Inhibitors as Antibody–Drug Conjugate Warheads

Yves Pommier, Anish Thomas
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (6): 991–993.
https://doi.org/10.1158/1078-0432.CCR-22-3640
Published: 14 March 2023
View article titled, New Life of Topoisomerase I Inhibitors as Antibody–Drug Conjugate Warheads
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Journal Articles

Targeting DNA Repair to Drive Immune Responses: It's Time to Reconsider the Strategy for Clinical Translation

Nobuyuki Takahashi, Ira Surolia, Anish Thomas
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11): 2452–2456.
https://doi.org/10.1158/1078-0432.CCR-19-3841
Published: 01 June 2020
View article titled, Targeting DNA Repair to Drive Immune Responses: It's Time to Reconsider the Strategy for Clinical Translation
Open the PDF for Targeting DNA Repair to Drive Immune Responses: It's Time to Reconsider the Strategy for Clinical Translation in another window
Includes: Supplementary data
Journal Articles

Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma

Christine Alewine, Mehwish Ahmad, Cody J. Peer, Zishuo I. Hu, Min-Jung Lee, Akira Yuno, Jessica D. Kindrick, Anish Thomas, Seth M. Steinberg, Jane B. Trepel, William D. Figg, Raffit Hassan, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (4): 828–836.
https://doi.org/10.1158/1078-0432.CCR-19-2586
Published: 14 February 2020
View article titled, Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma
Open the PDF for Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Targeting Topoisomerase I in the Era of Precision Medicine

Anish Thomas, Yves Pommier
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22): 6581–6589.
https://doi.org/10.1158/1078-0432.CCR-19-1089
Published: 15 November 2019
View article titled, Targeting Topoisomerase I in the Era of Precision Medicine
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Includes: Supplementary data
Journal Articles

Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Raffit Hassan, Evan Alley, Hedy Kindler, Scott Antonia, Thierry Jahan, Somayeh Honarmand, Nitya Nair, Chan C. Whiting, Amanda Enstrom, Ed Lemmens, Takahiro Tsujikawa, Sushil Kumar, Gina Choe, Anish Thomas, Katherine McDougall, Aimee L. Murphy, Elizabeth Jaffee, Lisa M. Coussens, Dirk G. Brockstedt
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 5787–5798.
https://doi.org/10.1158/1078-0432.CCR-19-0070
Published: 01 October 2019
View article titled, Clinical Response of Live-Attenuated, <em>Listeria monocytogenes</em> Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma
Open the PDF for Clinical Response of Live-Attenuated, <em>Listeria monocytogenes</em> Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma in another window
Includes: Supplementary data
Journal Articles

Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients

Swati Khanna, Suzanne Graef, Francis Mussai, Anish Thomas, Neha Wali, Bahar Guliz Yenidunya, Constance Yuan, Betsy Morrow, Jingli Zhang, Firouzeh Korangy, Tim F. Greten, Seth M. Steinberg, Maryalice Stetler-Stevenson, Gary Middleton, Carmela De Santo, Raffit Hassan
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2859–2872.
https://doi.org/10.1158/1078-0432.CCR-17-3757
Published: 14 June 2018
View article titled, Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
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Includes: Supplementary data
Journal Articles

Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors

Sai-Wen Tang, Anish Thomas, Junko Murai, Jane B. Trepel, Susan E. Bates, Vinodh N. Rajapakse, Yves Pommier
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (8): 1944–1953.
https://doi.org/10.1158/1078-0432.CCR-17-0443
Published: 12 April 2018
View article titled, Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (<em>SLFN11)</em> Expression with Class I Histone Deacetylase Inhibitors
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Includes: Supplementary data
Journal Articles

Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma

Raffit Hassan, Hedy L. Kindler, Thierry Jahan, Lyudmila Bazhenova, Martin Reck, Anish Thomas, Ira Pastan, Jeff Parno, Daniel J. O'Shannessy, Penny Fatato, Julia D. Maltzman, Bruce A. Wallin
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (23): 5927–5936.
https://doi.org/10.1158/1078-0432.CCR-14-0804
Published: 30 November 2014
View article titled, Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma
Open the PDF for Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma in another window
Includes: Supplementary data
Journal Articles

A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study

Anish Thomas, Arun Rajan, Eva Szabo, Yusuke Tomita, Corey A. Carter, Barbara Scepura, Ariel Lopez-Chavez, Min-Jung Lee, Christophe E. Redon, Ari Frosch, Cody J. Peer, Yuanbin Chen, Richard Piekarz, Seth M. Steinberg, Jane B. Trepel, William D. Figg, David S. Schrump, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5392–5402.
https://doi.org/10.1158/1078-0432.CCR-14-0968
Published: 30 October 2014
View article titled, A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study
Open the PDF for A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study in another window
Includes: Supplementary data
Journal Articles

18F-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Thymic Epithelial Tumors

Anish Thomas, Esther Mena, Karen Kurdziel, David Venzon, Sean Khozin, Arlene W. Berman, Peter Choyke, Eva Szabo, Arun Rajan, Giuseppe Giaccone
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1487–1493.
https://doi.org/10.1158/1078-0432.CCR-12-2929
Published: 14 March 2013
View article titled, <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Thymic Epithelial Tumors
Open the PDF for <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in the Management of Patients with Thymic Epithelial Tumors in another window
Includes: Supplementary data