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Andrew J. Steele
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Journal Articles

Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells

Adam J. Linley, Laura I. Karydis, Anil K. Mondru, Annalisa D'Avola, Humood Al Shmrany, Silvia Cicconi, Rebecca Griffin, Francesco Forconi, Andrew R. Pettitt, Nagesh Kalakonda, Andrew C. Rawstron, Peter Hillmen, Andrew J. Steele, David J. MacEwan, Graham Packham, Ian A. Prior, Joseph R. Slupsky
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5647–5659.
https://doi.org/10.1158/1078-0432.CCR-21-0161
Published: 15 October 2021
View article titled, Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells
Open the PDF for Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells in another window
Includes: Supplementary data
Journal Articles

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

Elizabeth A. Lemm, Beatriz Valle-Argos, Lindsay D. Smith, Johanna Richter, Yohannes Gebreselassie, Matthew J. Carter, Jana Karolova, Michael Svaton, Karel Helman, Nicola J. Weston-Bell, Laura Karydis, Chris T. Williamson, Georg Lenz, Jeremy Pettigrew, Curtis Harwig, Freda K. Stevenson, Mark Cragg, Francesco Forconi, Andrew J. Steele, Jennifer Cross, Lloyd Mackenzie, Pavel Klener, Graham Packham
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1700–1711.
https://doi.org/10.1158/1078-0432.CCR-19-2202
Published: 01 April 2020
View article titled, Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells
Open the PDF for Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells in another window
Includes: Supplementary data
Journal Articles

Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients

Samantha Drennan, Giorgia Chiodin, Annalisa D'Avola, Ian Tracy, Peter W. Johnson, Livio Trentin, Andrew J. Steele, Graham Packham, Freda K. Stevenson, Francesco Forconi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2503–2512.
https://doi.org/10.1158/1078-0432.CCR-18-1286
Published: 15 April 2019
View article titled, Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients
Open the PDF for Ibrutinib Therapy Releases Leukemic Surface IgM from Antigen Drive in Chronic Lymphocytic Leukemia Patients in another window
Includes: Supplementary data
Journal Articles

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

Matthew D. Blunt, Stefan Koehrer, Rachel C. Dobson, Marta Larrayoz, Sarah Wilmore, Alice Hayman, Jack Parnell, Lindsay D. Smith, Andrew Davies, Peter W.M. Johnson, Pamela B. Conley, Anjali Pandey, Jonathan C. Strefford, Freda K. Stevenson, Graham Packham, Francesco Forconi, Greg P. Coffey, Jan A. Burger, Andrew J. Steele
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2313–2324.
https://doi.org/10.1158/1078-0432.CCR-16-1662
Published: 30 April 2017
View article titled, The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia
Open the PDF for The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia in another window
Includes: Supplementary data