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Andrew D.J. Pearson
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Journal Articles

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors

Free
Mark W. Kieran, Birgit Geoerger, Ira J. Dunkel, Alberto Broniscer, Darren Hargrave, Pooja Hingorani, Isabelle Aerts, Anne-Isabelle Bertozzi, Kenneth J. Cohen, Trent R. Hummel, Violet Shen, Eric Bouffet, Christine A. Pratilas, Andrew D.J. Pearson, Lillian Tseng, Noelia Nebot, Steven Green, Mark W. Russo, James A. Whitlock
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (24): 7294–7302.
https://doi.org/10.1158/1078-0432.CCR-17-3572
Published: 13 December 2019
View articletitled, A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation–Positive Solid Tumors
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Includes: Supplementary data
Journal Articles

A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors

Free
Birgit Geoerger, Franck Bourdeaut, Steven G. DuBois, Matthias Fischer, James I. Geller, Nicholas G. Gottardo, Aurélien Marabelle, Andrew D.J. Pearson, Shakeel Modak, Thomas Cash, Giles W. Robinson, Marlyane Motta, Alessandro Matano, Suraj G. Bhansali, Jason R. Dobson, Sudha Parasuraman, Susan N. Chi
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (10): 2433–2441.
https://doi.org/10.1158/1078-0432.CCR-16-2898
Published: 14 May 2017
View articletitled, A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors
Open the PDF for A Phase I Study of the CDK4/6 Inhibitor Ribociclib (LEE011) in Pediatric Patients with Malignant Rhabdoid Tumors, Neuroblastoma, and Other Solid Tumors in another window
Includes: Supplementary data
Journal Articles

A Phase I Trial of AT9283 (a Selective Inhibitor of Aurora Kinases) in Children and Adolescents with Solid Tumors: A Cancer Research UK Study

Free
Lucas Moreno, Lynley V. Marshall, Andrew D.J. Pearson, Bruce Morland, Martin Elliott, Quentin Campbell-Hewson, Guy Makin, Sarah E.R. Halford, Gary Acton, Philip Ross, Shamim Kazmi-Stokes, Victoria Lock, Ana Rodriguez, John F. Lyons, Alan V. Boddy, Melanie J. Griffin, Murray Yule, Darren Hargrave
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (2): 267–273.
https://doi.org/10.1158/1078-0432.CCR-14-1592
Published: 14 January 2015
View articletitled, A Phase I Trial of AT9283 (a Selective Inhibitor of Aurora Kinases) in Children and Adolescents with Solid Tumors: A Cancer Research UK Study
Open the PDF for A Phase I Trial of AT9283 (a Selective Inhibitor of Aurora Kinases) in Children and Adolescents with Solid Tumors: A Cancer Research UK Study in another window
Includes: Supplementary data
Journal Articles

New Strategies in Neuroblastoma: Therapeutic Targeting of MYCN and ALK

Free
Giuseppe Barone, John Anderson, Andrew D.J. Pearson, Kevin Petrie, Louis Chesler
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (21): 5814–5821.
https://doi.org/10.1158/1078-0432.CCR-13-0680
Published: 31 October 2013
View articletitled, New Strategies in Neuroblastoma: Therapeutic Targeting of MYCN and ALK
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Journal Articles

Adaptive Dosing Approaches to the Individualization of 13-Cis-Retinoic Acid (Isotretinoin) Treatment for Children with High-Risk Neuroblastoma

Free
Gareth J. Veal, Julie Errington, Sophie E. Rowbotham, Nicola A. Illingworth, Ghada Malik, Michael Cole, Ann K. Daly, Andrew D.J. Pearson, Alan V. Boddy
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (2): 469–479.
https://doi.org/10.1158/1078-0432.CCR-12-2225
Published: 16 January 2013
View articletitled, Adaptive Dosing Approaches to the Individualization of 13-Cis-Retinoic Acid (Isotretinoin) Treatment for Children with High-Risk Neuroblastoma
Open the PDF for Adaptive Dosing Approaches to the Individualization of 13-Cis-Retinoic Acid (Isotretinoin) Treatment for Children with High-Risk Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma

Free
Jane Carr-Wilkinson, Kieran O'Toole, Katrina M. Wood, Christine C. Challen, Angela G. Baker, Julian R. Board, Laura Evans, Michael Cole, Nai-Kong V. Cheung, Joachim Boos, Gabriele Köhler, Ivo Leuschner, Andrew D.J. Pearson, John Lunec, Deborah A. Tweddle
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (4): 1108–1118.
https://doi.org/10.1158/1078-0432.CCR-09-1865
Published: 15 February 2010
View articletitled, High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma
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Journal Articles

EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines

Free
Dorine A. Bax, Nathalie Gaspar, Suzanne E. Little, Lynley Marshall, Lara Perryman, Marie Regairaz, Marta Viana-Pereira, Raisa Vuononvirta, Swee Y. Sharp, Jorge S. Reis-Filho, João N. Stávale, Safa Al-Sarraj, Rui M. Reis, Gilles Vassal, Andrew D.J. Pearson, Darren Hargrave, David W. Ellison, Paul Workman, Chris Jones
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (18): 5753–5761.
https://doi.org/10.1158/1078-0432.CCR-08-3210
Published: 14 September 2009
View articletitled, EGFRvIII Deletion Mutations in Pediatric High-Grade Glioma and Response to Targeted Therapy in Pediatric Glioma Cell Lines
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Includes: Supplementary data
Journal Articles

Pharmacokinetics of Dactinomycin in a Pediatric Patient Population: a United Kingdom Children's Cancer Study Group Study

Free
Gareth J. Veal, Michael Cole, Julie Errington, Annie Parry, Juliet Hale, Andrew D.J. Pearson, Karen Howe, Julia C. Chisholm, Carol Beane, Bernadette Brennan, Fiona Waters, Adam Glaser, Sue Hemsworth, Heather McDowell, Yvonne Wright, Kathy Pritchard-Jones, Ross Pinkerton, Gail Jenner, James Nicholson, Ann M. Elsworth, Alan V. Boddy, UKCCSG Pharmacology Working Group
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (16): 5893–5899.
https://doi.org/10.1158/1078-0432.CCR-04-2546
Published: 22 August 2005
View articletitled, Pharmacokinetics of Dactinomycin in a Pediatric Patient Population: a United Kingdom Children's Cancer Study Group Study
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