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Amy B. Heimberger
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Journal Articles

Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma

Open Access
Kirit Singh, Kristen A. Batich, Patrick Y. Wen, Aaron C. Tan, Stephen J. Bagley, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, Susan M. Chang, Rifaquat Rahman, Evanthia Galanis, Alireza Mansouri, Vinay K. Puduvalli, David A. Reardon, Solmaz Sahebjam, John H. Sampson, John Simes, Donald A. Berry, Gelareh Zadeh, Tim F. Cloughesy, Minesh P. Mehta, Steven Piantadosi, Michael Weller, Amy B. Heimberger, Mustafa Khasraw
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 585–593.
https://doi.org/10.1158/1078-0432.CCR-21-2681
Published: 15 February 2022
View articletitled, Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma
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Journal Articles

Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma

Open Access
C. Elizabeth Boudreau, Hinda Najem, Martina Ott, Craig Horbinski, Dexing Fang, Chase M. DeRay, Jonathan M. Levine, Michael A. Curran, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5528–5535.
https://doi.org/10.1158/1078-0432.CCR-21-1914
Published: 15 October 2021
View articletitled, Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
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Includes: Supplementary data
Journal Articles

Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

Open Access
Aria Sabbagh, Kevin Beccaria, Xiaoyang Ling, Anantha Marisetty, Martina Ott, Hillary Caruso, Emily Barton, Ling-Yuan Kong, Dexing Fang, Khatri Latha, Daniel Yang Zhang, Jun Wei, John DeGroot, Michael A. Curran, Ganesh Rao, Jian Hu, Carole Desseaux, Guillaume Bouchoux, Michael Canney, Alexandre Carpentier, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4325–4337.
https://doi.org/10.1158/1078-0432.CCR-20-3760
Published: 01 August 2021
View articletitled, Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models
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Includes: Supplementary data
Journal Articles

Radiation with STAT3 Blockade Triggers Dendritic Cell–T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy

Free
Martina Ott, Cynthia Kassab, Anantha Marisetty, Yuuri Hashimoto, Jun Wei, Daniel Zamler, Jia-Shiun Leu, Karl-Heinz Tomaszowski, Aria Sabbagh, Dexing Fang, Pravesh Gupta, Waldemar Priebe, Rafal J. Zielinski, Jared K. Burks, James P. Long, Ling-Yuan Kong, Gregory N. Fuller, John DeGroot, Erik P. Sulman, Amy B. Heimberger
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (18): 4983–4994.
https://doi.org/10.1158/1078-0432.CCR-19-4092
Published: 15 September 2020
View articletitled, Radiation with STAT3 Blockade Triggers Dendritic Cell–T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy
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Includes: Multimedia, Supplementary data
Journal Articles

Anti–PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells

Free
Ganesh Rao, Khatri Latha, Martina Ott, Aria Sabbagh, Anantha Marisetty, Xiaoyang Ling, Daniel Zamler, Tiffany A. Doucette, Yuhui Yang, Ling-Yuan Kong, Jun Wei, Gregory N. Fuller, Fernando Benavides, Adam M. Sonabend, James Long, Shulin Li, Michael Curran, Amy B. Heimberger
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (17): 4699–4712.
https://doi.org/10.1158/1078-0432.CCR-19-4110
Published: 01 September 2020
View articletitled, Anti–PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells
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Includes: Supplementary data
Journal Articles

CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas

Available to Purchase
Joshua R. Kane, Junfei Zhao, Takashi Tsujiuchi, Brice Laffleur, Víctor A. Arrieta, Aayushi Mahajan, Ganesh Rao, Angeliki Mela, Crismita Dmello, Li Chen, Daniel Y. Zhang, Edgar González-Buendia, Catalina Lee-Chang, Ting Xiao, Gerson Rothschild, Uttiya Basu, Craig Horbinski, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Peter Canoll, Adam M. Sonabend
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (16): 4390–4401.
https://doi.org/10.1158/1078-0432.CCR-19-3104
Published: 14 August 2020
View articletitled, CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas
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Includes: Supplementary data
Journal Articles

Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial

Available to Purchase
Shiao-Pei Weathers, Marta Penas-Prado, Be-Lian Pei, Xiaoyang Ling, Cynthia Kassab, Pinaki Banerjee, Mustafa Bdiwi, Hila Shaim, Abdullah Alsuliman, Mayra Shanley, John F. de Groot, Barbara J. O'Brien, Rebecca Harrison, Nazanin Majd, Carlos Kamiya-Matsuoka, Gregory N. Fuller, Jason T. Huse, Linda Chi, Ganesh Rao, Jeffrey S. Weinberg, Frederick F. Lang, Raymond Sawaya, Elizabeth J. Shpall, Katayoun Rezvani, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3565–3577.
https://doi.org/10.1158/1078-0432.CCR-20-0176
Published: 15 July 2020
View articletitled, Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial
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Includes: Supplementary data
Journal Articles

Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege

Available to Purchase
Peter E. Fecci, Amy B. Heimberger, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (22): 5620–5629.
https://doi.org/10.1158/1078-0432.CCR-14-0832
Published: 13 November 2014
View articletitled, Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege
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Journal Articles

Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype

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Kristine Dziurzynski, Jun Wei, Wei Qiao, Mustafa Aziz Hatiboglu, Ling-Yuan Kong, Adam Wu, Yongtao Wang, Daniel Cahill, Nicholas Levine, Sujit Prabhu, Ganesh Rao, Raymond Sawaya, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4642–4649.
https://doi.org/10.1158/1078-0432.CCR-11-0414
Published: 17 July 2011
View articletitled, Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype
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Includes: Supplementary data
Journal Articles

Intratumoral Mediated Immunosuppression is Prognostic in Genetically Engineered Murine Models of Glioma and Correlates to Immunotherapeutic Responses

Available to Purchase
Ling-Yuan Kong, Adam S. Wu, Tiffany Doucette, Jun Wei, Waldemar Priebe, Gregory N. Fuller, Wei Qiao, Raymond Sawaya, Ganesh Rao, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (23): 5722–5733.
https://doi.org/10.1158/1078-0432.CCR-10-1693
Published: 06 December 2010
View articletitled, Intratumoral Mediated Immunosuppression is Prognostic in Genetically Engineered Murine Models of Glioma and Correlates to Immunotherapeutic Responses
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Journal Articles

Inhibition of p-STAT3 Enhances IFN-α Efficacy against Metastatic Melanoma in a Murine Model

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Ling-Yuan Kong, Alexander Gelbard, Jun Wei, Chantal Reina-Ortiz, Yongtao Wang, Eric C. Yang, Yared Hailemichael, Izabela Fokt, Arumugam Jayakumar, Wei Qiao, Gregory N. Fuller, Willem W. Overwijk, Waldemar Priebe, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (9): 2550–2561.
https://doi.org/10.1158/1078-0432.CCR-10-0279
Published: 28 April 2010
View articletitled, Inhibition of p-STAT3 Enhances IFN-α Efficacy against Metastatic Melanoma in a Murine Model
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Journal Articles

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

Available to Purchase
Jun Wei, Jason Barr, Ling-Yuan Kong, Yongtao Wang, Adam Wu, Amit K. Sharma, Joy Gumin, Verlene Henry, Howard Colman, Raymond Sawaya, Frederick F. Lang, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 461–473.
https://doi.org/10.1158/1078-0432.CCR-09-1983
Published: 14 January 2010
View articletitled, Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression
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Journal Articles

The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas

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Mohamed Abou-Ghazal, David S. Yang, Wei Qiao, Chantal Reina-Ortiz, Jun Wei, Ling-Yuan Kong, Gregory N. Fuller, Nobuyoshi Hiraoka, Waldemar Priebe, Raymond Sawaya, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8228–8235.
https://doi.org/10.1158/1078-0432.CCR-08-1329
Published: 15 December 2008
View articletitled, The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas
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Journal Articles

A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

Available to Purchase
Ling-Yuan Kong, Mohamed K. Abou-Ghazal, Jun Wei, Arup Chakraborty, Wei Sun, Wei Qiao, Gregory N. Fuller, Izabela Fokt, Elizabeth A. Grimm, Robert J. Schmittling, Gary E. Archer, Jr., John H. Sampson, Waldemar Priebe, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5759–5768.
https://doi.org/10.1158/1078-0432.CCR-08-0377
Published: 14 September 2008
View articletitled, A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells
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Journal Articles

Incidence and Prognostic Impact of FoxP3+ Regulatory T Cells in Human Gliomas

Available to Purchase
Amy B. Heimberger, Mohamed Abou-Ghazal, Chantal Reina-Ortiz, David S. Yang, Wei Sun, Wei Qiao, Nobuyoshi Hiraoka, Gregory N. Fuller
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5166–5172.
https://doi.org/10.1158/1078-0432.CCR-08-0320
Published: 12 August 2008
View articletitled, Incidence and Prognostic Impact of FoxP3+ Regulatory T Cells in Human Gliomas
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Journal Articles

Cytochrome P450 1B1 Expression in Glial Cell Tumors: An Immunotherapeutic Target

Available to Purchase
Julia A. Barnett, Diana L. Urbauer, Graeme I. Murray, Gregory N. Fuller, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (12): 3559–3567.
https://doi.org/10.1158/1078-0432.CCR-06-2430
Published: 15 June 2007
View articletitled, Cytochrome P450 1B1 Expression in Glial Cell Tumors: An Immunotherapeutic Target
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Journal Articles

Prognostic Associations of Activated Mitogen-Activated Protein Kinase and Akt Pathways in Glioblastoma

Available to Purchase
Christopher E. Pelloski, E Lin, Li Zhang, W.K. Alfred Yung, Howard Colman, Juinn-Lin Liu, Shaio Y. Woo, Amy B. Heimberger, Dima Suki, Michael Prados, Susan Chang, Fredrick G. Barker, III, Gregory N. Fuller, Kenneth D. Aldape
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 3935–3941.
https://doi.org/10.1158/1078-0432.CCR-05-2202
Published: 03 July 2006
View articletitled, Prognostic Associations of Activated Mitogen-Activated Protein Kinase and Akt Pathways in Glioblastoma
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Journal Articles

Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients

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Amy B. Heimberger, Roman Hlatky, Dima Suki, David Yang, Jeff Weinberg, Mark Gilbert, Raymond Sawaya, Kenneth Aldape
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (4): 1462–1466.
https://doi.org/10.1158/1078-0432.CCR-04-1737
Published: 02 March 2005
View articletitled, Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients
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Journal Articles

Loss of the AP-2α Transcription Factor Is Associated with the Grade of Human Gliomas

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Amy B. Heimberger, Eric C. McGary, Dima Suki, Maribelis Ruiz, Huamin Wang, Gregory N. Fuller, Menashe Bar-Eli
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (1): 267–272.
https://doi.org/10.1158/1078-0432.267.11.1
Published: 21 January 2005
View articletitled, Loss of the AP-2α Transcription Factor Is Associated with the Grade of Human Gliomas
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Journal Articles

Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors

Available to Purchase
Amy B. Heimberger, Laura E. Crotty, Gary E. Archer, Kenneth R. Hess, Carol J. Wikstrand, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (11): 4247–4254.
Published: 30 September 2003
View articletitled, Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors
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