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Amy B. Heimberger
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Journal Articles

Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma

C. Elizabeth Boudreau, Hinda Najem, Martina Ott, Craig Horbinski, Dexing Fang, Chase M. DeRay, Jonathan M. Levine, Michael A. Curran, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5528–5535.
https://doi.org/10.1158/1078-0432.CCR-21-1914
Published: 15 October 2021
View article titled, Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
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Journal Articles

Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma

Kirit Singh, Kristen A. Batich, Patrick Y. Wen, Aaron C. Tan, Stephen J. Bagley, Michael Lim, Michael Platten, Howard Colman, David M. Ashley, Susan M. Chang, Rifaquat Rahman, Evanthia Galanis, Alireza Mansouri, Vinay K. Puduvalli, David A. Reardon, Solmaz Sahebjam, John H. Sampson, John Simes, Donald A. Berry, Gelareh Zadeh, Tim F. Cloughesy, Minesh P. Mehta, Steven Piantadosi, Michael Weller, Amy B. Heimberger, Mustafa Khasraw
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 585–593.
https://doi.org/10.1158/1078-0432.CCR-21-2681
Published: 24 September 2021
View article titled, Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma
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Journal Articles

Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

Aria Sabbagh, Kevin Beccaria, Xiaoyang Ling, Anantha Marisetty, Martina Ott, Hillary Caruso, Emily Barton, Ling-Yuan Kong, Dexing Fang, Khatri Latha, Daniel Yang Zhang, Jun Wei, John DeGroot, Michael A. Curran, Ganesh Rao, Jian Hu, Carole Desseaux, Guillaume Bouchoux, Michael Canney, Alexandre Carpentier, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4325–4337.
https://doi.org/10.1158/1078-0432.CCR-20-3760
Published: 01 August 2021
View article titled, Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models
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Journal Articles

Radiation with STAT3 Blockade Triggers Dendritic Cell–T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy

Martina Ott, Cynthia Kassab, Anantha Marisetty, Yuuri Hashimoto, Jun Wei, Daniel Zamler, Jia-Shiun Leu, Karl-Heinz Tomaszowski, Aria Sabbagh, Dexing Fang, Pravesh Gupta, Waldemar Priebe, Rafal J. Zielinski, Jared K. Burks, James P. Long, Ling-Yuan Kong, Gregory N. Fuller, John DeGroot, Erik P. Sulman, Amy B. Heimberger
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (18): 4983–4994.
https://doi.org/10.1158/1078-0432.CCR-19-4092
Published: 15 September 2020
View article titled, Radiation with STAT3 Blockade Triggers Dendritic Cell–T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy
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Includes: Multimedia, Supplementary data
Journal Articles

Anti–PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells

Ganesh Rao, Khatri Latha, Martina Ott, Aria Sabbagh, Anantha Marisetty, Xiaoyang Ling, Daniel Zamler, Tiffany A. Doucette, Yuhui Yang, Ling-Yuan Kong, Jun Wei, Gregory N. Fuller, Fernando Benavides, Adam M. Sonabend, James Long, Shulin Li, Michael Curran, Amy B. Heimberger
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (17): 4699–4712.
https://doi.org/10.1158/1078-0432.CCR-19-4110
Published: 01 September 2020
View article titled, Anti–PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells
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Includes: Supplementary data
Journal Articles

CD8+ T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas

Joshua R. Kane, Junfei Zhao, Takashi Tsujiuchi, Brice Laffleur, Víctor A. Arrieta, Aayushi Mahajan, Ganesh Rao, Angeliki Mela, Crismita Dmello, Li Chen, Daniel Y. Zhang, Edgar González-Buendia, Catalina Lee-Chang, Ting Xiao, Gerson Rothschild, Uttiya Basu, Craig Horbinski, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Peter Canoll, Adam M. Sonabend
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (16): 4390–4401.
https://doi.org/10.1158/1078-0432.CCR-19-3104
Published: 14 August 2020
View article titled, CD8<sup>+</sup> T-cell–Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas
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Includes: Supplementary data
Journal Articles

Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial

Shiao-Pei Weathers, Marta Penas-Prado, Be-Lian Pei, Xiaoyang Ling, Cynthia Kassab, Pinaki Banerjee, Mustafa Bdiwi, Hila Shaim, Abdullah Alsuliman, Mayra Shanley, John F. de Groot, Barbara J. O'Brien, Rebecca Harrison, Nazanin Majd, Carlos Kamiya-Matsuoka, Gregory N. Fuller, Jason T. Huse, Linda Chi, Ganesh Rao, Jeffrey S. Weinberg, Frederick F. Lang, Raymond Sawaya, Elizabeth J. Shpall, Katayoun Rezvani, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3565–3577.
https://doi.org/10.1158/1078-0432.CCR-20-0176
Published: 15 July 2020
View article titled, Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial
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Includes: Supplementary data
Journal Articles

Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege

Peter E. Fecci, Amy B. Heimberger, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (22): 5620–5629.
https://doi.org/10.1158/1078-0432.CCR-14-0832
Published: 13 November 2014
View article titled, Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege
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Journal Articles

Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype

Kristine Dziurzynski, Jun Wei, Wei Qiao, Mustafa Aziz Hatiboglu, Ling-Yuan Kong, Adam Wu, Yongtao Wang, Daniel Cahill, Nicholas Levine, Sujit Prabhu, Ganesh Rao, Raymond Sawaya, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4642–4649.
https://doi.org/10.1158/1078-0432.CCR-11-0414
Published: 17 July 2011
View article titled, Glioma-Associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype
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Includes: Supplementary data
Journal Articles

Intratumoral Mediated Immunosuppression is Prognostic in Genetically Engineered Murine Models of Glioma and Correlates to Immunotherapeutic Responses

Ling-Yuan Kong, Adam S. Wu, Tiffany Doucette, Jun Wei, Waldemar Priebe, Gregory N. Fuller, Wei Qiao, Raymond Sawaya, Ganesh Rao, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (23): 5722–5733.
https://doi.org/10.1158/1078-0432.CCR-10-1693
Published: 06 December 2010
View article titled, Intratumoral Mediated Immunosuppression is Prognostic in Genetically Engineered Murine Models of Glioma and Correlates to Immunotherapeutic Responses
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Journal Articles

Inhibition of p-STAT3 Enhances IFN-α Efficacy against Metastatic Melanoma in a Murine Model

Ling-Yuan Kong, Alexander Gelbard, Jun Wei, Chantal Reina-Ortiz, Yongtao Wang, Eric C. Yang, Yared Hailemichael, Izabela Fokt, Arumugam Jayakumar, Wei Qiao, Gregory N. Fuller, Willem W. Overwijk, Waldemar Priebe, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (9): 2550–2561.
https://doi.org/10.1158/1078-0432.CCR-10-0279
Published: 28 April 2010
View article titled, Inhibition of p-STAT3 Enhances IFN-α Efficacy against Metastatic Melanoma in a Murine Model
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Journal Articles

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

Jun Wei, Jason Barr, Ling-Yuan Kong, Yongtao Wang, Adam Wu, Amit K. Sharma, Joy Gumin, Verlene Henry, Howard Colman, Raymond Sawaya, Frederick F. Lang, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 461–473.
https://doi.org/10.1158/1078-0432.CCR-09-1983
Published: 14 January 2010
View article titled, Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression
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Journal Articles

The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas

Mohamed Abou-Ghazal, David S. Yang, Wei Qiao, Chantal Reina-Ortiz, Jun Wei, Ling-Yuan Kong, Gregory N. Fuller, Nobuyoshi Hiraoka, Waldemar Priebe, Raymond Sawaya, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8228–8235.
https://doi.org/10.1158/1078-0432.CCR-08-1329
Published: 15 December 2008
View article titled, The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas
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Journal Articles

A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

Ling-Yuan Kong, Mohamed K. Abou-Ghazal, Jun Wei, Arup Chakraborty, Wei Sun, Wei Qiao, Gregory N. Fuller, Izabela Fokt, Elizabeth A. Grimm, Robert J. Schmittling, Gary E. Archer, Jr., John H. Sampson, Waldemar Priebe, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5759–5768.
https://doi.org/10.1158/1078-0432.CCR-08-0377
Published: 14 September 2008
View article titled, A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells
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Journal Articles

Incidence and Prognostic Impact of FoxP3+ Regulatory T Cells in Human Gliomas

Amy B. Heimberger, Mohamed Abou-Ghazal, Chantal Reina-Ortiz, David S. Yang, Wei Sun, Wei Qiao, Nobuyoshi Hiraoka, Gregory N. Fuller
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5166–5172.
https://doi.org/10.1158/1078-0432.CCR-08-0320
Published: 12 August 2008
View article titled, Incidence and Prognostic Impact of FoxP3<sup>+</sup> Regulatory T Cells in Human Gliomas
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Journal Articles

Cytochrome P450 1B1 Expression in Glial Cell Tumors: An Immunotherapeutic Target

Julia A. Barnett, Diana L. Urbauer, Graeme I. Murray, Gregory N. Fuller, Amy B. Heimberger
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (12): 3559–3567.
https://doi.org/10.1158/1078-0432.CCR-06-2430
Published: 15 June 2007
View article titled, Cytochrome <em>P</em>450 1B1 Expression in Glial Cell Tumors: An Immunotherapeutic Target
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Journal Articles

Prognostic Associations of Activated Mitogen-Activated Protein Kinase and Akt Pathways in Glioblastoma

Christopher E. Pelloski, E Lin, Li Zhang, W.K. Alfred Yung, Howard Colman, Juinn-Lin Liu, Shaio Y. Woo, Amy B. Heimberger, Dima Suki, Michael Prados, Susan Chang, Fredrick G. Barker, III, Gregory N. Fuller, Kenneth D. Aldape
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 3935–3941.
https://doi.org/10.1158/1078-0432.CCR-05-2202
Published: 03 July 2006
View article titled, Prognostic Associations of Activated Mitogen-Activated Protein Kinase and Akt Pathways in Glioblastoma
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Journal Articles

Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients

Amy B. Heimberger, Roman Hlatky, Dima Suki, David Yang, Jeff Weinberg, Mark Gilbert, Raymond Sawaya, Kenneth Aldape
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (4): 1462–1466.
https://doi.org/10.1158/1078-0432.CCR-04-1737
Published: 02 March 2005
View article titled, Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients
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Journal Articles

Loss of the AP-2α Transcription Factor Is Associated with the Grade of Human Gliomas

Amy B. Heimberger, Eric C. McGary, Dima Suki, Maribelis Ruiz, Huamin Wang, Gregory N. Fuller, Menashe Bar-Eli
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (1): 267–272.
https://doi.org/10.1158/1078-0432.267.11.1
Published: 21 January 2005
View article titled, Loss of the AP-2α Transcription Factor Is Associated with the Grade of Human Gliomas
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Journal Articles

Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors

Amy B. Heimberger, Laura E. Crotty, Gary E. Archer, Kenneth R. Hess, Carol J. Wikstrand, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, John H. Sampson
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (11): 4247–4254.
Published: 30 September 2003
View article titled, Epidermal Growth Factor Receptor VIII Peptide Vaccination Is Efficacious against Established Intracerebral Tumors
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